nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2021-2-104-110nnp-1548Research ArticleREVIEWSОБЗОРЫDrug-induced (medication-induced) depression in neurology practiceЛекарственно-индуцированная (медикаментозная) депрессия в неврологической практикеЭбзееваЕ. Ю.EbzeevaE. Yu.

 Россия, 125993, Москва, ул. Баррикадная, 2/1, стр. 1 

 2/1, Barrikadnaya St., Build. 1, Moscow 125993, Russia 

ОстроумоваО. Д.OstroumovaO. D.

 Россия, 125993, Москва, ул. Баррикадная, 2/1, стр. 1 

 Россия, 119991, Москва, ул. Трубецкая, 8, стр. 2 

 2/1, Barrikadnaya St., Build. 1, Moscow 125993, Russia 

 8, Trubetskaya St., Build. 2, Moscow 119991 Moscow, Russia 

ostroumova.olga@mail.ruБатюкинаС. В.BatyukinaS. V.

 Россия, 125993, Москва, ул. Баррикадная, 2/1, стр. 1 

 2/1, Barrikadnaya St., Build. 1, Moscow 125993, Russia 

ОстроумоваТ. М.OstroumovaT. M.

 Россия, 119991, Москва, ул. Трубецкая, 8, стр. 2 

 8, Trubetskaya St., Build. 2, Moscow 119991 Moscow, Russia 

КочетковА. И.KochetkovA. I.

 Россия, 125993, Москва, ул. Баррикадная, 2/1, стр. 1 

 2/1, Barrikadnaya St., Build. 1, Moscow 125993, Russia 

КириченкоА. А.KirichenkoA. A.

 Россия, 125993, Москва, ул. Баррикадная, 2/1, стр. 1 

 2/1, Barrikadnaya St., Build. 1, Moscow 125993, Russia 

ФГБОУ ДПО «Российская медицинская академия непрерывного постдипломного образования» Минздрава РоссииРоссияRussian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian FederationRussian FederationФГБОУ ДПО «Российская медицинская академия непрерывного постдипломного образования» Минздрава России; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияRussian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian FederationФГБОУ ДПО «Российская медицинская академия непрерывного постдипломного образования» Минздрава РоссииРоссияRussian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian FederationRussian Federation202123042021132104110Copyright © Ebzeeva E.Y., Ostroumova O.D., Batyukina S.V., Ostroumova T.M., Kochetkov A.I., Kirichenko A.A., 20212021Эбзеева Е.Ю., Остроумова О.Д., Батюкина С.В., Остроумова Т.М., Кочетков А.И., Кириченко А.А.Ebzeeva E.Y., Ostroumova O.D., Batyukina S.V., Ostroumova T.M., Kochetkov A.I., Kirichenko A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1548

 One of the depression causes is the use of certain drugs, and in this case, the term drug-induced depression (DID), medication-induced or iatrogenic depression is used. Symptoms of DID are similar to those observed in patients with other types of depression. DID is also associated with morbidity and mortality. Its  development leads to a decrease in treatment adherence, and in  some cases, to discontinuation of drugs that have predictive value. The main point in the management of patients with DID is the rapid  detection and correction of symptoms and the application of prompt measures to prevent their development when prescribing  certain drugs. The features of the course of DID, pathogenetic  mechanisms and risk factors for its development, possible approaches to the treatment and prevention are discussed. 

 Одной из причин развития депрессии является прием некоторых лекарственных средств (ЛС), в таком случае используют термины «лекарственно-индуцированная депрессия» (ЛИД), «медикаментозная депрессия» или «ятрогенная депрессия». Симптомы ЛИД сходны с теми, которые наблюдаются у пациентов с другими типами депрессии. ЛИД  взаимосвязана с повышением заболеваемости и смертности. Ее  развитие приводит к снижению приверженности лечению, а в ряде  случаев – к прекращению приема препаратов, имеющих жизненно  важное значение. Главное в ведении пациентов с ЛИД – быстрое  выявление и коррекция симптомов, а также принятие своевременных мер, предупреждающих их развитие, при назначении определенных ЛС.  Обсуждаются особенности течения ЛИД, патогенетические  механизмы и факторы риска ее развития, возможные подходы к  терапии и профилактике. 

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The authors declare that there are no conflicts of interest present.