nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2023-4-89-93nnp-2064Research ArticleREVIEWSОБЗОРЫEndocrine-inactive pituitary tumors: pathology and current approaches to diagnosis and treatmentГормонально-неактивные опухоли гипофиза: морфология и современные подходы к диагностике и лечениюhttps://orcid.org/0000-0001-9532-9957НиколенкоВ. Н.NikolenkoV. N.

119991, Москва, ул. Трубецкая, 8, стр. 2

119991, Москва, Ленинские горы, 1

 

119991, Москва, ул. Трубецкая, 8, стр. 2

119991, Москва, Ленинские горы, 1

https://orcid.org/0000-0003-1667-5355ВолельБ. А.VolelB. A.

119991, Москва, ул. Трубецкая, 8, стр. 2

119991, Москва, ул. Трубецкая, 8, стр. 2

https://orcid.org/0000-0003-3445-3115ШкарубоА. Н.ShkaruboA. N.

125047, Москва, 4-я Тверская-Ямская ул., 16

16, 4th Tverskaya-Yamskaya St., Moscow 125047

https://orcid.org/0000-0002-4915-0793НагайцеваА. А.NagajtsevaA. A.

119991, Москва, ул. Трубецкая, 8, стр. 2

119991, Москва, ул. Трубецкая, 8, стр. 2

https://orcid.org/0000-0001-6842-1520ЖариковаТ. С.ZharikovaT. S.

Татьяна Сергеевна Жарикова

119991, Москва, ул. Трубецкая, 8, стр. 2

119991, Москва, Ленинские горы, 1

 

Tatyana Sergeevna Zharikova

119991, Москва, ул. Трубецкая, 8, стр. 2

119991, Москва, Ленинские горы, 1

dr_zharikova@mail.ruhttps://orcid.org/0000-0001-9636-3807ЖариковЮ. О.ZharikovYu. O.

119991, Москва, ул. Трубецкая, 8, стр. 2

119991, Москва, ул. Трубецкая, 8, стр. 2

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет); ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; Lomonosov Moscow State UniversityRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian FederationФГАУ «Национальный медицинский исследовательский центр нейрохирургии им. акад. Н.Н. Бурденко» Минздрава РоссииРоссияBurdenko National Medical Research Center for Neurosurgery, Ministry of Health of RussiaRussian Federation2023150820231548993Copyright © Nikolenko V.N., Volel B.A., Shkarubo A.N., Nagajtseva A.A., Zharikova T.S., Zharikov Y.O., 20232023Николенко В.Н., Волель Б.А., Шкарубо А.Н., Нагайцева А.А., Жарикова Т.С., Жариков Ю.О.Nikolenko V.N., Volel B.A., Shkarubo A.N., Nagajtseva A.A., Zharikova T.S., Zharikov Y.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/2064

pathological hormone secretion, the clinical presentation is determined by the localization of the tumor. Common symptoms include headache and visual field defects. This review addresses the pathology aspects of diagnosis, conservative treatment, and methods of radiation therapy. Drug therapy of endocrine-inactive adenomas is based on the presence of receptors for somatostatin and dopamine in pituitary adenoma cells. Data on stereotactic radiosurgery techniques such as gamma and cyberknife and disease prognosis are presented.

Гормонально-неактивные аденомы гипофиза – доброкачественные новообразования, вторые по частоте среди аденом гипофиза. Вследствие отсутствия патологической секреции гормонов клиническая картина определяется локализацией опухоли. Распространенными симптомами при этом заболевании являются головная боль, дефекты зрительного поля. В обзоре рассмотрены морфологические аспекты диагностики, консервативного лечения, а также методы лучевой терапии. Медикаментозная терапия гормонально-неактивных аденом основана на наличии рецепторов к соматостатину и дофамину в клетках аденомы гипофиза. Представлены данные о технологиях стереотаксической радиохирургии, таких как гамма-нож и кибер-нож, а также о прогнозе заболевания.

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The authors declare that there are no conflicts of interest present.