nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2021-1S-62-68nnp-1651Research ArticleREVIEWSОБЗОРЫInfluence of von Willebrand factor on common pathophysiological mechanisms of cerebrovascular diseases and multiple sclerosisВлияние фактора Виллебранда на общие патофизиологические механизмы цереброваскулярной патологии и рассеянного склерозаКольцовИ. А.KoltsovI. A.

Иван Алексеевич Кольцов

отдел нейроиммунологии

117997, Москва, ул. Островитянова, 1117997, Москва, улица Островитянова, 1, стр. 10

Ivan Alekseevich Koltsov

Department of Neuroimmunology

1, Ostrovityanov St., Moscow 1179971, Ostrovityanov St., Build 10, Moscow 117997

i-koltsov@mail.ruМартыновМ. Ю.MartynovM. Yu.

отдел нейроиммунологии

117997, Москва, ул. Островитянова, 1117997, Москва, улица Островитянова, 1, стр. 10

Department of Neuroimmunology

1, Ostrovityanov St., Moscow 1179971, Ostrovityanov St., Build 10, Moscow 117997

ЯсамановаА. Н.YasamanovaA. N.

117997, Москва, ул. Островитянова, 1

1, Ostrovityanov St., Moscow 117997

ЩукинИ. А.ShchukinI. A.

отдел нейроиммунологии

117997, Москва, ул. Островитянова, 1117997, Москва, улица Островитянова, 1, стр. 10

Department of Neuroimmunology

1, Ostrovityanov St., Moscow 1179971, Ostrovityanov St., Build 10, Moscow 117997

ФидлерМ. С.FidlerM. S.

117997, Москва, ул. Островитянова, 1

1, Ostrovityanov St., Moscow 117997

БойкоА. Н.BoykoA. N.

отдел нейроиммунологии

117997, Москва, ул. Островитянова, 1117997, Москва, улица Островитянова, 1, стр. 10

Department of Neuroimmunology

1, Ostrovityanov St., Moscow 1179971, Ostrovityanov St., Build 10, Moscow 117997

ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России; ФГБУ «Федеральный центр мозга и нейротехнологий» ФМБА РоссииРоссияN.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Federal Center of Brain and Neurotechnologies, FMBA of RussiaRussian FederationФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian Federation202116092021131SСпецвыпуск: рассеянный склероз6268Copyright © Koltsov I.A., Martynov M.Y., Yasamanova A.N., Shchukin I.A., Fidler M.S., Boyko A.N., 20212021Кольцов И.А., Мартынов М.Ю., Ясаманова А.Н., Щукин И.А., Фидлер М.С., Бойко А.Н.Koltsov I.A., Martynov M.Y., Yasamanova A.N., Shchukin I.A., Fidler M.S., Boyko A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1651

Endothelial dysfunction is a universal pathological mechanism underlying or contributing to the development/progression of many diseases, including cerebrovascular disease and multiple sclerosis. Von Willebrand factor is a multimeric glycoprotein synthesized by endothelial cells and megakaryocytes that participates in a range of physiological and pathological processes, including primary hemostasis and coagulation. It also regulates secretion and transport of a variety of molecules, exerts a proinflammatory effect, modulates angiogenesis and smooth muscle mitotic activity, influences atherogenesis. In this review, we discuss the synthesis, secretion, and regulation of the von Willebrand factor within the context of endothelial dysfunction and other common mechanisms that play a significant role in brain tissue damage in cerebrovascular diseases and multiple sclerosis.

Эндотелиальная дисфункция – универсальный патологический механизм, лежащий в основе или вносящий вклад в развитие/прогрессирование множества заболеваний, включая цереброваскулярные болезни и рассеянный склероз. Фактор Виллебранда – мультимерный гликопротеин, который синтезируется клетками эндотелия и мегакариоцитами и участвует в целом спектре физиологических и патологических процессов, в частности в сосудисто-тромбоцитарном и коагуляционном гемостазе, а также регулирует секрецию и транспортировку множества веществ, оказывает провоспалительный эффект, модулирует ангиогенез и митогенную активность гладкой мускулатуры сосудов, влияет на течение атеросклероза. В настоящем обзоре рассматриваются особенности образования, выделения, регуляции активности фактора Виллебранда во взаимосвязи с эндотелиальной дисфункцией и другими общими механизмами, играющими важную роль в повреждении вещества головного мозга при цереброваскулярной патологии и рассеянном склерозе.

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The authors declare that there are no conflicts of interest present.