Objective: to study the connection between smoking and sleep disorders in the open population of 45–64 year old in Novosibirsk.Patients and methods. IV screening of the population was carried out in 2003–2005, 1650 persons were examined (576 men, mean age – 54.23±0.2 years, response – 61%; 1074 women, mean age – 54.27±0.2 years, response – 72%). Attitudes towards smoking were studied using the scale “Knowledge and attitude to one's health” of the WHO “MONICA-psychosocial” program. To study sleep disorders and sleep duration, a standard Jenkins questionnaire was used.Results and discussion. In an open population of 45–64 years of age, 65.8% of men experienced sleep problems (satisfactory sleep – 53.6%, poor sleep – 12.2%) and 78.6% of women (satisfactory sleep – 58.9%, poor sleep – 19.7%; χ2 =38.553; df=2; p<0.001). 78.9% of men and 34.7% of women smoked (χ2 =313.175; df=5; p<0.001). Men who smoke more often rated sleep as “bad” (82.9%) than “good” (76.2%; χ2 =32.267; df=10; p<0.001). Women who tried to quit smoking were more likely to have “bad” sleep (4.7%) than “good” sleep (2.6%; χ2 =69.747; df=10; p<0.001). Among male smokers, the duration of sleep was 5–6 hours (76.9%) more often than 9–10 hours (67.6%; χ2 =3.696; df=2; p>0.05). Women who smoke were more likely to report 5–6 hours of sleep (30%) than 9–10 hours (18.2%).Conclusion. It has been established that smoking men and women aged 45–64 are more likely to experience both sleep disorders and lack of sleep.