<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2023-1-103-109</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-1963</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group></article-categories><title-group><article-title>Meniere's disease in the practice of a neurologist</article-title><trans-title-group xml:lang="ru"><trans-title>Болезнь Меньера в практике невролога</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5827-9428</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Косивцова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosivtsova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Владимировна Косивцова</p><p>119021, Москва, ул. Россолимо, 11, стр. 1</p></bio><bio xml:lang="en"><p>Olga Vladimirovna Kosivtsova</p><p>119021, Moscow, Rossolimo St., 11, Build. 1</p></bio><email xlink:type="simple">o.kosivtsova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6624-5500</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Старчина</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Starchina</surname><given-names>Y. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119021, Москва, ул. Россолимо, 11, стр. 1</p></bio><bio xml:lang="en"><p>119021, Moscow, Rossolimo St., 11, Build. 1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кафедра нервных болезней и нейрохирургии Института клинической медицины им. Н.В. Склифосовского ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Department of Nervous Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>19</day><month>02</month><year>2023</year></pub-date><volume>15</volume><issue>1</issue><fpage>103</fpage><lpage>109</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Kosivtsova O.V., Starchina Y.A., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Косивцова О.В., Старчина Ю.А.</copyright-holder><copyright-holder xml:lang="en">Kosivtsova O.V., Starchina Y.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/1963">https://nnp.ima-press.net/nnp/article/view/1963</self-uri><abstract><p>Meniere's disease (MD) is a chronic disease characterized by spontaneous recurrent attacks of vestibular vertigo, hearing loss, tinnitus, ear congestion, and other symptoms. Patients with acutely developed vestibular vertigo in most cases seek medical help from a neurologist. MD is characterized by the presence of endolymphatic hydrops, but there is no clear correlation between the severity of hydrops and the severity of clinical manifestations. The clinical presentation of MD is variable, with some patients having progressive auditory symptoms with occasional vertigo attacks, while others may have frequent vertigo attacks with minimal auditory symptoms. Diagnosis is based on a comprehensive assessment of the clinical picture, otoneurological examination, audiometry data, electrocochleography, vestibular evoked myogenic potentials; in complex cases, MRI of the inner ear with contrast enhancement is performed (currently, this method is not widely used in clinical practice) and MRI of the head to exclude intracranial pathology. Treatment of patients is aimed at relieving acute attacks of dizziness, informing the patient about the disease, prescribing a low-salt diet, betahistine or Arlevert administration to prevent attacks; in rare cases of ineffectiveness of conservative therapy, intratympanic administration of gentamicin or surgical methods of treatment are possible. The use of Arlevert in MD is discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Болезнь Меньера (БМ) представляет собой хроническое заболевание, характеризующееся спонтанными рецидивирующими приступами вестибулярного головокружения, снижением слуха, шумом в ушах, заложенностью уха и другими симптомами. Пациенты с остро развившимся вестибулярным головокружением в большинстве случаев обращаются за медицинской помощью к неврологу. Для БМ характерно наличие эндолимфатического гидропса, однако нет четкой корреляции между степенью выраженности гидропса и тяжестью клинических проявлений. Клиническая картина БМ вариабельна, у некоторых пациентов на первое место могут выходить прогрессирующие слуховые симптомы с редкими приступами головокружения, у других – частые приступы головокружения с минимальными слуховыми симптомами. Диагностика основывается на комплексной оценке клинической картины, отоневрологического обследования, данных аудиометрии, электрокохлеографии, вестибулярных вызванных миогенных потенциалов, в сложных случаях проводится МРТ внутреннего уха с контрастированием (в настоящее время данный метод не нашел широкого применения в клинической практике) и МРТ головы для исключения внутричерепной патологии. Лечение пациентов направлено на купирование острых приступов головокружения, информирование пациента о заболевании, назначение низкосолевой диеты, бетагистина или Арлеверта с целью профилактики приступов; в редких случаях неэффективности консервативной терапии возможны интратимпанальное введение гентамицина или хирургические методы лечения. Обсуждается применение Арлеверта при БМ.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>болезнь Меньера</kwd><kwd>вестибулярное головокружение</kwd><kwd>эндолимфатический гидропс</kwd><kwd>Арлеверт</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Meniere's disease</kwd><kwd>vestibular dizziness</kwd><kwd>endolymphatic hydrops</kwd><kwd>Arlevert</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА, Абдулина ОВ, Замерград МВ. Дифференциальная диагностика и лечение вестибулярного головокружения Неврология, нейропсихиатрия, психосоматика. 2010;2(2):49-54. doi:10.14412/2074-2711-2010-84</mixed-citation><mixed-citation xml:lang="en">Parfenov VA, Abdulina OV, Zamergrad MV. Differential diagnosis and treatment of vestibular vertigo. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2010;2(2):49-54. doi:10.14412/2074-2711-2010-84 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Baloh RW. Differentiating between peripheral and central causes of vertigo. Otolaryngol Head Neck Surg. 1998 Jul;119(1):55-9. doi:10.1016/S0194-5998(98)70173-1</mixed-citation><mixed-citation xml:lang="en">Baloh RW. Differentiating between peripheral and central causes of vertigo. Otolaryngol Head Neck Surg. 1998 Jul;119(1):55-9. doi:10.1016/S0194-5998(98)70173-1</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Абдулина ОВ. Частота, причины, дифференциальный диагноз, лечение и прогноз острого вестибулярного головокружения в неотложной неврологии: Автореф. дисс. … канд. мед. наук. Москва; 2007.</mixed-citation><mixed-citation xml:lang="en">Abdulina OV. Chastota, prichiny, differentsial'nyy diagnoz, lecheniye i prognoz ostrogo vestibulyarnogo golovokruzheniya v neotlozhnoy nevrologii: Avtoref. diss. … kand. med. nauk [Frequency, causes, differential diagnosis, treatment and prognosis of acute vestibular vertigo in emergency neurology: Abstract of the thesis. diss. … cand. med. sci.]. Moscow; 2007 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА, Абдулина ОВ, Замерград МВ. Периферическая вестибулопатия под маской инсульта. Неврологический журнал. 2005;10(6):28-31.</mixed-citation><mixed-citation xml:lang="en">Parfenov VA, Abdulina OV, Zamergrad MV. Peripheral vestibulopathy simulating a stroke. Nevrologicheskiy zhurnal. 2005;10(6):28-31 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Самородская ИВ, Андреев ЕМ, Заратьянц ОВ и др. Показатели смертности населения старше 50 лет от цереброваскулярных болезней за 15-летний период в России и США. Неврология, нейропсихиатрия, психосоматика. 2017;9(2):15-24. doi:10.14412/2074-2711-2017-2-15-24</mixed-citation><mixed-citation xml:lang="en">Samorodskaya IV, Andreev EM, Zaratyants OV, et al. Cerebrovascular disease mortality rates in the population over 50 years of age in Russia and the USA over a 15-year period. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2017;9(2):15-24. doi:10.14412/2074-2711-2017-2-15-24 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Mira E. Improving the quality of life in patients with vestibular disorders: the role of medical treatments and physical rehabilitation. Int J Clin Pract. 2008 Jan;62(1):109-14. doi:10.1111/j.1742-1241.2006.01091.x. Epub 2007 May 30.</mixed-citation><mixed-citation xml:lang="en">Mira E. Improving the quality of life in patients with vestibular disorders: the role of medical treatments and physical rehabilitation. Int J Clin Pract. 2008 Jan;62(1):109-14. doi:10.1111/j.1742-1241.2006.01091.x. Epub 2007 May 30.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Tyrrell JS, Whinney DJ, Ukoumunne OC, et al. Prevalence, associated factors, and comorbid conditions for Meniere's disease. Ear Hear. 2014 Jul-Aug;35(4):e162-9. doi:10.1097/AUD.0000000000000041</mixed-citation><mixed-citation xml:lang="en">Tyrrell JS, Whinney DJ, Ukoumunne OC, et al. Prevalence, associated factors, and comorbid conditions for Meniere's disease. Ear Hear. 2014 Jul-Aug;35(4):e162-9. doi:10.1097/AUD.0000000000000041</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Schessel DA, Minor LB, Nedzelski J. Meniere's disease and other peripheral vestibular disorders. In: Cummings CW, editor. Otolaryngology Head and Neck Surgery. St. Louis: Mosby; 1998. P. 2672.</mixed-citation><mixed-citation xml:lang="en">Schessel DA, Minor LB, Nedzelski J. Meniere's disease and other peripheral vestibular disorders. In: Cummings CW, editor. Otolaryngology Head and Neck Surgery. St. Louis: Mosby; 1998. P. 2672.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Havia M, Kentala E, Pyykkö I. Prevalence of Meniеre's disease in general population of Southern Finland. Otolaryngol Head Neck Surg. 2005 Nov;133(5):762-8. doi:10.1016/j.otohns.2005.06.015</mixed-citation><mixed-citation xml:lang="en">Havia M, Kentala E, Pyykkö I. Prevalence of Meniеre's disease in general population of Southern Finland. Otolaryngol Head Neck Surg. 2005 Nov;133(5):762-8. doi:10.1016/j.otohns.2005.06.015</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Shojaku H, Watanabe Y, Fujisaka M, et al. Epidemiologic characteristics of definite Meniere's disease in Japan. A long-term survey of Toyama and Niigata prefectures. ORL J Otorhinolaryngol Relat Spec. 2005;67(5):305-9. doi:10.1159/000089413. Epub 2005 Dec 15.</mixed-citation><mixed-citation xml:lang="en">Shojaku H, Watanabe Y, Fujisaka M, et al. Epidemiologic characteristics of definite Meniere's disease in Japan. A long-term survey of Toyama and Niigata prefectures. ORL J Otorhinolaryngol Relat Spec. 2005;67(5):305-9. doi:10.1159/000089413. Epub 2005 Dec 15.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">House JW, Doherty JK, Fisher LM, et al. Meniere's disease: prevalence of contralateral ear involvement. Otol Neurotol. 2006 Apr;27(3):355-61. doi:10.1097/00129492-200604000-00011</mixed-citation><mixed-citation xml:lang="en">House JW, Doherty JK, Fisher LM, et al. Meniere's disease: prevalence of contralateral ear involvement. Otol Neurotol. 2006 Apr;27(3):355-61. doi:10.1097/00129492-200604000-00011</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Huppert D, Strupp M, Brandt T. Long-term course of Meniere's disease revisited. Acta Otolaryngol. 2010 Jun;130(6):644-51. doi:10.3109/00016480903382808</mixed-citation><mixed-citation xml:lang="en">Huppert D, Strupp M, Brandt T. Long-term course of Meniere's disease revisited. Acta Otolaryngol. 2010 Jun;130(6):644-51. doi:10.3109/00016480903382808</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Harris JP, Alexander TH. Current-day prevalence of Meniere's syndrome. Audiol Neurootol. 2010;15(5):318-22. doi:10.1159/000286213. Epub 2010 Feb 18.</mixed-citation><mixed-citation xml:lang="en">Harris JP, Alexander TH. Current-day prevalence of Meniere's syndrome. Audiol Neurootol. 2010;15(5):318-22. doi:10.1159/000286213. Epub 2010 Feb 18.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Cha YH, Kane MJ, Baloh RW. Familial clustering of migraine, episodic vertigo, and Meniere's disease. Otol Neurotol. 2008 Jan;29(1):93-6. doi:10.1097/mao.0b013e31815c2abb</mixed-citation><mixed-citation xml:lang="en">Cha YH, Kane MJ, Baloh RW. Familial clustering of migraine, episodic vertigo, and Meniere's disease. Otol Neurotol. 2008 Jan;29(1):93-6. doi:10.1097/mao.0b013e31815c2abb</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Arweiler-Harbeck D, Horsthemke B, Jahnke K, Hennies HC. Genetic aspects of familial Meniere's disease. Otol Neurotol. 2011 Jun;32(4):695-700. doi:10.1097/MAO.0b013e318216074a</mixed-citation><mixed-citation xml:lang="en">Arweiler-Harbeck D, Horsthemke B, Jahnke K, Hennies HC. Genetic aspects of familial Meniere's disease. Otol Neurotol. 2011 Jun;32(4):695-700. doi:10.1097/MAO.0b013e318216074a</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang W, Hui L, Zhang B, et al. The Correlation Between Endolymphatic Hydrops and Clinical Features of Meniere Disease. Laryngoscope. 2021 Jan;131(1):E144-E150. doi:10.1002/lary.28576. Epub 2020 Feb 21.</mixed-citation><mixed-citation xml:lang="en">Zhang W, Hui L, Zhang B, et al. The Correlation Between Endolymphatic Hydrops and Clinical Features of Meniere Disease. Laryngoscope. 2021 Jan;131(1):E144-E150. doi:10.1002/lary.28576. Epub 2020 Feb 21.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kato M, Sugiura M, Shimono M, et al. Endolymphatic hydrops revealed by magnetic resonance imaging in patients with atypical Meniere's disease. Acta Otolaryngol. 2013 Feb;133(2):123-9. doi:10.3109/00016489.2012.726374. Epub 2012 Oct 29.</mixed-citation><mixed-citation xml:lang="en">Kato M, Sugiura M, Shimono M, et al. Endolymphatic hydrops revealed by magnetic resonance imaging in patients with atypical Meniere's disease. Acta Otolaryngol. 2013 Feb;133(2):123-9. doi:10.3109/00016489.2012.726374. Epub 2012 Oct 29.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Foster CA, Breeze RE. Endolymphatic hydrops in Meniere's disease: cause, consequence, or epiphenomenon? Otol Neurotol. 2013 Sep;34(7):1210-4. doi:10.1097/MAO.0b013e31829e83df</mixed-citation><mixed-citation xml:lang="en">Foster CA, Breeze RE. Endolymphatic hydrops in Meniere's disease: cause, consequence, or epiphenomenon? Otol Neurotol. 2013 Sep;34(7):1210-4. doi:10.1097/MAO.0b013e31829e83df</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Cha YH, Brodsky J, Ishiyama G, et al. The relevance of migraine in patients with Meniere's disease. Acta Otolaryngol. 2007 Dec;127(12):1241-5. doi:10.1080/00016480701242469</mixed-citation><mixed-citation xml:lang="en">Cha YH, Brodsky J, Ishiyama G, et al. The relevance of migraine in patients with Meniere's disease. Acta Otolaryngol. 2007 Dec;127(12):1241-5. doi:10.1080/00016480701242469</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Rauch SD. Clinical hints and precipitating factors in patients suffering from Meniere's disease. Otolaryngol Clin North Am. 2010 Oct;43(5):1011-7. doi:10.1016/j.otc.2010.05.003</mixed-citation><mixed-citation xml:lang="en">Rauch SD. Clinical hints and precipitating factors in patients suffering from Meniere's disease. Otolaryngol Clin North Am. 2010 Oct;43(5):1011-7. doi:10.1016/j.otc.2010.05.003</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Nadol JB Jr, Thornton AR. Ultrastructural findings in a case of Meniere's disease. Ann Otol Rhinol Laryngol. 1987 Jul-Aug;96(4):449-54. doi:10.1177/000348948709600420</mixed-citation><mixed-citation xml:lang="en">Nadol JB Jr, Thornton AR. Ultrastructural findings in a case of Meniere's disease. Ann Otol Rhinol Laryngol. 1987 Jul-Aug;96(4):449-54. doi:10.1177/000348948709600420</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Yamamoto M, Teranishi M, Naganawa S, et al. Relationship between the degree of endolymphatic hydrops and electrocochleography. Audiol Neurootol. 2010;15(4):254-60. doi:10.1159/000258681. Epub 2009 Nov 17.</mixed-citation><mixed-citation xml:lang="en">Yamamoto M, Teranishi M, Naganawa S, et al. Relationship between the degree of endolymphatic hydrops and electrocochleography. Audiol Neurootol. 2010;15(4):254-60. doi:10.1159/000258681. Epub 2009 Nov 17.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Coelho DH, Lalwani AK. Medical management of Meniere's disease. Laryngoscope. 2008 Jun;118(6):1099-108. doi:10.1097/MLG.0b013e31816927f0</mixed-citation><mixed-citation xml:lang="en">Coelho DH, Lalwani AK. Medical management of Meniere's disease. Laryngoscope. 2008 Jun;118(6):1099-108. doi:10.1097/MLG.0b013e31816927f0</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Kimura RS. Experimental blockage of the endolymphatic duct and sac and its effect on the inner ear of the guinea pig. A study on endolymphatic hydrops. Ann Otol Rhinol Laryngol. 1967 Aug;76(3):664-87. doi:10.1177/000348946707600311</mixed-citation><mixed-citation xml:lang="en">Kimura RS. Experimental blockage of the endolymphatic duct and sac and its effect on the inner ear of the guinea pig. A study on endolymphatic hydrops. Ann Otol Rhinol Laryngol. 1967 Aug;76(3):664-87. doi:10.1177/000348946707600311</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Yamamoto E, Mizukami C. Development of the vestibular aqueduct in Meniere's disease. Acta Otolaryngol Suppl. 1993;504:46-50. doi:10.3109/00016489309128121</mixed-citation><mixed-citation xml:lang="en">Yamamoto E, Mizukami C. Development of the vestibular aqueduct in Meniere's disease. Acta Otolaryngol Suppl. 1993;504:46-50. doi:10.3109/00016489309128121</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Alleman AM, Dornhoffer JL, Arenberg IK, Walker PD. Demonstration of autoantibodies to the endolymphatic sac in Meniere's disease. Laryngoscope. 1997 Feb;107(2):211-5. doi:10.1097/00005537-199702000-00013</mixed-citation><mixed-citation xml:lang="en">Alleman AM, Dornhoffer JL, Arenberg IK, Walker PD. Demonstration of autoantibodies to the endolymphatic sac in Meniere's disease. Laryngoscope. 1997 Feb;107(2):211-5. doi:10.1097/00005537-199702000-00013</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Evans KL, Baldwin DL, Bainbridge D, Morrison AW. Immune status in patients with Meniere's disease. Arch Otorhinolaryngol. 1988;245(5):287-92. doi:10.1007/BF00464632</mixed-citation><mixed-citation xml:lang="en">Evans KL, Baldwin DL, Bainbridge D, Morrison AW. Immune status in patients with Meniere's disease. Arch Otorhinolaryngol. 1988;245(5):287-92. doi:10.1007/BF00464632</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Gates P. Hypothesis: could Meniere's disease be a channelopathy? Intern Med J. 2005 Aug;35(8):488-9. doi:10.1111/j.1445-5994.2005.00891.x</mixed-citation><mixed-citation xml:lang="en">Gates P. Hypothesis: could Meniere's disease be a channelopathy? Intern Med J. 2005 Aug;35(8):488-9. doi:10.1111/j.1445-5994.2005.00891.x</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Klockars T, Kentala E. Inheritance of Meniere's disease in the Finnish population. Arch Otolaryngol Head Neck Surg. 2007 Jan;133(1):73-7. doi:10.1001/archotol.133.1.73</mixed-citation><mixed-citation xml:lang="en">Klockars T, Kentala E. Inheritance of Meniere's disease in the Finnish population. Arch Otolaryngol Head Neck Surg. 2007 Jan;133(1):73-7. doi:10.1001/archotol.133.1.73</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Radtke A, Lempert T, Gresty MA, et al. Migraine and Meniere's disease: is there a link? Neurology. 2002 Dec 10;59(11):1700-4. doi:10.1212/01.wnl.0000036903.22461.39</mixed-citation><mixed-citation xml:lang="en">Radtke A, Lempert T, Gresty MA, et al. Migraine and Meniere's disease: is there a link? Neurology. 2002 Dec 10;59(11):1700-4. doi:10.1212/01.wnl.0000036903.22461.39</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Hoa M, Friedman RA, Fisher LM, Derebery MJ. Prognostic implications of and audiometric evidence for hearing fluctuation in Meniere's disease. Laryngoscope. 2015 Dec;125 Suppl 12:S1-12. doi:10.1002/lary.25579. Epub 2015 Sep 7.</mixed-citation><mixed-citation xml:lang="en">Hoa M, Friedman RA, Fisher LM, Derebery MJ. Prognostic implications of and audiometric evidence for hearing fluctuation in Meniere's disease. Laryngoscope. 2015 Dec;125 Suppl 12:S1-12. doi:10.1002/lary.25579. Epub 2015 Sep 7.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Q, Dai C, Zhao M, Sha Y. The correlation between symptoms of definite Meniere's disease and endolymphatic hydrops visualized by magnetic resonance imaging. Laryngoscope. 2016 Apr;126(4):974-9. doi:10.1002/lary.25576. Epub 2015 Aug 29.</mixed-citation><mixed-citation xml:lang="en">Wu Q, Dai C, Zhao M, Sha Y. The correlation between symptoms of definite Meniere's disease and endolymphatic hydrops visualized by magnetic resonance imaging. Laryngoscope. 2016 Apr;126(4):974-9. doi:10.1002/lary.25576. Epub 2015 Aug 29.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Gibson WP. Hypothetical mechanism for vertigo in Meniere's disease. Otolaryngol Clin North Am. 2010 Oct;43(5):1019-27. doi:10.1016/j.otc.2010.05.013</mixed-citation><mixed-citation xml:lang="en">Gibson WP. Hypothetical mechanism for vertigo in Meniere's disease. Otolaryngol Clin North Am. 2010 Oct;43(5):1019-27. doi:10.1016/j.otc.2010.05.013</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Lackner JR. Motion sickness: more than nausea and vomiting. Exp Brain Res. 2014 Aug;232(8):2493-510. doi:10.1007/s00221-014-4008-8. Epub 2014 Jun 25.</mixed-citation><mixed-citation xml:lang="en">Lackner JR. Motion sickness: more than nausea and vomiting. Exp Brain Res. 2014 Aug;232(8):2493-510. doi:10.1007/s00221-014-4008-8. Epub 2014 Jun 25.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Ozeki H, Iwasaki S, Murofushi T. Vestibular drop attack secondary to Meniere's disease results from unstable otolithic function. Acta Otolaryngol. 2008 Aug;128(8):887-91. doi:10.1080/00016480701767390</mixed-citation><mixed-citation xml:lang="en">Ozeki H, Iwasaki S, Murofushi T. Vestibular drop attack secondary to Meniere's disease results from unstable otolithic function. Acta Otolaryngol. 2008 Aug;128(8):887-91. doi:10.1080/00016480701767390</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Committee on Hearing and Equilibrium. Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Meniere's disease. Otolaryngol Head Neck Surg. 1995 Sep;113(3):181-5. doi:10.1016/S0194-5998(95)70102-8</mixed-citation><mixed-citation xml:lang="en">Committee on Hearing and Equilibrium. Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Meniere's disease. Otolaryngol Head Neck Surg. 1995 Sep;113(3):181-5. doi:10.1016/S0194-5998(95)70102-8</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Lopez-Escamez JA, Carey J, Chung WH, et al; Classification Committee of the Barany Society; Japan Society for Equilibrium Research; European Academy of Otology and Neurotology (EAONO); Equilibrium Committee of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS); Korean Balance Society. Diagnostic criteria for Meniere's disease. J Vestib Res. 2015;25(1):1-7. doi:10.3233/VES150549</mixed-citation><mixed-citation xml:lang="en">Lopez-Escamez JA, Carey J, Chung WH, et al; Classification Committee of the Barany Society; Japan Society for Equilibrium Research; European Academy of Otology and Neurotology (EAONO); Equilibrium Committee of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS); Korean Balance Society. Diagnostic criteria for Meniere's disease. J Vestib Res. 2015;25(1):1-7. doi:10.3233/VES150549</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Conlon BJ, Gibson WP. Electrocochleography in the diagnosis of Meniere's disease. Acta Otolaryngol. 2000 Jun;120(4):480-3. doi:10.1080/000164800750045965</mixed-citation><mixed-citation xml:lang="en">Conlon BJ, Gibson WP. Electrocochleography in the diagnosis of Meniere's disease. Acta Otolaryngol. 2000 Jun;120(4):480-3. doi:10.1080/000164800750045965</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Rauch SD, Zhou G, Kujawa SG, et al. Vestibular evoked myogenic potentials show altered tuning in patients with Meniere's disease. Otol Neurotol. 2004 May;25(3):333-8. doi:10.1097/00129492-200405000-00022</mixed-citation><mixed-citation xml:lang="en">Rauch SD, Zhou G, Kujawa SG, et al. Vestibular evoked myogenic potentials show altered tuning in patients with Meniere's disease. Otol Neurotol. 2004 May;25(3):333-8. doi:10.1097/00129492-200405000-00022</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Lin MY, Timmer FC, Oriel BS, et al. Vestibular evoked myogenic potentials (VEMP) can detect asymptomatic saccular hydrops. Laryngoscope. 2006 Jun;116(6):987-92. doi:10.1097/01.mlg.0000216815.75512.03</mixed-citation><mixed-citation xml:lang="en">Lin MY, Timmer FC, Oriel BS, et al. Vestibular evoked myogenic potentials (VEMP) can detect asymptomatic saccular hydrops. Laryngoscope. 2006 Jun;116(6):987-92. doi:10.1097/01.mlg.0000216815.75512.03</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Gottschlich S, Billings PB, Keithley EM, et al. Assessment of serum antibodies in patients with rapidly progressive sensorineural hearing loss and Meniere's disease. Laryngoscope. 1995 Dec;105(12 Pt 1):1347-52. doi:10.1288/00005537-199512000-00016</mixed-citation><mixed-citation xml:lang="en">Gottschlich S, Billings PB, Keithley EM, et al. Assessment of serum antibodies in patients with rapidly progressive sensorineural hearing loss and Meniere's disease. Laryngoscope. 1995 Dec;105(12 Pt 1):1347-52. doi:10.1288/00005537-199512000-00016</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Nakashima T, Naganawa S, Sugiura M, et al. Visualization of endolymphatic hydrops in patients with Meniere's disease. Laryngoscope. 2007 Mar;117(3):415-20. doi:10.1097/MLG.0b013e31802c300c</mixed-citation><mixed-citation xml:lang="en">Nakashima T, Naganawa S, Sugiura M, et al. Visualization of endolymphatic hydrops in patients with Meniere's disease. Laryngoscope. 2007 Mar;117(3):415-20. doi:10.1097/MLG.0b013e31802c300c</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Fiorino F, Pizzini FB, Beltramello A, Barbieri F. MRI performed after intratympanic gadolinium administration in patients with Meniere's disease: correlation with symptoms and signs. Eur Arch Otorhinolaryngol. 2011 Feb;268(2):181-7. doi:10.1007/s00405-010-1353-5. Epub 2010 Aug 10.</mixed-citation><mixed-citation xml:lang="en">Fiorino F, Pizzini FB, Beltramello A, Barbieri F. MRI performed after intratympanic gadolinium administration in patients with Meniere's disease: correlation with symptoms and signs. Eur Arch Otorhinolaryngol. 2011 Feb;268(2):181-7. doi:10.1007/s00405-010-1353-5. Epub 2010 Aug 10.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Arab SF, Düwel P, Jüngling E, et al. Inhibition of voltage-gated calcium currents in type II vestibular hair cells by cinnarizine. Naunyn Schmiedebergs Arch Pharmacol. 2004 Jun;369(6):570-5. doi:10.1007/s00210-004-0936-3. Epub 2004 May 11.</mixed-citation><mixed-citation xml:lang="en">Arab SF, Düwel P, Jüngling E, et al. Inhibition of voltage-gated calcium currents in type II vestibular hair cells by cinnarizine. Naunyn Schmiedebergs Arch Pharmacol. 2004 Jun;369(6):570-5. doi:10.1007/s00210-004-0936-3. Epub 2004 May 11.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Düwel P, Haasler T, Jüngling E, et al. Effects of cinnarizine on calcium and pressure-dependent potassium currents in guinea pig vestibular hair cells. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jun;371(6):441-8. doi:10.1007/s00210-005-1077-z. Epub 2005 Jul 23.</mixed-citation><mixed-citation xml:lang="en">Düwel P, Haasler T, Jüngling E, et al. Effects of cinnarizine on calcium and pressure-dependent potassium currents in guinea pig vestibular hair cells. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jun;371(6):441-8. doi:10.1007/s00210-005-1077-z. Epub 2005 Jul 23.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Rascol O, Hain TC, Brefel C, et al. Antivertigo medications and drug-induced vertigo. A pharmacological review. Drugs. 1995 Nov;50(5):777-91. doi:10.2165/00003495-199550050-00002</mixed-citation><mixed-citation xml:lang="en">Rascol O, Hain TC, Brefel C, et al. Antivertigo medications and drug-induced vertigo. A pharmacological review. Drugs. 1995 Nov;50(5):777-91. doi:10.2165/00003495-199550050-00002</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Pianese CP, Hidalgo LO, Gonzalez RH, et al. New approaches to the management of peripheral vertigo: efficacy and safety of two calcium antagonists in a 12-week, multinational, double-blind study. Otol Neurotol. 2002 May;23(3):357-63. doi:10.1097/00129492-200205000-00023</mixed-citation><mixed-citation xml:lang="en">Pianese CP, Hidalgo LO, Gonzalez RH, et al. New approaches to the management of peripheral vertigo: efficacy and safety of two calcium antagonists in a 12-week, multinational, double-blind study. Otol Neurotol. 2002 May;23(3):357-63. doi:10.1097/00129492-200205000-00023</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Hahn A, Sejna I, Stefflova B, et al. A fixed combination of cinnarizine/dimenhydrinate for the treatment of patients with acute vertigo due to vestibular disorders: a randomized, reference-controlled clinical study. Clin Drug Investig. 2008;28(2):89-99. doi:10.2165/00044011-200828020-00003</mixed-citation><mixed-citation xml:lang="en">Hahn A, Sejna I, Stefflova B, et al. A fixed combination of cinnarizine/dimenhydrinate for the treatment of patients with acute vertigo due to vestibular disorders: a randomized, reference-controlled clinical study. Clin Drug Investig. 2008;28(2):89-99. doi:10.2165/00044011-200828020-00003</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Novotny M, Kostrica R. Fixed combination of cinnarizine and dimenhydrinate versus betahistine dimesylate in the treatment of Meniere's disease: a randomized, double-blind, parallel group clinical study. Int Tinnitus J. 2002;8(2):115-23.</mixed-citation><mixed-citation xml:lang="en">Novotny M, Kostrica R. Fixed combination of cinnarizine and dimenhydrinate versus betahistine dimesylate in the treatment of Meniere's disease: a randomized, double-blind, parallel group clinical study. Int Tinnitus J. 2002;8(2):115-23.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
