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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2022-3-32-37</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-1821</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИ</subject></subj-group></article-categories><title-group><article-title>Social adaptation level and its relationship with the main clinico-dynamic and psychological characteristics in the comorbidity of affective disorders and alcohol dependence</article-title><trans-title-group xml:lang="ru"><trans-title>Уровень социальной адаптации и его связь с основными клинико-динамическими и психологическими характеристиками при коморбидности аффективных расстройств и алкогольной зависимости</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2246-7045</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рощина</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Roshchina</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>634014, Томск, ул. Алеутская, 4</p></bio><bio xml:lang="en"><p>4, Aleutskaya St., Tomsk 634014</p></bio><email xlink:type="simple">roshchinaov@vtomske.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9813-3789</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симуткин</surname><given-names>Г. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Simutkin</surname><given-names>G. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>634014, Томск, ул. Алеутская, 4</p></bio><bio xml:lang="en"><p>4, Aleutskaya St., Tomsk 634014</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1052-855X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бохан</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bokhan</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>634014, Томск, ул. Алеутская, 4;</p><p>634050, Томск, Московский тракт, 2;</p><p>34050, Томск, проспект Ленина, 36</p></bio><bio xml:lang="en"><p>4, Aleutskaya St., Tomsk 634014;</p><p>2, Moskovskiy tract, Tomsk 634050;</p><p>36, Lenin Prospect, Tomsk 34050</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0045-2256</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Суровцева</surname><given-names>А. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Surovtseva</surname><given-names>A. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>634014, Томск, ул. Алеутская, 4</p></bio><bio xml:lang="en"><p>4, Aleutskaya St., Tomsk 634014</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт психического здоровья ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Mental Health Research Institute, Tomsk National Research Medical Center of Russian Academy Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научно-исследовательский институт психического здоровья ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук»; ФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава России; ФГАОУ ВО «Национальный исследовательский Томский государственный университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Mental Health Research Institute, Tomsk National Research Medical Center of Russian Academy Sciences; Siberian State Medical University, Ministry of Health of Russia; National Research Tomsk State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>20</day><month>06</month><year>2022</year></pub-date><volume>14</volume><issue>3</issue><fpage>32</fpage><lpage>37</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Roshchina O.V., Simutkin G.G., Bokhan N.A., Surovtseva A.K., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Рощина О.В., Симуткин Г.Г., Бохан Н.А., Суровцева А.К.</copyright-holder><copyright-holder xml:lang="en">Roshchina O.V., Simutkin G.G., Bokhan N.A., Surovtseva A.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/1821">https://nnp.ima-press.net/nnp/article/view/1821</self-uri><abstract><p>Alcohol dependence (AD) and mood disorders are not only a serious medical and socio-economic problem for modern society, but also the cause of social adaptation disorders that form even in the early stages of each of these disorders, as well as in case of their comorbidity.</p><sec><title>Objective</title><p>Objective: to determine the relationship between the level of subjective assessment of social adaptation and the main clinical, dynamic and psychological characteristics in patients with affective disorders (AFD) with comorbid AD.</p></sec><sec><title>Patients and methods</title><p>Patients and methods. The study included 126 patients treated for AFD in the departments of affective or addictive conditions of the clinic of the Research Institute of Mental Health of the Tomsk National Research Medical Center (F31 – F34.1 according to ICD-10; n=83) or AFD comorbid with AD (F10. 2; n=43). The study used clinical-dynamic, psychometric, pathopsychological and statistical methods.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. Patients with AFD without comorbidity at admission were characterized by a greater severity of subjective impairment of social adaptation and anhedonia; hypochondriacal, depressive, psychasthenic and schizoid traits predominated in the structure of their personality. At the same time, the condition of patients with AFD and AD comorbidity was objectively assessed as more severe. An inverse correlation was found between the level of subjective assessment of social adaptation and anhedonia in the group of patients with «pure» AFD, and in the group with AFD and AD comorbidity, with the severity of depressive symptoms (due to typical depressive symptoms), as well as with depressive and anxious personality traits of patients.</p></sec><sec><title>Conclusion</title><p>Conclusion. Self-assessment of social adaptation of patients with “pure” AFD depends on the intensity of anhedonia manifestations, and in patients with AFD and AD comorbidity, on depressive symptoms (due to typical depressive symptoms) and on the severity of such psychological characteristics as depression and psychasthenia.</p></sec></abstract><trans-abstract xml:lang="ru"><p>Алкогольная зависимость (АЗ) и расстройства настроения являются не только серьезной медицинской и социально-экономической проблемой для современного общества, но и причиной нарушений социальной адаптации, формирующихся уже на ранних этапах каждого из этих расстройств, а также в случае их коморбидности.</p><p>Цель исследования – определение взаимосвязи уровня субъективной оценки социальной адаптации с основными клинико-динамическими и психологическими характеристиками у пациентов с аффективными расстройствами (АР) с коморбидной АЗ.</p><sec><title>Пациенты и методы</title><p>Пациенты и методы. В исследование вошло 126 пациентов, получавших лечение в отделениях аффективных или аддиктивных состояний клиники НИИ психического здоровья Томского национального исследовательского медицинского центра по поводу АР (F31 – F34.1 по МКБ-10; n=83) или АР, коморбидного с АЗ (F10.2; n=43). В исследовании использованы клинико-динамический, психометрический, патопсихологический и статистический методы.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. Пациенты с АР без коморбидности при поступлении характеризовались большей выраженностью субъективного нарушения социальной адаптации и ангедонии, в структуре их личности преобладали ипохондрические, депрессивные, психастенические и шизоидные черты. При этом состояние пациентов с коморбидностью АР и АЗ объективно оценивалось как более тяжелое. Выявлена обратная корреляционная взаимосвязь уровня субъективной оценки социальной адаптации с ангедонией в группе пациентов с «чистыми» АР, а в группе с коморбидностью АР и АЗ – с выраженностью депрессивной симптоматики (за счет типичных депрессивных симптомов), а также с депрессивными и тревожными личностными чертами пациентов.</p></sec><sec><title>Заключение</title><p>Заключение. Самооценка социальной адаптации пациентов с «чистыми» АР зависит от интенсивности проявлений ангедонии, а у пациентов с коморбидностью АР и АЗ – от депрессивной симптоматики (за счет типичных депрессивных симптомов) и от выраженности таких психологических характеристик, как депрессивность и психастения.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>аффективные расстройства</kwd><kwd>алкогольная зависимость</kwd><kwd>коморбидность</kwd><kwd>социальная адаптация</kwd><kwd>клинико-динамические характеристики</kwd><kwd>патопсихологические характеристики</kwd></kwd-group><kwd-group xml:lang="en"><kwd>affective disorders</kwd><kwd>alcohol addiction</kwd><kwd>comorbidity</kwd><kwd>social adaptation</kwd><kwd>clinical and dynamic characteristics</kwd><kwd>pathopsychological characteristics</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено при поддержке гранта РНФ №19-15-00023 «Клинические особенности и поиск потенциальных биомаркеров коморбидности алкоголизма и аффективных расстройств».</funding-statement><funding-statement xml:lang="en">The study was supported by Russian Science Foundation grant №19-15-00023 «Clinical features and the search for potential biomarkers of comorbidity of alcoholism and affective disorders».</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Grant BF, Stinson FS, Dawson DA, et al. 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