nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2020-3-123-127nnp-1376Research ArticleREVIEWSОБЗОРЫEffective neuroprotection and organ protection: activation of the endogenous mechanisms of sanogenesisЭффективная нейро- и органопротекция -активация эндогенных механизмов саногенезаЕсинР. Г.EsinR. G.

Есин Радий Германович.

420012, Казань, ул. Муштари, 11; 420008, Казань, ул. Кремлевская, 18.

Radiy Germanovich Esin.

11, Mushtari St., Kazan 420012; 18, Kremlevskaya St., Kazan 420008.

radyesin@gmail.comЕсинО. Р.EsinO. R.ХакимоваА. Р.KhakimovaA. R.

11, Mushtari St., Kazan 420012.

Казанская государственная медицинская академия — филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России; Казанский (Приволжский) федеральный университет Минобрнауки РоссииРоссияKazan State Medical Academy, Branch, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia; Kazan (Volga) Federal University, Ministry of Education and Science of RussiaRussian FederationКазанский (Приволжский) федеральный университет Минобрнауки РоссииРоссияKazan (Volga) Federal University, Ministry of Education and Science of RussiaRussian FederationКазанская государственная медицинская академия — филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияKazan State Medical Academy, Branch, Russian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaRussian Federation202025062020123123127Copyright © Esin R.G., Esin O.R., Khakimova A.R., 20202020Есин Р.Г., Есин О.Р., Хакимова А.Р.Esin R.G., Esin O.R., Khakimova A.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1376

The review sets out modern ideas about the mechanisms of action of gamma-aminobutyric acid (GABA) in the central nervous system and other organs and systems. Current experimental and clinical studies have shown that GABA has numerous effects: neuroprotective, antihypertensive, antidiabetic, antitumor, anti-inflammatory, antimicrobial, anti-allergic, hepatoprotective, nephroprotective and enteroprotective, and others, which are currently the subject for study by biologists, physiologists, and physicians. Synthetic GABA analogues are widely used in clinical practice. One of these drugs is aminophenylbutyric acid hydrochloride (Anvifen®) that has demonstrated high efficiency and safety in clinical practice.

В обзоре изложены современные представления о механизмах действия гамма-аминомасляной кислоты (ГАМК) в ЦНС и других органах и системах. Современные экспериментальные и клинические исследования показали многочисленные эффекты ГАМК: нейро-протективный, антигипертензивный, антидиабетический, противоопухолевый, противовоспалительный, противомикробный, противоаллергический, гепато-, нефро- и энтеропротективный и др., которые в настоящее время являются предметом исследований биологов, физиологов и врачей. Синтетические аналоги ГАМК широко используются в клинической практике. Одним из таких препаратов является аминофенилмасляной кислоты гидрохлорид (Анвифен®), продемонстрировавший высокую эффективность и безопасность в клинической практике.

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The authors declare that there are no conflicts of interest present.