nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2023-5-39-45nnp-2103Research ArticleCLINICAL OBSERVATIONSКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯOsmotic demyelination syndrome: central pontine and extrapontine myelinolysis in a patient in the early postpartum period. Clinical observationСиндром осмотической демиелинизации: центральный понтинный и экстрапонтинный миелинолиз у пациентки в раннем послеродовом периоде. Клиническое наблюдениеhttps://orcid.org/0000-0002-0804-1128ИсаковаЕ. В.IsakovaE. V.

129110, Москва, ул. Щепкина, 61/2

61/2, Shchepkina St., Build. 1, Moscow 129110

https://orcid.org/0000-0002-9037-0034СтепановаЕ. А.StepanovaE. A.

129110, Москва, ул. Щепкина, 61/2

61/2, Shchepkina St., Build. 1, Moscow 129110

https://orcid.org/0000-0003-2988-5706КотовС. В.KotovS. V.

Сергей Викторович Котов

129110, Москва, ул. Щепкина, 61/2

Sergey Viktorovich Kotov

61/2, Shchepkina St., Build. 1, Moscow 129110

kotovsv@yandex.ruhttps://orcid.org/0000-0003-1509-9608БеловаЮ. А.BelovaYu. A.

129110, Москва, ул. Щепкина, 61/2

61/2, Shchepkina St., Build. 1, Moscow 129110

ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»РоссияM.F. Vladimirsky Moscow Regional Research Clinical InstituteRussian Federation2023231020231553945Copyright © Isakova E.V., Stepanova E.A., Kotov S.V., Belova Y.A., 20232023Исакова Е.В., Степанова Е.А., Котов С.В., Белова Ю.А.Isakova E.V., Stepanova E.A., Kotov S.V., Belova Y.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/2103

The article presents a review of the literature and a description of a clinical case of osmotic demyelination syndrome manifested by pontine and extrapontine myelinolysis in a 36-year-old woman after her third surgical preterm delivery. The reasons for the development of a demyelinating lesion of the central nervous system are discussed, and clinical cases described in world literature sources are presented. An analysis of the pathogenesis of the development of this disease in women during pregnancy, childbirth, and lactation is provided. The importance of this period in a woman's life as an independent significant risk factor for the development of osmotic demyelination syndrome is discussed.

В статье представлены обзор литературы и описание клинического случая синдрома осмотической демиелинизации, проявляющегося понтинным и экстрапонтинным миелинолизом у 36-летней женщины после третьих преждевременных оперативных родов. Обсуждаются причины развития демиелинизирующего поражения центральной нервной системы, приводятся случаи клинических наблюдений, представленные в мировых источниках. Проводится анализ патогенеза развития данного заболевания у женщин во время беременности, родов и лактации. Обсуждается значимость данного периода в жизни женщины как самостоятельного значимого фактора риска развития синдрома осмотической демиелинизации.

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The authors declare that there are no conflicts of interest present.