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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2021-1-67-73</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-1509</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group></article-categories><title-group><article-title>The behavioral variant of frontotemporal dementia: a clinical case</article-title><trans-title-group xml:lang="ru"><trans-title>Поведенческий вариант лобно-височной деменции: клиническое наблюдение</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коцюбинская</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kotsyubinskaya</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юлия Вадимовна Коцюбинская</p><p>192019, Санкт-Петербург, ул. Бехтерева, 3</p></bio><bio xml:lang="en"><p>Yulia Vadimovna Kotsyubinskaya</p><p>3, Bekhterev St., Saint Petersburg 192019</p></bio><email xlink:type="simple">juliak66@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Михайлов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mikhailov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>192019, Санкт-Петербург, ул. Бехтерева, 3</p></bio><bio xml:lang="en"><p>3, Bekhterev St., Saint Petersburg 192019</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Стулов</surname><given-names>И. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Stulov</surname><given-names>I. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>192019, Санкт-Петербург, ул. Бехтерева, 3</p></bio><bio xml:lang="en"><p>3, Bekhterev St., Saint Petersburg 192019</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ананьева</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Ananyeva</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>192019, Санкт-Петербург, ул. Бехтерева, 3</p></bio><bio xml:lang="en"><p>3, Bekhterev St., Saint Petersburg 192019</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ситник</surname><given-names>Л. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Sitnik</surname><given-names>L. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>192019, Санкт-Петербург, ул. Бехтерева, 3</p></bio><bio xml:lang="en"><p>3, Bekhterev St., Saint Petersburg 192019</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>17</day><month>02</month><year>2021</year></pub-date><volume>13</volume><issue>1</issue><fpage>67</fpage><lpage>73</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Kotsyubinskaya Y.V., Mikhailov V.A., Stulov I.K., Ananyeva N.I., Sitnik L.I., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Коцюбинская Ю.В., Михайлов В.А., Стулов И.К., Ананьева Н.И., Ситник Л.И.</copyright-holder><copyright-holder xml:lang="en">Kotsyubinskaya Y.V., Mikhailov V.A., Stulov I.K., Ananyeva N.I., Sitnik L.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/1509">https://nnp.ima-press.net/nnp/article/view/1509</self-uri><abstract><p>The paper is devoted to frontotemporal dementia (FTD), one of the most common forms of frontotemporal degeneration. The main symptoms of the disease include disinhibition, lack of empathy, obsessive-compulsive symptoms, apathy, cognitive impairment, appetite changes, and progressive changes in social behavior. In parallel, there are personality changes that are characterized by lower levels of self-awareness and by progressive psychological and social maladaptation of patients in society.</p><p>The paper describes a clinical case of FTD in a female patient with marked behavioral changes and personality disorder. A 52-year-old woman was admitted to the alcoholism treatment department for alcohol intoxication and symptoms of mental confusion. According to her relatives, drinking too much alcohol every day, she was found to become rude, indifferent to others and her own duties, sharply limited the range of her activities and communication, and showed a decline in memory for current events. Psychopathological examination determined a distinct motivational-volitional decrease, the patient’s inability to mobilize mental activity, non-critical thinking, and indifference. X-ray diagnosis revealed the changes characteristic of frontotemporal neurodegeneration (atrophy of the frontal and temporal lobes prevails). The described case confirms that alcohol abuse can mask organic disorders that develop in systemic cerebral atrophy.</p></abstract><trans-abstract xml:lang="ru"><p>Статья посвящена одной из наиболее частых форм лобно-височной дегенерации – лобно-височным деменциям (ЛВД). Основные симптомы заболевания включают расторможенность, отсутствие эмпатии, обсессивно-компульсивную симптоматику, апатию, когнитивные нарушения, изменения аппетита и прогрессирующие изменения социального поведения. Параллельно этому развиваются личностные изменения, которые характеризуются снижением уровня самосознания и нарастающей психологической и социальной дезадаптацией пациентов в социуме.</p><p>Представлен клинический случай ЛВД у пациентки с выраженными изменениями в поведении и личностным расстройством. Женщина 52 лет поступила в отделение лечения алкоголизма в состоянии алкогольного опьянения и с симптомами психической спутанности. Со слов родственников удалось выяснить, что на фоне ежедневного употребления алкоголя пациентка стала груба, безразлична к окружению и собственным обязанностям, резко ограничила круг деятельности и общения, демонстрировала снижение памяти на текущие события. Патопсихологическое обследование определило отчетливое мотивационно-волевое снижение, неспособность больной к мобилизации психической активности, некритичность, безразличие. Рентгенологическая диагностика выявила изменения, характерные для нейродегенерации лобно-височного типа (преобладает атрофия лобных и височных долей). Описанный случай подтверждает, что злоупотребление алкоголем может маскировать органические нарушения, развивающиеся при системной атрофии головного мозга.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лобно-височная деменция</kwd><kwd>поведенческий вариант лобно-височной деменции</kwd><kwd>когнитивные нарушения</kwd><kwd>деменция</kwd><kwd>дегенеративные заболевания головного мозга</kwd><kwd>функциональная магнитно-резонансная томография</kwd><kwd>трактография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>frontotemporal dementia</kwd><kwd>behavioral variant of frontotemporal dementia</kwd><kwd>cognitive impairment</kwd><kwd>dementia</kwd><kwd>degenerative brain diseases</kwd><kwd>functional magnetic resonance imaging</kwd><kwd>tractography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Riedl L, Mackenzie IR, Förstl H, et al. 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