nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2020-4-65-72nnp-1413Research ArticleCLINICAL OBSERVATIONSКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯThe syndrome of transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL): a description of three patientsСиндром транзиторной головной боли с неврологическим дефицитом и лимфоцитозом в цереброспинальной жидкости (HaNDL): описание трех пациентовКулешА. А.KuleshA. A.

Алексей Александрович Кулеш

614990, Пермь, ул. Петропавловская, 26614107, Пермь, ул. Ким, 2 

Aleksey Aleksandrovich Kulesh

26, Petropavlovskaya St., Perm 6149902, Kim St., Perm 614107 

aleksey.kulesh@gmail.comСтариковаН. Л.StarikovaN. L.

614990, Пермь, ул. Петропавловская, 26614107, Пермь, ул. Ким, 2

26, Petropavlovskaya St., Perm 6149902, Kim St., Perm 614107

ДробахаВ. Е.DrobakhaV. E.

614990, Пермь, ул. Петропавловская, 26614107, Пермь, ул. Ким, 2

26, Petropavlovskaya St., Perm 6149902, Kim St., Perm 614107

БрохинЛ. Ю.BrokhinL. Yu.

614990, Пермь, ул. Петропавловская, 26614107, Пермь, ул. Ким, 2

26, Petropavlovskaya St., Perm 6149902, Kim St., Perm 614107

ЧубаровА. С.ChubarovA. S.

614990, Пермь, ул. Петропавловская, 26614107, Пермь, ул. Ким, 2

26, Petropavlovskaya St., Perm 6149902, Kim St., Perm 614107

ФГБОУ ВО «Пермский государственный медицинский университет им. акад. Е.А. Вагнера» Минздрава России; ГАУЗ «Городская клиническая больница №4»РоссияAcad. E.A. Vagner Perm State Medical University, Ministry of Health of Russia; City Clinical Hospital FourRussian Federation2020270820201246572Copyright © Kulesh A.A., Starikova N.L., Drobakha V.E., Brokhin L.Y., Chubarov A.S., 20202020Кулеш А.А., Старикова Н.Л., Дробаха В.Е., Брохин Л.Ю., Чубаров А.С.Kulesh A.A., Starikova N.L., Drobakha V.E., Brokhin L.Y., Chubarov A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1413

Three clinical cases of the syndrome of transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL) are first described in Russian literature. The patients were young (aged 30–35 years), had symptoms characteristic of the prodromal period of infections. In all the patients, the disease started with intense headache, followed by focal neurological symptoms: aphasia and hemihypesthesia in all cases and confusion with psychomotor agitation in two cases. All the three patients showed spontaneous recovery within 2–3 days. Perfusion computed tomography, magnetic resonance imaging, and electroencephalography are compared in one of the cases. The differential diagnosis of HaNDL with acute cerebrovascular accident, herpetic encephalitis, epilepsy, and migraine is discussed.

Впервые в отечественной литературе представлено описание трех клинических случаев синдрома транзиторной головной боли с неврологическим дефицитом и лимфоцитозом в цереброспинальной жидкости (HaNDL). Больные были молодого возраста (30–35 лет), имели симптомы, характерные для продромального периода инфекций. У всех пациентов заболевание начиналось с интенсивной головной боли, вслед за которой развивалась очаговая неврологическая симптоматика: во всех случаях отмечались афазия и гемигипестезия, в двух – спутанность сознания с психомоторным возбуждением. У всех трех больных наблюдалось спонтанное выздоровление в течение 2–3 дней. В одном из наблюдений проведено сопоставление перфузионной компьютерной томографии, магнитно-резонансной томографии и электроэнцефалографии. Обсуждаются вопросы дифференциальной диагностики HaNDL с острым нарушением мозгового кровообращения, герпетическим энцефалитом, эпилепсией и мигренью.

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The authors declare that there are no conflicts of interest present.