nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2022-1-108-114nnp-1759Research ArticleCLINICAL OBSERVATIONSКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCOVID 19 in a family with rare genetic disease of the nervous systemCOVID-19 в семье с редким генетическим заболеванием нервной системыhttps://orcid.org/0000-0003-2797-7877МартыновМ. Ю.MartynovM. Yu.

117997, Москва, ул. Островитянова, 1;

117513, Москва, ул. Островитянова, 1, стр. 10

1, Ostrovityanov St., Moscow 117997;

1, Ostrovityanov St., Build 10, Moscow 117513

https://orcid.org/0000-0001-7535-8718КуташовВ. А.KutashovV. A.

394036, Воронеж, ул. Студенческая, 10

10, Studencheskaya St., Voronezh 394036

https://orcid.org/0000-0003-2754-2670УльяноваО. В.UlyanovaO. V.

394036, Воронеж, ул. Студенческая, 10

10, Studencheskaya St., Voronezh 394036

ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России; ФГБУ «Федеральный центр мозга и нейротехнологий» ФМБА РоссииРоссияN.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Federal Center of Brain and Neurotechnologies, FMBA of RussiaRussian FederationФГБОУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава РоссииРоссияN.N. Burdenko Voronezh State Medical University, Ministry of Health of RussiaRussian Federation202226022022141108114Copyright © Martynov M.Y., Kutashov V.A., Ulyanova O.V., 20222022Мартынов М.Ю., Куташов В.А., Ульянова О.В.Martynov M.Y., Kutashov V.A., Ulyanova O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1759

We present familial tuberous sclerosis (TS) case complicated by COVID-19. COVID-19 aggravates the course of TS and may lead to a fatal outcome. We review the role of mTORC1 (mechanistic/mammalian Target of Rapamycin Complex 1) in the development and functions of the nervous system and the pathogenesis of TS and COVID-19 with emphasis on the involvement of the brain and lungs. We observed that COVID-19 worsens the course of epilepsy in patients with TS. In TS patients, lymphangioleiomyomatosis may predispose to SARS-CoV-2 invasion into the respiratory system because of the increased expression of ACE2 and TMPRSS2 in type II pneumocytes and thus may worsen the prognosis. We also review the current data on the continuation/termination of everolimus administration in patients with TS associated with COVID-19. 

Приведено описание семейного случая туберозного склероза (ТС), осложненного COVID-19. Присоединение COVID-19 отягощает течение ТС и может приводить к неблагоприятному исходу. Рассмотрена роль mTORC1 (mechanistic/mammalian Target of Rapamycin Complex 1) в развитии и функционировании нервной системы и в патогенезе ТС и COVID-19, в частности в поражении головного мозга и легких. Показано, что у больных ТС присоединение COVID-19 утяжеляет течение эпилепсии. Отмечено, что наличие лимфангиолейомиоматоза может предрасполагать к проникновению вируса SARS-CoV-2 в легкие вследствие повышенной экспрессии ACE2 и TMPRSS2 в пневмоцитах II типа и отягощать прогноз. Рассмотрены вопросы прекращения/продолжения терапии эверолимусом у больных ТС при присоединении COVID-19. 

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The authors declare that there are no conflicts of interest present.