nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2021-1-145-153nnp-1510Research ArticleEXPERIMENTAL STUDIESЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯNociception: the roles of vitamin DНоцицепция: роли витамина DГромоваО. А.GromovaO. A.

Ольга Алексеевна Громова

Институт фармакоинформатики119333, Москва, ул. Вавилова, 44, корп. 2 

Центр хранения и анализа больших данных Национального центра цифровой экономики119234, Москва, Ленинские горы, 1 

Olga Alekseevna Gromova

Institute of Pharmacoinformatics44, Vavilov St., Build. 2, Moscow 119333 

Center for Big Data Storage and Analysis, National Center for Digital Economy1, Leninskie Gory, Moscow 119234 

unesco.gromova@gmail.comТоршинИ. Ю.TorshinI. Yu.

Институт фармакоинформатики119333, Москва, ул. Вавилова, 44, корп. 2 

Центр хранения и анализа больших данных Национального центра цифровой экономики119234, Москва, Ленинские горы, 1 

Institute of Pharmacoinformatics44, Vavilov St., Build. 2, Moscow 119333 

Center for Big Data Storage and Analysis, National Center for Digital Economy1, Leninskie Gory, Moscow 119234 

ПутилинаМ. В.PutilinaM. V.

117997, Москва, ул. Островитянова, 1

1, Ostrovityanov St., Moscow 117997

СардарянИ. С.SardaryanI. S.

194100, Санкт-Петербург, ул. Литовская, 2

2, Litovskaya St., Saint Petersburg 194100

ФедотоваЛ. Э.FedotovaL. E.

153012, Иваново, Шереметевский проспект, 8

8, Sheremetesky Prospect, Ivanovo 153012

ЛимановаО. А.LimanovaO. A.

153012, Иваново, Шереметевский проспект, 8

8, Sheremetesky Prospect, Ivanovo 153012

Федеральный исследовательский центр «Информатика и управление» Российской академии наук; ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»РоссияFederal Research Center for Informatics and Management, Russian Academy of Sciences; M.V. Lomonosov Moscow State UniversityRussian FederationФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian FederationФГБОУ ВО «Санкт-Петербургский государственный педиатрической университет» Минздрава РоссииРоссияSaint Petersburg State Pediatric Medical University, Ministry of Health of RussiaRussian FederationФГБОУ ВО «Ивановская государственная медицинская академия» Минздрава РоссииРоссияIvanovo State Medical Academy, Ministry of Health of RussiaRussian Federation202117022021131145153Copyright © Gromova O.A., Torshin I.Y., Putilina M.V., Sardaryan I.S., Fedotova L.E., Limanova O.A., 20212021Громова О.А., Торшин И.Ю., Путилина М.В., Сардарян И.С., Федотова Л.Э., Лиманова О.А.Gromova O.A., Torshin I.Y., Putilina M.V., Sardaryan I.S., Fedotova L.E., Limanova O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1510Objective

Objective: to carry out a systematic computer-assisted analysis of scientific literature on on the relationships between the effects of vitamin and nociception (including the impact of vitamin D deficiency on the development of pain syndrome.

Material and methods

Material and methods. For the query “(pain OR nociception) AND (vitamin D OR cholecalciferol OR VITD OR CALCITRIOL OR HYDROXYVITAMIN OR DIHYDROXYVITAMIN OR ALPHACALCIDOL)", 2318 references, including 77 references on alpha-calcidol, were found in the biomedical publications database PubMed. The computer-assisted analysis of this array of publications was carried out using the current big data analysis methods developed within the topological and metric approaches to recognition/classification problems.

Result and discussion

Result and discussion. A systematic computer-assisted text analysis of 2318 studies on the relationships between nociception and vitamin D showed that the analgesic effects of the vitamin are by anti-inflammatory action and the regulation of serotonergic, dopaminergic, and opioidergic neurotransmission. The lower blood levels of the major vitamin D metabolite 25 (OH)D is a risk factor for decreased pain threshold in myalgia, fibromyalgia, arthralgia, dorsalgia, and a number of neuralgias.

Conclusion

Conclusion. In patients with impaired renal conversion of active vitamin D metabolites (especially in the elderly), the efficacy of cholecalciferol-based drugs is reduced, which makes it necessary to use the active forms of vitamin D.

Цель исследования – систематический компьютерный анализ научной литературы по вопросу взаимосвязи между эффектами витамина D и ноцицепции (включая воздействие недостаточности/дефицита витамина D на формирование болевого синдрома).

Материал и методы

Материал и методы. По запросу «(pain OR nociception) AND (vitamin D OR cholecalciferol OR VITD OR CALCITRIOL OR HYDROXYVITAMIN OR DIHYDROXYVITAMIN OR ALPHACALCIDOL)» в базе данных биомедицинских публикаций PubMed найдено 2318 ссылок, в том числе 77 ссылок по альфакальцидолу. Компьютерный анализ данного массива публикаций был осуществлен посредством современных методов анализа больших данных, развиваемых в рамках топологического и метрического подходов к задачам распознавания/классификации.

Результаты и обсуждение

Результаты и обсуждение. Систематический компьютерный анализ текстов 2318 исследований взаимосвязей между ноцицепцией и витамином D показал, что анальгетические эффекты витамина осуществляются посредством противовоспалительного действия, а также регулирования серотонинергической, дофаминергической и опиоидергической нейротрансмиссии. Сниженные уровни основного метаболита витамина D – 25(OH)D – в крови являются фактором риска снижения болевого порога при миалгии, фибромиалгии, артралгии, дорсалгии и ряда невралгий.

Заключение

Заключение. У пациентов с нарушениями конвертации активных метаболитов витамина D в почках (прежде всего у пожилых) эффективность применения препаратов на основе холекальциферола снижена, что обусловливает необходимость использования активных форм витамина D.

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The authors declare that there are no conflicts of interest present.