nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2022-4-68-74nnp-1864Research ArticleREVIEWSОБЗОРЫThe role of oxidative stress in the development of Alzheimer's diseaseРоль оксидативного стресса в развитии болезни Альцгеймераhttps://orcid.org/0000-0001-9532-9957НиколенкоВ. Н.NikolenkoV. N.

119991, Москва, ул. Большая Пироговская, 2, стр. 4119991, Москва, Ленинские горы, 1

119991, Moscow, Bolshaya Pirogovskaya St., 2, Build. 4119991, Moscow, Leninskiye Gory, 1

https://orcid.org/0000-0003-4033-1202РизаеваН. А.RizaevaN. A.

119991, Москва, ул. Большая Пироговская, 2, стр. 4119991, Москва, Ленинские горы, 1

119991, Moscow, Bolshaya Pirogovskaya St., 2, Build. 4119991, Moscow, Leninskiye Gory, 1

https://orcid.org/0000-0002-2017-3596БулыгинК. В.BulyginK. V.

119991, Москва, ул. Большая Пироговская, 2, стр. 4119991, Москва, Ленинские горы, 1

119991, Moscow, Bolshaya Pirogovskaya St., 2, Build. 4119991, Moscow, Leninskiye Gory, 1

https://orcid.org/0000-0002-0401-3023АнохинаВ. М.AnokhinaV. M.

119991, Москва, ул. Большая Пироговская, 2, стр. 4

119991, Moscow, Bolshaya Pirogovskaya St., 2, Build. 4

https://orcid.org/0000-0002-5867-1152БолотскаяА. А.BolotskayaA. A.

Анастасия Александровна Болотская119991, Москва, ул. Большая Пироговская, 2, стр. 4

Anastasia Aleksandrovna Bolotskaya119991, Moscow, Bolshaya Pirogovskaya St., 2, Build. 4

NastasiaBolotskaia@mail.ruФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет); ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; Lomonosov Moscow State UniversityRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian Federation2022230820221446874Copyright © Nikolenko V.N., Rizaeva N.A., Bulygin K.V., Anokhina V.M., Bolotskaya A.A., 20222022Николенко В.Н., Ризаева Н.А., Булыгин К.В., Анохина В.М., Болотская А.А.Nikolenko V.N., Rizaeva N.A., Bulygin K.V., Anokhina V.M., Bolotskaya A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1864

Oxidative stress is one of the main mechanisms for the development of Alzheimer's disease (AD); it is closely related to other key mechanisms of neurodegeneration such as mitochondrial dysfunction, inflammation, dysregulation of metal homeostasis, and protein misfolding. We have considered the role of beta-amyloid plaques and neurofibrillary tau-glomeruli in the development of AD. We analyzed the role of the products of oxidation of proteins, lipids and nucleic acids in the pathogenesis of the disease, which can be considered as markers of an early stage of AD. The main mechanisms of mitochondrial dysfunction, the damaging effect of accumulating metals under oxidative stress, as well as the role of brain hypoperfusion in its occurrence are considered.

Окислительный стресс является одним из основных механизмов развития болезни Альцгеймера (БА); он тесно связан с другими ключевыми механизмами нейродегенерации, такими как митохондриальная дисфункция, воспаление, нарушение регуляции гомеостаза металлов, неправильный фолдинг белков. Нами рассмотрена роль бета-амилоидных бляшек и нейрофибриллярных тау-клубочков в развитии БА. Анализируется роль в патогенезе заболевания продуктов окисления белков, липидов и нуклеинов кислот, которые могут рассматриваться в качестве маркеров ранней формы БА. Рассмотрены основные механизмы митохондриальной дисфункции, повреждающего действия аккумулирующихся металлов при оксидативном стрессе, а также роль гипоперфузии головного мозга в его возникновении.

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The authors declare that there are no conflicts of interest present.