nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2023-1-4-17nnp-1947Research ArticleORIGINAL INVESTIGATIONSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИPredictive capabilities of the Cloninger Temperament and Character Inventory (TCI) in evaluating the effectiveness of antidepressant pharmacotherapy. Systematic review and meta-analysisПрогностические возможности Опросника темперамента и характера Клонингера (TCI) при оценке эффективности антидепрессивной фармакотерапии. Систематический обзор и метаанализhttps://orcid.org/0000-0002-9605-8527ОвчинниковА. В.OvchinnikovA. V.

Алексей Валерьевич Овчинников

119034, Москва, Кропоткинский пер., 23

119034, Moscow, Kropotkinsky Per., 23

ovchinnikov.alexy@yandex.ruhttps://orcid.org/0000-0002-6018-402XВазагаеваТ. И.VazagaevaT. I.

119034, Москва, Кропоткинский пер., 23

119034, Moscow, Kropotkinsky Per., 23

https://orcid.org/0000-0002-7045-0547АхапкинР. В.AkhapkinR. V.

119034, Москва, Кропоткинский пер., 23

119034, Moscow, Kropotkinsky Per., 23

https://orcid.org/0000-0003-1667-5355ВолельБ. А.VolelB. A.

119021, Москва, ул. Россолимо, 11, стр. 2

119021, Moscow, Rossolimo St., 11, Build. 2

ФГБУ «Национальный медицинский исследовательский центр психиатрии и наркологии им. В.П. Сербского»РоссияNational Medical Research Center for Psychiatry and Narcology named after V.P. Serbsky, Ministry of Health of RussiaRussian FederationИнститут клинической медицины им. Н.В. Склифосовского ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияN.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian Federation202316022023151417Copyright © Ovchinnikov A.V., Vazagaeva T.I., Akhapkin R.V., Volel B.A., 20232023Овчинников А.В., Вазагаева Т.И., Ахапкин Р.В., Волель Б.А.Ovchinnikov A.V., Vazagaeva T.I., Akhapkin R.V., Volel B.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1947

In the pharmacotherapy of depressive disorders, the problem of the predictors of a therapeutic response remains relevant, they may be important in determining treatment tactics.Objective: to determine the predictive power of the Cloninger Temperament and Character Inventory (TCI) in evaluating the results of antidepressant pharmacotherapy in patients with depression (major depressive disorder).Material and methods. PubMed and Google Scholar were searched for articles published between 1990 and November 2021. Only English-language prospective studies, that examined the relationship between pre-treatment TCI personality scores and antidepressant pharmacotherapy efficacy were selected.Results. A total of 18 studies were found (Ntot=3122). The most commonly cited statistically significant predictors of therapy effectiveness were: harm avoidance (HA) in 11 studies (Ntot=2413), reward dependence in 6 (Ntot=1941), cooperativeness (CO) in 6 (Ntot=1259). In only two studies (Ntot=234), personality parameters were not associated with treatment efficacy. In 10 studies (Ntot=1065) baseline values of personality characteristics were indicated, which made it possible to include them in the meta-analysis. HA (z=4.06; p<0.0001; I2 =49%) and CO (z=2.71; p=0.007; I2 =66%) were associated – in a statistically significant way – with the likelihood of achieving a response to antidepressant pharmacotherapy.Conclusion. Personality dimensions from the TCI questionnaire are predictors of the effectiveness of antidepressant pharmacotherapy

В фармакотерапии депрессивных расстройств остается актуальной проблема поиска предикторов терапевтического ответа, учет которых может иметь важное значение в определении тактики лечения.Целю настоящего обзора является определение прогностических возможностей Опросника темперамента и характера Клонингера (Temperament and Character Inventory, TCI) в оценке результатов антидепрессивной фармакотерапии у пациентов с депрессией (большим депрессивным расстройством).Материал и методы. Поиск литературы проводился в системах PubMed и Google Scholar среди статей, опубликованных в период с 1990 г. по ноябрь 2021 г. Отбирались только англоязычные проспективные исследования, в которых изучалась связь между значениями личностных характеристик из опросника TCI, полученными до начала лечения, и эффективностью антидепрессивной фармакотерапии.Результаты. Всего удалось найти 18 исследований (Nсум=3122). В качестве статистически значимых предикторов эффективности терапии чаще всего назывались: избегание опасности (ИО) – в 11 исследованиях (Nсум=2413), зависимость от вознаграждения – в 6 (Nсум=1941), сотрудничество (СО) – в 6 (Nсум=1259). Всего в двух исследованиях (Nсум= 234) параметры личности не были связаны с эффективностью терапии. В 10 исследованиях (Nсум=1065) указывались фоновые значения личностных характеристик, что позволило включить их в метаанализ. ИО (z=4,06; p<0,0001; I2=49%) и СО (z=2,71; p=0,007; I2=66%) были статистически значимо связаны с вероятностью достижения ответа на антидепрессивную фармакотерапию.Заключение. Личностные дименсии из опросника TCI являются предикторами эффективности антидепрессивной фармакотерапии.

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The authors declare that there are no conflicts of interest present.