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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2025-2-82-86</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-2489</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group></article-categories><title-group><article-title>Drug-induced dyskinesia when taking Fluvoxamine</article-title><trans-title-group xml:lang="ru"><trans-title>Лекарственные дискинезии при приеме флувоксамина</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9046-3532</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каток</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Katok</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра психиатрии и медицинской психологии </p><p>20012, Казань, ул. Бутлерова, 49;420141, Казань, ул. Кул Гали, 9/95</p></bio><bio xml:lang="en"><p>Department of psychiatry and medical psychology </p><p>49, Butlerova St., Kazan 420012;9/95, Kul Gali St., Kazan 420141</p></bio><email xlink:type="simple">alenaakatok@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1831-330X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хасанова</surname><given-names>Д. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Khasanova</surname><given-names>D. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>центр экстрапирамидных заболеваний;кафедра цифровых технологий в здравоохранении </p><p>420063, Казань, ул. Исаева, 5;420012, Казань, ул. Бутлерова, 49</p></bio><bio xml:lang="en"><p>Center for extrapyramidal diseases;Department of Digital Technologies in Healthcare </p><p>5, Isaeva St., Kazan 420063;49, Butlerova St., Kazan 420012</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9935-3284</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хасанов</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khasanov</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра цифровых технологий в здравоохранении </p><p>420012, Казань, ул. Бутлерова, 49</p></bio><bio xml:lang="en"><p>Department of Digital Technologies in Healthcare </p><p>49, Butlerova St., Kazan 420012</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России;&#13;
ООО «Научно-медицинский центр Яхиных»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kazan State Medical University, Ministry of Health of Russia;&#13;
“Scientific Medical Center Yakhinykh” LLC</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГАУЗ «Госпиталь для ветеранов войн»;&#13;
ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Hospital for War Veterans;&#13;
Kazan State Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kazan State Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>21</day><month>04</month><year>2025</year></pub-date><volume>17</volume><issue>2</issue><fpage>82</fpage><lpage>86</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Katok A.A., Khasanova D.M., Khasanov I.A., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Каток А.А., Хасанова Д.М., Хасанов И.А.</copyright-holder><copyright-holder xml:lang="en">Katok A.A., Khasanova D.M., Khasanov I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/2489">https://nnp.ima-press.net/nnp/article/view/2489</self-uri><abstract><p>Drug-induced movement disorders (DIMD) are a significant problem in clinical practice, especially in the context of the use of psychotropic drugs. These disorders can significantly worsen the quality of life of patients and lead to additional difficulties in the treatment of the underlying disease. In recent years, there has been a growing interest in this topic, which is associated with an increase in the number of antidepressants and antipsychotics prescribed and an increasing awareness of possible side effects. Fluvoxamine is one of the most common selective serotonin reuptake inhibitor, and its use is associated with the risk of developing adverse phenomena such as dystonia and tremor. This emphasizes the need for careful monitoring of the patient's condition and assessment of the risk/benefit ratio. The relevance of the problem is also reinforced by the fact that DIMD can manifest differently in different patients, requiring an individualized approach in each case. In this regard, it is important to continue research in this area in order to better understand the mechanisms of occurrence and methods of treatment of DIMD. We describe a clinical case of the development of dose-dependent DIMD in a patient with an obsessive-compulsive disorder who took Fluvoxamin at a dose of 225 mg/day. As a treatment of acute motor disorders caused by Fluvoxamin, the use of amantadine sulfate (PK-Merz) is being considered, which has a complex effect on neurotransmitter systems and has been shown to be effective in stopping this undesirable phenomenon. It should be noted that Fluvoxamin may have a beneficial effect in tardive dyskinesia and chorea, but the mechanisms of this effect are still poorly understood.</p></abstract><trans-abstract xml:lang="ru"><p>Лекарственно-индуцированные расстройства движений (ЛИДР) представляют собой значимую проблему в клинической практике, особенно в контексте использования психотропных препаратов. Эти расстройства могут существенно ухудшать качество жизни пациентов и приводить к дополнительным трудностям в лечении основного заболевания. В последние годы наблюдается рост интереса к этой теме, что связано с увеличением числа назначаемых антидепрессантов и антипсихотиков, а также с повышением осведомленности о возможных побочных эффектах. Флувоксамин является одним из наиболее распространенных селективных ингибиторов обратного захвата серотонина, и его назначение ассоциируется с риском развития таких нежелательных явлений, как дистония и тремор. Это подчеркивает необходимость внимательного мониторинга состояния пациентов и оценки соотношения риска и пользы при его назначении. Актуальность проблемы также усиливается тем фактом, что ЛИДР могут проявляться по-разному у разных пациентов, что требует индивидуального подхода в каждом конкретном случае. В связи с этим важно продолжать исследования в этой области для лучшего понимания механизмов возникновения и методов лечения ЛИДР. Представлен клинический случай развития дозозависимого ЛИДР у пациента с обсессивно-компульсивным расстройством, принимавшего флувоксамин в дозе 225 мг/сут. В качестве лечения острых двигательных расстройств, вызванных флувоксамином, рассматривается использование амантадина сульфата (ПК-Мерц), который обладает комплексным действием на нейротрансмиттерные системы и показал эффективность в купировании данного нежелательного явления. Следует отметить, что флувоксамин может иметь и потенциальное положительное влияние на поздние дискинезии и хорею, однако механизмы этого эффекта остаются недостаточно изученными.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лекарственно-индуцированные двигательные расстройства</kwd><kwd>лекарственная дистония</kwd><kwd>антидепрессант</kwd><kwd>флувоксамин</kwd><kwd>амантадина сульфат</kwd><kwd>ПК-Мерц</kwd></kwd-group><kwd-group xml:lang="en"><kwd>drug-induced motor disorders</kwd><kwd>dystonia drug-induced</kwd><kwd>antidepressant</kwd><kwd>Fluvoxamine</kwd><kwd>Amantadine Sulfate</kwd><kwd>PK-Merz</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bakheit A. The syndrome of motor restlessness – a treatable but under-recognised disorder. Postgrad Med J. 1997 Sep;73(863):529-30. doi: 10.1136/pgmj.73.863.529</mixed-citation><mixed-citation xml:lang="en">Bakheit A. 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