nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2021-4-81-87nnp-1634Research ArticleORIGINAL INVESTIGATIONSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИMedication adherence in migraine patients (data of an online survey)Приверженность терапии пациентов с мигренью (по данным интернет-опроса)КовальчукН. А.KovalchukN. A.

Ковальчук Надежда Александровна.

119991, Москва, ул. Россолимо, 11, стр. 1.

Nadezhda Aleksandrovna Kovalchuk.

11, Rossolimo St., Build. 1, Moscow 119021.

kowalchuk.n.a@gmail.comКирьяноваЕ. А.KiryanovaE. A.

119991, Москва, ул. Россолимо, 11, стр. 1.

11, Rossolimo St., Build. 1, Moscow 119021.

ТабееваГ. Р.TabeevaG. R.

119991, Москва, ул. Россолимо, 11, стр. 1.

11, Rossolimo St., Build. 1, Moscow 119021.

Кафедра нервных болезней и нейрохирургии Института клинической медицины им. Н.В. Склифосовского, Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России (Сеченовский Университет)РоссияDepartment of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian Federation2021140820211348187Copyright © Kovalchuk N.A., Kiryanova E.A., Tabeeva G.R., 20212021Ковальчук Н.А., Кирьянова Е.А., Табеева Г.Р.Kovalchuk N.A., Kiryanova E.A., Tabeeva G.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1634

Patient needs, drug intake patterns, and adherence to therapy are significant challenges in the management of migraine patients.

Objective

Objective: to identify drug treatment needs, drug use patterns and adherence factors in migraine patients.

Patients and methods

Patients and methods. An online survey was conducted among Internet users through social networks (Instagram, Facebook, Vkontakte) from 01/22/2020 to 02/22/2020. The selection of respondents was based on an anamnesis of headaches and passing the ID Migraine screener. One thousand five hundred ninety-eight individuals (93.8% women and 6.2% men) aged 18—39years participated in the survey.

Results and discussion

Results and discussion. Among 1598 participants, 1490 experienced any headache, 937 respondents noted migraine symptoms, and 542 (58.4%) had a migraine diagnosis. 899 (96%) of responders used medications to relieve headaches, and in 59% of them drugs were self-prescribed. 125 (13%) patients received prophylactic therapy for migraine, of which only 47 (37.6%) complied with the prescribed treatment. We found a significant (p=0.019) association between the degree of adherence to therapy and the number of days with migraine.

Conclusion

Conclusion. The study revealed a low referral rate in patients with headaches. In addition, more than half self-prescribed the drug for headache relief, and only a third of patients complied with the prescribed prophylactic treatment.

Потребности пациентов, паттерны приема препаратов и приверженность терапии являются основными проблемами, возникающими при ведении пациентов с мигренью.

Цель исследования — определение потребностей пациентов с мигренью в лекарственной терапии, паттернов использования лекарственных средств и факторов приверженности специфическому лечению.

Пациенты и методы

Пациенты и методы. В период с 22.01.2020 г. по 22.02.2020 г. проведен онлайн-опрос среди пользователей сети Интернет посредством социальных сетей (Instagram, Facebook, ВКонтакте). Отбор участников исследования производился на основании наличия головной боли в анамнезе и прохождения скринингового теста ID Migraine. В опросе приняли участие 1598 человек (93,8% женщин и 6,2% мужчин), преимущественно в возрасте от 18 до 39 лет.

Результаты и обсуждение

Результаты и обсуждение. Из 1598 обследованных 1490 испытывали головную боль, 937 участников опроса отметили у себя симптомы мигрени, диагноз мигрени установлен у 542 (58,4%) пациентов. Для купирования головной боли лекарственные препараты использовали 899 (96%) пациентов, из них 59% подбирали препарат самостоятельно. Профилактическую терапию мигрени получали 125 (13%) пациентов, из них только 47 (37,6%) соблюдали назначенное лечение. Установлена статистически значимая связь (p=0,019) между степенью приверженности терапии и количеством дней с мигренью.

Заключение

Заключение. Выявлен низкий уровень обращаемости пациентов с головной болью к врачам. Более половины подбирали препарат для купирования головной боли самостоятельно, и только треть пациентов соблюдали назначенное профилактическое лечение.

мигреньпрофилактическая терапия мигрениприверженность терапииmigrainemigraine preventive therapymedication adherenceReferencesGBD 2016 Neurology Collaborators. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019 May;18(5):459-80. doi: 10.1016/S1474-4422(18)30499-X. Epub 2019 Mar 14.GBD 2016 Neurology Collaborators. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019 May;18(5):459-80. doi: 10.1016/S1474-4422(18)30499-X. Epub 2019 Mar 14.Lipton RB, Serrano D, Holland S, et al. Barriers to the diagnosis and treatment of migraine: Effects of sex, income, and headache features. Headache. 2013 Jan;53(1):81-92. doi: 10.1111/j.1526-4610.2012.02265.x. Epub 2012 Oct 18.Lipton RB, Serrano D, Holland S, et al. Barriers to the diagnosis and treatment of migraine: Effects of sex, income, and headache features. Headache. 2013 Jan;53(1):81-92. doi: 10.1111/j.1526-4610.2012.02265.x. Epub 2012 Oct 18.Peh KQE, Kwan YH, Goh H, et al. An Adaptable Framework for Factors Contributing to Medication Adherence: Results from a Systematic Review of 102 Conceptual Frameworks. J Gen Intern Med. 2021 Mar 3. doi: 10.1007/s11606-021-06648-1. Epub ahead of print.Peh KQE, Kwan YH, Goh H, et al. An Adaptable Framework for Factors Contributing to Medication Adherence: Results from a Systematic Review of 102 Conceptual Frameworks. J Gen Intern Med. 2021 Mar 3. doi: 10.1007/s11606-021-06648-1. Epub ahead of print.Blumenfeld AM, Bloudek LM, Becker WJ, et al. Patterns of use and reasons for discontinuation of prophylactic medications for episodic migraine and chronic migraine: results from the second international burden of migraine study (IBMS-II). Headache. 2013 Apr;53(4):644-55. doi: 10.1111/head.12055. Epub 2013 Mar 4.Blumenfeld AM, Bloudek LM, Becker WJ, et al. Patterns of use and reasons for discontinuation of prophylactic medications for episodic migraine and chronic migraine: results from the second international burden of migraine study (IBMS-II). Headache. 2013 Apr;53(4):644-55. doi: 10.1111/head.12055. Epub 2013 Mar 4.Dodick DW, Loder EW, Manack Adams A, et al. Assessing Barriers to Chronic Migraine Consultation, Diagnosis, and Treatment: Results From the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study. Headache. 2016 May;56(5):821-34. doi: 10.1111/head.12774. Epub 2016 May 3.Dodick DW, Loder EW, Manack Adams A, et al. Assessing Barriers to Chronic Migraine Consultation, Diagnosis, and Treatment: Results From the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study. Headache. 2016 May;56(5):821-34. doi: 10.1111/head.12774. Epub 2016 May 3.Krause SJ, Tepper SJ, Hu HX, Bigal ME. Adherence to Acute Migraine Medication: What Does It Mean, Why Does It Matter? Headache. 2010 Jan;50(1):117-29. doi: 10.1111/j.1526-4610.2009.01535.x. Epub 2009 Oct 8.Krause SJ, Tepper SJ, Hu HX, Bigal ME. Adherence to Acute Migraine Medication: What Does It Mean, Why Does It Matter? Headache. 2010 Jan;50(1):117-29. doi: 10.1111/j.1526-4610.2009.01535.x. Epub 2009 Oct 8.Lipton RB, Dodick D, Sadovsky R, et al; ID Migraine validation study. A self-administered screener for migraine in primary care: The ID Migraine validation study. Neurology. 2003 Aug 12;61(3):375-82. doi: 10.1212/01.wnl.0000078940.53438.83Lipton RB, Dodick D, Sadovsky R, et al; ID Migraine validation study. A self-administered screener for migraine in primary care: The ID Migraine validation study. Neurology. 2003 Aug 12;61(3):375-82. doi: 10.1212/01.wnl.0000078940.53438.83Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a selfreported measure of medication adherence. Med Care. 1986 Jan;24(1):67-74. doi: 10.1097/00005650-198601000-00007Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a selfreported measure of medication adherence. Med Care. 1986 Jan;24(1):67-74. doi: 10.1097/00005650-198601000-00007Табеева ГР. Лечение приступа мигрени: пути оптимизации терапевтических подходов. Нервные болезни. 2015;(3):2-8.Tabeyeva GR. Treatment of a migraine attack: ways to optimize therapeutic approaches. Nervnyye bolezni. 2015;(3):2-8 (In Russ.).Филатова ЕГ, Осипова ВВ, Табеева ГР и др. Диагностика и лечение мигрени: рекомендации российских экспертов. Неврология, нейропсихиатрия, психосоматика. 2020;12(4):4-14. doi: 10.14412/2074-27112020-4-4-14Filatova EG, Osipova VV, Tabeeva GR, et al. Diagnosis and treatment of migraine: Russian experts' recommendations. Nevrologiya, neirop-sikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2020;12(4):4-14. doi: 10.14412/2074-2711-2020-4-4-14 (In Russ.).World Health Organisation. Adherence to long-term therapies, evidence for action. Geneva; 2003 Available from: http://www.who.int2World Health Organisation. Adherence to long-term therapies, evidence for action. Geneva; 2003 Available from: http://www.who.int2Fernandez-Lazaro CI, Garcia-Gonzalez JM, Adams DP, et al. Adherence to treatment and related factors among patients with chronic conditions in primary care: a cross-sectional study. BMC Fam Pract. 2019 Sep 14;20(1):132. doi: 10.1186/s12875-019-1019-3Fernandez-Lazaro CI, Garcia-Gonzalez JM, Adams DP, et al. Adherence to treatment and related factors among patients with chronic conditions in primary care: a cross-sectional study. BMC Fam Pract. 2019 Sep 14;20(1):132. doi: 10.1186/s12875-019-1019-3Россияне борются с недомоганиями: безрецептурный препарат или народная медицина вместо визита к врачу. Исследование Nielsen. Доступно по ссылке: www.acnielsen.ruRossiyane boryutsya s nedomoganiyami: bezret-septurnyy preparat ili narodnaya meditsina vmesto vizita k vrachu. Issledovaniye Nielsen [Russians are struggling with ailments: an over-the-counter drug or traditional medicine instead of a visit to the doctor. Nielsen Research]. Available from: www.acnielsen.ru (In Russ.).Simpson SH, Eurich DT, Majumdar SR, et al. A meta-analysis of the association between adherence to drug therapy and mortality. BMJ. 2006 Jul 1;333(7557):15. doi: 10.1136/bmj.38875.675486.55. Epub 2006 Jun 21.Simpson SH, Eurich DT, Majumdar SR, et al. A meta-analysis of the association between adherence to drug therapy and mortality. BMJ. 2006 Jul 1;333(7557):15. doi: 10.1136/bmj.38875.675486.55. Epub 2006 Jun 21.Lipton RB, Buse DC, Serrano D, et al. Examination of unmet treatment needs among persons with episodic migraine: Results of the American Migraine Prevalence and Prevention (AMPP) study. Headache. 2013 Sep;53(8):1300-11. doi: 10.1111/head.12154. Epub 2013 Jul 23.Lipton RB, Buse DC, Serrano D, et al. Examination of unmet treatment needs among persons with episodic migraine: Results of the American Migraine Prevalence and Prevention (AMPP) study. Headache. 2013 Sep;53(8):1300-11. doi: 10.1111/head.12154. Epub 2013 Jul 23.Buse DC, Manack AN, Fanning KM, et al. Chronic migraine prevalence, disability, and sociodemographic factors: Results from the American Migraine Prevalence and Prevention Study. Headache. Nov-Dec 2012;52(10):1456-70. doi: 10.1111/j.1526-4610.2012.02223.x. Epub 2012 Jul 25.Buse DC, Manack AN, Fanning KM, et al. Chronic migraine prevalence, disability, and sociodemographic factors: Results from the American Migraine Prevalence and Prevention Study. Headache. Nov-Dec 2012;52(10):1456-70. doi: 10.1111/j.1526-4610.2012.02223.x. Epub 2012 Jul 25.Ayzenberg I, Katsarava Z, Sborowski A, et al. Headache-attributed burden and its impact on productivity and quality of life in Russia: structured healthcare for headache is urgently needed. Eur J Neurol. 2014 May;21(5):758-65. doi: 10.1111/ene.12380. Epub 2014 Feb 13.Ayzenberg I, Katsarava Z, Sborowski A, et al. Headache-attributed burden and its impact on productivity and quality of life in Russia: structured healthcare for headache is urgently needed. Eur J Neurol. 2014 May;21(5):758-65. doi: 10.1111/ene.12380. Epub 2014 Feb 13.Ayzenberg I, Katsarava Z, Mathalikov R, et al. The burden of headache in Russia: validation of the diagnostic questionnaire in a population-based sample. Eur J Neurol. 2011 Mar;18(3):454-9. doi: 10.1111/j.1468-1331.2010.03177.x. Epub 2010 Aug 16.Ayzenberg I, Katsarava Z, Mathalikov R, et al. The burden of headache in Russia: validation of the diagnostic questionnaire in a population-based sample. Eur J Neurol. 2011 Mar;18(3):454-9. doi: 10.1111/j.1468-1331.2010.03177.x. Epub 2010 Aug 16.Ayzenberg I, Katsarava Z, Sborowski A, et al. The prevalence of primary headache disorders in Russia: A countrywide survey. Cephalalgia. 2012 Apr;32(5):373-81. doi: 10.1177/0333102412438977. Epub 2012 Mar 6.Ayzenberg I, Katsarava Z, Sborowski A, et al. The prevalence of primary headache disorders in Russia: A countrywide survey. Cephalalgia. 2012 Apr;32(5):373-81. doi: 10.1177/0333102412438977. Epub 2012 Mar 6.

The authors declare that there are no conflicts of interest present.