nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2020-4-4-14nnp-1404Research ArticleCLINICAL GUIDELINESКЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИDiagnosis and treatment of migraine: Russian experts' recommendationsДиагностика и лечение мигрени: рекомендации российских экспертовФилатоваЕ. Г.FilatovaE. G.

119991, Москва, ул. Трубецкая, 8, стр. 2

8, Trubetskaya St., Build. 2, Moscow 119991

ОсиповаВ. В.OsipovaV. V.

Вера Валентиновна Осипова

115419, Москва, ул. Донская, 43121467, Москва, ул. Молодогвардейская, 2, корп. 1 

Vera Valentinovna Osipova

43, Donskaya St., Moscow 1154192, Molodogvardeiskaya St., Build. 1, Moscow 121467 

osipova_v@mail.ruТабееваГ. Р.TabeevaG. R.

119991, Москва, ул. Трубецкая, 8, стр. 2

8, Trubetskaya St., Build. 2, Moscow 119991

ПарфеновВ. А.ParfenovV. A.

119991, Москва, ул. Трубецкая, 8, стр. 2

8, Trubetskaya St., Build. 2, Moscow 119991

ЕкушеваЕ. В.EkushevaE. V.

125371, Москва, Волоколамское шоссе, 91

91, Volokolamskoe Shosse, Moscow 125371

АзимоваЮ. Э.AzimovaYu. E.

121467, Москва, ул. Молодогвардейская, 2, корп. 1

2, Molodogvardeiskaya St., Build. 1, Moscow 121467

ЛатышеваН. В.LatyshevaN. V.

119991, Москва, ул. Трубецкая, 8, стр. 2

8, Trubetskaya St., Build. 2, Moscow 119991

НаприенкоМ. В.NaprienkoM. V.

119991, Москва, ул. Трубецкая, 8, стр. 2

8, Trubetskaya St., Build. 2, Moscow 119991

СкоробогатыхК. В.SkorobogatykhK. V.

121467, Москва, ул. Молодогвардейская, 2, корп. 1

2, Molodogvardeiskaya St., Build. 1, Moscow 121467

СергеевА. В.SergeevA. V.

119991, Москва, ул. Трубецкая, 8, стр. 2

8, Trubetskaya St., Build. 2, Moscow 119991

ГоловачеваВ. А.GolovachevaV. A.

119991, Москва, ул. Трубецкая, 8, стр. 2

8, Trubetskaya St., Build. 2, Moscow 119991

ЛебедеваЕ. Р.LebedevaE. R.

620028, Екатеринбург, ул. Репина, 3

3, Repin St., Yekaterinburg 620028

АртёменкоА. Р.ArtyomenkoA. R.

119991, Москва, ул. Трубецкая, 8, стр. 2

8, Trubetskaya St., Build. 2, Moscow 119991

КурушинаО. В.KurushinaO. V.

400049, Волгоград, ул. Ангарская, 13, корп. 7

13, Angarskaya St., Build. 7, Volgograd 400049

КорешкинаМ. И.KoreshkinaM. I.

191186, Санкт-Петербург, Литейный просп., 55А

55A, Liteinyi Prosp., Saint Petersburg 191186

АмелинА. В.AmelinA. V.

197022, Санкт-Петербург, ул. Льва Толстого, 6-8

6-8, Lev Tolstoy St., Saint Petersburg 197022

АхмадееваЛ. Р.AkhmadeevaL. R.

450008, Уфа, ул. Ленина, 3

3, Lenin St., Ufa 450008

РачинА. П.RachinA. R.

121099, Москва, ул. Новый Арбат, 32

32, Novyi Arbat St., Moscow 121099

ИсагулянЭ. Д.IsagulyanE. D.

125047, Москва, ул. 4-я Тверская-Ямская, 16, корп. 5

16, 4th Tverskaya-Yamskaya St., Build. 5, Moscow 125047

ДаниловАл. Б.DanilovAl. B.

119991, Москва, ул. Трубецкая, 8, стр. 2

8, Trubetskaya St., Build. 2, Moscow 119991

ГехтА. Б.GekhtA. B.

115419, Москва, ул. Донская, 43

43, Donskaya St., Moscow 115419

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian FederationГБУЗ «Научно-практический психоневрологический центр им. З.П. Соловьева» Департамента здравоохранения г. Москвы; Университетская клиника головной болиРоссияZ.P. Solovyev Research and Practical Center of Psychoneurology, Moscow Healthcare Department; University Headache ClinicRussian FederationАкадемия постдипломного образования при ФГБУ «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства России»РоссияAcademy of Postgraduate Education «Federal Research and Clinical Center for Specialized Medical Care Types and Medical Technologies, Federal Biomedical Agency of Russia»Russian FederationУниверситетская клиника головной болиРоссияUniversity Headache ClinicRussian FederationФГБОУ ВО «Уральский государственный медицинский университет» Минздрава РоссииРоссияUral State Medical University, Ministry of Health of RussiaRussian FederationФГБОУ ВО «Волгоградский государственный медицинский университет» Минздрава РоссииРоссияVolgograd State Medical University, Ministry of Health of RussiaRussian FederationКлиника «Скандинавия»РоссияScandinavia ClinicRussian FederationФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава РоссииРоссияAcad. I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaRussian FederationФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава РоссииРоссияBashkir State Medical University, Ministry of Health of RussiaRussian FederationФГБУ «Национальный медицинский исследовательский центр реабилитации и курортологии» Минздрава РоссииРоссияNational Medical Research Center for Rehabilitation and Balneology, Ministry of Health of RussiaRussian FederationФГАУ «Национальный медицинский исследовательский центр нейрохирургии им. академика Н.Н. Бурденко»РоссияAcademician N.N. Burdenko National Medical Research Center of NeurosurgeryRussian FederationГБУЗ «Научно-практический психоневрологический центр им. З.П. Соловьева» Департамента здравоохранения г. МосквыРоссияZ.P. Solovyev Research and Practical Center of Psychoneurology, Moscow Healthcare DepartmentRussian Federation202026082020124414Copyright © Filatova E.G., Osipova V.V., Tabeeva G.R., Parfenov V.A., Ekusheva E.V., Azimova Y.E., Latysheva N.V., Naprienko M.V., Skorobogatykh K.V., Sergeev A.V., Golovacheva V.A., Lebedeva E.R., Artyomenko A.R., Kurushina O.V., Koreshkina M.I., Amelin A.V., Akhmadeeva L.R., Rachin A.R., Isagulyan E.D., Danilov A.B., Gekht A.B., 20202020Филатова Е.Г., Осипова В.В., Табеева Г.Р., Парфенов В.А., Екушева Е.В., Азимова Ю.Э., Латышева Н.В., Наприенко М.В., Скоробогатых К.В., Сергеев А.В., Головачева В.А., Лебедева Е.Р., Артёменко А.Р., Курушина О.В., Корешкина М.И., Амелин А.В., Ахмадеева Л.Р., Рачин А.П., Исагулян Э.Д., Данилов А.Б., Гехт А.Б.Filatova E.G., Osipova V.V., Tabeeva G.R., Parfenov V.A., Ekusheva E.V., Azimova Y.E., Latysheva N.V., Naprienko M.V., Skorobogatykh K.V., Sergeev A.V., Golovacheva V.A., Lebedeva E.R., Artyomenko A.R., Kurushina O.V., Koreshkina M.I., Amelin A.V., Akhmadeeva L.R., Rachin A.R., Isagulyan E.D., Danilov A.B., Gekht A.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1404

Migraine is one of the most common types of headache, which can lead to a significant decrease in quality of life. Researchers identify migraine with aura, migraine without aura, and chronic migraine that substantially reduces the ability of patients to work and is frequently concurrent with mental disorders and drug-induced headache. The complications of migraine include status migrainosus, persistent aura without infarction, migrainous infarction (stroke), and a migraine aura-induced seizure. The diagnosis of migraine is based on complaints, past medical history, objective examination data, and the diagnostic criteria as laid down in the International Classification of Headache Disorders, 3 rd edition. Add-on trials are recommended only in the presence of red flags, such as the symptoms warning about the secondary nature of headache. Migraine treatment is aimed at reducing the frequency and intensity of attacks and the amount of analgesics taken. It includes three main approaches: behavioral therapy, seizure relief therapy, and preventive therapy. Behavioral therapy focuses on lifestyle modification. Nonsteroidal anti-inflammatory drugs, simple and combined analgesics, triptans, and antiemetic drugs for severe nausea or vomiting are recommended for seizure relief. Preventive therapy which includes antidepressants, anticonvulsants, beta-blockers, angiotensin II receptor antagonists, botulinum toxin type A-hemagglutinin complex and monoclonal antibodies to calcitonin gene-related peptide or its receptors, is indicated for frequent or severe migraine attacks and for chronic migraine. Pharmacotherapy is recommended to be combined with non-drug methods that involves cognitive behavioral therapy; progressive muscle relaxation; mindfulness; biofeedback; post-isometric relaxation; acupuncture; therapeutic exercises; greater occipital nerve block; non-invasive high-frequency repetitive transcranial magnetic stimulation; external stimulation of first trigeminal branch; and electrical stimulation of the occipital nerves (neurostimulation).

Мигрень – одна из самых распространенных форм головной боли, которая может приводить к значимому снижению качества жизни. Выделяют мигрень с аурой, мигрень без ауры, а также хроническую мигрень, которая значительно снижает трудоспособность пациентов и часто сочетается с психическими расстройствами и лекарственно-индуцированной головной болью. К осложнениям мигрени относятся мигренозный статус, персистирующая аура без инфаркта, мигренозный инфаркт (инсульт) и эпилептический припадок, вызванный мигренозной аурой. Диагноз мигрени устанавливается на основании жалоб, анамнеза заболевания, данных объективного осмотра и диагностических критериев Международной классификации головных болей 3-го пересмотра. Дополнительные методы исследования рекомендуются только при наличии «красных флажков» – симптомов, настораживающих в отношении вторичного характера головной боли.Лечение мигрени направлено на уменьшение частоты и интенсивности приступов, на снижение количества принимаемых обезболивающих препаратов. Оно включает три основных подхода: поведенческая терапия, терапия для купирования приступов и профилактическая терапия. Поведенческая терапия направлена на модификацию образа жизни. Для купирования приступов рекомендуются нестероидные противовоспалительные средства, простые и комбинированные анальгетики, триптаны, а также противорвотные препараты (при выраженной тошноте или рвоте). При частых или тяжелых приступах мигрени, а также при хронической мигрени показана профилактическая терапия, которая включает антидепрессанты, антиконвульсанты, бета-блокаторы, антагонисты рецепторов ангиотензина II, ботулинический токсин типа А – гемагглютинин комплекс и моноклональные антитела к кальцитонин-ген-связанному пептиду или его рецепторам. Фармакотерапию рекомендуется комбинировать с нелекарственными методами, к которым относятся когнитивно-поведенческая терапия, прогрессирующая мышечная релаксация, майндфулнесс, метод биологической обратной связи, постизометрическая релаксация, иглорефлексотерапия, лечебная гимнастика, блокада большого затылочного нерва, неинвазивная высокочастотная ритмическая транскраниальная магнитная стимуляция, внешняя стимуляция первой ветви тройничного нерва, электрическая стимуляция затылочных нервов (нейростимуляция).

мигреньдиагностикалечениеклинические рекомендациипрофилактическая терапиятерапия для купированиянелекарственные методыmigrainediagnosistreatmentclinical guidelinespreventive therapyseizure relief therapynon-drug methodsReferencesАмелин АВ, Игнатов ЮД, Скоромец АА, Соколов АЮ. Мигрень (патогенез, клиника, лечение). Москва: МЕДпресс; 2011. 265 с.Amelin AV, Ignatov YuD, Skoromets AA, Sokolov AYu. Migren' (patogenez, klinika, lechenie) [Migraine (pathogenesis, clinical features, treatment)]. Moscow: MEDpress; 2011. 265 p. (In Russ.).Осипова ВВ, Табеева ГР. Первичные головные боли: диагностика, клиника, терапия: Практическое руководство. Москва: Медицинское информационное агентство; 2014. 336 с.Osipova VV, Tabeeva GR. Pervichnye golovnye boli: diagnostika, klinika, terapiya: Prakticheskoe rukovodstvo [Primary headaches: diagnosis, clinic, therapy: A practical guide]. Moscow: Meditsinskoe informatsionnoe agentstvo; 2014. 336 p. (In Russ.).Табеева ГР, Яхно НН. Мигрень. Москва: ГЭОТАР-Медиа; 2011. 622 с.Tabeeva GR, Yakhno NN. Migren' [Migraine]. Moscow: GEOTAR-Media; 2011. 622 p. (In Russ.).Сергеев АВ, Табеева ГР, Азимова ЮЭ. Центральная нейрональная гипервозбудимость – предиспозиция к мигрени. Российский журнал боли. 2010;2(27):3-11.Sergeev AV, Tabeeva GR, Azimova SE. Central neuronal hyper-excitability is a predisposition to migraine. Rossiyskiy zhurnal boli. 2010;2(27):3-11 (In Russ.).Rasmussen BK, Jensen R, Schroll M, Olesen J. Epidemiology of headache in a general population – a prevalence study. J Clin Epidemiol. 1991;44:1147-57. doi: 10.1016/08954356(91)90147-2Rasmussen BK, Jensen R, Schroll M, Olesen J. Epidemiology of headache in a general population – a prevalence study. J Clin Epidemiol. 1991;44:1147-57. doi: 10.1016/08954356(91)90147-2Ayzenberg I, Katsarava Z, Sborowski A, et al. The prevalence of primary headache disorders in Russia: A countrywide survey. Cephalalgia. 2012;32(5):373-81. doi: 10.1177/0333102412438977Ayzenberg I, Katsarava Z, Sborowski A, et al. The prevalence of primary headache disorders in Russia: A countrywide survey. Cephalalgia. 2012;32(5):373-81. doi: 10.1177/0333102412438977Лебедева ЕР, Кобзева НР, Гилев ДВ, Олесен Ес. Анализ качества диагностики и лечения первичных головных болей в различных социальных группах Уральского региона. Неврология, нейропсихиатрия, психосоматика. 2015;7(1):19-26. doi: 10.14412/2074-2711-2015-1-19-26Lebedeva ER, Kobzeva NR, Gilev DV, Olesen E. Analysis of the quality of diagnosis and treatment of primary headache in different social groups of the Ural Region. Nevrologiya, neyropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2015;7(1):19-26. doi: 10.14412/2074-2711-2015-1-19-26 (In Russ.).GBD 2015 Neurological Disorders Collaborator Group Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Neurol. 2017 Nov;16(11):877-89.GBD 2015 Neurological Disorders Collaborator Group Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Neurol. 2017 Nov;16(11):877-89.Яхно НН, Парфенов ВА, Алексеев ВВ. Головная боль (справочное руководство для врачей). Москва: Р-врач; 2000. 150 с.Yakhno NN, Parfenov VA, Alekseev VV. Golovnaya bol' (spravochnoe rukovodstvo dlya vrachey) [Headache (reference guide for doctors)]. Moscow: R-vrach; 2000. 150 p. (In Russ.).Парфенов ВА, Головачева ВА. Хроническая боль и ее лечение в неврологии. Москва: ГЭОТАР-Медиа; 2018.Parfenov VA, Golovacheva VA. Khronicheskaya bol' i ee lechenie v nevrologii [Chronic pain and its treatment in neurology]. Moscow: GEOTAR-Media; 2018 (In Russ.).Головачева ВА, Парфенов ВА, Табеева ГР и др. Оптимизация ведения пациентов с хронической ежедневной головной болью. Журнал неврологии и психиатрии им. С.С. Корсакова. 2017;117(2):4-9. doi: 10.17116/jnevro2017117214-9Golovacheva VA, Parfenov VA, Tabeeva GR, et al. Optimization of management of patients with chronic daily headache. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2017;117(2):4-9. doi: 10.17116/jnevro2017117214-9 (In Russ.).Головачева ВА, Парфенов ВА. Когнитивно-поведенческая терапия в лечении хронической ежедневной головной боли. Анналы клинической и экспериментальной неврологии. 2019;13(3):63-70. doi: 10.25692/ACEN.2019.3Golovacheva VA, Parfenov VA. Cognitive behavioral therapy in the treatment of chronic daily headache. Annaly klinicheskoy i eksperimental'noy nevrologii. 2019;13(3):63-70. doi: 10.25692/ACEN.2019.3 (In Russ.).Осипова ВВ, Азимова ЮЭ, Табеева ГР и др. Диагностика головных болей в России и странах постсоветского пространства: состояние проблемы и пути ее решения. Анналы клинической и экспериментальной неврологии. 2012;6(2):16-21.Osipova VV, Azimova YuE, Tabeeva GR, et al. Diagnosis of headaches in Russia and the countries of the former Soviet Union: the state of the problem and ways to solve it. Annaly klinicheskoy i eksperimental'noy nevrologii. 2012;6(2):16-21 (In Russ.).Тарасова СВ, Амелин АВ, Скоромец АА. Распространенность и выявляемость первичных и симптоматических форм хронической ежедневной головной боли. Казанский медицинский журнал. 2008;89(4):427-31.Tarasova SV, Amelin AV, Skoromets AA. The prevalence and detection of primary and symptomatic forms of chronic daily headache. Kazanskiy meditsinskiy zhurnal. 2008;89(4):42731 (In Russ.).Kowacs PA, Twardowschy CA, Piovesan EJ, et al. General practice physician knowledge about headache: evaluation of the municipal continual medical education program. Arq Neuro-Psiquiatr. 2009;67:3. doi: 10.1590/s0004-282x2009000400004Kowacs PA, Twardowschy CA, Piovesan EJ, et al. General practice physician knowledge about headache: evaluation of the municipal continual medical education program. Arq Neuro-Psiquiatr. 2009;67:3. doi: 10.1590/s0004-282x2009000400004Cevoli S, D'Amico D, Martelletti P, et al. Underdiagnosis and undertreatment of survey migraine in Italy: a survey of patients attending for the first time 10 headache centers. Cephalalgia. 2009;29:1285-93. doi: 10.1111/j.1468-2982.2009.01874.xCevoli S, D'Amico D, Martelletti P, et al. Underdiagnosis and undertreatment of survey migraine in Italy: a survey of patients attending for the first time 10 headache centers. Cephalalgia. 2009;29:1285-93. doi: 10.1111/j.1468-2982.2009.01874.xThe International Classification of Headache Disorders, 3 rd edition (ICHD-3). Cephalalgia. 2018;38(1):1-211. doi: 10.1177/0333102417738202The International Classification of Headache Disorders, 3 rd edition (ICHD-3). Cephalalgia. 2018;38(1):1-211. doi: 10.1177/0333102417738202Осипова ВВ. Мигрень и головная боль напряжения. В кн.: Гусев ЕИ, Коновалов АН, редакторы. Клинические рекомендации. Неврология и нейрохирургия. 2-е изд., перераб. и доп. Москва: ГЭОТАР-Медиа; 2015. 424. с.Osipova VV. Migraine and tension headache.. In: Gusev EI, Konovalov AN, eds. Klinicheskie rekomendatsii. Nevrologiya i neyrokhirurgiya [Clinical recommendations. Neurology and neurosurgery]. 2 nd ed. Moscow: GEOTARMedia; 2015. 424 p. (In Russ.).Lebedeva ER, Gurary NM, Gilev DV, Olesen J. Prospective testing of ICHD-3 beta diagnostic criteria for migraine with aura and migraine with typical aura in patients with transient ischemic attacks. Cephalalgia. 2018;38(3):561-7. doi: 10.1177/0333102417702121Lebedeva ER, Gurary NM, Gilev DV, Olesen J. Prospective testing of ICHD-3 beta diagnostic criteria for migraine with aura and migraine with typical aura in patients with transient ischemic attacks. Cephalalgia. 2018;38(3):561-7. doi: 10.1177/0333102417702121Lebedeva ER, Gurary NM, Gilev DV, et al. Explicit diagnostic criteria for transient ischemic attacks to differentiate it from migraine with aura. Cephalalgia. 2018;38(8):1463-70. doi: 10.1177/0333102417736901Lebedeva ER, Gurary NM, Gilev DV, et al. Explicit diagnostic criteria for transient ischemic attacks to differentiate it from migraine with aura. Cephalalgia. 2018;38(8):1463-70. doi: 10.1177/0333102417736901Екушева ЕВ, Карпова МИ, Осипова ВВ. Гормональные контрацептивы и риск ишемического инсульта у женщин с мигренью: новый международный консенсус. Неврология, нейропсихиатрия и психосоматика. 2019;11(3):11-5. doi: 10.14412/2074-2711-2019-3-11-15Ekusheva EV, Karpova MI, Osipova VV. Hormonal contraceptives and the risk of ischemic stroke in women with migraine: a new international consensus. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2019;11(3):115. doi: 10.14412/2074-2711-2019-3-11-15 (In Russ.).Lipton RB, Serrano D, Buse DC, et al. Improving the detection of chronic migraine: Development and validation of Identify Chronic Migraine (ID-CM). Cephalalgia. 2016;36(3):203-15. doi: 10.1177/0333102415583982Lipton RB, Serrano D, Buse DC, et al. Improving the detection of chronic migraine: Development and validation of Identify Chronic Migraine (ID-CM). Cephalalgia. 2016;36(3):203-15. doi: 10.1177/0333102415583982Артеменко АР, Куренков АЛ, Беломестова КВ. Классификация, диагностика и лечение хронической мигрени: обзор новых данных. Журнал неврологии и психиатрии им. С.С. Корсакова. 2013;(11):91-6.Artemenko AR, Kurenkov AL, Belomestova KV. Classification, diagnosis and treatment of chronic migraine: a review of new data. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2013;(11):91-6 (In Russ.).Zeeberg P, Olesen J, Jensen R. Medication overuse headache and chronic migraine in a specialized headache centre: field-testing proposed new appendix criteria. Cephalalgia. 2009;29(2):214-20. doi: 10.1111/j.1468-2982.2008.01710.xZeeberg P, Olesen J, Jensen R. Medication overuse headache and chronic migraine in a specialized headache centre: field-testing proposed new appendix criteria. Cephalalgia. 2009;29(2):214-20. doi: 10.1111/j.1468-2982.2008.01710.xОсипова ВВ, Филатова ЕГ, Артеменко АР и др. Диагностика и лечение мигрени: рекомендации российских экспертов. Журнал неврологии и психиатрии им. Корсакова 2017;(2):28-42.Osipova VV, Filatova EG, Artemenko AR, et al. Diagnosis and treatment of migraine: recommendations of Russian experts. Zhurnal nevrologii i psikhiatrii im. Korsakova 2017;(2):28-42 (In Russ.).Steiner TJ, MacGregor EA, Davies PTG. Guidelines for all healthcare professionals in the diagnosis and management of migraine, tension-type, cluster and medication overuse headache. 3 rd ed. British Association for the Study of Headache; 2007.Steiner TJ, MacGregor EA, Davies PTG. Guidelines for all healthcare professionals in the diagnosis and management of migraine, tension-type, cluster and medication overuse headache. 3 rd ed. British Association for the Study of Headache; 2007.Reference programme: Diagnosis and treatment of headache disorders and facial pain. Danish Headache Society. 2 nd ed, 2012. J Headache Pain. 2012;13:S1-S29. doi: 10.1007/s10194-011-0402-9Reference programme: Diagnosis and treatment of headache disorders and facial pain. Danish Headache Society. 2 nd ed, 2012. J Headache Pain. 2012;13:S1-S29. doi: 10.1007/s10194-011-0402-9Mitsikostas D, Ashina M, Craven A, et al. EHF committee. European Headache Federation Consensus on Technical Investigation for Primary Headache Disorders. J Headache Pain. 2015;17:5. doi: 10.1186/s10194-016-0596-yMitsikostas D, Ashina M, Craven A, et al. EHF committee. European Headache Federation Consensus on Technical Investigation for Primary Headache Disorders. J Headache Pain. 2015;17:5. doi: 10.1186/s10194-016-0596-yAcademy of Neurology. The utility of neuroimaging in the evaluation of headache in patients with normal neurological examinations. Neurology. 1994;44:1353-4. doi: 10.1212/WNL.44.7.1353Academy of Neurology. The utility of neuroimaging in the evaluation of headache in patients with normal neurological examinations. Neurology. 1994;44:1353-4. doi: 10.1212/WNL.44.7.1353Mett A, Tfelt-Hansen P. Acute migraine therapy: recent evidence from randomized comparative trials. Curr Opin Neurol. 2008;21(3):331-7. doi: 10.1097/WCO.0b013e3282fee843Mett A, Tfelt-Hansen P. Acute migraine therapy: recent evidence from randomized comparative trials. Curr Opin Neurol. 2008;21(3):331-7. doi: 10.1097/WCO.0b013e3282fee843Orr SL, Aube M, Becker WJ, et al. Canadian Headache Society systematic review and recommendations on the treatment of migraine pain in emergency settings. Cephalalgia. 2015;35:271. doi: 10.1177/0333102414535997Orr SL, Aube M, Becker WJ, et al. Canadian Headache Society systematic review and recommendations on the treatment of migraine pain in emergency settings. Cephalalgia. 2015;35:271. doi: 10.1177/0333102414535997Kirthi V, Derry S, Moore R. Aspirin with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev. 2013;4:CD008041. doi: 10.1002/14651858.CD008041.pub3Kirthi V, Derry S, Moore R. Aspirin with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev. 2013;4:CD008041. doi: 10.1002/14651858.CD008041.pub3Lampl C, Voelker M, Diener HC. Efficacy and safety of 1,000 mg effervescent aspirin: individual patient data meta-analysis of three trials in migraine headache and migraine accompanying symptoms. J Neurol. 2007;254(6):705-12. doi: 10.1007/s00415-007-0547-2Lampl C, Voelker M, Diener HC. Efficacy and safety of 1,000 mg effervescent aspirin: individual patient data meta-analysis of three trials in migraine headache and migraine accompanying symptoms. J Neurol. 2007;254(6):705-12. doi: 10.1007/s00415-007-0547-2Suthisisang C, Poolsup N, Kittikulsuth W, et al. Efficacy of low-dose ibuprofen in acute migraine treatment: systematic review and meta-analysis. Ann Pharmacother. 2007;41(11):1782-91. doi: 10.1345/aph.1K121Suthisisang C, Poolsup N, Kittikulsuth W, et al. Efficacy of low-dose ibuprofen in acute migraine treatment: systematic review and meta-analysis. Ann Pharmacother. 2007;41(11):1782-91. doi: 10.1345/aph.1K121Rabbie R, Derry S, Moore RA. Ibuprofen with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev. 2013;4:CD008039. doi: 10.1002/14651858.CD008039.pub3Rabbie R, Derry S, Moore RA. Ibuprofen with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev. 2013;4:CD008039. doi: 10.1002/14651858.CD008039.pub3Suthisisang CC, Poolsup N, Suksomboon N, et al. Meta-analysis of the efficacy and safety of naproxen sodium in the acute treatment of migraine. Headache. 2010;50(5):808-18. doi: 10.1111/j.1526-4610.2010.01635.xSuthisisang CC, Poolsup N, Suksomboon N, et al. Meta-analysis of the efficacy and safety of naproxen sodium in the acute treatment of migraine. Headache. 2010;50(5):808-18. doi: 10.1111/j.1526-4610.2010.01635.xLaw S, Derry S, Moore RA. Naproxen with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev. 2013;10:CD009455. doi: 10.1002/14651858.CD009455.pub2Law S, Derry S, Moore RA. Naproxen with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev. 2013;10:CD009455. doi: 10.1002/14651858.CD009455.pub2Derry S, Rabbie R, Moore RA. Diclofenac with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev. 2013;4:CD008783. doi: 10.1002/14651858.CD008039.pub3Derry S, Rabbie R, Moore RA. Diclofenac with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev. 2013;4:CD008783. doi: 10.1002/14651858.CD008039.pub3Derry S, Moore RA. Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev. 2013;4:CD008040. doi: 10.1002/14651858.CD008040.pub3Derry S, Moore RA. Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev. 2013;4:CD008040. doi: 10.1002/14651858.CD008040.pub3Diener HC, Montagna P, Gacs G, et al. Efficacy and tolerability of diclofenac potassium sachets in migraine: A randomized, doubleblind, cross-over study in comparison with diclofenac potassium tablets and placebo. Cephalalgia. 2006;26:537-47. doi: 10.1111/j.1468-2982.2005.01064.xDiener HC, Montagna P, Gacs G, et al. Efficacy and tolerability of diclofenac potassium sachets in migraine: A randomized, doubleblind, cross-over study in comparison with diclofenac potassium tablets and placebo. Cephalalgia. 2006;26:537-47. doi: 10.1111/j.1468-2982.2005.01064.xColman I, Brown MD, Innes GD, et al. Parenteral metoclopramide for acute migraine: meta-analysis of randomised controlled trials. BMJ. 2004;329(7479):1369-73. doi: 10.1136/bmj.38281.595718.7CColman I, Brown MD, Innes GD, et al. Parenteral metoclopramide for acute migraine: meta-analysis of randomised controlled trials. BMJ. 2004;329(7479):1369-73. doi: 10.1136/bmj.38281.595718.7CShrestha M, Singh R, Moreden J, Hayes JE. Ketorolac vs chlorpromazine in the treatment of acute migraine without aura. A prospective, randomized, double-blind trial. Arch Intern Med. 1996;156:1725-8. doi: 10.1001/archinte.1996.00440140163017Shrestha M, Singh R, Moreden J, Hayes JE. Ketorolac vs chlorpromazine in the treatment of acute migraine without aura. A prospective, randomized, double-blind trial. Arch Intern Med. 1996;156:1725-8. doi: 10.1001/archinte.1996.00440140163017Cameron C, Kelly S, Hsieh SC, et al. Triptans in the acute treatment of migraine: a systematic review and network meta-analysis. Headache. 2015;55(Suppl 4):221-35. doi: 10.1111/head.12601Cameron C, Kelly S, Hsieh SC, et al. Triptans in the acute treatment of migraine: a systematic review and network meta-analysis. Headache. 2015;55(Suppl 4):221-35. doi: 10.1111/head.12601Ferrari MD, Goadsby PJ, Roon KI, Lipton RB. Triptans (serotonin, 5-HT1B/1D agonists) in migraine: detailed results and methods of a meta-analysis of 53 trials. Cephalalgia. 2002;22:633-58. doi: 10.1046/j.14682982.2002.00404.xFerrari MD, Goadsby PJ, Roon KI, Lipton RB. Triptans (serotonin, 5-HT1B/1D agonists) in migraine: detailed results and methods of a meta-analysis of 53 trials. Cephalalgia. 2002;22:633-58. doi: 10.1046/j.14682982.2002.00404.xLipton RB, Bigal ME, Goadsby PJ. Double-blind clinical trials of oral triptans vs other classes of acute migraine medication. A review. Cephalalgia. 2004;24:321-32. doi: 10.1111/j.1468-2982.2003.00690.xLipton RB, Bigal ME, Goadsby PJ. Double-blind clinical trials of oral triptans vs other classes of acute migraine medication. A review. Cephalalgia. 2004;24:321-32. doi: 10.1111/j.1468-2982.2003.00690.xPascual J, Mateos V, Roig C, et al. Marketed oral triptans in the acute treatment of migraine: A systematic review on efficacy and tolerability. Headache. 2007;47:1152-68. doi: 10.1111/j.1526-4610.2007.00849.xPascual J, Mateos V, Roig C, et al. Marketed oral triptans in the acute treatment of migraine: A systematic review on efficacy and tolerability. Headache. 2007;47:1152-68. doi: 10.1111/j.1526-4610.2007.00849.xSmith LA, Oldman AD, McQuay HJ, Moore RA. Eletriptan for acute migraine. Cochrane Database Syst Rev. 2001:CD003224. doi: 10.1002/14651858.CD003224.pub2Smith LA, Oldman AD, McQuay HJ, Moore RA. Eletriptan for acute migraine. Cochrane Database Syst Rev. 2001:CD003224. doi: 10.1002/14651858.CD003224.pub2Филатова ЕГ, Амелин АВ, Табеева ГР и др. Ready – первое российское мультицентровое исследование эффективности препарата релпакс (элетриптан) при лечении мигрени. Лечение нервных болезней. 2006;(2):19-22.Filatova EG, Amelin AV, Tabeeva GR, et al. Ready - the first Russian multicenter study of the effectiveness of the drug relpax (eletriptan) in the treatment of migraine. Lechenie nervnykh bolezney. 2006;(2):19-22 (In Russ.).Bigal ME, Bordini CA, Speciali JG. Intravenous chlorpromazine in the emergency department treatment of migraines: a randomized controlled trial. J Emerg Med. 2002;23(2):141-8. doi: 10.1016/S07364679(02)00502-4Bigal ME, Bordini CA, Speciali JG. Intravenous chlorpromazine in the emergency department treatment of migraines: a randomized controlled trial. J Emerg Med. 2002;23(2):141-8. doi: 10.1016/S07364679(02)00502-4Gungor F, Akyol KC, Kesapli M, et al. Intravenous dexketoprofen vs placebo for migraine attack in the emergency department: A randomized, placebo-controlled trial. Cephalalgia. 2016;36:179-84. doi: 10.1177/0333102415584604Gungor F, Akyol KC, Kesapli M, et al. Intravenous dexketoprofen vs placebo for migraine attack in the emergency department: A randomized, placebo-controlled trial. Cephalalgia. 2016;36:179-84. doi: 10.1177/0333102415584604Duarte C, Dunaway F, Turner L, et al. Ketorolac versus meperidine and hydroxyzine in the treatment of acute migraine headache: A randomized, prospective, double-blind trial. Ann Emerg Med. 1992;21:1116-21. doi: 10.1016/S0196-0644(05)80654-7Duarte C, Dunaway F, Turner L, et al. Ketorolac versus meperidine and hydroxyzine in the treatment of acute migraine headache: A randomized, prospective, double-blind trial. Ann Emerg Med. 1992;21:1116-21. doi: 10.1016/S0196-0644(05)80654-7Bigal ME, Bordini CA, Tepper SJ, et al. Intravenous magnesium sulphate in the acute treatment of migraine without aura and migraine with aura: A randomized, doubleblind, placebo-controlled study. Cephalalgia. 2002;22:345-53. doi: 10.1046/j.14682982.2002.00364.xBigal ME, Bordini CA, Tepper SJ, et al. Intravenous magnesium sulphate in the acute treatment of migraine without aura and migraine with aura: A randomized, doubleblind, placebo-controlled study. Cephalalgia. 2002;22:345-53. doi: 10.1046/j.14682982.2002.00364.xCorbo J, Esses D, Bijur PE, et al. Randomized clinical trial of intravenous magnesium sulfate as an adjunctive medication for emergency department treatment of migraine headache. Ann Emerg Med. 2001;38:621-7. doi: 10.1067/mem.2001.119424Corbo J, Esses D, Bijur PE, et al. Randomized clinical trial of intravenous magnesium sulfate as an adjunctive medication for emergency department treatment of migraine headache. Ann Emerg Med. 2001;38:621-7. doi: 10.1067/mem.2001.119424Cete Y, Dora B, Ertan C, et al. A randomized prospective placebo-controlled study of intravenous magnesium sulphate vs. metoclopramide in the management of acute migraine attacks in the emergency department. Cephalalgia. 2005;25:199-204. doi: 10.1111/j.1468-2982.2004.00840.xCete Y, Dora B, Ertan C, et al. A randomized prospective placebo-controlled study of intravenous magnesium sulphate vs. metoclopramide in the management of acute migraine attacks in the emergency department. Cephalalgia. 2005;25:199-204. doi: 10.1111/j.1468-2982.2004.00840.xLeniger T, Pageler L, Stude P, Diener HC, Limmroth V. Comparison of intravenous valproate with intravenous lysine-acetylsalicylic acid in acute migraine attacks. Headache. 2005;45:42-6. doi: 10.1111/j.15264610.2005.05009.xLeniger T, Pageler L, Stude P, Diener HC, Limmroth V. Comparison of intravenous valproate with intravenous lysine-acetylsalicylic acid in acute migraine attacks. Headache. 2005;45:42-6. doi: 10.1111/j.15264610.2005.05009.xTanen DA, Miller S, French T, Riffenburgh RH. Intravenous sodium valproate versus prochlorperazine for the emergency department treatment of acute migraine headaches: A prospective, randomized, doubleblind trial. Ann Emerg Med. 2003;41:847-53. doi: 10.1067/mem.2003.195Tanen DA, Miller S, French T, Riffenburgh RH. Intravenous sodium valproate versus prochlorperazine for the emergency department treatment of acute migraine headaches: A prospective, randomized, doubleblind trial. Ann Emerg Med. 2003;41:847-53. doi: 10.1067/mem.2003.195Woldeamanuel YW, Rapoport AM, Cowan RP. The place of corticosteroids in migraine attack management: a 65-year systematic review with pooled analysis and critical appraisal. Cephalalgia. 2015;35(11):996-1024. doi: 10.1177/0333102414566200Woldeamanuel YW, Rapoport AM, Cowan RP. The place of corticosteroids in migraine attack management: a 65-year systematic review with pooled analysis and critical appraisal. Cephalalgia. 2015;35(11):996-1024. doi: 10.1177/0333102414566200Friedman BW, Greenwald P, Bania TC, et al. Randomized trial of IV dexamethasone for acute migraine in the emergency department. Neurology. 2007;69:2038-44. doi: 10.1212/01.WNL.0000281105.78936.1dFriedman BW, Greenwald P, Bania TC, et al. Randomized trial of IV dexamethasone for acute migraine in the emergency department. Neurology. 2007;69:2038-44. doi: 10.1212/01.WNL.0000281105.78936.1dColman I, Friedman BW, Brown MD, et al. Parenteral dexamethasone for acute severe migraine headache: Meta-analysis of randomised controlled trials for preventing recurrence. BMJ. 2008;336:1359-61. doi: 10.1136/bmj.39566.806725.BEColman I, Friedman BW, Brown MD, et al. Parenteral dexamethasone for acute severe migraine headache: Meta-analysis of randomised controlled trials for preventing recurrence. BMJ. 2008;336:1359-61. doi: 10.1136/bmj.39566.806725.BENeill A, Brannigan D. Towards evidencebased emergency medicine: Best BETs from the Manchester Royal Infirmary. BET 2: Dexamethasone for reduction of migraine recurrence. Emerg Med J. 2013;30:165-6. doi: 10.1136/emermed-2012-202190.3Neill A, Brannigan D. Towards evidencebased emergency medicine: Best BETs from the Manchester Royal Infirmary. BET 2: Dexamethasone for reduction of migraine recurrence. Emerg Med J. 2013;30:165-6. doi: 10.1136/emermed-2012-202190.3Dekker F, Neven AK, Andriesse B, et al. Prophylactic treatment of migraine by GPs: a qualitative study. Br J Gen Pract. 2012;62(597):268-74. doi: 10.3399/bjgp12X636100Dekker F, Neven AK, Andriesse B, et al. Prophylactic treatment of migraine by GPs: a qualitative study. Br J Gen Pract. 2012;62(597):268-74. doi: 10.3399/bjgp12X636100Jackson JL, Cogbill E, Santana-Davila R, et al. Comparative effectiveness meta-analysis of drugs for the pophylaxis of migraine headache. PLoS One. 2015;10(7):e0130733. doi: 10.1371/journal.pone.0130733Jackson JL, Cogbill E, Santana-Davila R, et al. Comparative effectiveness meta-analysis of drugs for the pophylaxis of migraine headache. PLoS One. 2015;10(7):e0130733. doi: 10.1371/journal.pone.0130733He A, Song D, Zhang L, Li C. Unveiling the relative efficacy, safety and tolerability of prophylactic medications for migraine: pairwise and network-meta analysis. J Headache Pain. 2017;18(1):26. doi: 10.1186/s10194-017-0720-7He A, Song D, Zhang L, Li C. Unveiling the relative efficacy, safety and tolerability of prophylactic medications for migraine: pairwise and network-meta analysis. J Headache Pain. 2017;18(1):26. doi: 10.1186/s10194-017-0720-7Holroyd KA, Penzien DB, Cordingley GE. Propranolol in the management of recurrent migraine: a meta-analytic review. Headache. 1991;31(5):333-40. doi: 10.1111/j.15264610.1991.hed3105333.xHolroyd KA, Penzien DB, Cordingley GE. Propranolol in the management of recurrent migraine: a meta-analytic review. Headache. 1991;31(5):333-40. doi: 10.1111/j.15264610.1991.hed3105333.xKangasniemi P, Hedman C. Metoprolol and propranolol in the prophylactic treatment of classical and common migraine. A doubleblind study. Cephalalgia. 1984;4:91-6. doi: 10.1046/j.1468-2982.1984.0402091.xKangasniemi P, Hedman C. Metoprolol and propranolol in the prophylactic treatment of classical and common migraine. A doubleblind study. Cephalalgia. 1984;4:91-6. doi: 10.1046/j.1468-2982.1984.0402091.xChronicle EP, Mulleners WM. Anticonvulsant drugs for migraine prophylaxis. Cochrane Database Syst Rev. 2016;5:CD003226. doi: 10.1002/14651858.CD003226.pub3Chronicle EP, Mulleners WM. Anticonvulsant drugs for migraine prophylaxis. Cochrane Database Syst Rev. 2016;5:CD003226. doi: 10.1002/14651858.CD003226.pub3Linde M, Mulleners WM, Chronicle EP, McCrory DC. Valproate (valproic acid or sodium valproate or a combination of the two) for the prophylaxis of episodic migraine in adults. Cochrane Database Syst Rev. 2013;6:CD010611. doi: 10.1002/14651858.CD010611Linde M, Mulleners WM, Chronicle EP, McCrory DC. Valproate (valproic acid or sodium valproate or a combination of the two) for the prophylaxis of episodic migraine in adults. Cochrane Database Syst Rev. 2013;6:CD010611. doi: 10.1002/14651858.CD010611Bussone G, Diener HC, Pfeil J, Schwalen S. Topiramate 100 mg/day in migraine prevention: a pooled analysis of double-blind randomised controlled trials. Int J Clin Pract. 2005;59:961-8. doi: 10.1111/j.1368-5031.2005.00612.xBussone G, Diener HC, Pfeil J, Schwalen S. Topiramate 100 mg/day in migraine prevention: a pooled analysis of double-blind randomised controlled trials. Int J Clin Pract. 2005;59:961-8. doi: 10.1111/j.1368-5031.2005.00612.xSilberstein SD, Lipton RB, Dodick DW, et al. Efficacy and safety of topiramate for the treatment of chronic migraine: A randomized, double-blind, placebo-controlled trial. Headache. 2007;47:170-80. doi: 10.1111/j.15264610.2006.00684.xSilberstein SD, Lipton RB, Dodick DW, et al. Efficacy and safety of topiramate for the treatment of chronic migraine: A randomized, double-blind, placebo-controlled trial. Headache. 2007;47:170-80. doi: 10.1111/j.15264610.2006.00684.xHerd CP, Tomlinson CL, Rick C, et al. Botulinum toxins for the prevention of migraine in adults. Cochrane Database Syst Rev. 2018;6:CD011616. doi: 10.1002/14651858.CD011616.pub2Herd CP, Tomlinson CL, Rick C, et al. Botulinum toxins for the prevention of migraine in adults. Cochrane Database Syst Rev. 2018;6:CD011616. doi: 10.1002/14651858.CD011616.pub2Dodick DW, Ashina M, Brandes JL, et al. ARISE: a phase 3 randomized trial of erenumab for episodic migraine. Cephalalgia. 2018;38:1026-37. doi: 10.1177/0333102418759786Dodick DW, Ashina M, Brandes JL, et al. ARISE: a phase 3 randomized trial of erenumab for episodic migraine. Cephalalgia. 2018;38:1026-37. doi: 10.1177/0333102418759786Dodick DW, Silberstein SD, Bigal ME, et al. Effect of fremanezumab compared with placebo for prevention of episodic migraine a randomized clinical trial. JAMA. 2018;319(19):1999-2008. doi: 10.1001/jama.2018.4853Dodick DW, Silberstein SD, Bigal ME, et al. Effect of fremanezumab compared with placebo for prevention of episodic migraine a randomized clinical trial. JAMA. 2018;319(19):1999-2008. doi: 10.1001/jama.2018.4853Tepper S, Ashina M, Reuter U, et al. Safety and efficacy of erenumab forpreventive treatment of chronic migraine: a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Neurol. 2017;16:425-34. doi: 10.1016/S1474-4422(17)30083-2Tepper S, Ashina M, Reuter U, et al. Safety and efficacy of erenumab forpreventive treatment of chronic migraine: a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Neurol. 2017;16:425-34. doi: 10.1016/S1474-4422(17)30083-2Bigal M, Dodick DW, Rapoport AM, et al. Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study. Lancet Neurol. 2015;14:1081-90. doi: 10.1016/S1474-4422(15)00249-5Bigal M, Dodick DW, Rapoport AM, et al. Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study. Lancet Neurol. 2015;14:1081-90. doi: 10.1016/S1474-4422(15)00249-5Jackson JL, Shimeall W, Sessums L, et al. Tricyclic antidepressants and headaches: systematic review and meta-analysis. BMJ. 2010;341:c5222. doi: 10.1136/bmj.c5222Jackson JL, Shimeall W, Sessums L, et al. Tricyclic antidepressants and headaches: systematic review and meta-analysis. BMJ. 2010;341:c5222. doi: 10.1136/bmj.c5222Xu XM, Yang C, Liu Y, et al. Efficacy and feasibility of antidepressants for the prevention of migraine in adults: a meta-analysis. Eur J Neurol. 2017;24(8):1022-31. doi: 10.1111/ene.13320Xu XM, Yang C, Liu Y, et al. Efficacy and feasibility of antidepressants for the prevention of migraine in adults: a meta-analysis. Eur J Neurol. 2017;24(8):1022-31. doi: 10.1111/ene.13320Bulut S, Berilgen MS, Baran A, et al. Venlafaxine versus amitriptyline in the prophylactic treatment of migraine: randomized, double-blind, crossover study. Clin Neurol Neurosurg. 2004;107:44-8. doi: 10.1016/j.clineuro.2004.03.004Bulut S, Berilgen MS, Baran A, et al. Venlafaxine versus amitriptyline in the prophylactic treatment of migraine: randomized, double-blind, crossover study. Clin Neurol Neurosurg. 2004;107:44-8. doi: 10.1016/j.clineuro.2004.03.004Ozyalcin SN, Talu GK, Kiziltan E, et al. The efficacy and safety of venlafaxine in the prophylaxis of migraine. Headache. 2005;45:144-52. doi: 10.1111/j.15264610.2005.05029.xOzyalcin SN, Talu GK, Kiziltan E, et al. The efficacy and safety of venlafaxine in the prophylaxis of migraine. Headache. 2005;45:144-52. doi: 10.1111/j.15264610.2005.05029.xTronvik E, Stovner LJ, Helde G, et al. Prophylactic treatment of migraine with an angiotensin II receptor blocker: a randomized controlled trial. JAMA. 2003;289:65-9. doi: 10.1001/jama.289.1.65Tronvik E, Stovner LJ, Helde G, et al. Prophylactic treatment of migraine with an angiotensin II receptor blocker: a randomized controlled trial. JAMA. 2003;289:65-9. doi: 10.1001/jama.289.1.65Stovner LJ, Linde M, Gravdahl GB, et al. A comparative study of candesartan versus propranolol for migraine prophylaxis: A randomised, triple-blind, placebo-controlled, double crossover study. Cephalalgia. 2014;34(7):523-32. doi: 10.1177/0333102413515348Stovner LJ, Linde M, Gravdahl GB, et al. A comparative study of candesartan versus propranolol for migraine prophylaxis: A randomised, triple-blind, placebo-controlled, double crossover study. Cephalalgia. 2014;34(7):523-32. doi: 10.1177/0333102413515348Chiang CC, Schwedt TJ, Wang SJ, Dodick DW. Treatment of medication-overuse headache: A systematic review. Cephalalgia. 2016;36:371-86. doi: 10.1177/0333102415593088Chiang CC, Schwedt TJ, Wang SJ, Dodick DW. Treatment of medication-overuse headache: A systematic review. Cephalalgia. 2016;36:371-86. doi: 10.1177/0333102415593088De Goffau MJ, Klaver ARE, Willemsen MG, et al. The effectiveness of treatments for patients with medication overuse headache: a systematic review and meta-analysis. J Pain. 2017;18(6):615-27. doi: 10.1016/j.jpain.2016.12.005De Goffau MJ, Klaver ARE, Willemsen MG, et al. The effectiveness of treatments for patients with medication overuse headache: a systematic review and meta-analysis. J Pain. 2017;18(6):615-27. doi: 10.1016/j.jpain.2016.12.005Sandrini G, Perrotta A, Tassorelli C, et al. Botulinum toxin type-A in the prophylactic treatment of medication-overuse headache: A multicenter, double-blind, randomized, placebo-controlled, parallel group study. J Headache Pain. 2011;12:427-33. doi: 10.1007/s10194-011-0339-zSandrini G, Perrotta A, Tassorelli C, et al. Botulinum toxin type-A in the prophylactic treatment of medication-overuse headache: A multicenter, double-blind, randomized, placebo-controlled, parallel group study. J Headache Pain. 2011;12:427-33. doi: 10.1007/s10194-011-0339-zSilberstein SD, Blumenfeld AM, Cady R, et al. Onabotulinumtoxin A for treatment of chronic migraine: PREEMPT 24-week pooled subgroup analysis of patients who had acute headache medication overuse at baseline. J Neurol Sci. 2013;331:48-56. doi: 10.1016/j.jns.2013.05.003Silberstein SD, Blumenfeld AM, Cady R, et al. Onabotulinumtoxin A for treatment of chronic migraine: PREEMPT 24-week pooled subgroup analysis of patients who had acute headache medication overuse at baseline. J Neurol Sci. 2013;331:48-56. doi: 10.1016/j.jns.2013.05.003Kristoffersen ES, Straand J, Vetvik KG, et al. Brief intervention for medication-overuse headache in primary care. The BIMOH study: a double-blind pragmatic cluster randomised parallel controlled trial. J Neurol Neurosurg Psychiatry. 2015;86(5):505-10. doi: 10.1136/jnnp-2014-308548Kristoffersen ES, Straand J, Vetvik KG, et al. Brief intervention for medication-overuse headache in primary care. The BIMOH study: a double-blind pragmatic cluster randomised parallel controlled trial. J Neurol Neurosurg Psychiatry. 2015;86(5):505-10. doi: 10.1136/jnnp-2014-308548Hagen K, Albretsen C, Vilming ST, et al. Management of medication overuse headache: 1-year randomized multicentre open-label trial. Cephalalgia. 2009;29:221-32. doi: 10.1111/j.1468-2982.2008.01711.xHagen K, Albretsen C, Vilming ST, et al. Management of medication overuse headache: 1-year randomized multicentre open-label trial. Cephalalgia. 2009;29:221-32. doi: 10.1111/j.1468-2982.2008.01711.xBottiroli S, Allena M, Sances G, et al; COMOESTAS Consortium. Psychological, clinical, and therapeutic predictors of the outcome of detoxification in a large clinical population of medication-overuse headache: A sixmonth follow-up of the COMOESTAS Project. Cephalalgia. 2018;1:333102418783317. doi: 10.1177/0333102418783317Bottiroli S, Allena M, Sances G, et al; COMOESTAS Consortium. Psychological, clinical, and therapeutic predictors of the outcome of detoxification in a large clinical population of medication-overuse headache: A sixmonth follow-up of the COMOESTAS Project. Cephalalgia. 2018;1:333102418783317. doi: 10.1177/0333102418783317Luedtke K, Allers A, Schulte LH, May A. Efficacy of interventions used by physiotherapists for patients with headache and migraine. Systematic review and meta-analysis. Cephalalgia. 2016;36(5):474-92. doi: 10.1177/0333102415597889Luedtke K, Allers A, Schulte LH, May A. Efficacy of interventions used by physiotherapists for patients with headache and migraine. Systematic review and meta-analysis. Cephalalgia. 2016;36(5):474-92. doi: 10.1177/0333102415597889Millstine D, Chen CY, Bauer B. Complementary and integrative medicine in the management of headache. BMJ. 2017;16;357:j1805. doi: 10.1136/bmj.j1805Millstine D, Chen CY, Bauer B. Complementary and integrative medicine in the management of headache. BMJ. 2017;16;357:j1805. doi: 10.1136/bmj.j1805Giannitrapani KF, Holliday JR, Miake-Lye IM, et al. Synthesizing the strength of the evidence of complementary and integrative health therapies for pain. Pain Med. 2019;20(9):1831-40. doi: 10.1093/pm/pnz068Giannitrapani KF, Holliday JR, Miake-Lye IM, et al. Synthesizing the strength of the evidence of complementary and integrative health therapies for pain. Pain Med. 2019;20(9):1831-40. doi: 10.1093/pm/pnz068Andrasik F. What does the evidence show? Efficacy of behavioural treatments for recurrent headache in adults. Neurol Sci. 2007;28:70-7. doi: 10.1007/s10072-007-0754-8Andrasik F. What does the evidence show? Efficacy of behavioural treatments for recurrent headache in adults. Neurol Sci. 2007;28:70-7. doi: 10.1007/s10072-007-0754-8Wallasch T-M, Kropp P. Multidisciplinary integrated headache care: a prospective 12-month follow-up observational study. J Headache Pain. 2012;13:521-9. doi: 10.1007/s10194-012-0469-yWallasch T-M, Kropp P. Multidisciplinary integrated headache care: a prospective 12-month follow-up observational study. J Headache Pain. 2012;13:521-9. doi: 10.1007/s10194-012-0469-yGaul C, van Doorn C, Webering N, et al. Clinical outcome of a headache-specific multidisciplinary treatment program and adherence to treatment recommendations in a tertiary headache center: an observational study. J Headache Pain. 2011;12:475-83. doi: 10.1007/s10194-011-0348-yGaul C, van Doorn C, Webering N, et al. Clinical outcome of a headache-specific multidisciplinary treatment program and adherence to treatment recommendations in a tertiary headache center: an observational study. J Headache Pain. 2011;12:475-83. doi: 10.1007/s10194-011-0348-yWallasch TM, Angeli A, Kropp P. Outcomes of headache-specific cross-sectional multidisciplinary treatment program. Headache. 2012;52(7):1094-105. doi: 10.1111/j.1526-4610.2012.02189.xWallasch TM, Angeli A, Kropp P. Outcomes of headache-specific cross-sectional multidisciplinary treatment program. Headache. 2012;52(7):1094-105. doi: 10.1111/j.1526-4610.2012.02189.xKatsarava Z, Buse DC, Manack AN, Lipton RB. Defining the differences between episodic migraine and chronic migraine. Curr Pain Headache Rep. 2012;16(1):86-92. doi: 10.1007/s11916-011-0233-zKatsarava Z, Buse DC, Manack AN, Lipton RB. Defining the differences between episodic migraine and chronic migraine. Curr Pain Headache Rep. 2012;16(1):86-92. doi: 10.1007/s11916-011-0233-zОсипова ВВ. Психологические аспекты боли. Неврология, нейропсихиатрия, психосоматика. 2010;2(1):4-8. doi: 10.14412/2074-2711-2010-62Osipova VV. Pain: psychological aspects. Nevrologiya, neyropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2010;2(1):4-9. doi: 10.14412/2074-2711-201062 (In Russ.).Raggi A, Grignani E, Leonardi M, et al. Behavioral Approaches for Primary Headaches: Recent Advances. Headache. 2018;58(6):913-25. doi: 10.1111/head.13337Raggi A, Grignani E, Leonardi M, et al. Behavioral Approaches for Primary Headaches: Recent Advances. Headache. 2018;58(6):913-25. doi: 10.1111/head.13337Головачева ВА, Парфенов ВА. Когнитивно-поведенческая терапия в лечении пациентов с мигренью. Неврологический журнал. 2015;3(20):37-43.Golovacheva VA, Parfenov VA. Cognitive Behavioral Therapy in the Treatment of Migraine Patients. Nevrologicheskiy zhurnal. 2015;3(20):37-43 (In Russ.).Sharpe L, Dudeney J, Williams ACDC, et al. Psychological therapies for the prevention of migraine in adults. Cochrane Database Syst Rev. 2019;7:CD012295. doi: 10.1002/14651858.CD012295.pub2Sharpe L, Dudeney J, Williams ACDC, et al. Psychological therapies for the prevention of migraine in adults. Cochrane Database Syst Rev. 2019;7:CD012295. doi: 10.1002/14651858.CD012295.pub2Evers S, Afra J, Frese A, et al; European Federation of Neurological Societies. EFNS guideline on the drug treatment of migraine revised report of an EFNS task force. Eur J Neurol. 2009;16:968-81. doi: 10.1111/j.1468-1331.2009.02748.xEvers S, Afra J, Frese A, et al; European Federation of Neurological Societies. EFNS guideline on the drug treatment of migraine revised report of an EFNS task force. Eur J Neurol. 2009;16:968-81. doi: 10.1111/j.1468-1331.2009.02748.xHarris P, Loveman E, Clegg A, et al. Systematic review of cognitive behavioural therapy for the management of headaches and migraines in adults. Br J Pain. 2015;9(4):213-24. doi: 10.1177/2049463715578291Harris P, Loveman E, Clegg A, et al. Systematic review of cognitive behavioural therapy for the management of headaches and migraines in adults. Br J Pain. 2015;9(4):213-24. doi: 10.1177/2049463715578291Onur OS, Ertem DH, Karsidag C, et al. An open/pilot trial of cognitive behavioral therapy in Turkish patients with refractory chronic migraine. Cogn Neurodyn. 2019 Apr;13(2):183-9. doi: 10.1007/s11571-019-09519-yOnur OS, Ertem DH, Karsidag C, et al. An open/pilot trial of cognitive behavioral therapy in Turkish patients with refractory chronic migraine. Cogn Neurodyn. 2019 Apr;13(2):183-9. doi: 10.1007/s11571-019-09519-yOtis JD. Managing chronic pain: a cognitive-behavioral therapy: therapist guide. 1 st ed. New York: Oxford University Press; 2007. 114p.Otis JD. Managing chronic pain: a cognitive-behavioral therapy: therapist guide. 1 st ed. New York: Oxford University Press; 2007. 114p.Lee HJ, Lee JH, Cho EY, et al. Efficacy of psychological treatment for headache disorder: a systematic review and meta-analysis. J Headache Pain. 2019;20(1):17. doi: 10.1186/s10194-019-0965-4Lee HJ, Lee JH, Cho EY, et al. Efficacy of psychological treatment for headache disorder: a systematic review and meta-analysis. J Headache Pain. 2019;20(1):17. doi: 10.1186/s10194-019-0965-4Anheyer D, Leach MJ, Klose P, et al. Mindfulness-based stress reduction for treating chronic headache: A systematic review and meta-analysis. Cephalalgia. 2019;39(4):544-55. doi: 10.1177/0333102418781795Anheyer D, Leach MJ, Klose P, et al. Mindfulness-based stress reduction for treating chronic headache: A systematic review and meta-analysis. Cephalalgia. 2019;39(4):544-55. doi: 10.1177/0333102418781795Nestoriuc Y, Martin A. Efficacy of biofeedback for migraine: a meta-analysis. Pain. 2007;128(1-2):111-27. doi: 10.1016/j.pain.2006.09.007Nestoriuc Y, Martin A. Efficacy of biofeedback for migraine: a meta-analysis. Pain. 2007;128(1-2):111-27. doi: 10.1016/j.pain.2006.09.007Nestoriuc Y, Martin A, Rief W, Andrasik F. Biofeedback treatment for headache disorders: a comprehensive eficacy review. Appl Psychophysiol Biofeedback. 2008;33:125-40. doi: 10.1007/s10484-008-9060-3Nestoriuc Y, Martin A, Rief W, Andrasik F. Biofeedback treatment for headache disorders: a comprehensive eficacy review. Appl Psychophysiol Biofeedback. 2008;33:125-40. doi: 10.1007/s10484-008-9060-3Falsiroli Maistrello L, Geri T, Gianola S, et al. Effectiveness of trigger point manual treatment on the frequency, intensity, and duration of attacks in primary headaches: a systematic review and meta-analysis of randomized controlled trials. Front Neurol. 2018;9:254. doi: 10.3389/fneur.2018.00254Falsiroli Maistrello L, Geri T, Gianola S, et al. Effectiveness of trigger point manual treatment on the frequency, intensity, and duration of attacks in primary headaches: a systematic review and meta-analysis of randomized controlled trials. Front Neurol. 2018;9:254. doi: 10.3389/fneur.2018.00254Xu J, Zhang FQ, Pei J, Ji J. Acupuncture for migraine without aura: a systematic review and meta-analysis. J Integr Med. 2018;16(5):312-21. doi: 10.1016/j.joim.2018.06.002Xu J, Zhang FQ, Pei J, Ji J. Acupuncture for migraine without aura: a systematic review and meta-analysis. J Integr Med. 2018;16(5):312-21. doi: 10.1016/j.joim.2018.06.002Yin Jiang, Peng Bai, Hao Chen, et al. The effect of acupuncture on the quality of life in patients with migraine: a systematic review and meta-analysis. Front Pharmacol. 2018;9:1190. doi: 10.3389/fphar.2018.01190Yin Jiang, Peng Bai, Hao Chen, et al. The effect of acupuncture on the quality of life in patients with migraine: a systematic review and meta-analysis. Front Pharmacol. 2018;9:1190. doi: 10.3389/fphar.2018.01190Feng-Jiao Shen, Jia Xu, Yi-Jun Zhan, et al. Acupuncture for migraine: A systematic review and meta-analysis. World J Acupunct Moxibustion. 2019;29(1):7-14. doi: 10.1016/j.wjam.2019.03.004Feng-Jiao Shen, Jia Xu, Yi-Jun Zhan, et al. Acupuncture for migraine: A systematic review and meta-analysis. World J Acupunct Moxibustion. 2019;29(1):7-14. doi: 10.1016/j.wjam.2019.03.004Lemmens J, de Pauw J, van Soom T, et al. The effect of aerobic exercise on the number of migraine days, duration and pain intensity in migraine: a systematic literature review and meta-analysis. J Headache Pain. 2019;20(1):16. doi: 10.1186/s10194-019-0961-8Lemmens J, de Pauw J, van Soom T, et al. The effect of aerobic exercise on the number of migraine days, duration and pain intensity in migraine: a systematic literature review and meta-analysis. J Headache Pain. 2019;20(1):16. doi: 10.1186/s10194-019-0961-8Kroll LS, Hammarlund CS, Linde M, et al. The effects of aerobic exercise for persons with migraine and co-existing tension-type headache and neck pain. A randomized, controlled, clinical trial. Cephalalgia. 2018;38(12):1805-16. doi: 10.1177/0333102417752119Kroll LS, Hammarlund CS, Linde M, et al. The effects of aerobic exercise for persons with migraine and co-existing tension-type headache and neck pain. A randomized, controlled, clinical trial. Cephalalgia. 2018;38(12):1805-16. doi: 10.1177/0333102417752119Allen SM, Mookadam F, Cha SS, et al. Greater occipital nerve block for acute treatment of migraine headache: a large retrospective cohort study. J Am Board Fam Med. 2018;1(2):211-8. doi: 10.3122/jabfm.2018.02.170188Allen SM, Mookadam F, Cha SS, et al. Greater occipital nerve block for acute treatment of migraine headache: a large retrospective cohort study. J Am Board Fam Med. 2018;1(2):211-8. doi: 10.3122/jabfm.2018.02.170188Cuadrado ML, Aledo-Serrano A, Navarro P, et al. Short-term effects of greater occipital nerve blocks in chronic migraine: a double-blind, randomised, placebo-controlled clinical trial. Cephalalgia. 2017;37:864-72. doi: 10.1177/0333102416655159Cuadrado ML, Aledo-Serrano A, Navarro P, et al. Short-term effects of greater occipital nerve blocks in chronic migraine: a double-blind, randomised, placebo-controlled clinical trial. Cephalalgia. 2017;37:864-72. doi: 10.1177/0333102416655159Misra UK, Kalita J, Bhoi SK. High-rate repetitive transcranial magnetic stimulation in migraine prophylaxis: a randomized, placebocontrolled study. J Neurol. 2013;260(11):2793-801. doi: 10.1007/s00415-013-7072-2Misra UK, Kalita J, Bhoi SK. High-rate repetitive transcranial magnetic stimulation in migraine prophylaxis: a randomized, placebocontrolled study. J Neurol. 2013;260(11):2793-801. doi: 10.1007/s00415-013-7072-2Conforto AB, Amaro E Jr, Goncalves AL, et al. Randomized, proof-of-principle clinical trial of active transcranial magnetic stimulation in chronic migraine. Cephalalgia. 2014;34(6):464-72. doi: 10.1177/0333102413515340Conforto AB, Amaro E Jr, Goncalves AL, et al. Randomized, proof-of-principle clinical trial of active transcranial magnetic stimulation in chronic migraine. Cephalalgia. 2014;34(6):464-72. doi: 10.1177/0333102413515340Schoenen J, Vandersmissen B, Jeangette S, et al. Migraine prevention with a supraorbital transcutaneous stimulator. A-randomized-controlled-trial. Neurology. 2013;80:697-704. doi: 10.1212/WNL.0b013e3182825055Schoenen J, Vandersmissen B, Jeangette S, et al. Migraine prevention with a supraorbital transcutaneous stimulator. A-randomized-controlled-trial. Neurology. 2013;80:697-704. doi: 10.1212/WNL.0b013e3182825055Chou D, Yugrakh M, Winegarne D, et al. Acute-migraine-therapy-with-external-trigeminal-neurostimulation-ACME-A-randomized-controlled-trial. Cephalalgia. 2019;39(1):3-14. doi: 10.1177/0333102418811573Chou D, Yugrakh M, Winegarne D, et al. Acute-migraine-therapy-with-external-trigeminal-neurostimulation-ACME-A-randomized-controlled-trial. Cephalalgia. 2019;39(1):3-14. doi: 10.1177/0333102418811573Cadalso RT Jr, Daugherty J, Holmes C, et al. Efficacy of electrical stimulation of the occipital nerve in intractable primary headache disorders: a systematic review with meta-analyses. J Oral Facial Pain Headache. 2018;32(1):40-52. doi: 10.11607/ofph.1784Cadalso RT Jr, Daugherty J, Holmes C, et al. Efficacy of electrical stimulation of the occipital nerve in intractable primary headache disorders: a systematic review with meta-analyses. J Oral Facial Pain Headache. 2018;32(1):40-52. doi: 10.11607/ofph.1784Yang Y, Song M, Fan Y, Ma K. Occipital nerve stimulation for migraine: a systematic review. Pain Pract. 2016;16(4):509-17. doi: 10.1111/papr.12303Yang Y, Song M, Fan Y, Ma K. Occipital nerve stimulation for migraine: a systematic review. Pain Pract. 2016;16(4):509-17. doi: 10.1111/papr.12303Schulman EA, Lake AE 3rd , Goadsby PJ, et al. Defining refractory migraine and refractory chronic migraine: proposed criteria from the Refractory Headache Special Interest Section of the American Headache Society. Headache. 2008;48(6):778-82. doi: 10.1111/j.15264610.2008.01132.xSchulman EA, Lake AE 3rd , Goadsby PJ, et al. Defining refractory migraine and refractory chronic migraine: proposed criteria from the Refractory Headache Special Interest Section of the American Headache Society. Headache. 2008;48(6):778-82. doi: 10.1111/j.15264610.2008.01132.x

The authors declare that there are no conflicts of interest present.