nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2021-3-99-106nnp-1584Research ArticleREVIEWSОБЗОРЫPathogenesis, evaluation and pathogenetic therapy of diabetic polyneuropathyПатогенез, диагностика и патогенетическая терапия диабетической полиневропатииСтроковИ. А.StrokovI. A.

Игорь Алексеевич Строков

Кафедра нервных болезней и нейрохирургии Института клинической медицины им. Н.В. Склифосовского

119021, Москва, ул. Россолимо, 11, стр. 1

Igor Alekseyevich Strokov

Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine

11, Rossolimo St., Build. 1, Moscow 119021

strigoral@mail.ruОгановВ. В.OganovV. V.

Кафедра нервных болезней и нейрохирургии Института клинической медицины им. Н.В. Склифосовского

119021, Москва, ул. Россолимо, 11, стр. 1

Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine

11, Rossolimo St., Build. 1, Moscow 119021

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian Federation20212306202113399106Copyright © Strokov I.A., Oganov V.V., 20212021Строков И.А., Оганов В.В.Strokov I.A., Oganov V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1584

The increase in the number and life expectancy of patients with diabetes mellitus (DM) worldwide determines the high prevalence of late complications of diabetes, including diabetic polyneuropathy (DPN), the most common type of polyneuropathy. Oxidative stress is considered the main reason for the cellular pathology development in diabetes mellitus, which determines the use of antioxidants for the DPN treatment. Alpha-lipoic acid (ALA), a natural fat-soluble antioxidant, is the most effective drug for reducing DPN symptoms. Furthermore, the symptom-modifying effect of ALA has been shown in numerous randomized controlled trials. The article discusses the possible disease-modifying effect of ALA.

Увеличение числа и продолжительности жизни больных сахарным диабетом (СД) во всем мире определяет высокое распространение поздних осложнений СД, в том числе диабетической полиневропатии (ДПН) – самой распространенной разновидности полиневропатии. Основной причиной развития клеточной патологии при СД считается оксидативный стресс, что определяет применение для лечения ДПН антиоксидантов. Наиболее эффективным препаратом для уменьшения симптоматики при ДПН является альфа-липоевая кислота (АЛК) – естественный жирорастворимый антиоксидант. Симптом-модифицирующий эффект АЛК доказан в многочисленных рандомизированных контролируемых исследованиях. В статье обсуждается возможное болезнь-модифицирующее действие АЛК.

сахарный диабетдиабетическая полиневропатиядиагностикапатогенетическая терапияальфа-липоевая кислотасимптом-модифицирующая терапияболезнь-модифицирующая терапияdiabetes mellitusdiabetic polyneuropathyevaluationpathogenetic therapyalpha-lipoic acidsymptom-modifying treatmentdisease-modifying treatmentСтатья спонсируется компанией ЗАО «Канонфарма продакшн»This article has been supported by Kanonfarma prodakshnReferencesWang L, Gao P, Zhang M, et al. Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013. JAMA. 2017 Jun 27;317(24):2515-23. doi: 10.1001/jama.2017.7596Wang L, Gao P, Zhang M, et al. Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013. JAMA. 2017 Jun 27;317(24):2515-23. doi: 10.1001/jama.2017.7596International Diabetes Federation Atlas. 8th ed. 2017. Available from: https://diabetesatlas.org/upload/resources/previous/files/8/IDF_DA_8e-EN-final.pdfInternational Diabetes Federation Atlas. 8th ed. 2017. 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The authors declare that there are no conflicts of interest present.