nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-20236-4-9nnp-2132Research ArticleLECTURESЛЕКЦИЯAssociation of cognitive impairment and arterial hypertensionАссоциация когнитивных нарушений и артериальной гипертензииhttps://orcid.org/0000-0002-8939-0716ИсайкинаО. Ю.IsaykinaO. Yu.

Олеся Юрьевна Исайкина

101000, Москва, Петроверигский пер., 10

Olesya Yurievna Isaykina

110, Petroverigsky Lane, Build. 3, Moscow 101990

oisaykina@gnicpm.ruhttps://orcid.org/0000-0003-0900-4721ВеховаК. А.VekhovaK. A.

119991, Москва, ул. Трубецкая, 8 стр. 2

8, Trubetskaya St., Build. 2, Moscow 119991

https://orcid.org/0009-0003-5690-7808ДроботовГ. С.DrobotovG. S.

119991, Москва, ул. Трубецкая, 8 стр. 2

8, Trubetskaya St., Build. 2, Moscow 119991

https://orcid.org/0009-0000-2050-0553ТахировР. А.TakhirovR. A.

119991, Москва, ул. Трубецкая, 8 стр. 2

8, Trubetskaya St., Build. 2, Moscow 119991

https://orcid.org/0000-0001-6440-8636ИсайкинаМ. А.IsaykinaM. A.

119991, Москва, ул. Трубецкая, 8 стр. 2

8, Trubetskaya St., Build. 2, Moscow 119991

https://orcid.org/0000-0001-5195-8997ГорбуновВ. М.GorbunovV. M.

101000, Москва, Петроверигский пер., 10

110, Petroverigsky Lane, Build. 3, Moscow 101990

ФГБУ «Национальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава РоссииРоссияNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Health of RussiaRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)Russian Federation20231612202315649Copyright © Isaykina O.Y., Vekhova K.A., Drobotov G.S., Takhirov R.A., Isaykina M.A., Gorbunov V.M., 20232023Исайкина О.Ю., Вехова К.А., Дроботов Г.С., Тахиров Р.А., Исайкина М.А., Горбунов В.М.Isaykina O.Y., Vekhova K.A., Drobotov G.S., Takhirov R.A., Isaykina M.A., Gorbunov V.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/2132

Impaired cognitive function (CF) is a common manifestation of brain damage as a target organ of arterial hypertension (AH). The presence of hypertension in middle age increases the risk of developing cognitive impairment (CI) and dementia in old age. At the same time, changes in certain indicators characteristic of AH may serve as predictors of CI and dementia in the future. The review presents data on the effects of endothelial dysfunction and increased arterial stiffness on CF. The small number of papers on the effects of hypertension in middle-aged people on the development of CI emphasizes the importance of investigating this topic, as the incidence of CI in young and middle-aged people has increased in recent years.

Нарушение когнитивных функций (КФ) – частое проявление поражения головного мозга как органа-мишени при артериальной гипертензии (АГ). Наличие АГ в среднем возрасте повышает риск развития когнитивных нарушений (КН) и деменции в пожилом возрасте. При этом изменения определенных показателей, характерных для АГ, могут выступать предикторами КН и деменции в дальнейшем. В обзоре представлены данные о влиянии эндотелиальной дисфункции и повышенной артериальной жесткости на КФ. Небольшое количество работ в литературе о влиянии АГ у лиц среднего возраста на развитие КН подчеркивает важность изучения данного вопроса, поскольку в последние годы частота встречаемости КН у лиц молодого и среднего возраста растет.

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The authors declare that there are no conflicts of interest present.