nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2023-3-128-138nnp-2041Research ArticleEXPERIMENTAL STUDIESЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯMolecular mechanisms of synergistic analgesic and neuroprotective action of B group vitamins according to the results of proteomic analysisМолекулярные механизмы синергического противоболевого и нейропротективного действия витаминов группы В по результатам протеомного анализаhttps://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

Ольга Алексеевна Громова

211933, Москва, ул. Вавилова, 4,

Olga Alekseevna Gromova

44, Vavilovа St., Build. 2, Moscow 119333

unesco.gromova@gmail.comhttps://orcid.org/0000-0002-2659-7998ТоршинИ. Ю.TorshinI. Yu.

211933, Москва, ул. Вавилова, 4,

44, Vavilovа St., Build. 2, Moscow 119333

Федеральный исследовательский центр «Информатика и управление» Российской академии наукРоссияFederal Research Center “Computer Science and Management”, Russian Academy of SciencesRussian Federation202304072023153128138Copyright © Gromova O.A., Torshin I.Y., 20232023Громова О.А., Торшин И.Ю.Gromova O.A., Torshin I.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/2041

We present the results of a systemic biological analysis of human proteome proteins, biological functions of which are somehow related to the metabolism of B group vitamins and the molecular implementation of nociceptive processes. Among 983 proteins involved in the homeostasis of B vitamins, 21 proteins were involved in the molecular mechanisms of nociception, 91 proteins were involved in the regulation of inflammation processes, and 17 proteins were involved in the neuroprotective and neurotrophic effects of B vitamins. All these groups of proteins are important for the treatment of neuropathic pain associated with the degeneration of nervous tissue.

Представлены результаты системно-биологического анализа белков протеома человека, биологические функции которых так или иначе связаны с метаболизмом витаминов группы В и с молекулярной реализацией ноцицептивных процессов. Среди 983 белков, вовлеченных в гомеостаз витаминов группы В, в молекулярных механизмах ноцицепции участвовал 21 белок, в регуляции процессов воспаления – 91 белок, в осуществлении нейропротекторных и нейротрофических эффектов витаминов группы В – 17 белков. Все эти группы белков важны для лечения невропатической боли, связанной с дегенерацией нервной ткани.

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The authors declare that there are no conflicts of interest present.