<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2022-4-4-11</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-1854</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИЯ</subject></subj-group></article-categories><title-group><article-title>Neurological complications of infective endocarditis: 10 rules of patient management</article-title><trans-title-group xml:lang="ru"><trans-title>Неврологические осложнения инфекционного эндокардита: 10 правил ведения пациента</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2670-4172</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дёмин</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Demin</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>414011, Астрахань, ул. Покровcкая Роща, 4</p></bio><bio xml:lang="en"><p>414011, Astrakhan, Pokrovskaya Roscha St., 4</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6061-8118</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кулеш</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulesh</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексей Александрович Кулеш614990, Пермь, ул. Петропавловская, 26</p></bio><bio xml:lang="en"><p>Alexey Alexandrovich Kulesh614990, Perm, Petropavlovskaya St., 26</p></bio><email xlink:type="simple">aleksey.kulesh@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3847-9366</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Виноградов</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Vinogradov</surname><given-names>O. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>105203, Москва, ул. Нижняя Первомайская, 70</p></bio><bio xml:lang="en"><p>105203, Moscow, Nizhnyaya Pervomayskaya St., 70</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1506-179X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демецкая</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Demetskaya</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>414011, Астрахань, ул. Покровcкая Роща, 4</p></bio><bio xml:lang="en"><p>414011, Astrakhan, Pokrovskaya Roscha St., 4</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6999-9671</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козьмин</surname><given-names>Д. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozmin</surname><given-names>D. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>414011, Астрахань, ул. Покровcкая Роща, 4</p></bio><bio xml:lang="en"><p>414011, Astrakhan, Pokrovskaya Roscha St., 4</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8376-3104</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Энгиноев</surname><given-names>С. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Enginoev</surname><given-names>S. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>414011, Астрахань, ул. Покровcкая Роща, 4414000, Астрахань, ул. Бакинская, 121</p></bio><bio xml:lang="en"><p>414011, Astrakhan, Pokrovskaya Roscha St., 4414000, Astrakhan, Bakinskaya St., 121</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7097-296X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дёмина</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Demina</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>414011, Астрахань, ул. Покровcкая Роща, 4</p></bio><bio xml:lang="en"><p>414011, Astrakhan, Pokrovskaya Roscha St., 4</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5701-2449</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Николаева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikolaeva</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>357538, Пятигорск, ул. Адмиральского, 6</p></bio><bio xml:lang="en"><p>357538, Pyatigorsk, Admiralskogo St., 6</p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9065-1189</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шапошникова</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Shaposhnikova</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>414011, Астрахань, ул. Покровcкая Роща, 4</p></bio><bio xml:lang="en"><p>414011, Astrakhan, Pokrovskaya Roscha St., 4</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2400-8045</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Стомпель</surname><given-names>Д. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Stompel</surname><given-names>D. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>414011, Астрахань, ул. Покровcкая Роща, 4</p></bio><bio xml:lang="en"><p>414011, Astrakhan, Pokrovskaya Roscha St., 4</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Федеральный центр сердечно-сосудистой хирургии» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Center for Cardiovascular Surgery, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Пермский государственный медицинский университет им. акад. Е.А. Вагнера» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Acad. E.A. Vagner Perm State Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУ «Национальный медико-хирургический центр им. Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.I. Pirogov National Medical and Surgical Center, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБУ «Федеральный центр сердечно-сосудистой хирургии» Минздрава России; ФГБОУ ВО «Астраханский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Center for Cardiovascular Surgery, Ministry of Health of Russia; Astrakhan State Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ГБУЗ СК «Пятигорская городская клиническая больница №2»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pyatigorsk City Clinical Hospital No. 2</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>20</day><month>08</month><year>2022</year></pub-date><volume>14</volume><issue>4</issue><fpage>4</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Demin D.A., Kulesh A.A., Vinogradov O.I., Demetskaya V.V., Kozmin D.Y., Enginoev S.T., Demina E.V., Nikolaeva E.V., Shaposhnikova E.I., Stompel D.R., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Дёмин Д.А., Кулеш А.А., Виноградов О.И., Демецкая В.В., Козьмин Д.Ю., Энгиноев С.Т., Дёмина Е.В., Николаева Е.В., Шапошникова Е.И., Стомпель Д.Р.</copyright-holder><copyright-holder xml:lang="en">Demin D.A., Kulesh A.A., Vinogradov O.I., Demetskaya V.V., Kozmin D.Y., Enginoev S.T., Demina E.V., Nikolaeva E.V., Shaposhnikova E.I., Stompel D.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/1854">https://nnp.ima-press.net/nnp/article/view/1854</self-uri><abstract><p>Infective endocarditis is a serious diagnostic and therapeutic challenge for doctors of many specialties. In order to form a structured approach to patient management, the article discusses the key points regarding the neurological aspects of the disease, which are formulated in ten rules. They cover the clinical diagnosis of endocarditis in patients with stroke, features of reperfusion therapy, approaches to prescribing antithrombotic and antibiotic therapy, as well as issues of surgical treatment.</p></abstract><trans-abstract xml:lang="ru"><p>Инфекционный эндокардит – серьезный диагностический и лечебный вызов для врачей многих специальностей. С целью формирования структурированного подхода к ведению пациентов в статье обсуждаются ключевые положения, касающиеся неврологических аспектов заболевания, которые сформулированы в десяти правилах. Они охватывают клиническую диагностику эндокардита у пациентов с инсультом, особенности реперфузионной терапии, подходы к назначению антитромботической и антибактериальной терапии, а также вопросы хирургического лечения. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>инфекционный эндокардит</kwd><kwd>неврологические осложнения</kwd><kwd>инсульт</kwd><kwd>диагностика</kwd><kwd>лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>infective endocarditis</kwd><kwd>neurological complications</kwd><kwd>stroke</kwd><kwd>diagnostics</kwd><kwd>treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia-Cabrera E, Fernandez-Hidalgo N, Almirante B, et al; Group for the Study of Cardiovascular Infections of the Andalusian Society of Infectious Diseases; Spanish Network for Research in Infectious Diseases. Neurological complications of infective endocarditis: risk factors, outcome, and impact of cardiac surgery: a multicenter observational study. Circulation. 2013 Jun 11;127(23):2272-84. doi:10.1161/CIRCULATIONAHA.112.000813</mixed-citation><mixed-citation xml:lang="en">Garcia-Cabrera E, Fernandez-Hidalgo N, Almirante B, et al; Group for the Study of Cardiovascular Infections of the Andalusian Society of Infectious Diseases; Spanish Network for Research in Infectious Diseases. Neurological complications of infective endocarditis: risk factors, outcome, and impact of cardiac surgery: a multicenter observational study. Circulation. 2013 Jun 11;127(23):2272-84. doi:10.1161/CIRCULATIONAHA.112.000813</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Snygg-Martin U, Gustafsson L, Rosengren L, et al. Cerebrovascular complications in patients with left-sided infective endocarditis are common: a prospective study using magnetic resonance imaging and neurochemical brain damage markers. Clin Infect Dis. 2008 Jul 1;47(1):23-30. doi:10.1086/588663</mixed-citation><mixed-citation xml:lang="en">Snygg-Martin U, Gustafsson L, Rosengren L, et al. Cerebrovascular complications in patients with left-sided infective endocarditis are common: a prospective study using magnetic resonance imaging and neurochemical brain damage markers. Clin Infect Dis. 2008 Jul 1;47(1):23-30. doi:10.1086/588663</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Deprele C, Berthelot P, Lemetayer F, et al. Risk factors for systemic emboli in infective endocarditis. Clin Microbiol Infect. 2004 Jan;10(1):46-53. doi:10.1111/j.1469-0691.2004.00735.x</mixed-citation><mixed-citation xml:lang="en">Deprele C, Berthelot P, Lemetayer F, et al. Risk factors for systemic emboli in infective endocarditis. Clin Microbiol Infect. 2004 Jan;10(1):46-53. doi:10.1111/j.1469-0691.2004.00735.x</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Valenzuela I, Hunter MD, Sundheim K, et al. Clinical risk factors for acute ischaemic and haemorrhagic stroke in patients with infective endocarditis. Intern Med J. 2018;48(9):1072-80. doi:10.1111/imj.13958</mixed-citation><mixed-citation xml:lang="en">Valenzuela I, Hunter MD, Sundheim K, et al. Clinical risk factors for acute ischaemic and haemorrhagic stroke in patients with infective endocarditis. Intern Med J. 2018;48(9):1072-80. doi:10.1111/imj.13958</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Yang A, Tan C, Daneman N, et al. Clinical and echocardiographic predictors of embolism in infective endocarditis: systematic review and meta-analysis. Clin Microbiol Infect. 2019 Feb;25(2):178-87. doi:10.1016/j.cmi.2018.08.010</mixed-citation><mixed-citation xml:lang="en">Yang A, Tan C, Daneman N, et al. Clinical and echocardiographic predictors of embolism in infective endocarditis: systematic review and meta-analysis. Clin Microbiol Infect. 2019 Feb;25(2):178-87. doi:10.1016/j.cmi.2018.08.010</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Habib G, Lancellotti P, Antunes MJ, et al; ESC Scientific Document Group. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J. 2015 Nov 21;36(44):3075-128. doi:10.1093/eurheartj/ehv319</mixed-citation><mixed-citation xml:lang="en">Habib G, Lancellotti P, Antunes MJ, et al; ESC Scientific Document Group. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J. 2015 Nov 21;36(44):3075-128. doi:10.1093/eurheartj/ehv319</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the Early Management of Patients with Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association. Stroke. 2019 Dec;50(12):e344-e418. doi:10.1161/STR.0000000000000211</mixed-citation><mixed-citation xml:lang="en">Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the Early Management of Patients with Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association. Stroke. 2019 Dec;50(12):e344-e418. doi:10.1161/STR.0000000000000211</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Berge E, Whiteley W, Audebert H, et al. European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke. Eur Stroke J. 2021 Mar;6(1):I-LXII. doi:10.1177/2396987321989865</mixed-citation><mixed-citation xml:lang="en">Berge E, Whiteley W, Audebert H, et al. European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke. Eur Stroke J. 2021 Mar;6(1):I-LXII. doi:10.1177/2396987321989865</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Asaithambi G, Adil MM, Qureshi AI. Thrombolysis for ischemic stroke associated with infective endocarditis: results from the nationwide inpatient sample. Stroke. 2013 Oct;44(10):2917-9. doi:10.1161/STROKEAHA.113.001602. Epub 2013 Aug 13.</mixed-citation><mixed-citation xml:lang="en">Asaithambi G, Adil MM, Qureshi AI. Thrombolysis for ischemic stroke associated with infective endocarditis: results from the nationwide inpatient sample. Stroke. 2013 Oct;44(10):2917-9. doi:10.1161/STROKEAHA.113.001602. Epub 2013 Aug 13.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Bettencourt S, Ferro JM. Acute Ischemic Stroke Treatment in Infective Endocarditis: Systematic Review. J Stroke Cerebrovasc Dis. 2020 Apr;29(4):104598. doi:10.1016/j.jstrokecerebrovasdis.2019.104598. Epub 2020 Feb 3.</mixed-citation><mixed-citation xml:lang="en">Bettencourt S, Ferro JM. Acute Ischemic Stroke Treatment in Infective Endocarditis: Systematic Review. J Stroke Cerebrovasc Dis. 2020 Apr;29(4):104598. doi:10.1016/j.jstrokecerebrovasdis.2019.104598. Epub 2020 Feb 3.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Zmaili MA, Alzubi JM, Kocyigit D, et al. A Contemporary 20-Year Cleveland Clinic Experience of Nonbacterial Thrombotic Endocarditis: Etiology, Echocardiographic Imaging, Management, and Outcomes. Am J Med. 2021 Mar;134(3):361-9. doi:10.1016/j.amjmed.2020.06.047. Epub 2020 Aug 19.</mixed-citation><mixed-citation xml:lang="en">Zmaili MA, Alzubi JM, Kocyigit D, et al. A Contemporary 20-Year Cleveland Clinic Experience of Nonbacterial Thrombotic Endocarditis: Etiology, Echocardiographic Imaging, Management, and Outcomes. Am J Med. 2021 Mar;134(3):361-9. doi:10.1016/j.amjmed.2020.06.047. Epub 2020 Aug 19.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Duval X, Iung B, Klein I, et al; IMAGE (Resonance Magnetic Imaging at the Acute Phase of Endocarditis) Study Group. Effect of early cerebral magnetic resonance imaging on clinical decisions in infective endocarditis: a prospective study. Ann Intern Med. 2010 Apr 20;152(8):497-504, W175. doi:10.7326/0003-4819-152-8-201004200-00006</mixed-citation><mixed-citation xml:lang="en">Duval X, Iung B, Klein I, et al; IMAGE (Resonance Magnetic Imaging at the Acute Phase of Endocarditis) Study Group. Effect of early cerebral magnetic resonance imaging on clinical decisions in infective endocarditis: a prospective study. Ann Intern Med. 2010 Apr 20;152(8):497-504, W175. doi:10.7326/0003-4819-152-8-201004200-00006</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Wilbring M, Irmscher L, Alexiou K, et al. The impact of preoperative neurological events in patients suffering from native infective valve endocarditis. Interact Cardiovasc Thorac Surg. 2014 Jun;18(6):740-7. doi:10.1093/icvts/ivu039. Epub 2014 Mar 4.</mixed-citation><mixed-citation xml:lang="en">Wilbring M, Irmscher L, Alexiou K, et al. The impact of preoperative neurological events in patients suffering from native infective valve endocarditis. Interact Cardiovasc Thorac Surg. 2014 Jun;18(6):740-7. doi:10.1093/icvts/ivu039. Epub 2014 Mar 4.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Nishiguchi S, Nishino K, Kitagawa I, Tokuda Y. Factors associated with delayed diagnosis of infective endocarditis: A retrospective cohort study in a teaching hospital in Japan. Medicine (Baltimore). 2020 Jul 24;99(30):e21418. doi:10.1097/MD.0000000000021418</mixed-citation><mixed-citation xml:lang="en">Nishiguchi S, Nishino K, Kitagawa I, Tokuda Y. Factors associated with delayed diagnosis of infective endocarditis: A retrospective cohort study in a teaching hospital in Japan. Medicine (Baltimore). 2020 Jul 24;99(30):e21418. doi:10.1097/MD.0000000000021418</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">N'Guyen Y, Duval X, Revest M, et al; AEPEI study group. Time interval between infective endocarditis first symptoms and diagnosis: relationship to infective endocarditis characteristics, microorganisms and prognosis. Ann Med. 2017 Mar;49(2):117-25. doi:10.1080/07853890.2016.1235282</mixed-citation><mixed-citation xml:lang="en">N'Guyen Y, Duval X, Revest M, et al; AEPEI study group. Time interval between infective endocarditis first symptoms and diagnosis: relationship to infective endocarditis characteristics, microorganisms and prognosis. Ann Med. 2017 Mar;49(2):117-25. doi:10.1080/07853890.2016.1235282</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Champey J, Pavese P, Bouvaist H, et al. Value of brain MRI in infective endocarditis: a narrative literature review. Eur J Clin Microbiol Infect Dis. 2016 Feb;35(2):159-68. doi:10.1007/s10096-015-2523-6. Epub 2015 Nov 19.</mixed-citation><mixed-citation xml:lang="en">Champey J, Pavese P, Bouvaist H, et al. Value of brain MRI in infective endocarditis: a narrative literature review. Eur J Clin Microbiol Infect Dis. 2016 Feb;35(2):159-68. doi:10.1007/s10096-015-2523-6. Epub 2015 Nov 19.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ducruet AF, Hickman ZL, Zacharia BE, et al. Intracranial infectious aneurysms: a comprehensive review. Neurosurg Rev. 2010 Jan;33(1):37-46. doi:10.1007/s10143-009-0233-1. Epub 2009 Oct 16.</mixed-citation><mixed-citation xml:lang="en">Ducruet AF, Hickman ZL, Zacharia BE, et al. Intracranial infectious aneurysms: a comprehensive review. Neurosurg Rev. 2010 Jan;33(1):37-46. doi:10.1007/s10143-009-0233-1. Epub 2009 Oct 16.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Chukwudelunzu FE, Brown RD Jr, Wijdicks EF, Steckelberg JM. Subarachnoid haemorrhage associated with infectious endocarditis: case report and literature review. Eur J Neurol. 2002 Jul;9(4):423-7. doi:10.1046/j.1468-1331.2002.00432.x</mixed-citation><mixed-citation xml:lang="en">Chukwudelunzu FE, Brown RD Jr, Wijdicks EF, Steckelberg JM. Subarachnoid haemorrhage associated with infectious endocarditis: case report and literature review. Eur J Neurol. 2002 Jul;9(4):423-7. doi:10.1046/j.1468-1331.2002.00432.x</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Baddour LM, Wilson WR, Bayer AS, et al; American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Stroke Council. Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association. Circulation. 2015 Oct 13;132(15):1435-86. doi:10.1161/CIR.0000000000000296</mixed-citation><mixed-citation xml:lang="en">Baddour LM, Wilson WR, Bayer AS, et al; American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Stroke Council. Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association. Circulation. 2015 Oct 13;132(15):1435-86. doi:10.1161/CIR.0000000000000296</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Carbone A, Lieu A, Mouhat B, et al. Spondylodiscitis complicating infective endocarditis. Heart. 2020 Dec;106(24):1914-8. doi:10.1136/heartjnl-2019-316492. Epub 2020 May 28.</mixed-citation><mixed-citation xml:lang="en">Carbone A, Lieu A, Mouhat B, et al. Spondylodiscitis complicating infective endocarditis. Heart. 2020 Dec;106(24):1914-8. doi:10.1136/heartjnl-2019-316492. Epub 2020 May 28.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Calderaro D, Gualandro DM, Yu PC, et al. Spondylodiscitis and infectious endocarditis: a round-trip to be considered. Braz J Infect Dis. 2008 Dec;12(6):544-5. doi:10.1590/s1413-86702008000600021</mixed-citation><mixed-citation xml:lang="en">Calderaro D, Gualandro DM, Yu PC, et al. Spondylodiscitis and infectious endocarditis: a round-trip to be considered. Braz J Infect Dis. 2008 Dec;12(6):544-5. doi:10.1590/s1413-86702008000600021</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Lucas MJ, Brouwer MC, van der Ende A, van de Beek D. Endocarditis in adults with bacterial meningitis. Circulation. 2013 May 21;127(20):2056-62. doi:10.1161/CIRCULATIONAHA.113.001545. Epub 2013 Apr 17.</mixed-citation><mixed-citation xml:lang="en">Lucas MJ, Brouwer MC, van der Ende A, van de Beek D. Endocarditis in adults with bacterial meningitis. Circulation. 2013 May 21;127(20):2056-62. doi:10.1161/CIRCULATIONAHA.113.001545. Epub 2013 Apr 17.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Pedersen M, Benfield TL, Skinhoej P, Jensen AG. Haematogenous Staphylococcus aureus meningitis. A 10-year nationwide study of 96 consecutive cases. BMC Infect Dis. 2006 Mar 16;6:49. doi:10.1186/1471-2334-6-49</mixed-citation><mixed-citation xml:lang="en">Pedersen M, Benfield TL, Skinhoej P, Jensen AG. Haematogenous Staphylococcus aureus meningitis. A 10-year nationwide study of 96 consecutive cases. BMC Infect Dis. 2006 Mar 16;6:49. doi:10.1186/1471-2334-6-49</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Schlesinger LS, Ross SC, Schaberg DR. Staphylococcus aureus meningitis: a broad-based epidemiologic study. Medicine (Baltimore). 1987 Mar;66(2):148-56. doi:10.1097/00005792-198703000-00006</mixed-citation><mixed-citation xml:lang="en">Schlesinger LS, Ross SC, Schaberg DR. Staphylococcus aureus meningitis: a broad-based epidemiologic study. Medicine (Baltimore). 1987 Mar;66(2):148-56. doi:10.1097/00005792-198703000-00006</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
