nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2020-4-143-152nnp-1415Research ArticleREVIEWSОБЗОРЫCurrent concept of the pathophysiology of migraine and new targets for its therapyСовременная концепция патофизиологии и новые мишени терапии мигрениТабееваГ. Р.TabeevaG. R.

Гюзяль Рафкатовна Табеева

Кафедра нервных болезней и нейрохирургии

2119021, Москва, ул. Россолимо, 11, стр. 1

Guzyal Rafkatovna Tabeeva

Department of Nervous System Diseases and Neurosurgery

11, Rossolimo St., Build. 1, Moscow 119021

grtabeeva@gmail.comКацараваЗ.KatsapavaZ.

2119021, Москва, ул. Россолимо, 11, стр. 1

Department of Nervous System Diseases and Neurosurgery, I.M. Sechenov First Moscow State Medical University

Department of Neurology, University of Duisburg-Essen, University Hospital

Department of Neurology, Evangelical Hospital

11, Rossolimo St., Build. 1, Moscow 119021Hufelandstr. 55, 45122 Essen, GermanyHolbeinstr 10, 59423 Unna, Germany40 Vazha-Pshavela Avenue, Tbilisi 0177, Georgia 

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет); University of Duisburg-Essen, University Hospital; Evangelical Hospital; EVEX Medical CorporationРоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; University of Duisburg-Essen, University Hospital; Evangelical Hospital; EVEX Medical CorporationRussian Federation202027082020124143152Copyright © Tabeeva G.R., Katsapava Z., 20202020Табеева Г.Р., Кацарава З.Tabeeva G.R., Katsapava Z.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1415

Migraine is a common chronic neurological disease. Many neurogenic, vascular, autonomic, and other mechanisms at different levels of the central and peripheral nervous systems are assumed to be implicated in the pathophysiology of headache and other manifestations of migraine. Advances in understanding the neurobiology of migraine have made it possible to clarify the main patterns of neurogenic-vascular relationships that explain the leading clinical manifestations of migraine, as well as to identify some biological markers that have triggered the creation of new targeted therapies for the disease. This review is dedicated to the latest advances in studying the pathophysiology of migraine and to new pharmacological approaches to its treatment.

Мигрень является распространенным хроническим неврологическим заболеванием. Патофизиология головной боли и других проявлений мигрени предполагает участие множества нейрогенных, сосудистых, вегетативных и других механизмов, реализующихся на разных уровнях центральной и периферической нервной системы. Достижения в понимании нейробиологии мигрени позволили уточнить основные закономерности функционирования нейрогенно-сосудистых взаимоотношений, объясняющих ведущие клинические проявления мигрени, а также выявить некоторые биологические маркеры, которые послужили толчком к созданию новых классов таргетной терапии заболевания. Данный обзор посвящен последним достижениям в изучении патофизиологии мигрени и новым фармакологическим подходам к ее лечению.

мигреньпатофизиологиятригеминоваскулярная системакальцитонин-ген родственный пептиданти-CGRP моноклональные антителаmigrainepathophysiologytrigeminovascular systemcalcitonin gene-related peptide (CGRP)anti-CGRP monoclonal antibodiesСтатья публикуется при поддержке ООО «Тева». Авторы не получали финансовое вознаграждение за подготовку статьи.This article has been supported by Teva. The authors have not received any funding for the preparation of the article.ReferencesGlobal, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017 Sep 16;390(10100):1211-59. doi: 10.1016/S0140-6736(17)32154-2Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. 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The authors declare that there are no conflicts of interest present.