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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2020-100-104</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-1270</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group></article-categories><title-group><article-title>The fixed combination of diclofenac and orphenadrine in the treatment of acute pain syndromes</article-title><trans-title-group xml:lang="ru"><trans-title>Фиксированная комбинация диклофенака и орфенадрина в лечении острых болевых синдромов</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ушкалова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ushkalova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зырянов</surname><given-names>С. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Zyryanov</surname><given-names>S. K.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><email xlink:type="simple">sergey.k.zyryanov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Затолочина</surname><given-names>К. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Zatolochina</surname><given-names>K. E.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кафедра общей и клинической фармакологии ФГАОУ ВО «Российский университет дружбы народов» Минобрнауки России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Department of General and Clinical Pharmacology, Peoples' Friendship University of Russia, Ministry of Education and Science of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>21</day><month>02</month><year>2020</year></pub-date><volume>12</volume><issue>1</issue><fpage>100</fpage><lpage>104</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ushkalova E.A., Zyryanov S.K., Zatolochina K.E., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Ушкалова Е.А., Зырянов С.К., Затолочина К.Э.</copyright-holder><copyright-holder xml:lang="en">Ushkalova E.A., Zyryanov S.K., Zatolochina K.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/1270">https://nnp.ima-press.net/nnp/article/view/1270</self-uri><abstract/><trans-abstract xml:lang="ru"/><kwd-group xml:lang="ru"><kwd>острая боль</kwd><kwd>скелетно-мышечная боль</kwd><kwd>послеоперационная боль</kwd><kwd>нестероидные противовоспалительные препараты</kwd><kwd>центральные миорелаксанты</kwd><kwd>диклофенак</kwd><kwd>орфенадрин</kwd><kwd>фиксированная комбинация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute pain</kwd><kwd>musculoskeletal pain</kwd><kwd>postoperative pain</kwd><kwd>nonsteroidal anti-inflammatory drugs</kwd><kwd>centrally acting muscle relaxants</kwd><kwd>diclofenac</kwd><kwd>orphenadrine</kwd><kwd>fixed combination</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Allegri M, Clark MR, De Andres J, Jensen TS. 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