nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2021-4-25-29nnp-1627Research ArticleORIGINAL INVESTIGATIONSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИMethionine synthase reductase A66G polymorphism and ischemic stroke in younger patientsКлинические особенности ишемических инсультов в молодом возрасте при носительстве полиморфизма метионин-синтазы-редуктазы A66GЦыганенкоО. В.TsyganenkoO. V.

Цыганенко Ольга Владимировна.

620102, Екатеринбург, ул. Волгоградская, 185.

Olga Vladimirovna Tsyganenko.

185, Volgogradskaya St., Yekaterinburg 620102.

cyganenko.olga@mail.ruВолковаЛ. И.VolkovaL. I.

620102, Екатеринбург, ул. Волгоградская, 185; 620028, Екатеринбург, ул. Репина, 3.

185, Volgogradskaya St., Yekaterinburg 620102; 3, Repin St., Yekaterinburg 620028.

АлашеевА. М.AlasheevA. M.

620102, Екатеринбург, ул. Волгоградская, 185.

185, Volgogradskaya St., Yekaterinburg 620102.

Свердловская областная клиническая больница №1РоссияSverdlovsk Regional Clinical Hospital №1Russian FederationСвердловская областная клиническая больница №1; Кафедра нервных болезней, нейрохирургии и медицинской генетики, Уральский государственный медицинский университет Минздрава РоссииРоссияSverdlovsk Regional Clinical Hospital №1; Department of Nervous System Diseases, Neurosurgery, and Medical Genetics, Ural State Medical University, Ministry of Health of RussiaRussian Federation2021140820211342529Copyright © Tsyganenko O.V., Volkova L.I., Alasheev A.M., 20212021Цыганенко О.В., Волкова Л.И., Алашеев А.М.Tsyganenko O.V., Volkova L.I., Alasheev A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1627

In the past decade, stroke incidence in younger adults increased. Methionine synthase reductase (MTRR) A66G polymorphism is one of the risk factors for ischemic stroke (IS). However, clinical features of IS in MTRR A66G polymorphism are not yet studied.

Objective

Objective: to investigate clinical features of IS in MTRR A66G polymorphism.

Patients and methods

Patients and methods. One hundred forty-one younger patients with IS, hospitalized in the neurological department of Sverdlovsk Regional Clinical Hospital №1, were included in the study. MTRR A66G polymorphism was detected by the real-time polymerase chain reaction in all participants.

Results and discussion

Results and discussion. MTRR A66G polymorphism was present in 83.7% of younger patients with IS. Participants with MTRR A66G polymorphism had a significantly higher prevalence of arterial hypertension (р=0.029). In addition, protein C level was significantly lower in patients with MTRR A66G mutation (р=0.001).

Conclusion

Conclusion. The majority of younger patients with IS have MTRR A66G polymorphism. Therefore, the inclusion of MTRR A66G polymorphism screening in the diagnostic algorithm of stroke in young adults seems necessary.

В последнее десятилетие зарегистрирован рост частоты инсультов среди молодых людей. Одним из факторов риска развития ишемического инсульта (ИИ) признается носительство полиморфизма A66G гена метионин-синтазы-редуктазы (MTRR). Клинические особенности ИИ у носителей полиморфизма MTRR A66G в настоящее время не изучены.

Цель исследования — изучить клинические особенности ИИ при носительстве полиморфизма MTRR A66G.

Пациенты и методы

Пациенты и методы. В исследование включен 141 пациент с ИИ в молодом возрасте, проходивший лечение на базе неврологического отделения Свердловской областной клинической больницы №1. У всех пациентов определен полиморфизм MTRR A66G методом полимеразной цепной реакции в режиме реального времени.

Результаты и обсуждение

Результаты и обсуждение. Носителями полиморфизма MTRR A66G являются 83,7% пациентов с ИИ, развившимся в молодом возрасте. У лиц с полиморфизмом MTRR A66G достоверно чаще встречается артериальная гипертензия (р=0,029). Уровень протеина С статистически значимо ниже среди лиц с мутацией MTRR A66G (р=0,001).

Заключение

Заключение. Большинство пациентов с ИИ в молодом возрасте являются носителями полиморфизма MTRR A66G. Необходимо включение исследования полиморфизма MTRR A66G в алгоритм диагностики при инсульте у молодых.

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The authors declare that there are no conflicts of interest present.