nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2013-2396nnp-175Research ArticleArticlesСтатьиSkeletal muscle involvement in patients with chronic alcoholic intoxicationПоражение скелетных мышц у пациентов с хронической алкогольной интоксикациейZinovyevaOlga EvgenyevnaZinovyevaOlga Evgenyevna

Department of Nervous System Diseases

Department of Nervous System Diseases

zinovyevaolga@yandex.ruShcheglovaN SShcheglovaN S

Department of Nervous System Diseases

Department of Nervous System Diseases

-KazantsevaY VKazantsevaY V

Department of Nervous System Diseases

Department of Nervous System Diseases

-ShenkmanB SShenkmanB S-AltayevaE GAltayevaE G-20131503201351NO1 (2013)3942Copyright © Zinovyeva O.E., Shcheglova N.S., Kazantseva Y.V., Shenkman B.S., Altayeva E.G., 20132013Zinovyeva O.E., Shcheglova N.S., Kazantseva Y.V., Shenkman B.S., Altayeva E.G.Zinovyeva O.E., Shcheglova N.S., Kazantseva Y.V., Shenkman B.S., Altayeva E.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/175

Chronic alcoholic myopathy (CAM) is a common manifestation of alcoholic disease; however, the pathogenesis of the former has not been fully investigated. The main mechanism for the development of CAM is postulated to be impaired protein synthesis in the muscle fibers. A comprehensive clinical, biochemical, electromyographic, and morphological examination was made in 51 patients with chronic alcoholic intoxication. Morphological and morphometric studies were shown to play a determining role in the diagnosis of CAM. The clinical manifestations of skeletal muscle involvement corresponded to the magnitude of the atrophic process. Abnormalities were found in the basic components of protein synthesis at both the intracellular and systemic levels of regulation.

Хроническая алкогольная миопатия (ХАМ) является одним из частых проявлений алкогольной болезни, однако патогенез ее до конца не изучен. Предполагают, что основным механизмом развития ХАМ является нарушение процессов синтеза белка в мышечных волокнах. Проведено комплексное клиническое, биохимическое, электромиографическое и морфологическое обследование 51 пациента с хронической алкогольной интоксикацией. Показана определяющая роль морфологического и морфометрического исследования в диагностике ХАМ. Клинические проявления поражения скелетных мышц соответствовали выраженности атрофического процесса. Выявлено нарушение основных звеньев синтеза белка как на внутриклеточном, так и на системном уровне регуляции.

хроническая алкогольная миопатиядиагностикабиопсия мышцыинсулиноподобный фактор роста 1синтез белкаchronic alcoholic myopathydiagnosismuscle biopsyinsulin-growth-like growth factor 1protein synthesisReferences<div><p>Ангельчева О.И. Характеристика болевого синдрома при алкогольной полиневропатиии, оценка эффективности лечения. Дисс.. канд. мед. наук. М., 2005.</p><p>Mills K.R., Ward K., Martin F., Paters T.J. Peripheral neuropathy and myopathy in chronic alcoholism. Alcohol Alcoholism 1986;21:357-62.</p><p>Пауков В.С., Беляева Н.Ю., Воронина Т.М. Алкоголизм и алкогольная болезнь. Тер арх 2001;73(2):65—7.</p><p>Estruch R., Sacanella E., Fernandez-Sola J. et al. Natural history of alcoholic myopathy: 5-year study. Alcoholism Clin Exp Res 1998;22:2023-8.</p><p>Preedy V.R., Adachi J., Ueno Y. et al. Alcoholic skeletal muscle myopathy: definitions, features, contribution of neuropathy, impact and diagnosis. Eur J Neurol 2001;8:677-87.</p><p>Preedy V.R., Ohlendieck K., Adachi J. et al. The importance of alcohol-induced muscle dis ease. J Muscle Res Cell Motil 2003;24(1):55—63.</p><p>Fernandez-Sola J., Sacanella E., Estruch R. et al. Serum and muscle levels of alpha-tocopherol, ascorbic acid, and retinol are normal in chronic alcoholic myopathy. Alcoholism Clin Exр Res 1998;22:422-7.</p><p>Казанцева Ю.В. Патогенетические механизмы хронической алкогольной миопатии: Дисс.. канд. мед. наук. М., 2005.</p><p>Martin F., Ward K., Slavin G. et al. Alcoholic skeletal myopathy, a clinical and pathological study. Q J Med 1985;55:233-51.</p><p>Зиновьева О.Е., Шенкман Б.С. Алкогольная миопатия. Неврол журн 2007;5(12):4—8.</p><p>Sharma S.C., Ray R.C., Banerjee A.K., Lakshmanan C. Chronic muscle wasting in alcoholics - a histochemical and biochemical study. Indian J Pathol Microbiol 1990;33:244-9.</p><p>Vargas R., Lang C.H. Alcohol accelerates loss of muscle and impairs recovery of muscle mass resulting from disuse atrophy. Alcoholism Clin Exр Res 2008;32(l):128—37.</p><p>Lang C.H., Frost R.A. Role of growth hormone, insulin-like growth factor-I, and insulinlike growth factor binding proteins in the catabolic response to injury and infection. Anabolic and catabolic signals. Cur Opin Clin Nutr Metab Care 2002;5(3):271-9.</p><p>Kumar V., Frost R.A., Lang C.H. Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscle. Am J Physiol Endocrinol Metab 2002;283(5):917—28.</p><p>Lang С.Н., Frost R.A., Svanberg Е., Vary T.C. IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats. Am J Physiol Endocrinol Metab 2004;286:916-26.</p><p>Fernandez-Sola J., Nicolas J-M., Fatjo F. et al. Evidence of apoptosis in chronic alcoholic skeletal myopathy. Hum Pathol 2003;34(12):1247—52.</p></div><br /><div><p>Ангельчева О.И. Характеристика болевого синдрома при алкогольной полиневропатиии, оценка эффективности лечения. Дисс.. канд. мед. наук. М., 2005.</p><p>Mills K.R., Ward K., Martin F., Paters T.J. Peripheral neuropathy and myopathy in chronic alcoholism. Alcohol Alcoholism 1986;21:357-62.</p><p>Пауков В.С., Беляева Н.Ю., Воронина Т.М. Алкоголизм и алкогольная болезнь. Тер арх 2001;73(2):65—7.</p><p>Estruch R., Sacanella E., Fernandez-Sola J. et al. Natural history of alcoholic myopathy: 5-year study. Alcoholism Clin Exp Res 1998;22:2023-8.</p><p>Preedy V.R., Adachi J., Ueno Y. et al. Alcoholic skeletal muscle myopathy: definitions, features, contribution of neuropathy, impact and diagnosis. Eur J Neurol 2001;8:677-87.</p><p>Preedy V.R., Ohlendieck K., Adachi J. et al. The importance of alcohol-induced muscle dis ease. J Muscle Res Cell Motil 2003;24(1):55—63.</p><p>Fernandez-Sola J., Sacanella E., Estruch R. et al. Serum and muscle levels of alpha-tocopherol, ascorbic acid, and retinol are normal in chronic alcoholic myopathy. Alcoholism Clin Exр Res 1998;22:422-7.</p><p>Казанцева Ю.В. Патогенетические механизмы хронической алкогольной миопатии: Дисс.. канд. мед. наук. М., 2005.</p><p>Martin F., Ward K., Slavin G. et al. Alcoholic skeletal myopathy, a clinical and pathological study. Q J Med 1985;55:233-51.</p><p>Зиновьева О.Е., Шенкман Б.С. Алкогольная миопатия. Неврол журн 2007;5(12):4—8.</p><p>Sharma S.C., Ray R.C., Banerjee A.K., Lakshmanan C. Chronic muscle wasting in alcoholics - a histochemical and biochemical study. Indian J Pathol Microbiol 1990;33:244-9.</p><p>Vargas R., Lang C.H. Alcohol accelerates loss of muscle and impairs recovery of muscle mass resulting from disuse atrophy. Alcoholism Clin Exр Res 2008;32(l):128—37.</p><p>Lang C.H., Frost R.A. Role of growth hormone, insulin-like growth factor-I, and insulinlike growth factor binding proteins in the catabolic response to injury and infection. Anabolic and catabolic signals. Cur Opin Clin Nutr Metab Care 2002;5(3):271-9.</p><p>Kumar V., Frost R.A., Lang C.H. Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscle. Am J Physiol Endocrinol Metab 2002;283(5):917—28.</p><p>Lang С.Н., Frost R.A., Svanberg Е., Vary T.C. IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats. Am J Physiol Endocrinol Metab 2004;286:916-26.</p><p>Fernandez-Sola J., Nicolas J-M., Fatjo F. et al. Evidence of apoptosis in chronic alcoholic skeletal myopathy. Hum Pathol 2003;34(12):1247—52.</p></div><br />

The authors declare that there are no conflicts of interest present.