nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2022-1-76-81nnp-1753Research ArticleREVIEWSОБЗОРЫBiological basis of aggressive behaviorБиологические основы агрессивного поведенияhttps://orcid.org/0000-0002-9081-8257МакушкинаО. А.MakushkinaO. A.

119034, Москва, Кропоткинский пер., 23

23, Kropotkinskiy per., Moscow 119034

makushkina@serbsky.ruhttps://orcid.org/0000-0002-1066-5423ГуринаО. И.GurinaO. I.

119034, Москва, Кропоткинский пер., 23

23, Kropotkinskiy per., Moscow 119034

https://orcid.org/0000-0003-4617-1916ГоленковаВ. А.GolenkovaV. A.

119034, Москва, Кропоткинский пер., 23

23, Kropotkinskiy per., Moscow 119034

ФГБУ «Национальный медицинский исследовательский центр психиатрии и наркологии им. В.П. Сербского» Минздрава РоссииРоссияV.P. Serbsky National Medical Research Center of Psychiatry and Narcology, Ministry of Health of RussiaRussian Federation2022260220221417681Copyright © Makushkina O.A., Gurina O.I., Golenkova V.A., 20222022Макушкина О.А., Гурина О.И., Голенкова В.А.Makushkina O.A., Gurina O.I., Golenkova V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1753

This scientific review highlights the results of domestic and foreign studies aimed at researching the biological aspects of failure to control aggressive impulses. We analyze the role of serotonergic, dopaminergic, noradrenergic, glutamatergic systems, and neuroendocrine mechanisms in aggression manifestation. We discuss the inconsistency of modern concepts about the neurochemical nature of aggressive behavior. The relevance of evaluating the biomarkers of public danger is substantiated. Finally, questions of psychopharmacotherapy of aggressive behavior are reviewed. 

Настоящий научный обзор освещает результаты отечественных и зарубежных работ, направленных на изучение биологических аспектов нарушения контроля агрессивных импульсов. Анализируется роль серотонинергической, дофаминергической, норадренергической и глутаматергической систем, а также нейроэндокринных механизмов в формировании проявлений агрессии. Обсуждается противоречивость современных представлений о нейрохимической природе агрессивного поведения. Обосновывается актуальность определения биологических маркеров общественной опасности. Рассматриваются вопросы психофармакотерапии агрессивного поведения. 

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The authors declare that there are no conflicts of interest present.