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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2021-4-12-17</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-1619</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИ</subject></subj-group></article-categories><title-group><article-title>Menstrual cycle and gynecologic pathology in menstrual-related migraine</article-title><trans-title-group xml:lang="ru"><trans-title>Особенности менструального цикла и гинекологической патологии при менструально-ассоциированной мигрени</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кирьянова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kiryanova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кирьянова Екатерина Андреевна.</p><p>119021, Москва, ул. Россолимо, 11, стр. 1.</p></bio><bio xml:lang="en"><p>Ekaterina Andreevna Kiryanova.</p><p>11, Rossolimo St., Build. 1, Moscow 119021.</p></bio><email xlink:type="simple">terraaeternita@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Табеева</surname><given-names>Г. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Tabeeva</surname><given-names>G. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119021, Москва, ул. Россолимо, 11, стр. 1.</p></bio><bio xml:lang="en"><p>11, Rossolimo St., Build. 1, Moscow 119021.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кафедра нервных болезней и нейрохирургии Института клинической медицины им. Н.В. Склифосовского ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>13</day><month>08</month><year>2021</year></pub-date><volume>13</volume><issue>4</issue><fpage>12</fpage><lpage>17</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Kiryanova E.A., Tabeeva G.R., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Кирьянова Е.А., Табеева Г.Р.</copyright-holder><copyright-holder xml:lang="en">Kiryanova E.A., Tabeeva G.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/1619">https://nnp.ima-press.net/nnp/article/view/1619</self-uri><abstract><p>Migraine is the first most frequent cause of disability among women of reproductive age globally, and up to 60% of patients note the association of headache attacks with menstruation.</p><sec><title>Objective</title><p>Objective: to determine the features of menstrual cycle and gynecologic pathology in women with menstrual-related migraine (MRM).</p></sec><sec><title>Patients and methods</title><p>Patients and methods. A prospective comparative study included 69 women of reproductive age with a migraine diagnosis who did not receive hormonal contraception. Depending on the association of migraine attacks with menstruation (according to headache diaries), the patients were divided into two groups: the 1st group consisted of 44 patients with MRM; group 2 — 25 patients with non-menstrual migraine (without the association of attacks with menstruation).</p></sec><sec><title>Results and discussion</title><p>Results and discussion. Patients with MRM had heavier menstrual bleeding, longer menstruations (more than six days), abnormal menstrual cycle length and regularity, dysmenorrhea. In addition, the obtained data indicate a comorbid estrogen-associated gynecological pathology (endometriosis, adenomyosis, endometrial polyps, myoma) in MRM.</p></sec><sec><title>Conclusion</title><p>Conclusion. Presumably, the hypothalamic-pituitary-ovarian axis dysfunction plays the leading role in the MRM. It presents with menstrual cycle abnormalities and increased presence of estrogen-associated gynecological pathology, which should be considered during patient evaluation and suggesting recommendations.</p></sec></abstract><trans-abstract xml:lang="ru"><p>Мигрень является первой по частоте причиной нетрудоспособности среди женщин репродуктивного возраста в мире, причем до 60% пациенток отмечают ассоциацию приступов головной боли с менструацией.</p><p>Цель исследования — определение особенностей менструальной функции и гинекологической патологии у пациенток с менструально-ассоциированной мигренью (МАМ).</p><sec><title>Пациенты и методы</title><p>Пациенты и методы. Проведено проспективное сравнительное исследование, включающее 69 пациенток репродуктивного возраста с диагнозом «мигрень», не использующих на момент исследования терапию гормональными контрацептивами. В зависимости от ассоциации приступов мигрени с менструацией, по данным дневников головной боли, исследуемые разделены на две группы: 1-ю группу составили 44 пациентки с МАМ; 2-ю — 25 пациенток с неменструальной мигренью (без ассоциации приступов с менструацией). Результаты и обсуждение. Для пациенток с МАМ характерны более обильные менструации, длительность менструального кровотечения свыше 6 дней, аномальные по длительности и регулярности менструальные циклы, дисменорея. Полученные данные указывают на коморбидную эстроген-ассоциированную гинекологическую патологию (эндометриоз/аденомиоз, полипы эндометрия, миома) при МАМ.</p></sec><sec><title>Заключение</title><p>Заключение. Вероятно, в формировании МАМ ведущую роль играет дисфункция гипоталамо-гипофизарно-яичниковой системы, которая проявляется в виде особенностей менструальной функции и увеличения представленности эстроген-ассоциированной гинекологической патологии, что необходимо учитывать при диагностике заболевания и составлении рекомендаций для пациенток.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>менструально-ассоциированная мигрень</kwd><kwd>неменструальная мигрень</kwd><kwd>мигрень без ауры</kwd><kwd>эстроген</kwd><kwd>гинекологическая патология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>menstrual-related migraine</kwd><kwd>non-menstrual migraine</kwd><kwd>migraine without aura</kwd><kwd>estrogen</kwd><kwd>gynecologic pathology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Buse DC, Fanning KM, Reed ML. 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