nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2023-3-16-21nnp-2024Research ArticleORIGINAL INVESTIGATIONSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИAssociation of the circadian rhythm gene ARNTL/BMAL1 with personal anxiety among people aged 25–64 (WHO international program “MONICA-psychosocial (MOPSY)”)Ассоциация гена циркадного ритма ARNTL/BMAL1 с личностной тревожностью среди лиц 25–64 лет (международная программа ВОЗ «MONICA-психосоциальная (MOPSY)»)https://orcid.org/0000-0001-5701-7856ГафаровВ. В.GafarovV. V.

Валерий Васильевич Гафаров

630089, Новосибирск, ул. Б. Богаткова, 175/1

Valery Vasilyevich Gafarov

Novosibirsk 1, 2175/1, B. Bogatkova St., Novosibirsk 630089

valery.gafarov@gmail.comhttps://orcid.org/0000-0001-8313-3893ГромоваЕ. А.GromovaE. A.

630089, Новосибирск, ул. Б. Богаткова, 175/1

Novosibirsk 1, 2175/1, B. Bogatkova St., Novosibirsk 630089

https://orcid.org/0000-0001-5255-5647ГагулинИ. В.GagulinI. V.

630089, Новосибирск, ул. Б. Богаткова, 175/1

Novosibirsk 1, 2175/1, B. Bogatkova St., Novosibirsk 630089

https://orcid.org/0000-0002-8101-6121ПановД. О.PanovD. O.

630089, Новосибирск, ул. Б. Богаткова, 175/1

Novosibirsk 1, 2175/1, B. Bogatkova St., Novosibirsk 630089

https://orcid.org/0000-0002-7165-4496МаксимовВ. Н.MaksimovV. N.

630089, Новосибирск, ул. Б. Богаткова, 175/1

Novosibirsk 1, 2175/1, B. Bogatkova St., Novosibirsk 630089

https://orcid.org/0000-0001-5380-9434ГафароваА. В.GafarovaА. V.

630089, Новосибирск, ул. Б. Богаткова, 175/1

Novosibirsk 1, 2175/1, B. Bogatkova St., Novosibirsk 630089

Научно-исследовательский институт терапии и профилактической медицины – филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики СО РАН»; Межведомственная лаборатория эпидемиологии сердечно-сосудистых заболеванийРоссияScientific Research Institute for Therapy and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics, Russian Academy of Sciences; Interdepartmental Laboratory of Epidemiology of Cardiovascular DiseasesRussian FederationНаучно-исследовательский институт терапии и профилактической медицины – филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики СО РАН»РоссияScientific Research Institute for Therapy and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics, Russian Academy of SciencesRussian Federation2023030720231531621Copyright © Gafarov V.V., Gromova E.A., Gagulin I.V., Panov D.O., Maksimov V.N., Gafarova А.V., 20232023Гафаров В.В., Громова Е.А., Гагулин И.В., Панов Д.О., Максимов В.Н., Гафарова А.В.Gafarov V.V., Gromova E.A., Gagulin I.V., Panov D.O., Maksimov V.N., Gafarova А.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/2024Objective

Objective: to study associations between personal anxiety (PA) and single nucleotide polymorphism rs2278749 of the ARNTL gene among individuals aged 25–64 years living in Novosibirsk.

Material and methods

Material and methods. Under the WHO program “MONICA-psychosocial (MOPSY)”, a random representative sample of the population aged 25–64 years in Novosibirsk was studied (725 men, mean age – 43.4±0.4 years, response – 71.3%; 710 women, mean age – 44.8±0.4 years, response – 72%). The general examination was carried out according to standard methods included in the protocol of the WHO program. To assess PA, a form of Spielberger self-assessment scales was proposed. Every second respondent underwent genotyping of the studied polymorphisms of the ARNTL gene.

Results

Results. The C/C genotype of the ARNTL gene was found in the general population in 60.7% of individuals (in 61.2% of men and 60.5% of women); the C/T genotype was found in 34.1% of individuals (in 35.1% of men and 33.5% of women) and the T/T genotype in the general population was found in 5.2% of individuals (in 3.7% of men and 6% women). The probability of PA development among carriers of the CT+TT genotypes of the ARNTL gene was 2 times higher (p<0.05) in the general population and 2.4 times (p<0.05) among women; among T allele carriers, it was 1.8 times higher (p<0.05) in the population and 2.1 times (p<0.05) among women. Carriers of the C/T genotype of the ARNTL gene were 30.3% more likely to believe that they almost always take everything too personally (p=0.024). Carriers of the C/T genotype (21%) almost always, and carriers of the T/T genotype (27.8%) often would like to be as happy as others (p=0.031). The answer “I often feel satisfaction” prevailed (38.2%) among the carriers of the C/C genotype, and the answer “Almost never feel satisfaction” among the carriers of the C/T genotype (5.9%) of the ARNTL gene (p=0.044) .

Conclusion

Conclusion. It was found that the C/C genotype of the ARNTL gene was the most common in the population; the probability of PA occurrence among carriers of CT+TT genotypes, carriers of the T allele is 2 times higher than in carriers of other genotypes of the ARNTL gene.

Цель исследования – изучить ассоциативные связи между личностной тревожностью (ЛТ) и однонуклеотидным полиморфизмом rs2278749 гена ARNTL среди лиц в возрасте 25–64 лет, проживающих в г. Новосибирске.

Материал и методы

Материал и методы. По программе ВОЗ «MONICA-психосоциальная (MOPSY)» была изучена случайная репрезентативная выборка населения 25–64 лет г. Новосибирска (725 мужчин, средний возраст – 43,4±0,4 года, респонс – 71,3%; 710 женщин, средний возраст – 44,8±0,4 года, респонс –72%). Общее обследование проводилось по стандартным методикам, включенным в протокол программы ВОЗ. Для проведения оценки ЛТ предлагался бланк шкал самооценки Спилбергера. У каждого второго респондента было проведено генотипирование изучаемых полиморфизмов гена ARNTL.

Результаты

Результаты. Генотип С/С гена ARNTL встречался вобщей популяции у60,7% лиц (у61,2% мужчин и60,5% женщин); генотип С/Т встречался у 34,1% лиц (у 35,1% мужчин и 33,5% женщин) и генотип T/Т в общей популяции выявлен у 5,2% лиц (у 3,7% мужчин и 6% женщин). Вероятность возникновения ЛТ среди носителей генотипов CT+TT гена ARNTL была в 2 раза выше (p<0,05) в общей популяции и в 2,4 раза (p<0,05) – среди женщин; среди носителей аллеля T она была в 1,8 раза выше (p<0,05) в популяции и в 2,1 раза (p<0,05)– среди женщин. Носители генотипа C/Т гена ARNTL 30,3% чаще полагали, что почти всегда принимают все слишком близко к сердцу (p=0,024). Носители генотипа С/Т (21%) почти всегда, а носители генотипа Т/Т (27,8%) часто хотели бы быть такими же счастливыми, как и другие (p=0,031). Ответ «Я часто испытываю удовлетворение» преобладал (38,2%) среди носителей генотипа С/С, а ответ «Почти никогда не испытываю удовлетворение» – среди носителей генотипа С/T (5,9%) гена ARNTL (p=0,044).

Заключение

Заключение. Установлено, что генотип С/С гена ARNTL чаще всего встречался в популяции; вероятность возникновения ЛТ среди носителей генотипов CT+TT, носителей аллеля T в 2 раза выше, чем у носителей других генотипов гена ARNTL.

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The authors declare that there are no conflicts of interest present.