nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2025-1-94-101nnp-2454Research ArticleREVIEWSОБЗОРЫTenoxicam. Pharmacological and clinical profileТеноксикам. Фармакологические и клинические особенности действияhttps://orcid.org/0000-0002-9156-7883АфанасьевВ. В.AfanasyevV. V.

195067, Санкт-Петербург, Пискаревский просп., 47, павильон 12

Vasily Vladimirovich Afanasyev

47, Piskarevsky Prosp., pavilion 12, St. Petersburg 195067

https://orcid.org/0000-0003-4947-4779ИскраД. А.IskraD. A.

194100, Санкт-Петербург, ул. Литовская, 2

47, Piskarevsky Prosp., pavilion 12, St. Petersburg 195067

ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииРоссияI.I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaRussian FederationФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава РоссииРоссияSaint-Petersburg State Pediatric Medical University, Ministry of Health of RussiaRussian Federation20251702202517194101Copyright © Afanasyev V.V., Iskra D.A., 20252025Афанасьев В.В., Искра Д.А.Afanasyev V.V., Iskra D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/2454

The review contains information on the pharmacodynamics, pharmacokinetics and clinical pharmacology of the non-steroidal anti-inflammatory drug (NSAID) tenoxicam (trade name – Texared®). Some features of the chemical structure of tenoxicam and the specificity of pharmacological action based on them are discussed, as well as clinical effects that distinguish tenoxicam from its homologues. The efficacy is compared with that of other NSAIDs. Issues of clinical pharmacokinetics (low dissociation constant – pK; exposure levels; long T0.5; Cmax, etc.) are discussed. The clinical part of the review presents comparative studies on tenoxicam and its homologues as well as on combinations of tenoxicam with drugs from other groups.

В обзоре представлены сведения по фармакодинамике, фармакокинетике и клинической фармакологии нестероидного противовоспалительного препарата (НПВП) теноксикам (торговое название – Тексаред®). Рассмотрены некоторые особенности химической структуры теноксикама и обусловленные ею механизмы действия, особенности клинических эффектов, отличающие теноксикам от его гомологов. Представлена сравнительная эффективность с другими НПВП. Обсуждаются вопросы клинической фармакокинетики (низкий показатель константы диссоциации – рК; уровни воздействия; длительный Т0,5; Сmax и др.). В клинической части обзора приведены сравнительные исследования теноксикама и его гомологов, а также комбинации теноксикама с препаратами других групп.

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The authors declare that there are no conflicts of interest present.