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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2025-1-34-40</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-2446</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS AND METHODS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИ</subject></subj-group></article-categories><title-group><article-title>Emotional disturbances in patients in the remote postoperative period after surgical treatment of cerebral aneurysms</article-title><trans-title-group xml:lang="ru"><trans-title>Эмоциональные нарушения у пациентов в отдаленном периоде хирургического лечения аневризм головного мозга</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8975-7875</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шетова</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Shetova I.M</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ирма Мухамедовна Шетова</p><p>125367, Москва, Волоколамское ш., 80</p><p>129090, Москва, Большая Сухаревская пл., 3</p></bio><bio xml:lang="en"><p>Irma Mukhamedovna Shetova</p><p>80, Volokolamskoe Shosse, Moscow, 125367</p><p>3, Bolshaya Sukharevskaya Sq., Moscow, 129090</p></bio><email xlink:type="simple">shetova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2864-9675</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шатохин</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shatokhin</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>125367, Москва, Волоколамское ш., 80</p><p>129090, Москва, Большая Сухаревская пл., 3</p><p>117513, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>80, Volokolamskoe Shosse, Moscow, 125367</p><p>3, Bolshaya Sukharevskaya Sq., Moscow, 129090</p><p>1, Ostrovityanovа St., Moscow, 117997</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4518-9874</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лукьянчиков</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Luk'yanchikov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>125367, Москва, Волоколамское ш., 80</p><p>129090, Москва, Большая Сухаревская пл., 3</p><p>117513, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>80, Volokolamskoe Shosse, Moscow, 125367</p><p>3, Bolshaya Sukharevskaya Sq., Moscow, 129090</p><p>1, Ostrovityanovа St., Moscow, 117997</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2546-5130</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яковлев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Yakovlev</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117485, Москва, ул. Бутлерова, 5А</p></bio><bio xml:lang="en"><p>5A, Butlerova St., Moscow, 117485</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6338-0392</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пирадов</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Piradov</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>125367, Москва, Волоколамское ш., 80</p></bio><bio xml:lang="en"><p>80, Volokolamskoe Shosse, Moscow, 125367</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7206-8926</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крылов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Krylov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>125367, Москва, Волоколамское ш., 80</p><p>129090, Москва, Большая Сухаревская пл., 3</p><p>117513, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>80, Volokolamskoe Shosse, Moscow, 125367</p><p>3, Bolshaya Sukharevskaya Sq., Moscow, 129090</p><p>1, Ostrovityanovа St., Moscow, 117997</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научный центр неврологии»; ГБУЗ г. Москвы «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского» Департамента здравоохранения г. Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Center of Neurology; N.V. Sklifosovsky Research Institute for Emergency Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Научный центр неврологии»; ГБУЗ г. Москвы «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского» Департамента здравоохранения г. Москвы; ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Center of Neurology; N.V. Sklifosovsky Research Institute for Emergency Medicine; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Лаборатория функциональной биохимии нервной системы ФГБУН «Институт высшей нервной деятельности и нейрофизиологии» Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Laboratory of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБНУ «Научный центр неврологии»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Center of Neurology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>16</day><month>02</month><year>2025</year></pub-date><volume>17</volume><issue>1</issue><fpage>34</fpage><lpage>40</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Shetova I.M I.M., Shatokhin T.A., Luk'yanchikov V.A., Yakovlev A.A., Piradov M.A., Krylov V.V., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Шетова И.М., Шатохин Т.А., Лукьянчиков В.А., Яковлев А.А., Пирадов М.А., Крылов В.В.</copyright-holder><copyright-holder xml:lang="en">Shetova I.M I.M., Shatokhin T.A., Luk'yanchikov V.A., Yakovlev A.A., Piradov M.A., Krylov V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/2446">https://nnp.ima-press.net/nnp/article/view/2446</self-uri><abstract><p>Aneurysmal subarachnoid haemorrhage is one of the most severe forms of cerebral stroke, associated with a high mortality and disability rate. Development of emotional disorders (anxiety and depression), as well as functional and cognitive deficits, interfere with resocialisation of patients who have undergone surgery for a cerebral aneurysm, and impair quality of life and exacerbate cognitive impairment.</p><sec><title>Objective</title><p>Objective: to investigate the prevalence of emotional disturbances in the remote postoperative period after surgical treatment of cerebral aneurysms (CA).</p></sec><sec><title>Material and methods</title><p>Material and methods. The prevalence and severity of emotional disturbances in the remote postoperative period after surgical treatment of CA was analysed, mean time after surgery was 3.5 years. Two hundred and one patients underwent surgery for a CA rupture, 110 for a non-ruptured aneurysm. On admission to hospital for surgical treatment, patients underwent a clinical and diagnostic examination to confirm the diagnosis and determine the extent, timing and type of intervention. In the remote postoperative period, the degree of limitation of self-care and functional capacity (using the Barthel Index and the modified Rankin Scale), cognitive functioning (using the MoCA test) and emotional domain (using the HADS scale) were assessed.</p></sec><sec><title>Results</title><p>Results. In the remote postoperative period following surgical treatment of CA, subclinical and clinically significant anxiety was found in 110 (36.3%) patients and depression – in 117 (38.6%). The severity of anxiety and depressive disorders did not decrease over time. The mean score on the HADS anxiety scale during the first year after surgery was 5.9±2.8; after 5 years and more – 6.1±3.4. The mean score on the depression scale in patients tested within 1 year after surgery was 7.3±3.3; after 5 years and more – 6.7±3.5. A correlation was found between the severity of vasospasm and anxiety disorders in the remote postoperative period: anxiety symptoms predominated in patients with normal linear blood flow velocity compared to patients diagnosed with vasospasm (p=0.03). The condition of patients at hospital discharge was also associated with the severity of anxiety symptoms in the remote postoperative period: as the Glasgow Outcome Scale (GOS) score increased, so did the severity of anxiety disorders. A statistically significant correlation was found between the groups of patients with a GOS score of 3 and 5 points (p=0.016). A significant predominance of anxiety and depressive disturbances was found in female patients in the remote postoperative phase of surgical treatment (p&lt;0.001 and p=0.002, respectively). Conclusion. Emotional disturbances in patients who underwent surgery for CA persist for a long time, with anxiety disorders predominating in patients without overt neurological disorders during hospitalization. Both anxiety disorders and depressive disorders occur most frequently in female patients. The persistence of emotional disturbances over a long period of time after the exclusion of the aneurysm from the circulation shows the need for their correction in terms of 0.001 and p=0.002, respectively).</p></sec><sec><title>Conclusion</title><p>Conclusion. Emotional disturbances in patients who underwent surgery for CA persist for a long time, with anxiety disorders predominating in patients without overt neurological disorders during hospitalization. Both anxiety disorders and depressive disorders occur most frequently in female patients. The persistence of emotional disturbances over a long period of time after the exclusion of the aneurysm from the circulation shows the need for their correction in terms of patient's social adaptation.</p></sec></abstract><trans-abstract xml:lang="ru"><p>Аневризматическое субарахноидальное кровоизлияние – один из самых тяжелых типов церебральных инсультов, сопровождающийся высокими показателями летальности и инвалидности. Ресоциализации пациентов, оперированных по поводу аневризм головного мозга, наряду с формированием функционального и когнитивного дефицита, препятствует развитие эмоциональных расстройств (тревоги и депрессии), снижающих качество жизни и усугубляющих когнитивные нарушения.</p><p>Цель исследования – изучить распространенность эмоциональных расстройств в отдаленном периоде хирургического лечения церебральных аневризм (ЦА).</p><sec><title>Материал и методы</title><p>Материал и методы. Проведен анализ распространенности и выраженности эмоциональных нарушений в отдаленном периоде хирургического лечения ЦА в среднем через 3,5 года после операции. Двести один пациент был прооперирован после разрыва ЦА, 110 – по поводу неразорвавшейся аневризмы. При поступлении в стационар для хирургического лечения пациентам выполняли клиникодиагностическое обследование с целью подтверждения диагноза и определения объема, сроков и вида вмешательства. В отдаленном периоде проводили оценку степени ограничения самообслуживания и функциональной дееспособности (с использованием индекса Бартел и Модифицированной шкалы Рэнкина), когнитивных функций (с помощью MoCA-теста) и эмоциональной сферы (с использованием шкалы HADS).</p></sec><sec><title>Результаты</title><p>Результаты. В отдаленном периоде хирургического лечения аневризм головного мозга субклинически и клинически значимая тревога установлена у 110 (36,3%) пациентов, депрессия – у 117 (38,6%). Выраженность тревожно-депрессивных расстройств со временем не снижалась. Средний балл по шкале тревоги HADS в течение первого года после перенесенной операции составил 5,9±2,8; спустя 5 лет и более – 6,1±3,4. Средний балл по шкале депрессии у пациентов, тестированных в течение 1 года после перенесенного хирургического вмешательства, составил 7,3±3,3; спустя 5 лет и более – 6,7±3,5. Выявлена связь между выраженностью сосудистого спазма и тревожными расстройствами в отдаленном периоде: у пациентов с нормальной линейной скоростью кровотока симптомы тревоги преобладали по сравнению с пациентами, у которых был диагностирован сосудистый спазм (р=0,03). Состояние пациентов при выписке из стационара также было ассоциировано с выраженностью симптомов тревоги в отдаленном периоде: по мере увеличения балла по Шкале исходов Глазго (ШИГ) увеличивалась выраженность тревожных расстройств. Статистически значимая связь установлена между группами пациентов с оценкой по ШИГ, соответствовавшей 3 и 5 баллам (р=0,016). Установлено значимое преобладание тревожных и депрессивных расстройств у пациентов женского пола в отдаленном периоде хирургического лечения (р&lt;0,001и р=0,002 соответственно).</p></sec><sec><title>Заключение</title><p>Заключение. Эмоциональные расстройства у пациентов, перенесших хирургическое вмешательство по поводу аневризм головного мозга, сохраняются в течение длительного времени. Тревожные расстройства преобладают у пациентов без выраженных неврологических расстройств на период госпитализации. Расстройства как тревожного, так и депрессивного спектра преобладают у пациентов женского пола. Персистирование эмоциональных нарушений в течение длительного времени после выключения аневризмы из кровотока диктует необходимость их коррекции с целью социальной адаптации пациента.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>аневризма головного мозга</kwd><kwd>субарахноидальное кровоизлияние</kwd><kwd>хирургическое лечение</kwd><kwd>эмоциональные нарушения</kwd><kwd>тревога</kwd><kwd>депрессия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cerebral aneurysm</kwd><kwd>subarachnoid hemorrhage</kwd><kwd>surgical treatment</kwd><kwd>emotional disturbances</kwd><kwd>anxiety</kwd><kwd>depression</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование не имело спонсорской поддержки</funding-statement><funding-statement xml:lang="en">The investigation has not been sponsored</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nieuwkamp DJ, Vaartjes I, Algra A, et al. 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