nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2024-1-75-81nnp-2186Research ArticleCLINICAL OBSERVATIONSКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯClinical case of an atypical course of autoimmune anti-NMDA encephalitisКлинический случай нетипичного течения аутоиммунного анти-NMDA-энцефалитаhttps://orcid.org/0000-0001-9245-8067ГолдобинВ. В.GoldobinV. V.

195067, Санкт-Петербург, Пискаревский просп., 47, павильон 12

47, Piskarevsky Prosp., pavilion 12, St. Petersburg 195067

Vitalii.Goldobin@szgmu.ruhttps://orcid.org/0000-0001-6814-0454КлочеваЕ. Г.KlochevaE. G.

195067, Санкт-Петербург, Пискаревский просп., 47, павильон 12

47, Piskarevsky Prosp., pavilion 12, St. Petersburg 195067

https://orcid.org/0000-0002-3708-3378ДильА. В.DilA. V.

195067, Санкт-Петербург, Пискаревский просп., 47, павильон 12

47, Piskarevsky Prosp., pavilion 12, St. Petersburg 195067

https://orcid.org/0000-0002-7507-8609ГоловкинВ. И.GolovkinV. I.

195067, Санкт-Петербург, Пискаревский просп., 47, павильон 12

47, Piskarevsky Prosp., pavilion 12, St. Petersburg 195067

https://orcid.org/0000-0003-3307-0083ЧистоваИ. В.ChistovaI. V.

195067, Санкт-Петербург, Пискаревский просп., 47, павильон 12

47, Piskarevsky Prosp., pavilion 12, St. Petersburg 195067

ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииРоссияNorth-Western State Medical University named after I.I. Mechnikov, Ministry of Health of RussiaRussian Federation2024220220241617581Copyright © Goldobin V.V., Klocheva E.G., Dil A.V., Golovkin V.I., Chistova I.V., 20242024Голдобин В.В., Клочева Е.Г., Диль А.В., Головкин В.И., Чистова И.В.Goldobin V.V., Klocheva E.G., Dil A.V., Golovkin V.I., Chistova I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/2186

Autoimmune encephalitis with antibodies against NMDA receptor (anti-NMDA encephalitis) is a relatively newly described disease that occupies a leading position among encephalitis of various etiologies. The article presents diagnostic criteria for this disease and describes a case of an atypical course of confirmed anti-NMDA encephalitis. The peculiarities of this observation are the relatively mild course of the disease with the development of generalized seizures, mental and cognitive disorders at the onset of the disease. The difficulties in diagnosis and possible pathogenetic aspects of the disease are discussed.

Аутоиммунный энцефалит с образованием антител к NMDA-рецептору (анти-NMDA-энцефалит) является относительно недавно описанным заболеванием, которое занимает лидирующую позицию по встречаемости среди энцефалитов различной этиологии. В статье приведены диагностические критерии данного заболевания, описан случай нетипичного течения достоверного антиNMDA-энцефалита. Особенностями данного наблюдения являются относительно легкое течение заболевания, при развитии генерализованных судорожных припадков, психических и когнитивных нарушений в дебюте заболевания. Обсуждаются сложности диагностики и возможные патогенетические аспекты заболевания.

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The authors declare that there are no conflicts of interest present.