nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2023-4-94-99nnp-2065Research ArticleREVIEWSОБЗОРЫParamagnetic rim sign in multiple sclerosisПризнак парамагнитного обода при рассеянном склерозеhttps://orcid.org/0009-0000-0266-0596КапканецД. В.KapkanetsD. V.

Данила Вадимович Капканец

117997, Москва, ул. Островитянова, 1

Danila Vadimovich Kapkanets

1, Ostrovityanova St., Moscow 117997

kkapkanetsdv@gmail.comhttps://orcid.org/0000-0002-4373-2215БеловС. Е.BelovS. E.

117997, Москва, ул. Островитянова, 1

1, Ostrovityanova St., Moscow 117997

https://orcid.org/0000-0003-3930-5998ДолгушинМ. Б.DolgushinM. B.

117997, Москва, ул. Островитянова, 1, стр. 10

1, Ostrovityanova St., Build. 10, Moscow117997

https://orcid.org/0000-0002-2975-4151БойкоА. Н.BoykoA. N.

117997, Москва, ул. Островитянова, 1

117997, Москва, ул. Островитянова, 1, стр. 10

1, Ostrovityanova St., Moscow 117997

1, Ostrovityanova St., Build. 10, Moscow117997

Кафедра неврологии, нейрохирургии и медицинской генетики ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияDepartment of Neurology, Neurosurgery and Medical Genetics of N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian Federationотдел нейроиммунологии Института клинической неврологии ФГБУ «Федеральный центр мозга и нейротехнологий» ФМБА РоссииРоссияDepartment of Neuroimmunology, Institute of Clinical Neurology, Federal Center for Brain and Neurotechnologies, Federal Medical and Biological Agency of RussiaRussian FederationКафедра неврологии, нейрохирургии и медицинской генетики ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России; отдел нейроиммунологии Института клинической неврологии ФГБУ «Федеральный центр мозга и нейротехнологий» ФМБА РоссииРоссияDepartment of Neurology, Neurosurgery and Medical Genetics of N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Department of Neuroimmunology, Institute of Clinical Neurology, Federal Center for Brain and Neurotechnologies, Federal Medical and Biological Agency of RussiaRussian Federation20231508202315494–99Copyright © Kapkanets D.V., Belov S.E., Dolgushin M.B., Boyko A.N., 20232023Капканец Д.В., Белов С.Е., Долгушин М.Б., Бойко А.Н.Kapkanets D.V., Belov S.E., Dolgushin M.B., Boyko A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/2065

To date, there is no accepted highly specific pattern for the detection of multiple sclerosis. Correct diagnosis is particularly difficult in situations where an atypical clinical picture of the disease is observed or nonstandard neuroimaging patterns are detected. Therefore, the scientific community has high hopes for the discovery of new markers that will allow clarification of the diagnosis in controversial cases. Currently, there is a lot of research focused on the study of an additional diagnostic MRI pattern – a sign of a paramagnetic rim. This symptom is associated with chronic smoldering central nervous system (CNS) lesions, is more commonly seen in young males, is found primarily in the periventricular region, and is also a promising predictor of disability and cognitive impairment. There is evidence that it is present in earlier stages of disease in “fresh” lesions of the CNS. However, further studies are needed to use this diagnostic MRI pattern in clinical practice.

На сегодняшний день не существует единогласно одобренного высокоспецифичного паттерна для выявления рассеянного склероза. Нередко особенные сложности для постановки правильного диагноза вызывают ситуации, когда наблюдается атипичная клиническая картина заболевания или обнаруживаются нестандартные нейровизуализационные паттерны. Поэтому научным сообществом возлагаются большие надежды на открытие новых маркеров, позволяющих уточнять диагноз в спорных случаях. На данный момент имеется много работ, посвященных изучению дополнительного диагностического МРТ-паттерна – признака парамагнитного обода. Данный симптом связан с хроническими тлеющими очагами поражения центральной нервной системы (ЦНС), чаще выявляется у молодых мужчин, обнаруживается преимущественно в перивентрикулярной области, а также является перспективным предиктором инвалидизации и когнитивных нарушений. Имеются данные о его наличии на более ранних стадиях заболевания в «свежих» очагах поражения ЦНС. Тем не менее для использования данного диагностического МРТ-паттерна в клинической практике требуются дальнейшие расширенные исследования.

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The authors declare that there are no conflicts of interest present.