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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2020-4-73-78</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-1414</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group></article-categories><title-group><article-title>Severe drug-induced headache with its possible recurrent statuses in a patient with chronic tension headache</article-title><trans-title-group xml:lang="ru"><trans-title>Тяжелая лекарственно-индуцированная головная боль с возможными повторными ее статусами у пациента с хронической головной болью напряжения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Осипова</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Osipova</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вера Валентиновна Осипова</p><p>115419, Москва, ул. Донская, 43121467, Москва, ул. Молодогвардейская, 2, корп. 1 </p></bio><bio xml:lang="en"><p>Vera Valentinovna Osipova</p><p>43, Donskaya St., Moscow 1154192, Molodogvardeiskaya St., Build. 1, Moscow 121467 </p></bio><email xlink:type="simple">osipova_v@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скоробогатых</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Skorobogatykh</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>121467, Москва, ул. Молодогвардейская, 2, корп. 1</p></bio><bio xml:lang="en"><p>2, Molodogvardeiskaya St., Build. 1, Moscow 121467</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Артеменко</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Artemenko</surname><given-names>A. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119991, Москва, ул. Трубецкая, 8, стр. 2</p></bio><bio xml:lang="en"><p>8, Trubetskaya St., Build. 2, Moscow 119991</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сергеев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sergeev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119991, Москва, ул. Трубецкая, 8, стр. 2125047, Москва, ул. Лесная, 9</p></bio><bio xml:lang="en"><p>8, Trubetskaya St., Build. 2, Moscow 1199919, Lesnaya St., Moscow 125047</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ «Научно-практический психоневрологический центр им. З.П. Соловьева Департамента здравоохранения города Москвы»; ООО «Университетская клиника головной боли»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Z.P. Solovyev Research and Practical Psychoneurology Center, Moscow Healthcare Department; LTD «University Headache Clinic»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ООО «Университетская клиника головной боли»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>LTD «University Headache Clinic»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Минздрава России (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Минздрава России (Сеченовский Университет); Центр неврологии клиник «Чайка»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; Center of Neurology, Chaika Clinic</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>27</day><month>08</month><year>2020</year></pub-date><volume>12</volume><issue>4</issue><fpage>73</fpage><lpage>78</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Osipova V.V., Skorobogatykh K.V., Artemenko A.R., Sergeev A.V., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Осипова В.В., Скоробогатых К.В., Артеменко А.Р., Сергеев А.В.</copyright-holder><copyright-holder xml:lang="en">Osipova V.V., Skorobogatykh K.V., Artemenko A.R., Sergeev A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/1414">https://nnp.ima-press.net/nnp/article/view/1414</self-uri><abstract><p>The paper deals with the actual problem of managing patients with drug-induced headache (DIH) in patients with primary headaches. It describes a clinical case of extremely severe DIH in a patient with chronic tension headache (TH). The paper analyzes the typical and atypical manifestations of DIH and discusses the role of prolonged stress in the development of TH. Special attention is paid to the problems with therapy and compliance during a long-term follow-up of the patient. Based on the clinical features of pain syndrome in the described patient, the authors suggest for the first time that the use of extremely high number of daily doses of combined narcotic analgesics for many years can result in recurrent DIH statuses. The paper discusses whether it is expedient to introduce the concept “DIH severity” and whether an additional clinical parameter “the number of doses of painkillers per month” can be of informative value, which has not been proposed yet in the literature. All the issues given in the paper are conjectural and are raised by the authors for further investigation of the DIH problem.</p></abstract><trans-abstract xml:lang="ru"><p>Статья посвящена актуальной проблеме ведения пациентов с лекарственно-индуцированной головной болью (ЛИГБ) у пациентов с первичными формами головной боли. Представлен клинический случай крайне тяжелой ЛИГБ у пациента с хронической головной болью напряжения (ГБН). Проведен анализ типичных и нетипичных проявлений ЛИГБ; обсуждается роль длительного стресса в формировании ГБН. Отдельное внимание уделено трудностям терапии и проблемам комплаентности в ходе длительного наблюдения за пациентом. На основании клинических особенностей болевого синдрома у описанного пациента в статье впервые высказывается предположение о возможности развития повторных статусов ЛИГБ на фоне многолетнего ежедневного приема огромного числа доз комбинированных наркотических анальгетиков. Обсуждаются целесообразность введения понятия «степень тяжести ЛИГБ», а также возможная информативность дополнительного клинического параметра «число доз обезболивающих в месяц», что до сих пор не предлагалось в литературе. Все поставленные в статье вопросы имеют предположительный характер и выдвинуты авторами в интересах дальнейшего изучения проблемы ЛИГБ.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая головная боль напряжения</kwd><kwd>лекарственный абузус</kwd><kwd>лекарственно-индуцированная головная боль</kwd><kwd>диагностические критерии</kwd><kwd>лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic tension headache</kwd><kwd>drug overuse</kwd><kwd>drug-induced headache</kwd><kwd>diagnostic criteria</kwd><kwd>treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bigal ME, Lipton RB. 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