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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2023-5-46-53</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-2104</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group></article-categories><title-group><article-title>Metamorphosis of a herniated lumbar disc</article-title><trans-title-group xml:lang="ru"><trans-title>Метаморфоз грыжи межпозвоночного поясничного диска</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4950-144X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исайкин</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Isaykin</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексей Иванович Исайкин - кафедра нервных болезней и нейрохирургии.</p><p>119021, Москва, ул. Россолимо, 11, стр. 1</p></bio><bio xml:lang="en"><p>Alexey Ivanovich Isaykin - Department of Nervous Diseases and Neurosurgery.</p><p>11, Rossolimo St., Build. 1, Moscow 119021</p></bio><email xlink:type="simple">alexisa68@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7384-6715</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахмеджанова</surname><given-names>Л. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Akhmedzhanova</surname><given-names>L. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119021, Москва, ул. Россолимо, 11, стр. 1</p></bio><bio xml:lang="en"><p>11, Rossolimo St., Build. 1, Moscow 119021</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-9194-200X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федосеев</surname><given-names>С. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedoseev</surname><given-names>S. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119021, Москва, ул. Россолимо, 11, стр. 1</p></bio><bio xml:lang="en"><p>11, Rossolimo St., Build. 1, Moscow 119021</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-8461-1084</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Заграничная</surname><given-names>В. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Zagranichnaya</surname><given-names>V. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119021, Москва, ул. Россолимо, 11, стр. 1</p></bio><bio xml:lang="en"><p>11, Rossolimo St., Build. 1, Moscow 119021</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Института клинической медицины им. Н.В. Склифосовского ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>23</day><month>10</month><year>2023</year></pub-date><volume>15</volume><issue>5</issue><fpage>46</fpage><lpage>53</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Isaykin A.I., Akhmedzhanova L.T., Fedoseev S.R., Zagranichnaya V.D., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Исайкин А.И., Ахмеджанова Л.Т., Федосеев С.Р., Заграничная В.Д.</copyright-holder><copyright-holder xml:lang="en">Isaykin A.I., Akhmedzhanova L.T., Fedoseev S.R., Zagranichnaya V.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/2104">https://nnp.ima-press.net/nnp/article/view/2104</self-uri><abstract><p>Compression of nerve roots by herniated intervertebral discs (IVD) is a major cause of lumbosacral radiculopathy and often causes problems in patient management. We present a case report of a patient whose initial pain was axial discogenic in nature, probably due to a fissure of the annulus fibrosus, and who later developed LIII–IV radiculopathy. The timing of formation of a sequestered IVD hernia was recorded on MRI. There was no prolonged gradual formation of IVD hernia (bulging, fissure, protrusion, extrusion/sequestration), an acute formation of disc herniation occurred. Conservative treatment, including nonpharmacological (McKenzie gymnastics, educational program) and drug treatment (nonsteroidal anti-inflammatory drugs, anticonvulsants), as well as minimally invasive measures (epidural administration of local anesthetics and glucorticoids), allowed rapid regression of clinical symptoms and improvement of functional and emotional status. MRI of the lumbar spine performed six months after onset showed complete resorption of the IVD hernia. The patient follows ergonomic recommendations and performs therapeutic exercises (Nordic walking); no deterioration was observed within 9 months.</p></abstract><trans-abstract xml:lang="ru"><p>Компрессия нервного корешка грыжей межпозвоночного диска (МПД) является основной причиной пояснично-крестцовой радикулопатии и часто вызывает проблемы при ведении пациентов. Представлено наблюдение пациентки, у которой боль в дебюте носила аксиальный дискогенный характер, вероятно, вследствие трещины фиброзного кольца, а в последующем развилась радикулопатия LIII–IV. Был зафиксирован момент образования секвестрированной грыжи МПД по данным МРТ. Не наблюдалось стадийности образования грыжи МПД (выбухание, трещина, протрузия, экструзия/секвестрация), пролонгированного во времени, – произошло острое образование грыжи диска. Консервативное лечение, включающее немедикаментозные (гимнастика МакКензи, образовательная программа) имедикаметозное лечение (нестероидные противовоспалительные препараты, антиконвульсанты), атакже малоинвазивные мероприятия (эпидуральное введение местных анестетиков сглюкокортикоидами), позволило достичь быстрого регресса клинических симптомов, улучшения функционального иэмоционального статуса. ПриМРТ поясничного отдела позвоночника, выполненной через полгода от дебюта заболевания, выявлена полная резорбция грыжи МПД. Пациентка соблюдает рекомендации по эргономике, выполняет лечебную гимнастику в виде скандинавской ходьбы; в течение 9 мес не наблюдается обострений.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>грыжа диска</kwd><kwd>дискогенная радикулопатия</kwd><kwd>дискогенная боль</kwd><kwd>возникновение грыжи диска</kwd><kwd>регресс грыжи диска</kwd><kwd>патогенез грыжи диска</kwd><kwd>нестероидные противовоспалительные препараты</kwd><kwd>ацеклофенак</kwd><kwd>консервативное лечение грыжи диска</kwd></kwd-group><kwd-group xml:lang="en"><kwd>disc herniation</kwd><kwd>discogenic radiculopathy</kwd><kwd>discogenic pain</kwd><kwd>incidence of disc herniation</kwd><kwd>regression of disc herniation</kwd><kwd>pathogenesis of disc herniation</kwd><kwd>nonsteroidal anti-inflammatory drugs</kwd><kwd>aceclofenac</kwd><kwd>conservative treatment of disc herniation</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Статья спонсируется компанией «Гедеон Рихтер»</funding-statement><funding-statement xml:lang="en">This article has been supported by Gedeon Richter</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА, Яхно НН, Давыдов ОС и др. 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