nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2023-1S-71-75nnp-2082Research ArticleREVIEWSОБЗОРЫDiagnostic criteria and treatment of neuromyelitis optica spectrum disorders (NMOSD)Заболевания спектра оптиконевромиелита (ЗСОНМ) – диагностические критерии и подходы к терапииhttps://orcid.org/0000-0001-7256-2668СиманивТ. О.SimanivT. O.

119991, Ломоносовский проспект, 27, корп. 1

27, Lomonosovsky Prosp., Build. 1, Moscow 119192

https://orcid.org/0000-0003-0982-4324БахтияроваК. З.BakhtiyarovaK. Z.

450008, Уфа, ул. Заки Валиди, 47

47, Zaki Validi St., Ufa 450008

https://orcid.org/0000-0001-9719-6772БеловаА. Н.BelovaA. N.

603005, Нижний Новгород, пл. Минина и Пожарского, 10/1

10/1, Minina and Pozharskogo Sq., Nizhny Novgorod 603005

https://orcid.org/0000-0001-7093-9548ГончароваЗ. А.GoncharovaZ. A.

344022, Ростов-на-Дону, ул. Суворова, 119

119, Suvorova St., Rostov-on-Don 344022

https://orcid.org/0000-0002-9293-5932СиверцеваС. А.SivertsevaS. A.

610998, Киров, ул. К. Маркса, 112

625000, Тюмень, ул. Юрия Семовских, 8/1

112, Karla Marksa St., Kirov 610998

8/1, Yuriya Semovskih St., Tyumen 625000

https://orcid.org/0000-0001-9078-589XСпиринН. Н.SpirinN. N.

150000, Ярославль, ул. Революционная, 5

5, Revolutsionnaya St., Yaroslavl 150000

https://orcid.org/0000-0002-6715-8203ТотолянН. А.TotolyanN. A.

197022, Санкт-Петербург, ул. Льва Толстого, 6-8

6-8, Lva Tolstogo St., St. Petersburg 197022

https://orcid.org/0000-0001-9199-7392ТрушниковаТ. Н.TrushnikovaT. N.

614990, Пермь, ул. Петропавловская, 26

614990, Пермь, ул. Пушкина, 85

26, Petropavlovskaya St., Perm 614990

85, Pushkina St., Perm 614990

ТуроваЕ. Л.TurovaE. L.

620102, Екатеринбург, ул. Волгоградская, 185

185, Volgogradskaya St., Yekaterinburg 620102

https://orcid.org/0000-0002-5009-6683ХайбуллинТ. И.KhaibullinT. I.

420012, Казань ул. Бутлерова, 36

420021, Казань, ул. Ватутина, 13

36, Butlerova St., Kazan 420012

13, Vatutina St., Kazan 420021

https://orcid.org/0000-0001-5740-1022ШерманМ. А.ShermanM. A.

610998, Киров, ул. К. Маркса, 112

112, Karla Marksa St., Kirov 610998

https://orcid.org/0000-0003-4731-3250БойкоА. Н.BoykoA. N.

Алексей Николаевич Бойко

117997, Москва, ул. Островитянова, 1

117997, Москва, ул. Островитянова, 1, стр. 10

Alexey Nikolaevich Boyko

1, Ostrovityanova St., Moscow 117997

1, Ostrovityanova St., Build. 10, Moscow 117997

boykoan13@gmail.comФакультет фундаментальной медицины ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»РоссияDepartment of Fundamental Medicine, M.V. Lomonosov Moscow State UniversityRussian FederationФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава РоссииРоссияBashkir State Medical University, Ministry of Health of RussiaRussian FederationФГБНУ «Приволжский исследовательский медицинский университет» Минздрава РоссииРоссияVolga Research Medical University, Ministry of Health of RussiaRussian Federationкафедра нервных болезней и нейрохирургии ФГБОУ ВО «Ростовский государственный медицинский университет»РоссияDepartment of Nervous Diseases and Neurosurgery, Rostov State Medical University, Ministry of Health of RussiaRussian Federationкафедра неврологии, нейрохирургии и нейрореабилитации ФГБОУ ВО «Кировский государственный медицинский университет» Минздрава России; АО МСЧ «Нефтяник»РоссияDepartment of Neurology, Neurosurgery, and Neurorehabilitation, Kirov State Medical University, Ministry of Health of Russia; Medical and Sanitary Unit “Neftyanik”Russian Federationкафедра нервных болезней с медицинской генетикой и нейрохирургией ФГБОУ ВО «Ярославский государственный медицинский университет» Минздрава РоссииРоссияDepartment of Neurology, Medical Genetics and Neurosurgery, Yaroslavl State Medical University, Ministry of Health of RussiaRussian Federationкафедра неврологии ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава РоссииРоссияDepartment of Neurology, Acad. I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaRussian FederationФГБОУ ВО «Пермский государственный медицинский университет» Минздрава России; Центр рассеянного склероза Пермского края ГБУЗ «Ордена “Знак Почета” Пермская краевая клиническая больница»РоссияDepartment of Neurology, Perm State Medical University, Ministry of Health of Russia; Center for Multiple Sclerosis of the Perm Territory, The “Badge of Honor” Order Perm Regional Clinical HospitalRussian FederationГАУЗ Свердловской области «Свердловская областная клиническая больница №1»РоссияSverdlovsk State Regional Clinical Hospital No 1Russian Federationкафедра неврологии и мануальной терапии Казанской государственной медицинской академии – филиала ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России; Республиканский клинико-диагностический центр по демиелинизирующим заболеваниям Минздрава Республики ТатарстанРоссияDepartment of Neurology and Manual Therapy, Kazan State Medical Academy, Branch of the Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia; Republican Clinical and Diagnostic Center for Demyelinating Diseases Ministry of Health of the Republic of TatarstanRussian Federationкафедра неврологии, нейрохирургии и нейрореабилитации ФГБОУ ВО «Кировский государственный медицинский университет» Минздрава РоссииРоссияDepartment of Neurology, Neurosurgery, and Neurorehabilitation, Kirov State Medical University, Ministry of Health of RussiaRussian Federationкафедра неврологии, нейрохирургии и медицинской генетики ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России; отдел нейроиммунологии Института клинической неврологии ФГБУ «Федеральный центр мозга и нейротехнологий» ФМБА РоссииРоссияDepartment of Neurology, Neurosurgery and Medical Genetics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Department of Neuroimmunology, Institute of Clinical NeurologyRussian Federation202321082023150(Suppl. 1)7175Copyright © Simaniv T.O., Bakhtiyarova K.Z., Belova A.N., Goncharova Z.A., Sivertseva S.A., Spirin N.N., Totolyan N.A., Trushnikova T.N., Turova E.L., Khaibullin T.I., Sherman M.A., Boyko A.N., 20232023Симанив Т.О., Бахтиярова К.З., Белова А.Н., Гончарова З.А., Сиверцева С.А., Спирин Н.Н., Тотолян Н.А., Трушникова Т.Н., Турова Е.Л., Хайбуллин Т.И., Шерман М.А., Бойко А.Н.Simaniv T.O., Bakhtiyarova K.Z., Belova A.N., Goncharova Z.A., Sivertseva S.A., Spirin N.N., Totolyan N.A., Trushnikova T.N., Turova E.L., Khaibullin T.I., Sherman M.A., Boyko A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/2082

Neuromyelitis optic spectrum disorders (NMOSD) are rare, severely disabling diseases of the central nervous system. They are characterized by periodic, unpredictable exacerbations that lead to an accumulation of irreversible neurologic damage. Despite existing possibilities for diagnosing NMOSD, it can be difficult to make the correct diagnosis in clinical practice. Current treatment options for NMOSD include drugs that affect the pathogenesis of the disease, including complement C5 inhibitors, with which experience is still limited, but published data from clinical trials demonstrate high efficacy of these drugs with an acceptable safety profile. The article reviews the main current approaches to the diagnosis and treatment of NMOSD.

Заболевания спектра оптиконевромиелита (ЗСОНМ) представляют собой редкие, вызывающие тяжелую инвалидизацию заболевания центральной нервной системы. Они характеризуются периодическими, непредсказуемыми обострениями, которые приводят к накоплению необратимых неврологических нарушений. Несмотря на существующие возможности диагностики ЗСНОМ, в клинической практике постановка правильного диагноза может вызывать сложности. Современные опции терапии ЗСНОМ включают препараты, воздействующие на патогенез заболевания, в том числе ингибиторы С5-компонента комплемента, опыт применения которых пока ограничен, однако опубликованные данные клинических исследований демонстрируют высокую эффективность этих препаратов при приемлемом профиле безопасности. В статье отражены основные актуальные подходы к диагностике и терапии ЗСНОМ.

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The authors declare that there are no conflicts of interest present.