nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2022-5-90-95nnp-1897Research ArticleREVIEWSОБЗОРЫEmotional disorders and their therapy in chronic low back painЭмоциональные нарушения и их терапия при хронической поясничной болиhttps://orcid.org/0000-0003-4950-144XИсайкинА. И.IsaikinA. I.

Кафедра нервных болезней и нейрохирургии Института клинической медицины им. Н.В. Склифосовского,

119021, Москва, ул. Россолимо, 11, стр. 1

Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine, 

11, Rossolimo St., Build. 1, Moscow 119021

alexisa68@mail.ruhttps://orcid.org/0000-0003-4971-9254НасоноваТ. И.NasonovaT. I.

Кафедра нервных болезней и нейрохирургии Института клинической медицины им. Н.В. Склифосовского,

119021, Москва, ул. Россолимо, 11, стр. 1

Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine, 

11, Rossolimo St., Build. 1, Moscow 119021

https://orcid.org/0000-0002-0827-9427МухаметзяноваА. Х.MukhametzyanovaA. Kh.

Кафедра нервных болезней и нейрохирургии Института клинической медицины им. Н.В. Склифосовского,

119021, Москва, ул. Россолимо, 11, стр. 1

Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine, 

11, Rossolimo St., Build. 1, Moscow 119021

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian Federation2022251020221459095Copyright © Isaikin A.I., Nasonova T.I., Mukhametzyanova A.K., 20222022Исайкин А.И., Насонова Т.И., Мухаметзянова А.Х.Isaikin A.I., Nasonova T.I., Mukhametzyanova A.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1897

Chronic low back pain (CLBP) is the most common chronic pain syndrome that causes deterioration of the quality of life and disability. Anxiety and depressive disorders are significantly more common in patients with CLBP. The negative impact of CLBP on cognitive abilities and sleep was revealed. Treatment of patients with CLBP should be started with non-pharmacological methods, including an educational program, kinesiotherapy, and cognitive behavioral therapy. Antidepressants are prescribed for CLBP to reduce the severity of associated anxiety and depressive disorders, improve sleep and relieve pain. The efficacy and safety of sertraline (Serenatа) in CLBP, its additional neurochemical mechanisms of action due to its effect on dopamine reuptake, interaction with sigma receptors, low incidence of side effects, and high adherence of patients to therapy are discussed. 

Хроническая боль в нижней части спины (ХБНС) – самый частый хронический болевой синдром, который приводит к снижению качества жизни и к нетрудоспособности. У пациентов с ХБНС значимо чаще встречаются тревожные и депрессивные расстройства. Выявлено негативное влияние ХБНС на когнитивные способности и сон. Лечение пациентов с ХБНС следует начинать с немедикаментозных методов, в том числе с образовательной программы, кинезиотерапии, когнитивно-поведенческой терапии. Антидепрессанты назначают при ХБНС для уменьшения выраженности сопутствующих тревожных и депрессивных расстройств, улучшения сна и облегчения боли. Обсуждаются эффективность и безопасность применения сертралина (Серенаты) при ХБНС, его дополнительные нейрохимические механизмы действия в виде влияния на обратный захват дофамина, взаимодействия с сигма-рецепторами, низкая частота побочных эффектов, высокая приверженность пациентов терапии. 

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The authors declare that there are no conflicts of interest present.