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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2021-2-111-116</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-1549</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group></article-categories><title-group><article-title>Anxiety and depression in COVID-19: treatment options</article-title><trans-title-group xml:lang="ru"><trans-title>Расстройства тревожно-депрессивного спектра на фоне COVID-19: возможности терапии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Медведев</surname><given-names>В. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Medvedev</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p> Россия, 117198, Москва, ул. Миклухо-Маклая, 21, корп. 3 </p></bio><bio xml:lang="en"><p> 6, Miklukho-Maklai St., Moscow 117198, Russia </p></bio><email xlink:type="simple">medvedev_ve@rudn.university.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кафедра психиатрии, психотерапии и психосоматической патологии факультета непрерывного медицинского образования ФГАОУ ВО «Российский университет дружбы народов»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Department of Psychiatry, Psychotherapy, and Psychosomatic Pathology, Faculty of Advanced Training of Medical Workers, Medical Institute, Peoples' Friendship University of Russia (RUDN University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>23</day><month>04</month><year>2021</year></pub-date><volume>13</volume><issue>2</issue><fpage>111</fpage><lpage>116</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Medvedev V.E., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Медведев В.Э.</copyright-holder><copyright-holder xml:lang="en">Medvedev V.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/1549">https://nnp.ima-press.net/nnp/article/view/1549</self-uri><abstract><p> During the examination of post-COVID patients, a direct and indirect negative effect of COVID-19 on the nervous system is found. Among the mediated subjectively significant stress factors of the pandemic, a potential long-term threat to life,  prolonged quarantine measures with selfisolation, lack of stable  immunity, restriction of access to medical services, etc. are of  particular importance.An increased frequency of depression (up to 53.5%), anxiety (up  to 50.9%), and mixed anxiety/depressive disorders were  reported during the pandemic.Psychopharmacotherapy in patients with COVID-19 should include drugs not only with minimally expressed undesirable effects and adverse drug interactions but also with the presence of additional therapeutic procognitive and somatotropic properties, similar to those identified in the antidepressant fluvoxamine. </p></abstract><trans-abstract xml:lang="ru"><p> В ходе обследования пациентов, перенесших коронавирус,  обнаруживается прямое и опосредованное негативное влияние COVID-19 на нервную систему. Среди опосредованных субъективно значимых  стрессогенных факторов пандемии особое значение имеют длительная  потенциальная угроза жизни, продолжительные карантинные меры с  самоизоляцией, отсутствие устойчивого иммунитета, ограничение доступа к  медицинским услугам и др.На фоне пандемии отмечается увеличение частоты депрессивных (до  53,5%), тревожных (до 50,9%) и смешанных тревожно-депрессивных  расстройств. При проведении психофармакотерапии пациентам с COVID-19  предпочтение следует отдавать препаратам не только с минимально  выраженными нежелательными эффектами и неблагоприятными  лекарственными взаимодействиями, но и с наличием дополнительных  терапевтических прокогнитивных и соматотропных свойств, подобных  выявленным у антидепрессанта флувоксамина. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>пандемия</kwd><kwd>COVID-19</kwd><kwd>тревожно-депрессивные расстройства</kwd><kwd>терапия</kwd><kwd>антидепрессанты</kwd><kwd>флувоксамин</kwd><kwd>Феварин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pandemic</kwd><kwd>COVID-19</kwd><kwd>anxiety/depressive disorders</kwd><kwd>treatment</kwd><kwd>antidepressants</kwd><kwd>fluvoxamine</kwd><kwd>Fevarin</kwd></kwd-group><funding-group><funding-statement xml:lang="en">This article has been supported by Abbott.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Samkari H, Leaf RK, Dzik WH, et al. 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