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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2023-1S-8-14</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-2071</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИ</subject></subj-group></article-categories><title-group><article-title>The place of virtual reality in the rehabilitation of patients with multiple sclerosis</article-title><trans-title-group xml:lang="ru"><trans-title>Место виртуальной реальности в реабилитации пациентов с рассеянным склерозом</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1315-7587</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коржова</surname><given-names>Ю. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Korzhova</surname><given-names>Iu. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>125367, Москва, Волоколамское шоссе, 80</p></bio><bio xml:lang="en"><p>80, Volokolamskoe Shosse, Moscow 125367</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4335-6344</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фукс</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fuks</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>125367, Москва, Волоколамское шоссе, 80</p></bio><bio xml:lang="en"><p>80, Volokolamskoe Shosse, Moscow 125367</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4730-3338</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клочков</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Klochkov</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>125367, Москва, Волоколамское шоссе, 80</p></bio><bio xml:lang="en"><p>80, Volokolamskoe Shosse, Moscow 125367</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1395-6645</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хижникова</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Khizhnikova</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>125367, Москва, Волоколамское шоссе, 80</p></bio><bio xml:lang="en"><p>80, Volokolamskoe Shosse, Moscow 125367</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3956-6362</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Супонева</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Suponeva</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>125367, Москва, Волоколамское шоссе, 80</p></bio><bio xml:lang="en"><p>80, Volokolamskoe Shosse, Moscow 125367</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1072-9968</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Захарова</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zakharova</surname><given-names>M. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мария Николаевна Захарова</p><p>125367, Москва, Волоколамское шоссе, 80</p></bio><bio xml:lang="en"><p>Mariya Nikolaevna Zakharova</p><p>80, Volokolamskoe Shosse, Moscow 125367</p></bio><email xlink:type="simple">zakharova@neurology.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научный центр неврологии»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Center of Neurology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>21</day><month>08</month><year>2023</year></pub-date><volume>15</volume><issue>0</issue><issue-title>(Suppl. 1)</issue-title><fpage>8</fpage><lpage>14</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Korzhova I.E., Fuks A.A., Klochkov A.S., Khizhnikova A.E., Suponeva N.A., Zakharova M.N., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Коржова Ю.Е., Фукс А.А., Клочков А.С., Хижникова А.Е., Супонева Н.А., Захарова М.Н.</copyright-holder><copyright-holder xml:lang="en">Korzhova I.E., Fuks A.A., Klochkov A.S., Khizhnikova A.E., Suponeva N.A., Zakharova M.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/2071">https://nnp.ima-press.net/nnp/article/view/2071</self-uri><abstract><p>Multiple sclerosis (MS) is a chronic autoimmune disease that limits the ability to work and lead an active lifestyle, mostly in young adults. Physical activity, along with drug therapy, is an essential part of the life of a person with MS. In the last decades, rehabilitation of MS patients has made great progress. However, the problem of compliance is still relevant. Virtual reality (VR) based rehabilitation can not only improve the quality of the training process but also increase patient compliance.Objective: to study the literature data on the effectiveness of the techniques of VR in reducing the severity of symptoms of MS and improving the quality of life.Materials and methods. A thorough literature search of the MEDLINE (Pubmed), eLibrary, and Google Schcolar databases was performed. Papers that met two criteria were included in the study: study population – patients with MS; presence of at least one comparison group (standard therapy or no therapy).Results. Based on the results of the analysis, 44 articles were selected. The efficacy of VR in reducing symptoms of MS such as fatigue, balance disturbances, risk factors for falls, mobility, apraxia, impaired hand function was described, as well as the impact on overall quality of life and its components.Conclusions. The VR rehabilitation can have its own place in the general system of physical rehabilitation and also become an effective tool to increase motivation and quality of life at all stages of rehabilitation.</p></abstract><trans-abstract xml:lang="ru"><p>Рассеянный склероз (РС) – это хроническое аутоиммунное заболевание, вследствие которого снижается трудоспособность и активная жизнедеятельность преимущественно молодого населения. Помимо лекарственной терапии, неотъемлемой частью жизни человека с РС становится физическая активность. За последние десятилетия реабилитация пациентов с РС шагнула вперед. Однако по-прежнему актуальна проблема приверженности реабилитации. Методы реабилитации с применением виртуальной реальности (ВР) позволяют не только повысить качество тренировочного процесса, но и увеличить приверженность реабилитационному процессу.Цель исследования – изучить имеющиеся в литературе данные об эффективности методик с применением ВР в отношении уменьшения выраженности симптомов РС и улучшения качества жизни.Материал и методы. Был проведен обзор литературы с использованием баз данных MEDLINE (PubMed), eLibrary, Google Schcolar. В исследование включались работы, соответствующие двум критериям: исследуемая популяция – пациенты с РС; наличие хотя бы одной группы сравнения (стандартная терапия или без терапии).Результаты. По результатам анализа были отобраны 44 статьи. Описана эффективность ВР в снижении таких проявлений РС, как усталость, нарушение равновесия, риск падений, мобильность, апраксия, нарушение функции рук, а также влияние на общее качество жизни и его составляющие.Заключение. Методы реабилитации с применением ВР могут не только занять свое место в общей системе физической реабилитации, но и стать мощным инструментом в повышении мотивации и качества жизни на всех этапах восстановительного лечения.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рассеянный склероз</kwd><kwd>реабилитация</kwd><kwd>виртуальная реальность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>multiple sclerosis</kwd><kwd>rehabilitation</kwd><kwd>virtual reality</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Faissner S, Plemel JR, Gold R, Yong VW. Progressive multiple sclerosis: from pathophysiology to therapeutic strategies. Nat Rev Drug Discov. 2019 Dec;18(12):905-22. doi: 10.1038/s41573-019-0035-2. Epub 2019 Aug 9.</mixed-citation><mixed-citation xml:lang="en">Faissner S, Plemel JR, Gold R, Yong VW. Progressive multiple sclerosis: from pathophysiology to therapeutic strategies. Nat Rev Drug Discov. 2019 Dec;18(12):905-22. doi: 10.1038/s41573-019-0035-2. Epub 2019 Aug 9.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Straudi S, Basaglia N. Neuroplasticity-Based Technologies and Interventions for Restoring Motor Functions in Multiple Sclerosis. In: Asea A, Geraci F, Kaur P (eds). Multiple Sclerosis: Bench to Bedside: Global Perspectives on a Silent Killer. Springer International Publishing; 2017. P. 171-85. doi: 10.1007/978-3-319-47861-6_11</mixed-citation><mixed-citation xml:lang="en">Straudi S, Basaglia N. Neuroplasticity-Based Technologies and Interventions for Restoring Motor Functions in Multiple Sclerosis. In: Asea A, Geraci F, Kaur P (eds). Multiple Sclerosis: Bench to Bedside: Global Perspectives on a Silent Killer. Springer International Publishing; 2017. P. 171-85. doi: 10.1007/978-3-319-47861-6_11</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Tomassini V, Matthews PM, Thompson AJ, et al. Neuroplasticity and functional recovery in multiple sclerosis. Nat Rev Neurol. 2012 Sep;8(11):635-46. doi: 10.1038/nrneurol. 2012.179</mixed-citation><mixed-citation xml:lang="en">Tomassini V, Matthews PM, Thompson AJ, et al. Neuroplasticity and functional recovery in multiple sclerosis. Nat Rev Neurol. 2012 Sep;8(11):635-46. doi: 10.1038/nrneurol. 2012.179</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Rocca MA, Colombo B, Falini A, et al. Cortical adaptation in patients with MS: a cross-sectional functional MRI study of disease phenotypes. Lancet Neurol. 2005 Oct;4(10):618-26. doi: 10.1016/S1474-4422(05)70171-X</mixed-citation><mixed-citation xml:lang="en">Rocca MA, Colombo B, Falini A, et al. Cortical adaptation in patients with MS: a cross-sectional functional MRI study of disease phenotypes. Lancet Neurol. 2005 Oct;4(10):618-26. doi: 10.1016/S1474-4422(05)70171-X</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kleim JA, Jones TA. Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage. J Speech Lang Hear Res. 2008 Feb;51(1):S225-39. doi: 10.1044/1092-4388(2008/018)</mixed-citation><mixed-citation xml:lang="en">Kleim JA, Jones TA. Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage. J Speech Lang Hear Res. 2008 Feb;51(1):S225-39. doi: 10.1044/1092-4388(2008/018)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Shobeiri P, Karimi A, Momtazmanesh S, et al. Exercise-induced increase in blood-based brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis: A systematic review and meta-analysis of exercise intervention trials. PLoS One. 2022 Mar 3;17(3):e0264557. doi: 10.1371/journal.pone.0264557</mixed-citation><mixed-citation xml:lang="en">Shobeiri P, Karimi A, Momtazmanesh S, et al. Exercise-induced increase in blood-based brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis: A systematic review and meta-analysis of exercise intervention trials. PLoS One. 2022 Mar 3;17(3):e0264557. doi: 10.1371/journal.pone.0264557</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Briken S, Rosenkranz SC, Keminer O, et al. Effects of exercise on Irisin, BDNF and IL-6 serum levels in patients with progressive multiple sclerosis. J Neuroimmunol. 2016 Oct 15;299:53-8. doi: 10.1016/j.jneuroim.2016.08.007. Epub 2016 Aug 5.</mixed-citation><mixed-citation xml:lang="en">Briken S, Rosenkranz SC, Keminer O, et al. Effects of exercise on Irisin, BDNF and IL-6 serum levels in patients with progressive multiple sclerosis. J Neuroimmunol. 2016 Oct 15;299:53-8. doi: 10.1016/j.jneuroim.2016.08.007. Epub 2016 Aug 5.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Устинова КИ, Черникова ЛА, Хижникова АЕ и др. Теоретическое обоснование классических методов двигательной реабилитации в неврологии. Анналы клинической и экспериментальной неврологии. 2018;12(3):54-60. doi: 10.25692/ACEN.2018.3.7</mixed-citation><mixed-citation xml:lang="en">Ustinova KI, Chernikova LA, Khizhnikova AE, et al. Theoretical basis for classical methods of motor rehabilitation in neurology. Annaly klinicheskoy i eksperimental'noy nevrologii = Annals of Clinical and Experimental Neurology. 2018;12(3):54-60. doi: 10.25692/ACEN.2018.3.7 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hao J, Xie H, Harp K, et al. Effects of Virtual Reality Intervention on Neural Plasticity in Stroke Rehabilitation: A Systematic Review. Arch Phys Med Rehabil. 2022 Mar;103(3):523-41. doi: 10.1016/j.apmr.2021.06.024. Epub 2021 Aug 2.</mixed-citation><mixed-citation xml:lang="en">Hao J, Xie H, Harp K, et al. Effects of Virtual Reality Intervention on Neural Plasticity in Stroke Rehabilitation: A Systematic Review. Arch Phys Med Rehabil. 2022 Mar;103(3):523-41. doi: 10.1016/j.apmr.2021.06.024. Epub 2021 Aug 2.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Naro A, Calabro RS. What Do We Know about The Use of Virtual Reality in the Rehabilitation Field? A Brief Overview. Electronics (Basel). 2021;10(9). doi: 10.3390/electronics10091042</mixed-citation><mixed-citation xml:lang="en">Naro A, Calabro RS. What Do We Know about The Use of Virtual Reality in the Rehabilitation Field? A Brief Overview. Electronics (Basel). 2021;10(9). doi: 10.3390/electronics10091042</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Laver KE, Lange B, George S, et al. Virtual reality for stroke rehabilitation. Cochrane Database Syst Rev. 2017 Nov 20;11(11):CD008349. doi: 10.1002/14651858.CD008349.pub4</mixed-citation><mixed-citation xml:lang="en">Laver KE, Lange B, George S, et al. Virtual reality for stroke rehabilitation. Cochrane Database Syst Rev. 2017 Nov 20;11(11):CD008349. doi: 10.1002/14651858.CD008349.pub4</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Tieri G, Morone G, Paolucci S, Iosa M. Virtual reality in cognitive and motor rehabilitation: facts, fiction and fallacies. Expert Rev Med Devices. 2018 Feb;15(2):107-17. doi: 10.1080/17434440.2018.1425613. Epub 2018 Jan 10.</mixed-citation><mixed-citation xml:lang="en">Tieri G, Morone G, Paolucci S, Iosa M. Virtual reality in cognitive and motor rehabilitation: facts, fiction and fallacies. Expert Rev Med Devices. 2018 Feb;15(2):107-17. doi: 10.1080/17434440.2018.1425613. Epub 2018 Jan 10.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Maggio MG, Russo M, Cuzzola MF, et al. Virtual reality in multiple sclerosis rehabilitation: A review on cognitive and motor outcomes. J Clin Neurosci. 2019 Jul;65:106-11. doi: 10.1016/j.jocn.2019.03.017. Epub 2019 Mar 18.</mixed-citation><mixed-citation xml:lang="en">Maggio MG, Russo M, Cuzzola MF, et al. Virtual reality in multiple sclerosis rehabilitation: A review on cognitive and motor outcomes. J Clin Neurosci. 2019 Jul;65:106-11. doi: 10.1016/j.jocn.2019.03.017. Epub 2019 Mar 18.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Dockx K, Bekkers EM, Van den Bergh V, et al. Virtual reality for rehabilitation in Parkinson's disease. Cochrane Database Syst Rev. 2016 Dec 21;12(12):CD010760. doi: 10.1002/14651858.CD010760.pub2</mixed-citation><mixed-citation xml:lang="en">Dockx K, Bekkers EM, Van den Bergh V, et al. Virtual reality for rehabilitation in Parkinson's disease. Cochrane Database Syst Rev. 2016 Dec 21;12(12):CD010760. doi: 10.1002/14651858.CD010760.pub2</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Weiss PL, Kizony R, Feintuch U, et al. Virtual reality applications in neurorehabilitation. In: Kwakkel G, Cohen LG, Selzer ME, Miller RH, Clarke S (eds). Textbook of Neural Repair and Rehabilitation. Vol. 2: Medical Neurorehabilitation. 2nd ed. Cambridge University Press; 2014. P. 198-218. doi: 10.1017/CBO9780511995590.021</mixed-citation><mixed-citation xml:lang="en">Weiss PL, Kizony R, Feintuch U, et al. Virtual reality applications in neurorehabilitation. In: Kwakkel G, Cohen LG, Selzer ME, Miller RH, Clarke S (eds). Textbook of Neural Repair and Rehabilitation. Vol. 2: Medical Neurorehabilitation. 2nd ed. Cambridge University Press; 2014. P. 198-218. doi: 10.1017/CBO9780511995590.021</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">An CM, Park YH. The effects of semiimmersive virtual reality therapy on standing balance and upright mobility function in individuals with chronic incomplete spinal cord injury: A preliminary study. J Spinal Cord Med. 2018 Mar;41(2):223-9. doi: 10.1080/10790268.2017.1369217. Epub 2017 Sep 7.</mixed-citation><mixed-citation xml:lang="en">An CM, Park YH. The effects of semiimmersive virtual reality therapy on standing balance and upright mobility function in individuals with chronic incomplete spinal cord injury: A preliminary study. J Spinal Cord Med. 2018 Mar;41(2):223-9. doi: 10.1080/10790268.2017.1369217. Epub 2017 Sep 7.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Maggio MG, De Luca R, Manuli A, et al. Do patients with multiple sclerosis benefit from semi-immersive virtual reality? A randomized clinical trial on cognitive and motor outcomes. Appl Neuropsychol Adult. 2022 Jan-Feb;29(1):59-65. doi: 10.1080/23279095.2019.1708364. Epub 2020 Jan 10.</mixed-citation><mixed-citation xml:lang="en">Maggio MG, De Luca R, Manuli A, et al. Do patients with multiple sclerosis benefit from semi-immersive virtual reality? A randomized clinical trial on cognitive and motor outcomes. Appl Neuropsychol Adult. 2022 Jan-Feb;29(1):59-65. doi: 10.1080/23279095.2019.1708364. Epub 2020 Jan 10.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Truijen S, Abdullahi A, Bijsterbosch D, et al. Effect of home-based virtual reality training and telerehabilitation on balance in individuals with Parkinson disease, multiple sclerosis, and stroke: a systematic review and meta-analysis. Neurol Sci. 2022 May;43(5):2995-3006. doi: 10.1007/s10072-021-05855-2. Epub 2022 Feb 17.</mixed-citation><mixed-citation xml:lang="en">Truijen S, Abdullahi A, Bijsterbosch D, et al. Effect of home-based virtual reality training and telerehabilitation on balance in individuals with Parkinson disease, multiple sclerosis, and stroke: a systematic review and meta-analysis. Neurol Sci. 2022 May;43(5):2995-3006. doi: 10.1007/s10072-021-05855-2. Epub 2022 Feb 17.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Perrochon A, Borel B, Istrate D, et al. Exercise-based games interventions at home in individuals with a neurological disease: A systematic review and meta-analysis. Ann Phys Rehabil Med. 2019 Sep;62(5):366-78. doi: 10.1016/j.rehab.2019.04.004. Epub 2019 May 9.</mixed-citation><mixed-citation xml:lang="en">Perrochon A, Borel B, Istrate D, et al. Exercise-based games interventions at home in individuals with a neurological disease: A systematic review and meta-analysis. Ann Phys Rehabil Med. 2019 Sep;62(5):366-78. doi: 10.1016/j.rehab.2019.04.004. Epub 2019 May 9.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Llorens R, Noe E, Colomer C, Alcaniz M. Effectiveness, usability, and cost-benefit of a virtual reality-based telerehabilitation program for balance recovery after stroke: a randomized controlled trial. Arch Phys Med Rehabil. 2015 Mar;96(3):418-425.e2. doi: 10.1016/j.apmr.2014.10.019. Epub 2014 Nov 13.</mixed-citation><mixed-citation xml:lang="en">Llorens R, Noe E, Colomer C, Alcaniz M. Effectiveness, usability, and cost-benefit of a virtual reality-based telerehabilitation program for balance recovery after stroke: a randomized controlled trial. Arch Phys Med Rehabil. 2015 Mar;96(3):418-425.e2. doi: 10.1016/j.apmr.2014.10.019. Epub 2014 Nov 13.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Webster A, Poyade M, Rooney S, Paul L. Upper limb rehabilitation interventions using virtual reality for people with multiple sclerosis: A systematic review. Mult Scler Relat Disord. 2021 Jan;47:102610. doi: 10.1016/j.msard.2020.102610. Epub 2020 Oct 31.</mixed-citation><mixed-citation xml:lang="en">Webster A, Poyade M, Rooney S, Paul L. Upper limb rehabilitation interventions using virtual reality for people with multiple sclerosis: A systematic review. Mult Scler Relat Disord. 2021 Jan;47:102610. doi: 10.1016/j.msard.2020.102610. Epub 2020 Oct 31.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Peruzzi A, Cereatti A, Della Croce U, Mirelman A. Effects of a virtual reality and treadmill training on gait of subjects with multiple sclerosis: a pilot study. Mult Scler Relat Disord. 2016 Jan;5:91-6. doi: 10.1016/j.msard.2015.11.002. Epub 2015 Nov 6.</mixed-citation><mixed-citation xml:lang="en">Peruzzi A, Cereatti A, Della Croce U, Mirelman A. Effects of a virtual reality and treadmill training on gait of subjects with multiple sclerosis: a pilot study. Mult Scler Relat Disord. 2016 Jan;5:91-6. doi: 10.1016/j.msard.2015.11.002. Epub 2015 Nov 6.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Bertoni R, Mestanza Mattos FG, Porta M, et al. Effects of immersive virtual reality on upper limb function in subjects with multiple sclerosis: A cross-over study. Mult Scler Relat Disord. 2022 Sep;65:104004. doi: 10.1016/j.msard.2022.104004. Epub 2022 Jun 30.</mixed-citation><mixed-citation xml:lang="en">Bertoni R, Mestanza Mattos FG, Porta M, et al. Effects of immersive virtual reality on upper limb function in subjects with multiple sclerosis: A cross-over study. Mult Scler Relat Disord. 2022 Sep;65:104004. doi: 10.1016/j.msard.2022.104004. Epub 2022 Jun 30.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Ozdogar AT, Ertekin O, Kahraman T, et al. Effect of video-based exergaming on arm and cognitive function in persons with multiple sclerosis: A randomized controlled trial. Mult Scler Relat Disord. 2020 May;40:101966. doi: 10.1016/j.msard.2020.101966. Epub 2020 Jan 24.</mixed-citation><mixed-citation xml:lang="en">Ozdogar AT, Ertekin O, Kahraman T, et al. Effect of video-based exergaming on arm and cognitive function in persons with multiple sclerosis: A randomized controlled trial. Mult Scler Relat Disord. 2020 May;40:101966. doi: 10.1016/j.msard.2020.101966. Epub 2020 Jan 24.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Leonardi S, Maggio MG, Russo M, et al. Cognitive recovery in people with relapsing/remitting multiple sclerosis: A randomized clinical trial on virtual realitybased neurorehabilitation. Clin Neurol Neurosurg. 2021 Sep;208:106828. doi: 10.1016/j.clineuro.2021.106828. Epub 2021 Jul 21.</mixed-citation><mixed-citation xml:lang="en">Leonardi S, Maggio MG, Russo M, et al. Cognitive recovery in people with relapsing/remitting multiple sclerosis: A randomized clinical trial on virtual realitybased neurorehabilitation. Clin Neurol Neurosurg. 2021 Sep;208:106828. doi: 10.1016/j.clineuro.2021.106828. Epub 2021 Jul 21.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Khalil H, Al-Sharman A, El-Salem K, et al. The development and pilot evaluation of virtual reality balance scenarios in people with multiple sclerosis (MS): A feasibility study. NeuroRehabilitation. 2018;43(4):473-82. doi: 10.3233/NRE-182471</mixed-citation><mixed-citation xml:lang="en">Khalil H, Al-Sharman A, El-Salem K, et al. The development and pilot evaluation of virtual reality balance scenarios in people with multiple sclerosis (MS): A feasibility study. NeuroRehabilitation. 2018;43(4):473-82. doi: 10.3233/NRE-182471</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Munari D, Fonte C, Varalta V, et al. Effects of robot-assisted gait training combined with virtual reality on motor and cognitive functions in patients with multiple sclerosis: A pilot, single-blind, randomized controlled trial. Restor Neurol Neurosci. 2020;38(2):151-64. doi: 10.3233/RNN-190974</mixed-citation><mixed-citation xml:lang="en">Munari D, Fonte C, Varalta V, et al. Effects of robot-assisted gait training combined with virtual reality on motor and cognitive functions in patients with multiple sclerosis: A pilot, single-blind, randomized controlled trial. Restor Neurol Neurosci. 2020;38(2):151-64. doi: 10.3233/RNN-190974</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Russo M, Dattola V, De Cola MC, et al. The role of robotic gait training coupled with virtual reality in boosting the rehabilitative outcomes in patients with multiple sclerosis. Int J Rehabil Res. 2018 Jun;41(2):166-72. doi: 10.1097/MRR.0000000000000270</mixed-citation><mixed-citation xml:lang="en">Russo M, Dattola V, De Cola MC, et al. The role of robotic gait training coupled with virtual reality in boosting the rehabilitative outcomes in patients with multiple sclerosis. Int J Rehabil Res. 2018 Jun;41(2):166-72. doi: 10.1097/MRR.0000000000000270</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Norouzi E, Gerber M, Pühse U, et al. Combined virtual reality and physical training improved the bimanual coordination of women with multiple sclerosis. Neuropsychol Rehabil. 2021 May;31(4):552-69. doi: 10.1080/09602011.2020.1715231. Epub 2020 Jan 23.</mixed-citation><mixed-citation xml:lang="en">Norouzi E, Gerber M, Pühse U, et al. Combined virtual reality and physical training improved the bimanual coordination of women with multiple sclerosis. Neuropsychol Rehabil. 2021 May;31(4):552-69. doi: 10.1080/09602011.2020.1715231. Epub 2020 Jan 23.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Sharman A, Khalil H, El-Salem K, et al. Motor performance improvement through virtual reality task is related to fatigue and cognition in people with multiple sclerosis. Physiother Res Int. 2019 Oct;24(4):e1782. doi: 10.1002/pri.1782. Epub 2019 May 23.</mixed-citation><mixed-citation xml:lang="en">Al-Sharman A, Khalil H, El-Salem K, et al. Motor performance improvement through virtual reality task is related to fatigue and cognition in people with multiple sclerosis. Physiother Res Int. 2019 Oct;24(4):e1782. doi: 10.1002/pri.1782. Epub 2019 May 23.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Brichetto G, Spallarossa P, de Carvalho ML, Battaglia MA. The effect of Nintendo® Wii® on balance in people with multiple sclerosis: a pilot randomized control study. Mult Scler. 2013 Aug;19(9):1219-21. doi: 10.1177/1352458512472747. Epub 2013 Jan 15.</mixed-citation><mixed-citation xml:lang="en">Brichetto G, Spallarossa P, de Carvalho ML, Battaglia MA. The effect of Nintendo® Wii® on balance in people with multiple sclerosis: a pilot randomized control study. Mult Scler. 2013 Aug;19(9):1219-21. doi: 10.1177/1352458512472747. Epub 2013 Jan 15.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Yazgan YZ, Tarakci E, Tarakci D, et al. Comparison of the effects of two different exergaming systems on balance, functionality, fatigue, and quality of life in people with multiple sclerosis: A randomized controlled trial. Mult Scler Relat Disord. 2020 Apr;39:101902. doi: 10.1016/j.msard.2019.101902. Epub 2019 Dec 21.</mixed-citation><mixed-citation xml:lang="en">Yazgan YZ, Tarakci E, Tarakci D, et al. Comparison of the effects of two different exergaming systems on balance, functionality, fatigue, and quality of life in people with multiple sclerosis: A randomized controlled trial. Mult Scler Relat Disord. 2020 Apr;39:101902. doi: 10.1016/j.msard.2019.101902. Epub 2019 Dec 21.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Lamargue D, Koubiyr I, Deloire M, et al. Effect of cognitive rehabilitation on neuropsychological and semiecological testing and on daily cognitive functioning in multiple sclerosis: The REACTIV randomized controlled study. J Neurol Sci. 2020 Aug 15;415:116929. doi: 10.1016/j.jns.2020.116929. Epub 2020 May 20.</mixed-citation><mixed-citation xml:lang="en">Lamargue D, Koubiyr I, Deloire M, et al. Effect of cognitive rehabilitation on neuropsychological and semiecological testing and on daily cognitive functioning in multiple sclerosis: The REACTIV randomized controlled study. J Neurol Sci. 2020 Aug 15;415:116929. doi: 10.1016/j.jns.2020.116929. Epub 2020 May 20.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Cuesta-Gomez A, Sanchez-Herrera-Baeza P, Ona-Simbana ED, et al. Effects of virtual reality associated with serious games for upper limb rehabilitation inpatients with multiple sclerosis: randomized controlled trial. J Neuroeng Rehabil. 2020 Jul 13;17(1):90. doi: 10.1186/s12984-020-00718-x</mixed-citation><mixed-citation xml:lang="en">Cuesta-Gomez A, Sanchez-Herrera-Baeza P, Ona-Simbana ED, et al. Effects of virtual reality associated with serious games for upper limb rehabilitation inpatients with multiple sclerosis: randomized controlled trial. J Neuroeng Rehabil. 2020 Jul 13;17(1):90. doi: 10.1186/s12984-020-00718-x</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Ozkul C, Guclu-Gunduz A, Yazici G, et al. Effect of immersive virtual reality on balance, mobility, and fatigue in patients with multiple sclerosis: A single-blinded randomized controlled trial. Eur J Integr Med. 2020 Apr;35:101092. doi: 10.1016/j.eujim.2020.101092</mixed-citation><mixed-citation xml:lang="en">Ozkul C, Guclu-Gunduz A, Yazici G, et al. Effect of immersive virtual reality on balance, mobility, and fatigue in patients with multiple sclerosis: A single-blinded randomized controlled trial. Eur J Integr Med. 2020 Apr;35:101092. doi: 10.1016/j.eujim.2020.101092</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Cortes-Perez I, Sanchez-Alcala M, Nieto-Escamez FA, et al. Virtual Reality-Based Therapy Improves Fatigue, Impact, and Quality of Life in Patients with Multiple Sclerosis. A Systematic Review with a Meta-Analysis. Sensors (Basel). 2021 Nov 6;21(21):7389. doi: 10.3390/s21217389</mixed-citation><mixed-citation xml:lang="en">Cortes-Perez I, Sanchez-Alcala M, Nieto-Escamez FA, et al. Virtual Reality-Based Therapy Improves Fatigue, Impact, and Quality of Life in Patients with Multiple Sclerosis. A Systematic Review with a Meta-Analysis. Sensors (Basel). 2021 Nov 6;21(21):7389. doi: 10.3390/s21217389</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Thomas S, Fazakarley L, Thomas PW, et al. Mii-vitaliSe: a pilot randomised controlled trial of a home gaming system (Nintendo Wii) to increase activity levels, vitality and well-being in people with multiple sclerosis. BMJ Open. 2017 Sep 27;7(9):e016966. doi: 10.1136/bmjopen-2017-016966</mixed-citation><mixed-citation xml:lang="en">Thomas S, Fazakarley L, Thomas PW, et al. Mii-vitaliSe: a pilot randomised controlled trial of a home gaming system (Nintendo Wii) to increase activity levels, vitality and well-being in people with multiple sclerosis. BMJ Open. 2017 Sep 27;7(9):e016966. doi: 10.1136/bmjopen-2017-016966</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Ware Jr. JE, Gandek B. Overview of the SF-36 Health Survey and the International Quality of Life Assessment (IQOLA) Project. J Clin Epidemiol. 1998 Nov;51(11):903-12. doi: 10.1016/S0895-4356(98)00081-X</mixed-citation><mixed-citation xml:lang="en">Ware Jr. JE, Gandek B. Overview of the SF-36 Health Survey and the International Quality of Life Assessment (IQOLA) Project. J Clin Epidemiol. 1998 Nov;51(11):903-12. doi: 10.1016/S0895-4356(98)00081-X</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Vickrey BG, Hays RD, Harooni R, et al. A health-related quality of life measure for multiple sclerosis. Qual Life Res. 1995 Jun;4(3):187-206. doi: 10.1007/BF02260859</mixed-citation><mixed-citation xml:lang="en">Vickrey BG, Hays RD, Harooni R, et al. A health-related quality of life measure for multiple sclerosis. Qual Life Res. 1995 Jun;4(3):187-206. doi: 10.1007/BF02260859</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Mattioli F, Stampatori C, Scarpazza C, et al. Persistence of the effects of attention and executive functions intensive rehabilitation in relapsing remitting multiple sclerosis. Mult Scler Relat Disord. 2012 Oct;1(4):168-73. doi: 10.1016/j.msard.2012.06.004. Epub 2012 Jul 21.</mixed-citation><mixed-citation xml:lang="en">Mattioli F, Stampatori C, Scarpazza C, et al. Persistence of the effects of attention and executive functions intensive rehabilitation in relapsing remitting multiple sclerosis. Mult Scler Relat Disord. 2012 Oct;1(4):168-73. doi: 10.1016/j.msard.2012.06.004. Epub 2012 Jul 21.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Nascimento AS, Fagundes CV, Mendes FADS, Leal JC. Effectiveness of Virtual Reality Rehabilitation in Persons with Multiple Sclerosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Mult Scler Relat Disord. 2021 Sep;54:103128. doi: 10.1016/j.msard.2021.103128. Epub 2021 Jul 9.</mixed-citation><mixed-citation xml:lang="en">Nascimento AS, Fagundes CV, Mendes FADS, Leal JC. Effectiveness of Virtual Reality Rehabilitation in Persons with Multiple Sclerosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Mult Scler Relat Disord. 2021 Sep;54:103128. doi: 10.1016/j.msard.2021.103128. Epub 2021 Jul 9.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Galperin I, Mirelman A, Schmitz-Hübsch T, et al. Treadmill training with virtual reality to enhance gait and cognitive function among people with multiple sclerosis: a randomized controlled trial. J Neurol. 2023 Mar;270(3):1388-401. doi: 10.1007/s00415-022-11469-1. Epub 2022 Nov 11.</mixed-citation><mixed-citation xml:lang="en">Galperin I, Mirelman A, Schmitz-Hübsch T, et al. Treadmill training with virtual reality to enhance gait and cognitive function among people with multiple sclerosis: a randomized controlled trial. J Neurol. 2023 Mar;270(3):1388-401. doi: 10.1007/s00415-022-11469-1. Epub 2022 Nov 11.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Winter C, Kern F, Gall D, et al. Immersive virtual reality during gait rehabilitation increases walking speed and motivation: a usability evaluation with healthy participants and patients with multiple sclerosis and stroke. J Neuroeng Rehabil. 2021 Apr 22;18(1):68. doi: 10.1186/s12984-021-00848-w</mixed-citation><mixed-citation xml:lang="en">Winter C, Kern F, Gall D, et al. Immersive virtual reality during gait rehabilitation increases walking speed and motivation: a usability evaluation with healthy participants and patients with multiple sclerosis and stroke. J Neuroeng Rehabil. 2021 Apr 22;18(1):68. doi: 10.1186/s12984-021-00848-w</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Peruzzi A, Zarbo IR, Cereatti A, et al. An innovative training program based on virtual reality and treadmill: effects on gait of persons with multiple sclerosis. Disabil Rehabil. 2017 Jul;39(15):1557-63. doi: 10.1080/09638288.2016.1224935. Epub 2016 Nov 3.</mixed-citation><mixed-citation xml:lang="en">Peruzzi A, Zarbo IR, Cereatti A, et al. An innovative training program based on virtual reality and treadmill: effects on gait of persons with multiple sclerosis. Disabil Rehabil. 2017 Jul;39(15):1557-63. doi: 10.1080/09638288.2016.1224935. Epub 2016 Nov 3.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Calabro RS, Russo M, Naro A, et al. Robotic gait training in multiple sclerosis rehabilitation: Can virtual reality make the difference? Findings from a randomized controlled trial. J Neurol Sci. 2017 Jun 15;377:25-30. doi: 10.1016/j.jns.2017.03.047. Epub 2017 Mar 29.</mixed-citation><mixed-citation xml:lang="en">Calabro RS, Russo M, Naro A, et al. Robotic gait training in multiple sclerosis rehabilitation: Can virtual reality make the difference? Findings from a randomized controlled trial. J Neurol Sci. 2017 Jun 15;377:25-30. doi: 10.1016/j.jns.2017.03.047. Epub 2017 Mar 29.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Stratton ME, Pilutti LA, Crowell JA, et al. Virtual street-crossing performance in persons with multiple sclerosis: Feasibility and task performance characteristics. Traffic Inj Prev. 2017 Jan 2;18(1):47-55. doi: 10.1080/15389588.2016.1195494. Epub 2016 Sep 7.</mixed-citation><mixed-citation xml:lang="en">Stratton ME, Pilutti LA, Crowell JA, et al. Virtual street-crossing performance in persons with multiple sclerosis: Feasibility and task performance characteristics. Traffic Inj Prev. 2017 Jan 2;18(1):47-55. doi: 10.1080/15389588.2016.1195494. Epub 2016 Sep 7.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Castellano-Aguilera A, Bivia-Roig G, Cuenca-Martinez F, et al. Effectiveness of Virtual Reality on Balance and Risk of Falls in People with Multiple Sclerosis: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2022 Oct 30;19(21):14192. doi: 10.3390/ijerph192114192</mixed-citation><mixed-citation xml:lang="en">Castellano-Aguilera A, Bivia-Roig G, Cuenca-Martinez F, et al. Effectiveness of Virtual Reality on Balance and Risk of Falls in People with Multiple Sclerosis: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2022 Oct 30;19(21):14192. doi: 10.3390/ijerph192114192</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Eftekharsadat B, Babaei-Ghazani A, Mohammadzadeh M, et al. Effect of virtual reality-based balance training in multiple sclerosis. Neurol Res. 2015 Jun;37(6):539-44. doi: 10.1179/1743132815Y.0000000013. Epub 2015 Feb 10.</mixed-citation><mixed-citation xml:lang="en">Eftekharsadat B, Babaei-Ghazani A, Mohammadzadeh M, et al. Effect of virtual reality-based balance training in multiple sclerosis. Neurol Res. 2015 Jun;37(6):539-44. doi: 10.1179/1743132815Y.0000000013. Epub 2015 Feb 10.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Casuso-Holgado MJ, Martin-Valero R, Carazo AF, et al. Effectiveness of virtual reality training for balance and gait rehabilitation in people with multiple sclerosis: a systematic review and meta-analysis. Clin Rehabil. 2018 Sep;32(9):1220-34. doi: 10.1177/0269215518768084. Epub 2018 Apr 13.</mixed-citation><mixed-citation xml:lang="en">Casuso-Holgado MJ, Martin-Valero R, Carazo AF, et al. Effectiveness of virtual reality training for balance and gait rehabilitation in people with multiple sclerosis: a systematic review and meta-analysis. Clin Rehabil. 2018 Sep;32(9):1220-34. doi: 10.1177/0269215518768084. Epub 2018 Apr 13.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Calafiore D, Invernizzi M, Ammendolia A, et al. Efficacy of Virtual Reality and Exergaming in Improving Balance in Patients With Multiple Sclerosis: A Systematic Review and Meta-Analysis. Front Neurol. 2021 Dec 10;12:773459. doi: 10.3389/fneur.2021.773459</mixed-citation><mixed-citation xml:lang="en">Calafiore D, Invernizzi M, Ammendolia A, et al. Efficacy of Virtual Reality and Exergaming in Improving Balance in Patients With Multiple Sclerosis: A Systematic Review and Meta-Analysis. Front Neurol. 2021 Dec 10;12:773459. doi: 10.3389/fneur.2021.773459</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Hao Z, Zhang X, Chen P. Effects of Different Exercise Therapies on Balance Function and Functional Walking Ability in Multiple Sclerosis Disease Patients – A Network Meta-Analysis of Randomized Controlled Trials. Int J Environ Res Public Health. 2022 Jun 11;19(12):7175. doi: 10.3390/ijerph19127175</mixed-citation><mixed-citation xml:lang="en">Hao Z, Zhang X, Chen P. Effects of Different Exercise Therapies on Balance Function and Functional Walking Ability in Multiple Sclerosis Disease Patients – A Network Meta-Analysis of Randomized Controlled Trials. Int J Environ Res Public Health. 2022 Jun 11;19(12):7175. doi: 10.3390/ijerph19127175</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Molhemi F, Monjezi S, Mehravar M, et al. Effects of Virtual Reality vs Conventional Balance Training on Balance and Falls in People With Multiple Sclerosis: A Randomized Controlled Trial. Arch Phys Med Rehabil. 2021 Feb;102(2):290-9. doi: 10.1016/j.apmr.2020.09.395. Epub 2020 Nov 5.</mixed-citation><mixed-citation xml:lang="en">Molhemi F, Monjezi S, Mehravar M, et al. Effects of Virtual Reality vs Conventional Balance Training on Balance and Falls in People With Multiple Sclerosis: A Randomized Controlled Trial. Arch Phys Med Rehabil. 2021 Feb;102(2):290-9. doi: 10.1016/j.apmr.2020.09.395. Epub 2020 Nov 5.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Lozano-Quilis JA, Gil-Gomez H, Gil-Gomez JA, et al. Virtual rehabilitation for multiple sclerosis using a kinect-based system: randomized controlled trial. JMIR Serious Games. 2014 Nov 12;2(2):e12. doi: 10.2196/games.2933</mixed-citation><mixed-citation xml:lang="en">Lozano-Quilis JA, Gil-Gomez H, Gil-Gomez JA, et al. Virtual rehabilitation for multiple sclerosis using a kinect-based system: randomized controlled trial. JMIR Serious Games. 2014 Nov 12;2(2):e12. doi: 10.2196/games.2933</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Akkan H, Kallem Seyyar G, Aslan B, Karabulut E. The effect of virtual reality-based therapy on fear of falling in multiple sclerosis: A systematic review and meta-analysis. Mult Scler Relat Disord. 2022 Jul;63:103791. doi: 10.1016/j.msard.2022.103791. Epub 2022 Apr 10.</mixed-citation><mixed-citation xml:lang="en">Akkan H, Kallem Seyyar G, Aslan B, Karabulut E. The effect of virtual reality-based therapy on fear of falling in multiple sclerosis: A systematic review and meta-analysis. Mult Scler Relat Disord. 2022 Jul;63:103791. doi: 10.1016/j.msard.2022.103791. Epub 2022 Apr 10.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Walino-Paniagua CN, Gomez-Calero C, Jimenez-Trujillo MI, et al. Effects of a Game-Based Virtual Reality Video Capture Training Program Plus Occupational Therapy on Manual Dexterity in Patients with Multiple Sclerosis: A Randomized Controlled Trial. J Healthc Eng. 2019 Apr 22;2019:9780587. doi: 10.1155/2019/9780587</mixed-citation><mixed-citation xml:lang="en">Walino-Paniagua CN, Gomez-Calero C, Jimenez-Trujillo MI, et al. Effects of a Game-Based Virtual Reality Video Capture Training Program Plus Occupational Therapy on Manual Dexterity in Patients with Multiple Sclerosis: A Randomized Controlled Trial. J Healthc Eng. 2019 Apr 22;2019:9780587. doi: 10.1155/2019/9780587</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Pau M, Porta M, Bertoni R, et al. Effect of immersive virtual reality training on hand-tomouth task performance in people with Multiple Sclerosis: A quantitative kinematic study. Mult Scler Relat Disord. 2023 Jan;69:104455. doi: 10.1016/j.msard.2022.104455. Epub 2022 Dec 5.</mixed-citation><mixed-citation xml:lang="en">Pau M, Porta M, Bertoni R, et al. Effect of immersive virtual reality training on hand-tomouth task performance in people with Multiple Sclerosis: A quantitative kinematic study. Mult Scler Relat Disord. 2023 Jan;69:104455. doi: 10.1016/j.msard.2022.104455. Epub 2022 Dec 5.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Dogan M, Ayvat E, Kilinc M. Telerehabilitation versus virtual reality supported task-oriented circuit therapy on upper limbs and trunk functions in patients with multiple sclerosis: A randomized controlled study. Mult Scler Relat Disord. 2023 Mar;71:104558. doi: 10.1016/j.msard.2023.104558. Epub 2023 Feb 11.</mixed-citation><mixed-citation xml:lang="en">Dogan M, Ayvat E, Kilinc M. Telerehabilitation versus virtual reality supported task-oriented circuit therapy on upper limbs and trunk functions in patients with multiple sclerosis: A randomized controlled study. Mult Scler Relat Disord. 2023 Mar;71:104558. doi: 10.1016/j.msard.2023.104558. Epub 2023 Feb 11.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Jonsdottir J, Perini G, Ascolese A, et al. Unilateral arm rehabilitation for persons with multiple sclerosis using serious games in a virtual reality approach: Bilateral treatment effect? Mult Scler Relat Disord. 2019 Oct;35:76-82. doi: 10.1016/j.msard.2019.07.010. Epub 2019 Jul 20.</mixed-citation><mixed-citation xml:lang="en">Jonsdottir J, Perini G, Ascolese A, et al. Unilateral arm rehabilitation for persons with multiple sclerosis using serious games in a virtual reality approach: Bilateral treatment effect? Mult Scler Relat Disord. 2019 Oct;35:76-82. doi: 10.1016/j.msard.2019.07.010. Epub 2019 Jul 20.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Maggio MG, Stagnitti MC, Rizzo E, et al. Limb apraxia in individuals with multiple sclerosis: Is there a role of semi-immersive virtual reality in treating the Cinderella of neuropsychology? Mult Scler Relat Disord. 2023 Jan;69:104405. doi: 10.1016/j.msard.2022.104405. Epub 2022 Nov 9.</mixed-citation><mixed-citation xml:lang="en">Maggio MG, Stagnitti MC, Rizzo E, et al. Limb apraxia in individuals with multiple sclerosis: Is there a role of semi-immersive virtual reality in treating the Cinderella of neuropsychology? Mult Scler Relat Disord. 2023 Jan;69:104405. doi: 10.1016/j.msard.2022.104405. Epub 2022 Nov 9.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Motl RW, Mowry EM, Ehde DM, et al. Wellness and multiple sclerosis: The National MS Society establishes a Wellness Research Working Group and research priorities. Mult Scler. 2018 Mar;24(3):262-7. doi: 10.1177/1352458516687404. Epub 2017 Jan 12.</mixed-citation><mixed-citation xml:lang="en">Motl RW, Mowry EM, Ehde DM, et al. Wellness and multiple sclerosis: The National MS Society establishes a Wellness Research Working Group and research priorities. Mult Scler. 2018 Mar;24(3):262-7. doi: 10.1177/1352458516687404. Epub 2017 Jan 12.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
