nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2022-4-25-32nnp-1857Research ArticleORIGINAL INVESTIGATIONSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИEffect of statins on oxidative stress and cognitive function in patients with cerebral atherosclerosis: results of a prospective cohort studyОценка влияния статинов на показатели окислительного стресса и когнитивные функции у пациентов с церебральным атеросклерозом: результаты проспективного когортного исследованияhttps://orcid.org/0000-0003-0411-3638НикулинаК. В.NikulinaK. V.

Ксения Владимировна Никулина119991, Москва, ул. Трубецкая, 8, стр. 2

Ksenia Vladimirovna Nikulina119991, Moscow, Trubetskaya St., 8, Build. 2

ksenikk@mail.ruhttps://orcid.org/0000-0001-5070-926XВоробьеваО. В.VorobievaO. V.

119991, Москва, ул. Трубецкая, 8, стр. 2

119991, Moscow, Trubetskaya St., 8, Build. 2

https://orcid.org/0000-0001-9935-3962ФатееваВ. В.FateevaV. V.

119991, Москва, ул. Трубецкая, 8, стр. 2

119991, Moscow, Trubetskaya St., 8, Build. 2

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian Federation2022210820221442532Copyright © Nikulina K.V., Vorobieva O.V., Fateeva V.V., 20222022Никулина К.В., Воробьева О.В., Фатеева В.В.Nikulina K.V., Vorobieva O.V., Fateeva V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1857

The widespread use of statins for cardiovascular complications prevention makes it important to study their effects on the body. There is still no unambiguous opinion regarding the effect of statins on cognitive functions (CF).Objective: to evaluate the effect of a 12-week course of statins on the parameters of oxidative stress and CF in patients with cerebral atherosclerosis (CA) and moderate cognitive impairment.Patients and methods. 106 patients aged 45–75 years with CA and vascular risks were included, they received stable therapy for 12 weeks, including antihypertensive, nootropic drugs, antiplatelet agents and statins with stable dose and combination of drugs. At baseline and after 12 weeks of treatment, parameters of oxidative stress using Fe2+-induced chemiluminescence and cognitive phenotype, using the MoCA test, including MoCA indices, were assessed in two groups of patients: treated with statins (group 1; n=34) and those who did not receive statins (group 2; n=72).Results and discussion. In patients of group 1, more pronounced manifestations of oxidative stress and lower initial values of CF indicators were revealed. The therapy made it possible to achieve an improvement in cognitive performance in all patients, but an improvement in oxidative performance was only in group 1. The positive effect of statins on CF was manifested as a significant increase in attention- (by 1.5 points versus 0.1 points; p<0.05) and memory- (by 0.9 points against 0.2 points; p<0.05) indicators; and on the oxidative status – an increase of the indicator of resistance of lipoproteins to lipid peroxidation (LPO) by 25.9 sec vs. 3.5 sec (p<0.05) and a decrease in the activity of LPO processes (-13.6 mV vs. 39.1 mV; p<0.05).Conclusion. The 3 month therapeutic course of statins in patients with CA and vascular risks helps to reduce the manifestations of oxidative stress and improve attention and mnestic function.

Широкое применение статинов с целью профилактики сердечно-сосудистых осложнений обусловливает важность тщательного изучения их воздействия на организм. До сих пор отсутствует однозначное мнение относительно влияния статинов на когнитивные функции (КФ).Цель исследования – оценить влияние 12-недельного курса статинов на параметры окислительного стресса и КФ у больных с церебральным атеросклерозом (ЦА) и умеренными когнитивными нарушениями.Пациенты и методы. В исследование включено 106 пациентов в возрасте 45–75 лет с ЦА и сосудистыми рисками, которые в течение 12 нед получали стабильную терапию, включающую антигипертензивные, ноотропные средства, антиагреганты и статины с неизменными дозой и комбинацией препаратов. Исходно и через 12 нед лечения оценивали параметры окислительного стресса с помощью Fe2+-индуцированной хемилюминесцении и когнитивный фенотип с помощью МоСА-теста, включая индексы МоСА, в группах пациентов, получавших (группа 1; n=34) и не получавших статины (группа 2; n=72).Результаты и обсуждение. У пациентов группы 1 выявлены более выраженные проявления окислительного стресса и более низкие исходные значения показателей КФ. Проведенная терапия позволила добиться улучшения когнитивных показателей у всех пациентов, а улучшения окислительных показателей – только в группе 1. Положительное влияние статинов на КФ проявлялось в виде значительного прироста показателей, отвечающих за внимание (на 1,5 балла против 0,1 балла; р<0,05) и память (на 0,9 балла против 0,2 балла; р<0,05), а на окислительный статус – в виде прироста показателя резистентности липопротеинов к перекисному окислению липидов (ПОЛ) на 25,9 с против 3,5 с (р<0,05) и снижения активности процессов ПОЛ (-13,6 мВ против 39,1 мВ; р<0,05).Заключение. Курсовое применение статинов в течение 3 мес у пациентов с ЦА и сосудистыми рисками способствует снижению проявлений окислительного стресса и улучшению внимания и мнестической функции.

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The authors declare that there are no conflicts of interest present.