nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2021-5-76-82nnp-1669Research ArticleREVIEWSОБЗОРЫBiological basis of aggressive behaviorБиологические основы агрессивного поведенияМакушкинаО. А.MakushkinaO. A.

Оксана Анатольевна Макушкина

119034, Москва, Кропоткинский пер., 23

Oksana Anatolevna Makushkina

23, Kropotkinskiy per., Moscow 119034

makushkina@serbsky.ruГуринаО. И.GurinaO. I.

119034, Москва, Кропоткинский пер., 23

23, Kropotkinskiy per., Moscow 119034

ГоленковаВ. А.GolenkovaV. A.

119034, Москва, Кропоткинский пер., 23

23, Kropotkinskiy per., Moscow 119034

ФГБУ «Национальный медицинский исследовательский центр психиатрии и наркологии им. В.П. Сербского» Минздрава РоссииРоссияV.P. Serbsky National Medical Research Center of Psychiatry and Narcology, Ministry of Health of RussiaRussian Federation2021161020211357682Copyright © Makushkina O.A., Gurina O.I., Golenkova V.A., 20212021Макушкина О.А., Гурина О.И., Голенкова В.А.Makushkina O.A., Gurina O.I., Golenkova V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1669

The review analyzes the role of serotonergic, dopaminergic, noradrenergic, and glutamatergic systems and neuroendocrine mechanisms, neuropeptides, and inflammatory mediators in aggression manifestation. We discuss the inconsistency of modern concepts about the neurochemical nature of aggressive behavior and the urgency of determining biological markers of social danger. Finally, questions of psychopharmacotherapy of aggressive behavior are reviewed.

В обзоре анализируется роль серотонинергической, дофаминергической, норадренергической и глутаматергической систем, а также нейроэндокринных механизмов, нейропептидов и медиаторов воспаления в формировании проявлений агрессии. Обсуждается противоречивость современных представлений о нейрохимической природе агрессивного поведения. Обосновывается актуальность определения биологических маркеров общественной опасности. Рассматриваются вопросы психофармакотерапии агрессивного поведения.

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The authors declare that there are no conflicts of interest present.