nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2021-5-90-95nnp-1671Research ArticleREVIEWSОБЗОРЫTreatment of cognitive impairment in arterial hypertensionЛечение когнитивных нарушений при артериальной гипертензииСтарчинаЮ. А.StarchinaYu. A.

Юлия Александровна Старчина

Кафедра нервных болезней и нейрохирургии Института клинической медицины им. Н.В. Склифосовского

119021, Москва, ул. Россолимо, 11, стр. 1

Yulia Aleksandrovna Starchina

Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine

11, Rossolimo St., Build. 1, Moscow 119021

yul-starchina@yandex.ruСлепцоваК. С.SleptcovaK. S.

Кафедра нервных болезней и нейрохирургии Института клинической медицины им. Н.В. Склифосовского

119021, Москва, ул. Россолимо, 11, стр. 1

Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine

11, Rossolimo St., Build. 1, Moscow 119021

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian Federation2021161020211359095Copyright © Starchina Y.A., Sleptcova K.S., 20212021Старчина Ю.А., Слепцова К.С.Starchina Y.A., Sleptcova K.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1671

Cognitive impairment (CI) is one of the earliest and most frequent neurological disorders in patients with arterial hypertension. Arterial hypertension is a leading modifiable risk factor for stroke and cerebral microangiopathy, which underlies the development of non-stroke associated CI. Antihypertensive therapy plays an essential role in preventing the development and slowing the progression of CI by controlling blood pressure. The review discusses the use of memantine – a reversible inhibitor of NMDA receptors (akatinol memantine) – in vascular CI.

Когнитивные нарушения (КН) входят в число наиболее ранних и часто встречающихся у пациентов с артериальной гипертензией неврологических нарушений. Артериальная гипертензия является ведущим модифицируемым фактором риска развития инсульта и церебральной микроангиопатии, лежащей в основе развития КН, не связанных с инсультом. Антигипертензивная терапия играет существенную роль в профилактике развития и замедлении прогрессирования КН посредством контроля артериального давления. В обзоре обсуждается применение обратимого ингибитора NMDA-рецепторов мемантина (акатинола мемантина) при сосудистых КН.

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The authors declare that there are no conflicts of interest present.