nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2023-1-43-49nnp-1952Research ArticleORIGINAL INVESTIGATIONSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИAssociation of sleep disorders with various polymorphic variants of the 5-HTTLPR SNP rs25531 A>G gene in people aged 25–44Ассоциация нарушения сна с различными полиморфными вариантами гена 5-HTTLPR SNP rs25531 A>G у лиц 25–44 летhttps://orcid.org/0000-0001-5701-7856ГафаровВ. В.GafarovV. V.

Валерий Васильевич Гафаров

630089, Новосибирск, ул. Б. Богаткова, 175/1

Valery Vasilyevich Gafarov

630089, Novosibirsk, B. Bogatkova St., 175/1

valery.gafarov@gmail.comhttps://orcid.org/0000-0001-8313-3893ГромоваЕ. А.GromovaE. A.

630089, Новосибирск, ул. Б. Богаткова, 175/1

630089, Novosibirsk, B. Bogatkova St., 175/1

https://orcid.org/0000-0001-5255-5647ГагулинИ. В.GagulinI. V.

630089, Новосибирск, ул. Б. Богаткова, 175/1

630089, Novosibirsk, B. Bogatkova St., 175/1

https://orcid.org/0000-0002-8101-6121ПановД. О.PanovD. O.

630089, Новосибирск, ул. Б. Богаткова, 175/1

630089, Novosibirsk, B. Bogatkova St., 175/1

https://orcid.org/0000-0002-7165-4496МаксимовВ. Н.MaksimovV. N.

630089, Новосибирск, ул. Б. Богаткова, 175/1

630089, Novosibirsk, B. Bogatkova St., 175/1

https://orcid.org/0000-0002-6285-4162ГубинаМ. А.GubinaM. A.

630089, Новосибирск, ул. Б. Богаткова, 175/1

630089, Novosibirsk, B. Bogatkova St., 175/1

https://orcid.org/0000-0001-5380-9434ГафароваА. В.GafarovaA. V.

630089, Новосибирск, ул. Б. Богаткова, 175/1

630089, Novosibirsk, B. Bogatkova St., 175/1

Научно-исследовательский институт терапии и профилактической медицины – филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики СО РАН»; Межведомственная лаборатория эпидемиологии сердечно-сосудистых заболеванийРоссияScientific Research Institute for Therapy and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics, Russian Academy of Sciences; Interdepartmental Laboratory of Epidemiology of Cardiovascular DiseasesRussian FederationНаучно-исследовательский институт терапии и профилактической медицины – филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики СО РАН»РоссияScientific Research Institute for Therapy and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics, Russian Academy of SciencesRussian Federation2023170220231514349Copyright © Gafarov V.V., Gromova E.A., Gagulin I.V., Panov D.O., Maksimov V.N., Gubina M.A., Gafarova A.V., 20232023Гафаров В.В., Громова Е.А., Гагулин И.В., Панов Д.О., Максимов В.Н., Губина М.А., Гафарова А.В.Gafarov V.V., Gromova E.A., Gagulin I.V., Panov D.O., Maksimov V.N., Gubina M.A., Gafarova A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1952

Objective: to study the associations between polymorphic variants of the 5-HTTLPR SNP rs25531 A>G gene and sleep disorders in the open population of the able-bodied population aged 25–44 years in Novosibirsk.Material and methods. A representative sample of the population aged 25–44 years in Novosibirsk was surveyed in 2013–2016 (403 men, mean age – 34±0.4 years, response – 71%; 531 women, mean age – 35±0.4 years, response – 72%). The general examination, included in the WHO MONICA-psychosocial (MOPSY) program was carried out according to standard methods. Sleep disturbance was assessed using the Jenkins scale. Three hundred forty nine (349) people who underwent genotyping were selected from the total sample using the method of random numbers generation.Results. In the studied population aged 25–44 years, 42.8% of respondents gave a negative assessment of their sleep, 39.7% of men and 45.3% of women had sleep disorders (χ2 =11.397; df=4; p<0.05). In 19.6% of men and 21.5% of women, sleep duration was 6 hours per day, 5.7% of men and 4.5% of women reported 5 hours of sleep per day (χ2 =2.269; df=5; p>0.05).The most common genotype of the 5-HTTLPR SNP rs25531 A>G gene was SLA (43.3%), LALA (26.4%) was on the second place, SS (17.8%) was on the third place, less represented genotypes in our population were LALG (6.9%), SLG (4.4%), LGLG (1.4%) genotypes.Among individuals with the SLA genotype more common was 5–6 hour sleep (55.3%) (χ2 =4.121; df=1; p<0.05) and 8–10 hour sleep (63.5%) (OR=4.863; 95% CI 1.625–14.555; χ2 =7.625; df=1; p<0.01), among LALA carriers – 8–10 hour sleep (58.5%) (χ2 =4.862; df=1; p< 0.05), compared with carriers of the LALG genotype, among whom 7-hour sleep was more common (73.7%).Conclusion. The effect of the 5-HTTLPR SNP rs25531 A>G gene on serotonin neurotransmission contributes significantly to the etiology of sleep disorders.

Цель исследования – изучить ассоциации между полиморфными вариантами гена 5-HTTLPR SNP rs25531 A>G и нарушениями сна в открытой популяции трудоспособного населения 25–44 лет г. Новосибирска.Материал и методы. Была обследована репрезентативная выборка населения 25–44 лет г. Новосибирска в 2013–2016 гг. (403 мужчины, средний возраст – 34±0,4 года, респонс – 71%; 531 женщина, средний возраст – 35±0,4 года, респонс – 72%). Общее обследование проводилось по стандартным методикам, включенным в программу ВОЗ MONICA-psychosocial (MOPSY). Нарушение сна оценивали с помощью шкалы Дженкинса. Методом случайных чисел из общей выборки было отобрано 349 человек, которым было проведено генотипирование.Результаты. В изучаемой популяции 25–44 лет 42,8% респондентов дали негативную оценку своему сну, 39,7% мужчин и 45,3% женщин имели нарушение сна (χ2 =11,397; df=4; p<0,05). У 19,6% мужчин и 21,5% женщин продолжительность сна составила 6 ч в сутки, 5,7% мужчин и 4,5% женщин сообщали о 5 ч сна в сутки (χ2 =2,269; df=5; p>0,05).Наиболее распространенным генотипом гена 5-HTTLPR SNP rs25531 A>G оказался SLA (43,3%), на втором месте – LALA (26,4%), на третьем – SS (17,8%), менее представленными генотипами в нашей популяции оказались генотипы LALG (6,9%), SLG (4,4%), LGLG (1,4%).Среди лиц с генотипом SLA чаще встречался 5–6-часовой сон (55,3%) (χ2 =4,121; df=1; p<0,05) и 8–10-часовой сон (63,5%) (ОШ=4,863; 95% ДИ 1,625–14,555; χ2 =7,625; df=1; p<0,01), среди носителей LALA – 8–10-часовой сон (58,5%) (χ2 =4,862; df=1; p<0,05), в сравнении с носителями генотипа LALG, среди которых чаще встречался 7-часовой сон (73,7%).Заключение. Действие гена 5-HTTLPR SNP rs25531 A>G на нейротрансмиссию серотонина вносит значительный вклад в этиологию нарушений сна.

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The authors declare that there are no conflicts of interest present.