nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2023-3-27-34nnp-2026Research ArticleORIGINAL INVESTIGATIONSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИFunctional characteristics of the right ventral frontal/anterior insular cortex in the pathogenesis of delusions: a pilot studyФункциональные характеристики вентральной лобной/переднеостровковой коры правого полушария в патогенезе бредовых убеждений: пилотное исследованиеhttps://orcid.org/0000-0002-5698-4251ПаникратоваЯ. Р.PanikratovaYa. R.

Яна Романовна Паникратова

115522, Москва, Каширское шоссе, 34

Yana Romanovna Panikratova

34, Kashirskoe Shosse, Moscow 115522

panikratova@mail.ruhttps://orcid.org/0000-0002-7328-8397АбдуллинаЕ. Г.AbdullinaE. G.

115522, Москва, Каширское шоссе, 34

34, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0002-0649-6663ЛебедеваИ. С.LebedevaI. S.

115522, Москва, Каширское шоссе, 34

34, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0002-3390-5047ДмитренкоК. Ю.DmitrenkoK. Yu.

119991, Москва, ул. Большая Пироговская, 2, стр. 4

2/4, Bolshaya Pirogovskaya St., Moscow 119991

https://orcid.org/0000-0002-7441-5546ЮзбашянП. Г.YuzbashianP. G.

119991, Москва, ул. Большая Пироговская, 2, стр. 4

2/4, Bolshaya Pirogovskaya St., Moscow 119991

https://orcid.org/0000-0003-0091-4294ИльинаЕ. В.IlyinaE. V.

119991, Москва, ул. Большая Пироговская, 2, стр. 4

2/4, Bolshaya Pirogovskaya St., Moscow 119991

https://orcid.org/0000-0002-3073-6305КостюкГ. П.KostyukG. P.

119991, Москва, ул. Большая Пироговская, 2, стр. 4; 117152, Москва, Загородное шоссе, 2

2/4, Bolshaya Pirogovskaya St., Moscow 119991; 2, Zagorodnoe Shosse, Moscow 117152

https://orcid.org/0000-0002-7702-6343АндрющенкоА. В.AndrushchenkoA. V.

117152, Москва, Загородное шоссе, 2

2, Zagorodnoe Shosse, Moscow 117152

https://orcid.org/0000-0001-6605-4851ВороноваЕ. И.VoronovaE. I.

115522, Москва, Каширское шоссе, 34; 119991, Москва, ул. Большая Пироговская, 2, стр. 4

34, Kashirskoe Shosse, Moscow 115522; 2/4, Bolshaya Pirogovskaya St., Moscow 119991

https://orcid.org/0000-0003-1613-2510ДороженокИ. Ю.DorozhenokI. Yu.

115522, Москва, Каширское шоссе, 34; 119991, Москва, ул. Большая Пироговская, 2, стр. 4

34, Kashirskoe Shosse, Moscow 115522; 2/4, Bolshaya Pirogovskaya St., Moscow 119991

https://orcid.org/0000-0002-1822-8973РомановД. В.RomanovD. V.

115522, Москва, Каширское шоссе, 34; 119991, Москва, ул. Большая Пироговская, 2, стр. 4

34, Kashirskoe Shosse, Moscow 115522; 2/4, Bolshaya Pirogovskaya St., Moscow 119991

ФГБНУ «Научный центр психического здоровья»РоссияMental Health Research CenterRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)Russian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет); ГБУЗ г. Москвы «Психиатрическая клиническая больница № 1 им. Н.А. Алексеева Департамента здравоохранения г. Москвы»РоссияI.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University); Psychiatric Hospital No. 1 named after N.A. Alexeev of the Department of Health of MoscowRussian FederationГБУЗ г. Москвы «Психиатрическая клиническая больница № 1 им. Н.А. Алексеева Департамента здравоохранения г. Москвы»РоссияPsychiatric Hospital No. 1 named after N.A. Alexeev of the Department of Health of MoscowRussian FederationФГБНУ «Научный центр психического здоровья»; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияMental Health Research Center; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)Russian Federation2023030720231532734Copyright © Panikratova Y.R., Abdullina E.G., Lebedeva I.S., Dmitrenko K.Y., Yuzbashian P.G., Ilyina E.V., Kostyuk G.P., Andrushchenko A.V., Voronova E.I., Dorozhenok I.Y., Romanov D.V., 20232023Паникратова Я.Р., Абдуллина Е.Г., Лебедева И.С., Дмитренко К.Ю., Юзбашян П.Г., Ильина Е.В., Костюк Г.П., Андрющенко А.В., Воронова Е.И., Дороженок И.Ю., Романов Д.В.Panikratova Y.R., Abdullina E.G., Lebedeva I.S., Dmitrenko K.Y., Yuzbashian P.G., Ilyina E.V., Kostyuk G.P., Andrushchenko A.V., Voronova E.I., Dorozhenok I.Y., Romanov D.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/2026

Brain lesion studies demonstrated that the right ventral frontal/anterior insular cortex (r-VF/AI) and its functional connectivity (FC) can play an important role in belief evaluation and delusions of various content.

Objective

Objective: to test the hypothesis about the associations between the functional characteristics of this region and delusions in patients with mental disorders.

Material and methods

Material and methods. The sample included 16 patients with delusional disorder and paranoid schizophrenia. We analyzed the whole-brain FC of the r-VF/AI as well as the local coherence and amplitude of low-frequency fluctuations of BOLD signal in this region.

Results

Results. The “Conviction” item of the Brown Assessment of Beliefs Scale was positively correlated with the FC between the region of interest and a cluster in the right occipital cortex (located predominantly in the occipital fusiform gyrus and the occipital pole and slightly extending to the lingual gyrus and inferior lateral occipital cortex). Local coherence and amplitude of low-frequency fluctuations in the region of interest were not associated with clinical characteristics related to delusions.

Conclusion

Conclusion. The correlations of delusional conviction with FC between the regions involved in belief evaluation and visual perception may reflect aberrant top-down/bottom-up or cyclic processes described within the Bayesian models of delusions.

Ранее на модели органических поражений головного мозга было показано, что вентральная лобная/переднеостровковая кора правого полушария (п-ВЛ/ПО) и ее функциональные связи (ФС) могут играть важную роль в оценке собственных убеждений и формировании бреда различного содержания.

Цель исследования – проверка гипотезы о связи функциональных характеристик данной области с бредовыми идеями у пациентов психиатрической клиники.

Материал и методы

Материал и методы. Выборка включала 16 пациентов с бредовым расстройством и параноидной шизофренией. Анализировали ФС области в п-ВЛ/ПО с остальными вокселами в головном мозге, а также локальную согласованность и амплитуду низкочастотных колебаний BOLD-сигнала в этой области.

Результаты

Результаты. «Убежденность» (Браунская шкала оценки убеждений, BABS) положительно коррелировала сФС зоны интереса иобласти взатылочной коре правого полушария (преимущественно взатылочной части веретеновидной извилины изатылочном полюсе, а также в язычной извилине и нижней части латеральной затылочной коры). Корреляций клинических характеристик, связанных с бредовыми убеждениями, с локальной согласованностью и амплитудой низкочастотных колебаний BOLD-сигнала в области интереса обнаружено не было.

Заключение

Заключение. Выявленные корреляции между бредовой убежденностью и ФС областей, связанных с оценкой убеждений и зрительным восприятием, могут отражать аберрантные нисходящие и/или восходящие процессы либо циклические процессы, описанные в байесовских моделях бреда.

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The authors declare that there are no conflicts of interest present.