References

nnp

Neurology, Neuropsychiatry, Psychosomatics

Неврология, нейропсихиатрия, психосоматика

2074-27112310-1342

"IMA-Press", LLC

10.14412/2074-2711-2021-4-94-102

nnp-1622

Research Article

REVIEWS

ОБЗОРЫ

Neuroprotective therapy in acute ischemic stroke

Нейропротективная терапия в остром периоде ишемического инсульта

Кулеш

А. А.

Kulesh

A. A.

Кулеш Алексей Александрович.

614590, Пермь, ул. Петропавловская, 26.

Aleksey Aleksandrovich Kulesh.

26, Petropavlovskaya St., Perm 614990.

aleksey.kulesh@gmail.com

Кафедра неврологии и медицинской генетики, Пермский государственный медицинский университет им. акад. Е.А. Вагнера Минздрава РоссииРоссияDepartment of neurology and medical genetics, Acad. E.A. Vagner Perm State Medical University, Ministry of Health of RussiaRussian Federation

2021

14082021

13494102

2021

Кулеш А.А.

Kulesh A.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://nnp.ima-press.net/nnp/article/view/1622

The review discusses the role of neuroprotective therapy in the acute period of ischemic stroke in the era of active introduction of reperfusion treatment methods. The main mechanisms of brain damage during ischemia/reperfusion and the leading neuroprotective strategies studied in clinical trials are considered. Neuroprotective approaches aimed at suppressing excitotoxicity, oxidative stress, and neuroinflammation are presented. Current data on the safety and efficacy of uric acid, edaravone, fingolimod, natalizumab, interleukin 1 receptors antagonists, cerebrolysin, and other drugs have been analyzed. Non-drug methods of neuroprotection are characterized, including remote ischemic conditioning, therapeutic hypothermia, and neurostimulation. According to the author's position, the safest and most effective neuroprotective agent in acute ischemic stroke is cerebrolysin.

В обзоре обсуждается роль нейропротективной терапии в остром периоде ишемического инсульта в эпоху активного внедрения методов реперфузионного лечения. Рассмотрены основные механизмы поражения головного мозга при ишемии/реперфузии и ведущие нейропротективные стратегии, изученные в клинических исследованиях. Представлены нейропротективные подходы, направленные на подавление эксайтотоксичности, оксидантного стресса и нейровоспаления. Проанализированы современные данные о безопасности и эффективности мочевой кислоты, эдаравона, финголимода, натализумаба, антагонистов к рецепторам интерлейкина 1, церебролизина и других препаратов. Охарактеризованы немедикаментозные методы нейропротекции, в числе которых дистанционное ишемическое кондиционирование, терапевтическая гипотермия и нейростимуляция. Аргументирована позиция, согласно которой наиболее безопасным и эффективным нейропротективным агентом при остром ишемическом инсульте является церебролизин.

инсультнейропротекциявоспалениеишемическое кондиционированиецеребролизин

strokeneuroprotectioninflamationischemic conditioningcerebrolysin

Статья спонсируется компанией EVER Pharma.

This article has been supported by EVER Pharma.

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The authors declare that there are no conflicts of interest present.