nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2021-6-105-110nnp-1714Research ArticleREVIEWSОБЗОРЫRole of chondroitin sulfate in the regulation of neuroimmunoendocrine network interactions in patients with neurological symptoms in the post-covid periodРоль хондроитина сульфата в регуляции нейроиммуноэндокринных сетевых взаимодействий в организме пациентов с неврологическими симптомами в постковидном периодеhttps://orcid.org/0000-0002-5933-5732СарвилинаИ. В.SarvilinaI. V.

 Россия, 344002, Ростов-на-Дону, ул. Социалистическая, 74 

 74, Sotsialisticheskaya St., Rostov-on-Don 344002, Russia 

isarvilina@mail.ruhttps://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

Россия, 119333, Москва, ул. Вавилова, 44, корп. 2

Россия, 119192, Москва, Ломоносовский проспект, 27, корп. 1 

 42, Vavilova St., Build. 2, Moscow 119333, Russia

27, Lomonosovsky Prosp., Build. 1, Moscow 119192, Russia 

https://orcid.org/0000-0002-7682-6672МаксимоваМ. Ю.MaksimovaM. Yu.

 Россия, 125367, Москва, Волоколамское ш., 80 

 80, Volokolamskoe Shosse, Moscow 125367, Russia 

https://orcid.org/0000-0001-9634-346XШаровМ. Н.SharovM. N.

Россия, 127473, Москва, ул. Делегатская, 20, стр. 1

Россия, 127206, Москва, ул. Вучетича, 21 

20, Delegatskaya St., Build. 1, Moscow 127473, Russia

21, Vuchetich St., Moscow 127206, Russia 

https://orcid.org/0000-0003-4454-7174ПрокофьеваЮ. С.ProkofyevaYu. S.

Россия, 127473, Москва, ул. Делегатская, 20, стр. 1

 20, Delegatskaya St., Build. 1, Moscow 127473, Russia 

ООО «Медицинский центр «Новомедицина»РоссияMedical Centre «Novomeditsina»Russian FederationИнститут фармакоинформатики Федерального исследовательского центра «Информатика и управление» Российской академии наук; Центр хранения и анализа больших данных Национального центра цифровой экономики ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»РоссияInstitute of pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, National Center for Digital Economy, M.V. Lomonosov Moscow State UniversityRussian FederationФГБНУ «Научный центр неврологии»РоссияResearch Center of NeurologyRussian FederationФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России; ГБУ «Городская клиническая больница им. С.И. Спасокукоцкого Департамента здравоохранения города Москвы»РоссияA.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia; S.I. Spasokukotsky Moscow City Clinical Hospital, Moscow Healthcare DepartmentRussian FederationФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РоссииРоссияA.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of RussiaRussian Federation202115122021136105110Copyright © Sarvilina I.V., Gromova O.A., Maksimova M.Y., Sharov M.N., Prokofyeva Y.S., 20212021Сарвилина И.В., Громова О.А., Максимова М.Ю., Шаров М.Н., Прокофьева Ю.С.Sarvilina I.V., Gromova O.A., Maksimova M.Y., Sharov M.N., Prokofyeva Y.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1714

 The review discusses the prospects for the use of chondroitin sulfate and its derivatives for new indications in patients with and myalgic encephalomyelitis/chronic fatigue syndrome after SARS-CoV-2 infection. The epidemiology, clinical  manifestations, main mechanisms of the development of the dysregulation of neuroimmunoendocrine network interactions  in long-term COVID-19 are considered. Modern data on the relationship between mechanisms of neuroprotective effects of  chondroitin sulfate and its derivatives and their chemical  structure characteristics have been analyzed. The position is  argued according to which chondroitin sulfate and its  derivatives can become promising drugs in prevention of the  development of neuroimmunoendocrine network interactions  disorders in COVID-19. 

 В обзоре обсуждаются перспективы применения по новым показаниям хондроитина сульфата и его производных при миалгическом энцефаломиелите / синдроме хронической усталости у пациентов,  перенесших инфекцию SARS-CoV-2. Рассмотрены эпидемиология,  клинические проявления, основные механизмы развития дисрегуляции  нейроиммуноэндокринных сетевых взаимодействий при долгосрочном COVID-19. Проанализированы современные данные о взаимосвязи  механизмов возникновения нейропротективных эффектов хондроитина  сульфата и его производных и особенностей их химической структуры.  Аргументирована позиция, согласно которой перспективным средством лекарственной профилактики развития нарушений в системе  нейроиммуноэндокринных сетевых взаимодействий при COVID-19  могут стать хондроитина сульфат и его производные.  

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The authors declare that there are no conflicts of interest present.