nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2020-1-61-67nnp-1263Research ArticleEXPERIMENTAL STUDIESЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯGeroprotective properties of neuroprotective and neurotrophic peptidesГеропротективные свойства нейропротективных и нейротрофических пептидовГромоваО. А.GromovaO. A.

119333, Москва, ул. Вавилова, 44, корп. 2

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1, Leninskie Gory, Moscow 119234

unesco.gromova@gmail.comТоршинИ. Ю.TorshinI. Yu.

119333, Москва, ул. Вавилова, 44, корп. 2

119234, Москва, Ленинские горы, 1 

44, Vavilov St., Build. 2, Moscow 119333

1, Leninskie Gory, Moscow 119234 

ЗгодаВ. Г.ZgodaV. G.СорокинА. И.SorokinA. I.

1, Leninskie Gory, Moscow 119234 

ТихоноваО. В.TikhonovaO. V.Федеральный исследовательский центр «Информатика и управление» Российской академии наук; Центр хранения и анализа больших данных ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»РоссияFederal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, M.V. Lomonosov Moscow State UniversityRussian FederationФГБНУ «Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича»РоссияV.N. Orekhovich Research Institute of Biomedical ChemistryRussian FederationЦентр хранения и анализа больших данных ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»РоссияBig Data Storage and Analysis Center, M.V. Lomonosov Moscow State UniversityRussian Federation2020200220201216167Copyright © Gromova O.A., Torshin I.Y., Zgoda V.G., Sorokin A.I., Tikhonova O.V., 20202020Громова О.А., Торшин И.Ю., Згода В.Г., Сорокин А.И., Тихонова О.В.Gromova O.A., Torshin I.Y., Zgoda V.G., Sorokin A.I., Tikhonova O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1263геропротекциянейропротекторыцеребролизинбольшие данныефармакоинформатикакином человекаgeroprotectionneuroprotectorscerebrolysinbig datapharmacoinformaticshuman kinomeReferencesZeeh J. Medication review – seven steps to improve pharmacotherapy in elderly adults. MMW Fortschr Med. 2016 Jun 9;158(11):54-7. doi: 10.1007/s15006-016-8383-x.Zeeh J. Medication review – seven steps to improve pharmacotherapy in elderly adults. MMW Fortschr Med. 2016 Jun 9;158(11):54-7. doi: 10.1007/s15006-016-8383-x.Glossmann HH, Lutz OMD. Metformin and Aging: A Review. Gerontology. 2019;65(6):581-590. doi: 10.1159/000502257. Epub 2019 Sep 13.Glossmann HH, Lutz OMD. Metformin and Aging: A Review. Gerontology. 2019;65(6):581-590. doi: 10.1159/000502257. Epub 2019 Sep 13.Bornstein NM, Guekht A, Vester J, et al. Safety and efficacy of Cerebrolysin in early post-stroke recovery: a meta-analysis of nine randomized clinical trials. Neurol Sci. 2018 Apr;39(4):629-640. doi: 10.1007/s10072-017-3214-0.Bornstein NM, Guekht A, Vester J, et al. Safety and efficacy of Cerebrolysin in early post-stroke recovery: a meta-analysis of nine randomized clinical trials. Neurol Sci. 2018 Apr;39(4):629-640. doi: 10.1007/s10072-017-3214-0.Zhang D, Dong Y, Li Y, et al. Efficacy and Safety of Cerebrolysin for Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials. Biomed Res Int. 2017;2017: 4191670. doi: 10.1155/2017/4191670.Zhang D, Dong Y, Li Y, et al. Efficacy and Safety of Cerebrolysin for Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials. Biomed Res Int. 2017;2017: 4191670. doi: 10.1155/2017/4191670.Ghaffarpasand F, Torabi S, Rasti A, et al. Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis. Neuropsychiatr Dis Treat. 2018 Dec 27;15:127-135. doi: 10.2147/NDT.S186865. eCollection 2019.Ghaffarpasand F, Torabi S, Rasti A, et al. Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis. Neuropsychiatr Dis Treat. 2018 Dec 27;15:127-135. doi: 10.2147/NDT.S186865. eCollection 2019.Gauthier S, ProaЦo JV, Jia J, et al. Cerebrolysin in mild-to-moderate Alzheimer's disease: a meta-analysis of randomized controlled clinical trials. Dement Geriatr Cogn Disord. 2015;39(5-6):332-47. doi: 10.1159/000377672.Gauthier S, ProaЦo JV, Jia J, et al. Cerebrolysin in mild-to-moderate Alzheimer's disease: a meta-analysis of randomized controlled clinical trials. Dement Geriatr Cogn Disord. 2015;39(5-6):332-47. doi: 10.1159/000377672.Громова ОА, Торшин ИЮ. Мультимодальный эффект церебролизина против воинствующего редукционизма. Неврологический вестник. 2008;(3):83-91.Gromova OA, Torshin IYu. Multimodal effect of Cerebrolysin against militant reductionism. Nevrologicheskii vestnik. 2008;(3):83-91. (In Russ.).Chemer N, Bilanovskyi V. Cerebrolysin as a New Treatment Option for Post-Stroke Spasticity: Patient and Physician Perspectives. Neurol Ther. 2019 Jun;8(1):25-27. doi: 10.1007/s40120-019-0128-1.Chemer N, Bilanovskyi V. Cerebrolysin as a New Treatment Option for Post-Stroke Spasticity: Patient and Physician Perspectives. Neurol Ther. 2019 Jun;8(1):25-27. doi: 10.1007/s40120-019-0128-1.Рохлина МЛ, Козлов АА, Усманова НН, Смирнова ЕА. Применение церебролизина при героиновой наркомании. Психиатрия и психофармакотерапия. 2001;(3):98-102.Rokhlina ML, Kozlov AA, Usmanova NN, Smirnova EA. The use of Cerebrolysin in heroin addiction. Psikhiatriya i psikhofarmakoterapiya. 2001;(3):98-102. (In Russ.).Громова ОА, Торшин ИЮ, Згода ВГ, Тихонова ОВ. Комплексный протеомный анализ «легкой» пептидной фракции препарата Церебролизин. Журнал неврологии и психиатрии им. С.С. Корсакова. 2019;119(8): 75-83.Rokhlina ML, Kozlov AA, Usmanova NN, Smirnova EA. The use of Cerebrolysin in heroin addiction. Psikhiatriya i psikhofarmakoterapiya. 2001;(3):98-102. (In Russ.).Торшин ИЮ, Громова ОА, Згода ВГ и др. О пептидах Церебролизина, способствующих нормотимии. Журнал неврологии и психиатрии им. С.С. Корсакова. 2019;119(12): 68-74.Gromova OA, Torshin IYu, Zgoda VG, Tikhonova OV. Complex proteomic analysis of the "light" peptide fraction of Cerebrolysin. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2019;119(8):75-83. (InRuss.).UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515. doi: 10.1093/nar/gky1049.Gromova OA, Torshin IYu, Zgoda VG, Tikhonova OV. Complex proteomic analysis of the "light" peptide fraction of Cerebrolysin. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2019;119(8):75-83. (InRuss.).Torshin IYu. Sensing the change from molecular genetics to personalized medicine. New York: Nova Biomedical Books.Torshin IYu, Gromova OA, Zgoda VG, et al. About the peptides of Cerebrolysin contributing mood stabilization. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2019;119(12): 68-74. (In Russ.).Torshin IY, Rudakov KV. On metric spaces arising during formalization of recognition and classification problems. Part 1: Properties of compactness. Pattern Recognition and Image Analysis. 2016;26(2):274-84.Torshin IYu, Gromova OA, Zgoda VG, et al. About the peptides of Cerebrolysin contributing mood stabilization. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2019;119(12): 68-74. (In Russ.).Torshin IYu, Rudakov KV. On metric spaces arising during formalization of problems of recognition and classification. Part 2: Density properties. Pattern Recognition and Image Analysis. 2016;26(3):483-96.UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515. doi: 10.1093/nar/gky1049.Torshin IYu, Rudakov KV. Combinatorial analysis of the solvability properties of the problems of recognition and completeness of algorithmic models. Part 2: metric approach within the framework of the theory of classification of feature values. Pattern Recognition and Image Analysis. 2017;27(2):184-99.UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515. doi: 10.1093/nar/gky1049.Torshin IYu, Rudakov KV. On the theoretical basis of metric analysis of poorly formalized problems of recognition and classification. Pattern Recognition and Image Analysis. 2015; 25(4):577-87.Torshin IYu. Sensing the change from molecular genetics to personalized medicine. New York: Nova Biomedical Books.Торшин ИЮ, Громова ОА, Лила АМ и др. Таргетное действие глюкозамина сульфата при сочетании остеоартрита и опухолевой патологии. 2019;(6):23-30.Torshin IYu. Sensing the change from molecular genetics to personalized medicine. New York: Nova Biomedical Books.Schmeisser K, Parker JA. Pleiotropic Effects of mTOR and Autophagy During Development and Aging. Front Cell Dev Biol. 2019 Sep 11;7:192. doi: 10.3389/fcell.2019.00192. eCollection 2019.Torshin IY, Rudakov KV. On metric spaces arising during formalization of recognition and classification problems. Part 1: Properties of compactness. Pattern Recognition and Image Analysis. 2016;26(2):274-84.Lim JS, Kim WI, Kang HC, et al. Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy. Nat Med. 2015 Apr;21(4):395-400. doi: 10.1038/nm.3824.Torshin IY, Rudakov KV. On metric spaces arising during formalization of recognition and classification problems. Part 1: Properties of compactness. Pattern Recognition and Image Analysis. 2016;26(2):274-84.Dephoure N, Zhou C, Villen J, et al. A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008;105(31):10762-7. doi: 10.1073/pnas.0805139105.Torshin IYu, Rudakov KV. On metric spaces arising during formalization of problems of recognition and classification. Part 2: Density properties. Pattern Recognition and Image Analysis. 2016;26(3):483-96.Koren I, Reem E, Kimchi A. DAP1, a novel substrate of mTOR, negatively regulates autophagy. Curr Biol. 2010;22;20(12):1093-8. doi: 10.1016/j.cub.2010.04.041.Torshin IYu, Rudakov KV. On metric spaces arising during formalization of problems of recognition and classification. Part 2: Density properties. Pattern Recognition and Image Analysis. 2016;26(3):483-96.Blagosklonny MV. Rapamycin for longevity: opinion article. Aging (Albany NY). 2019 Oct 4; 11(19):8048-8067. doi: 10.18632/aging.102355. Epub 2019 Oct 4.Torshin IYu, Rudakov KV. Combinatorial analysis of the solvability properties of the problems of recognition and completeness of algorithmic models. Part 2: metric approach within the framework of the theory of classification of feature values. Pattern Recognition and Image Analysis. 2017;27(2):184-99.Numazaki M, Tominaga T, Toyooka H, Tominaga M. Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. J Biol Chem. 2002;277(16):13375-8. doi: 10.1074/jbc.C200104200.Torshin IYu, Rudakov KV. Combinatorial analysis of the solvability properties of the problems of recognition and completeness of algorithmic models. Part 2: metric approach within the framework of the theory of classification of feature values. Pattern Recognition and Image Analysis. 2017;27(2):184-99.Wang S, Ge W, Harns C, et al. Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1- mediated regulation of autophagy. J Mol Cell Cardiol. 2018 Jun; 119:40-50. doi: 10.1016/j.yjmcc.2018.04.009. Epub 2018 Apr 13.Torshin IYu, Rudakov KV. On the theoretical basis of metric analysis of poorly formalized problems of recognition and classification. Pattern Recognition and Image Analysis. 2015; 25(4):577-87.Ruan X, Arendshorst WJ. Role of protein kinase C in angiotensin II-induced renal vasoconstriction in genetically hypertensive rats. Am J Physiol. 1996 Jun;270(6 Pt 2):F945-52. doi: 10.1152/ajprenal.1996.270.6.F945.Torshin IYu, Rudakov KV. On the theoretical basis of metric analysis of poorly formalized problems of recognition and classification. Pattern Recognition and Image Analysis. 2015; 25(4):577-87.Uneda K, Wakui H, Maeda A, et al. Angiotensin II Type 1 Receptor-Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin. J Am Heart Assoc. 2017 Jul 27;6(8). pii: e006120. doi: 10.1161/JAHA.117.006120.Torshin IYu, Gromova OA, Lila AM, et al. Targeted action of glucosamine sulfate in combination of osteoarthritis and tumor pathology. Russkii meditsinskii zhurnal. 2019;(6):23-30. (In Russ.).Fluhrer R, Friedlein A, Haass C, Walter J. Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis. J Biol Chem. 2004 Jan 16;279(3):1585-93. Epub 2003 Oct 22.Torshin IYu, Gromova OA, Lila AM, et al. Targeted action of glucosamine sulfate in combination of osteoarthritis and tumor pathology. Russkii meditsinskii zhurnal. 2019;(6):23-30. (In Russ.).Торшин ИЮ, Громова ОА. Экспертный анализ данных в молекулярной фармакологии. Москва: МЦНМО; 2012. 748 с.Schmeisser K, Parker JA. Pleiotropic Effects of mTOR and Autophagy During Development and Aging. Front Cell Dev Biol. 2019 Sep 11;7:192. doi: 10.3389/fcell.2019.00192. eCollection 2019.Садин АВ, Жидоморов НЮ, Гоголева ИВ и др. Исследование нейрорегенеративного действия церебролизина при травматическом повреждении головного мозга. Журнал неврологии и психиатрии им. С.С. Корсакова. 2013;113(4):57-60.Schmeisser K, Parker JA. Pleiotropic Effects of mTOR and Autophagy During Development and Aging. Front Cell Dev Biol. 2019 Sep 11;7:192. doi: 10.3389/fcell.2019.00192. eCollection 2019.Yu Z, Zhou X, Wang W, et al. Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres. Dev Cell. 2015 Jan 12;32(1):68-81. doi: 10.1016/j.devcel.2014.11.030.Lim JS, Kim WI, Kang HC, et al. Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy. Nat Med. 2015 Apr;21(4):395-400. doi: 10.1038/nm.3824.Marlier Q, Jibassia F, Verteneuil S, et al. Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death. Cell Death Discov. 2018 Mar 16;4:43. doi: 10.1038/s41420-018-0044-7.Lim JS, Kim WI, Kang HC, et al. Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy. Nat Med. 2015 Apr;21(4):395-400. doi: 10.1038/nm.3824.Masuda F, Ishii M, Mori A, et al. Glucose restriction induces transient G2 cell cycle arrest extending cellular chronological lifespan. Sci Rep. 2016 Jan 25;6:19629. doi: 10.1038/srep19629.Dephoure N, Zhou C, Villen J, et al. A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008;105(31):10762-7. doi: 10.1073/pnas.0805139105.Hu S, Xie Z, Onishi A, et al. Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell. 2009;139(3):610-22. doi: 10.1016/j.cell.2009.08.037.Dephoure N, Zhou C, Villen J, et al. A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008;105(31):10762-7. doi: 10.1073/pnas.0805139105.Chen CH, Wang WJ, Kuo JC, et al. Bidirectional signals transduced by DAPKERK interaction promote the apoptotic effect of DAPK. EMBO J. 2005 Jan 26;24(2):294-304. Epub 2004 Dec 16. doi: 10.1038/sj.emboj.7600510.Koren I, Reem E, Kimchi A. DAP1, a novel substrate of mTOR, negatively regulates autophagy. Curr Biol. 2010;22;20(12):1093-8. doi: 10.1016/j.cub.2010.04.041.Nandi S, Reinert LS, Hachem A, et al. Phosphorylation of MCT-1 by p44/42 MAPK is required for its stabilization in response to DNA damage. Oncogene. 2007 Apr 5;26(16): 2283-9. doi: 10.1038/sj.onc.1210030.Koren I, Reem E, Kimchi A. DAP1, a novel substrate of mTOR, negatively regulates autophagy. Curr Biol. 2010;22;20(12):1093-8. doi: 10.1016/j.cub.2010.04.041.Steiner H, Romig H, Pesold B, et al. Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis. Biochemistry. 1999 Nov 2; 38(44):14600-5. doi: 10.1021/bi9914210.Blagosklonny MV. Rapamycin for longevity: opinion article. Aging (Albany NY). 2019 Oct 4; 11(19):8048-8067. doi: 10.18632/aging.102355. Epub 2019 Oct 4.Marambaud P, Shioi J, Serban G, et al. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 2002 Apr 15;21(8):1948-56. doi: 10.1093/emboj/21.8.1948.Blagosklonny MV. Rapamycin for longevity: opinion article. Aging (Albany NY). 2019 Oct 4; 11(19):8048-8067. doi: 10.18632/aging.102355. Epub 2019 Oct 4.Dovey HF, John V, Anderson JP, et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 2001 Jan;76(1):173-81. doi: 10.1046/j.1471-4159.2001.00012.x.Numazaki M, Tominaga T, Toyooka H, Tominaga M. Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. J Biol Chem. 2002;277(16):13375-8. doi: 10.1074/jbc.C200104200.Ye J, Rawson RB, Komuro R, et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell. 2000 Dec;6(6):1355-64. doi: 10.1016/s1097-2765(00)00133-7.Numazaki M, Tominaga T, Toyooka H, Tominaga M. Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. J Biol Chem. 2002;277(16):13375-8. doi: 10.1074/jbc.C200104200.He P, Lee SJ, Lin S, et al. Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids. Mol Biol Cell. 2011 Oct;22(20):3812-25. doi: 10.1091/mbc.E11-04-0328.Wang S, Ge W, Harns C, et al. Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1- mediated regulation of autophagy. J Mol Cell Cardiol. 2018 Jun; 119:40-50. doi: 10.1016/j.yjmcc.2018.04.009. Epub 2018 Apr 13.Yoo D, Kim BY, Campo C, et al. Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. J Biol Chem. 2003 Jun 20;278(25):23066-75. doi: 10.1074/jbc.M212301200.Wang S, Ge W, Harns C, et al. Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1- mediated regulation of autophagy. J Mol Cell Cardiol. 2018 Jun; 119:40-50. doi: 10.1016/j.yjmcc.2018.04.009. Epub 2018 Apr 13.Lee JM, Lee JS, Kim H, et al. EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol Cell. 2012 Nov 30;48(4):572-86. doi: 10.1016/j.molcel.2012.09.004.Ruan X, Arendshorst WJ. Role of protein kinase C in angiotensin II-induced renal vasoconstriction in genetically hypertensive rats. Am J Physiol. 1996 Jun;270(6 Pt 2):F945-52. doi: 10.1152/ajprenal.1996.270.6.F945.Tamori Y, Bialucha CU, Tian AG, et al. Involvement of Lgl and Mahjong/VprBP in cell competition. PLoS Biol. 2010 Jul 13;8(7): e1000422. doi: 10.1371/journal.pbio.1000422.Ruan X, Arendshorst WJ. Role of protein kinase C in angiotensin II-induced renal vasoconstriction in genetically hypertensive rats. Am J Physiol. 1996 Jun;270(6 Pt 2):F945-52. doi: 10.1152/ajprenal.1996.270.6.F945.Воскресенская ОН, Захаров НБ, Тарасова ЮС и др. О возможных механизмах возникновения когнитивной дисфункции у больных с хроническими формами цереброваскулярных заболеваний. Неврология, нейропсихиатрия, психосоматика. 2018;10(1):32-6. doi: 10.14412/2074-2711-2018-1-32-36Uneda K, Wakui H, Maeda A, et al. Angiotensin II Type 1 Receptor-Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin. J Am Heart Assoc. 2017 Jul 27;6(8). pii: e006120. doi: 10.1161/JAHA.117.006120.Громова ОА, Торшин ИЮ, Федотова ЛЭ. Геронтоинформационный анализ свойств молекулы мексидола. Неврология, нейропсихиатрия, психосоматика. 2017;9(4): 46–54. doi: 10.14412/2074-2711-2017-4-46-54.Uneda K, Wakui H, Maeda A, et al. Angiotensin II Type 1 Receptor-Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin. J Am Heart Assoc. 2017 Jul 27;6(8). pii: e006120. doi: 10.1161/JAHA.117.006120.Торшин ИЮ, Громова ОА, Федотова ЛЭ, Громов АН. Сравнительный хемореактомный анализ декскетопрофена, кетопрофена и диклофенака. Неврология, нейропсихиатрия, психосоматика. 2018;10(1):47–54. doi: 10.14412/2074-2711-2018-1-47-54.Fluhrer R, Friedlein A, Haass C, Walter J. Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis. J Biol Chem. 2004 Jan 16;279(3):1585-93. Epub 2003 Oct 22.Fluhrer R, Friedlein A, Haass C, Walter J. Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis. J Biol Chem. 2004 Jan 16;279(3):1585-93. Epub 2003 Oct 22.Fluhrer R, Friedlein A, Haass C, Walter J. Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis. J Biol Chem. 2004 Jan 16;279(3):1585-93. Epub 2003 Oct 22.Torshin IYu, Gromova OA. Ekspertnyi analiz dannykh v molekulyarnoi farmakologii [Expert data analysis in molecular pharmacology]. Moscow: MTsNMO; 2012. 748 pTorshin IYu, Gromova OA. Ekspertnyi analiz dannykh v molekulyarnoi farmakologii [Expert data analysis in molecular pharmacology]. Moscow: MTsNMO; 2012. 748 pTorshin IYu, Gromova OA. Ekspertnyi analiz dannykh v molekulyarnoi farmakologii [Expert data analysis in molecular pharmacology]. Moscow: MTsNMO; 2012. 748 pTorshin IYu, Gromova OA. Ekspertnyi analiz dannykh v molekulyarnoi farmakologii [Expert data analysis in molecular pharmacology]. Moscow: MTsNMO; 2012. 748 pSadin AV, Zhidomorov NYu, Gogoleva IV, et al. Study of the neuroregenerative effect of Cerebrolysin in traumatic brain injury. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2013;113(4): 57-60. (In Russ.).Sadin AV, Zhidomorov NYu, Gogoleva IV, et al. Study of the neuroregenerative effect of Cerebrolysin in traumatic brain injury. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2013;113(4): 57-60. (In Russ.).Sadin AV, Zhidomorov NYu, Gogoleva IV, et al. Study of the neuroregenerative effect of Cerebrolysin in traumatic brain injury. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2013;113(4): 57-60. (In Russ.).Sadin AV, Zhidomorov NYu, Gogoleva IV, et al. Study of the neuroregenerative effect of Cerebrolysin in traumatic brain injury. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2013;113(4): 57-60. (In Russ.).Yu Z, Zhou X, Wang W, et al. Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres. Dev Cell. 2015 Jan 12;32(1):68-81. doi: 10.1016/j.devcel.2014.11.030.Yu Z, Zhou X, Wang W, et al. Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres. Dev Cell. 2015 Jan 12;32(1):68-81. doi: 10.1016/j.devcel.2014.11.030.Yu Z, Zhou X, Wang W, et al. Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres. Dev Cell. 2015 Jan 12;32(1):68-81. doi: 10.1016/j.devcel.2014.11.030.Yu Z, Zhou X, Wang W, et al. Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres. Dev Cell. 2015 Jan 12;32(1):68-81. doi: 10.1016/j.devcel.2014.11.030.Marlier Q, Jibassia F, Verteneuil S, et al. Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death. Cell Death Discov. 2018 Mar 16;4:43. doi: 10.1038/s41420-018-0044-7.Marlier Q, Jibassia F, Verteneuil S, et al. Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death. Cell Death Discov. 2018 Mar 16;4:43. doi: 10.1038/s41420-018-0044-7.Marlier Q, Jibassia F, Verteneuil S, et al. Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death. Cell Death Discov. 2018 Mar 16;4:43. doi: 10.1038/s41420-018-0044-7.Marlier Q, Jibassia F, Verteneuil S, et al. Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death. Cell Death Discov. 2018 Mar 16;4:43. doi: 10.1038/s41420-018-0044-7.Masuda F, Ishii M, Mori A, et al. Glucose restriction induces transient G2 cell cycle arrest extending cellular chronological lifespan. Sci Rep. 2016 Jan 25;6:19629. doi: 10.1038/srep19629.Masuda F, Ishii M, Mori A, et al. Glucose restriction induces transient G2 cell cycle arrest extending cellular chronological lifespan. Sci Rep. 2016 Jan 25;6:19629. doi: 10.1038/srep19629.Masuda F, Ishii M, Mori A, et al. Glucose restriction induces transient G2 cell cycle arrest extending cellular chronological lifespan. Sci Rep. 2016 Jan 25;6:19629. doi: 10.1038/srep19629.Masuda F, Ishii M, Mori A, et al. Glucose restriction induces transient G2 cell cycle arrest extending cellular chronological lifespan. Sci Rep. 2016 Jan 25;6:19629. doi: 10.1038/srep19629.Hu S, Xie Z, Onishi A, et al. Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell. 2009;139(3):610-22. doi: 10.1016/j.cell.2009.08.037.Hu S, Xie Z, Onishi A, et al. Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell. 2009;139(3):610-22. doi: 10.1016/j.cell.2009.08.037.Hu S, Xie Z, Onishi A, et al. Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell. 2009;139(3):610-22. doi: 10.1016/j.cell.2009.08.037.Hu S, Xie Z, Onishi A, et al. Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell. 2009;139(3):610-22. doi: 10.1016/j.cell.2009.08.037.Chen CH, Wang WJ, Kuo JC, et al. Bidirectional signals transduced by DAPKERK interaction promote the apoptotic effect of DAPK. EMBO J. 2005 Jan 26;24(2):294-304. Epub 2004 Dec 16. doi: 10.1038/sj.emboj.7600510.Chen CH, Wang WJ, Kuo JC, et al. Bidirectional signals transduced by DAPKERK interaction promote the apoptotic effect of DAPK. EMBO J. 2005 Jan 26;24(2):294-304. Epub 2004 Dec 16. doi: 10.1038/sj.emboj.7600510.Chen CH, Wang WJ, Kuo JC, et al. Bidirectional signals transduced by DAPKERK interaction promote the apoptotic effect of DAPK. EMBO J. 2005 Jan 26;24(2):294-304. Epub 2004 Dec 16. doi: 10.1038/sj.emboj.7600510.Chen CH, Wang WJ, Kuo JC, et al. Bidirectional signals transduced by DAPKERK interaction promote the apoptotic effect of DAPK. EMBO J. 2005 Jan 26;24(2):294-304. Epub 2004 Dec 16. doi: 10.1038/sj.emboj.7600510.Nandi S, Reinert LS, Hachem A, et al. Phosphorylation of MCT-1 by p44/42 MAPK is required for its stabilization in response to DNA damage. Oncogene. 2007 Apr 5;26(16): 2283-9. doi: 10.1038/sj.onc.1210030.Nandi S, Reinert LS, Hachem A, et al. Phosphorylation of MCT-1 by p44/42 MAPK is required for its stabilization in response to DNA damage. Oncogene. 2007 Apr 5;26(16): 2283-9. doi: 10.1038/sj.onc.1210030.Nandi S, Reinert LS, Hachem A, et al. Phosphorylation of MCT-1 by p44/42 MAPK is required for its stabilization in response to DNA damage. Oncogene. 2007 Apr 5;26(16): 2283-9. doi: 10.1038/sj.onc.1210030.Nandi S, Reinert LS, Hachem A, et al. Phosphorylation of MCT-1 by p44/42 MAPK is required for its stabilization in response to DNA damage. Oncogene. 2007 Apr 5;26(16): 2283-9. doi: 10.1038/sj.onc.1210030.Steiner H, Romig H, Pesold B, et al. Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis. Biochemistry. 1999 Nov 2; 38(44):14600-5. doi: 10.1021/bi9914210.Steiner H, Romig H, Pesold B, et al. Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis. Biochemistry. 1999 Nov 2; 38(44):14600-5. doi: 10.1021/bi9914210.Steiner H, Romig H, Pesold B, et al. Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis. Biochemistry. 1999 Nov 2; 38(44):14600-5. doi: 10.1021/bi9914210.Steiner H, Romig H, Pesold B, et al. Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis. Biochemistry. 1999 Nov 2; 38(44):14600-5. doi: 10.1021/bi9914210.Marambaud P, Shioi J, Serban G, et al. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 2002 Apr 15;21(8):1948-56. doi: 10.1093/emboj/21.8.1948.Marambaud P, Shioi J, Serban G, et al. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 2002 Apr 15;21(8):1948-56. doi: 10.1093/emboj/21.8.1948.Marambaud P, Shioi J, Serban G, et al. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 2002 Apr 15;21(8):1948-56. doi: 10.1093/emboj/21.8.1948.Marambaud P, Shioi J, Serban G, et al. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 2002 Apr 15;21(8):1948-56. doi: 10.1093/emboj/21.8.1948.Dovey HF, John V, Anderson JP, et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 2001 Jan;76(1):173-81. doi: 10.1046/j.1471-4159.2001.00012.x.Dovey HF, John V, Anderson JP, et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 2001 Jan;76(1):173-81. doi: 10.1046/j.1471-4159.2001.00012.x.Dovey HF, John V, Anderson JP, et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 2001 Jan;76(1):173-81. doi: 10.1046/j.1471-4159.2001.00012.x.Dovey HF, John V, Anderson JP, et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 2001 Jan;76(1):173-81. doi: 10.1046/j.1471-4159.2001.00012.x.Ye J, Rawson RB, Komuro R, et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell. 2000 Dec;6(6):1355-64. doi: 10.1016/s1097-2765(00)00133-7.Ye J, Rawson RB, Komuro R, et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell. 2000 Dec;6(6):1355-64. doi: 10.1016/s1097-2765(00)00133-7.Ye J, Rawson RB, Komuro R, et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell. 2000 Dec;6(6):1355-64. doi: 10.1016/s1097-2765(00)00133-7.Ye J, Rawson RB, Komuro R, et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell. 2000 Dec;6(6):1355-64. doi: 10.1016/s1097-2765(00)00133-7.Ye J, Rawson RB, Komuro R, et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell. 2000 Dec;6(6):1355-64. doi: 10.1016/s1097-2765(00)00133-7.Ye J, Rawson RB, Komuro R, et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell. 2000 Dec;6(6):1355-64. doi: 10.1016/s1097-2765(00)00133-7.He P, Lee SJ, Lin S, et al. Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids. Mol Biol Cell. 2011 Oct;22(20):3812-25. doi: 10.1091/mbc.E11-04-0328.He P, Lee SJ, Lin S, et al. Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids. Mol Biol Cell. 2011 Oct;22(20):3812-25. doi: 10.1091/mbc.E11-04-0328.He P, Lee SJ, Lin S, et al. Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids. Mol Biol Cell. 2011 Oct;22(20):3812-25. doi: 10.1091/mbc.E11-04-0328.He P, Lee SJ, Lin S, et al. Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids. Mol Biol Cell. 2011 Oct;22(20):3812-25. doi: 10.1091/mbc.E11-04-0328.He P, Lee SJ, Lin S, et al. Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids. Mol Biol Cell. 2011 Oct;22(20):3812-25. doi: 10.1091/mbc.E11-04-0328.He P, Lee SJ, Lin S, et al. Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids. Mol Biol Cell. 2011 Oct;22(20):3812-25. doi: 10.1091/mbc.E11-04-0328.Yoo D, Kim BY, Campo C, et al. Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. J Biol Chem. 2003 Jun 20;278(25):23066-75. doi: 10.1074/jbc.M212301200.Yoo D, Kim BY, Campo C, et al. Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. J Biol Chem. 2003 Jun 20;278(25):23066-75. doi: 10.1074/jbc.M212301200.Yoo D, Kim BY, Campo C, et al. Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. J Biol Chem. 2003 Jun 20;278(25):23066-75. doi: 10.1074/jbc.M212301200.Yoo D, Kim BY, Campo C, et al. Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. J Biol Chem. 2003 Jun 20;278(25):23066-75. doi: 10.1074/jbc.M212301200.Yoo D, Kim BY, Campo C, et al. Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. J Biol Chem. 2003 Jun 20;278(25):23066-75. doi: 10.1074/jbc.M212301200.Yoo D, Kim BY, Campo C, et al. Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. J Biol Chem. 2003 Jun 20;278(25):23066-75. doi: 10.1074/jbc.M212301200.Lee JM, Lee JS, Kim H, et al. EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol Cell. 2012 Nov 30;48(4):572-86. doi: 10.1016/j.molcel.2012.09.004.Lee JM, Lee JS, Kim H, et al. EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol Cell. 2012 Nov 30;48(4):572-86. doi: 10.1016/j.molcel.2012.09.004.Lee JM, Lee JS, Kim H, et al. EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol Cell. 2012 Nov 30;48(4):572-86. doi: 10.1016/j.molcel.2012.09.004.Lee JM, Lee JS, Kim H, et al. EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol Cell. 2012 Nov 30;48(4):572-86. doi: 10.1016/j.molcel.2012.09.004.Lee JM, Lee JS, Kim H, et al. EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol Cell. 2012 Nov 30;48(4):572-86. doi: 10.1016/j.molcel.2012.09.004.Lee JM, Lee JS, Kim H, et al. EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol Cell. 2012 Nov 30;48(4):572-86. doi: 10.1016/j.molcel.2012.09.004.Tamori Y, Bialucha CU, Tian AG, et al. Involvement of Lgl and Mahjong/VprBP in cell competition. PLoS Biol. 2010 Jul 13;8(7): e1000422. doi: 10.1371/journal.pbio.1000422.Tamori Y, Bialucha CU, Tian AG, et al. Involvement of Lgl and Mahjong/VprBP in cell competition. PLoS Biol. 2010 Jul 13;8(7): e1000422. doi: 10.1371/journal.pbio.1000422.Tamori Y, Bialucha CU, Tian AG, et al. Involvement of Lgl and Mahjong/VprBP in cell competition. PLoS Biol. 2010 Jul 13;8(7): e1000422. doi: 10.1371/journal.pbio.1000422.Tamori Y, Bialucha CU, Tian AG, et al. Involvement of Lgl and Mahjong/VprBP in cell competition. PLoS Biol. 2010 Jul 13;8(7): e1000422. doi: 10.1371/journal.pbio.1000422.Tamori Y, Bialucha CU, Tian AG, et al. Involvement of Lgl and Mahjong/VprBP in cell competition. PLoS Biol. 2010 Jul 13;8(7): e1000422. doi: 10.1371/journal.pbio.1000422.Tamori Y, Bialucha CU, Tian AG, et al. Involvement of Lgl and Mahjong/VprBP in cell competition. PLoS Biol. 2010 Jul 13;8(7): e1000422. doi: 10.1371/journal.pbio.1000422.Voskresenskaya ON, Zakharov NB, Tarasova YuS, et al. Possible mechanisms of cognitive dysfunction in patients with chronic forms of cerebrovascular diseases. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1):32-36. (In Russ.). doi: 10.14412/2074-2711-2018-1-32-36Voskresenskaya ON, Zakharov NB, Tarasova YuS, et al. Possible mechanisms of cognitive dysfunction in patients with chronic forms of cerebrovascular diseases. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1):32-36. (In Russ.). doi: 10.14412/2074-2711-2018-1-32-36Voskresenskaya ON, Zakharov NB, Tarasova YuS, et al. Possible mechanisms of cognitive dysfunction in patients with chronic forms of cerebrovascular diseases. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1):32-36. (In Russ.). doi: 10.14412/2074-2711-2018-1-32-36Voskresenskaya ON, Zakharov NB, Tarasova YuS, et al. Possible mechanisms of cognitive dysfunction in patients with chronic forms of cerebrovascular diseases. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1):32-36. (In Russ.). doi: 10.14412/2074-2711-2018-1-32-36Voskresenskaya ON, Zakharov NB, Tarasova YuS, et al. Possible mechanisms of cognitive dysfunction in patients with chronic forms of cerebrovascular diseases. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1):32-36. (In Russ.). doi: 10.14412/2074-2711-2018-1-32-36Voskresenskaya ON, Zakharov NB, Tarasova YuS, et al. Possible mechanisms of cognitive dysfunction in patients with chronic forms of cerebrovascular diseases. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1):32-36. (In Russ.). doi: 10.14412/2074-2711-2018-1-32-36Gromova OA, Torshin IYu, Fedotova LE. Geriatric information analysis of the molecular properties of mexidole. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2017;9(4):46–54. (In Russ.). doi: 10.14412/2074-2711-2017-4-46-54.Gromova OA, Torshin IYu, Fedotova LE. Geriatric information analysis of the molecular properties of mexidole. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2017;9(4):46–54. (In Russ.). doi: 10.14412/2074-2711-2017-4-46-54.Gromova OA, Torshin IYu, Fedotova LE. Geriatric information analysis of the molecular properties of mexidole. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2017;9(4):46–54. (In Russ.). doi: 10.14412/2074-2711-2017-4-46-54.Gromova OA, Torshin IYu, Fedotova LE. Geriatric information analysis of the molecular properties of mexidole. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2017;9(4):46–54. (In Russ.). doi: 10.14412/2074-2711-2017-4-46-54.Gromova OA, Torshin IYu, Fedotova LE. Geriatric information analysis of the molecular properties of mexidole. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2017;9(4):46–54. (In Russ.). doi: 10.14412/2074-2711-2017-4-46-54.Gromova OA, Torshin IYu, Fedotova LE. Geriatric information analysis of the molecular properties of mexidole. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2017;9(4):46–54. (In Russ.). doi: 10.14412/2074-2711-2017-4-46-54.Torshin IYu, Gromova OA, Fedotova LE, Gromov AN. Comparative chemoreactome analysis of dexketoprofen, ketoprofen, and diclofenac. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1):47-54. (In Russ.). doi: 10.14412/2074-2711-2018-1-47-54.Torshin IYu, Gromova OA, Fedotova LE, Gromov AN. Comparative chemoreactome analysis of dexketoprofen, ketoprofen, and diclofenac. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1):47-54. (In Russ.). doi: 10.14412/2074-2711-2018-1-47-54.Torshin IYu, Gromova OA, Fedotova LE, Gromov AN. Comparative chemoreactome analysis of dexketoprofen, ketoprofen, and diclofenac. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1):47-54. (In Russ.). doi: 10.14412/2074-2711-2018-1-47-54.Torshin IYu, Gromova OA, Fedotova LE, Gromov AN. Comparative chemoreactome analysis of dexketoprofen, ketoprofen, and diclofenac. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1):47-54. (In Russ.). doi: 10.14412/2074-2711-2018-1-47-54.Torshin IYu, Gromova OA, Fedotova LE, Gromov AN. Comparative chemoreactome analysis of dexketoprofen, ketoprofen, and diclofenac. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1):47-54. (In Russ.). doi: 10.14412/2074-2711-2018-1-47-54.Torshin IYu, Gromova OA, Fedotova LE, Gromov AN. Comparative chemoreactome analysis of dexketoprofen, ketoprofen, and diclofenac. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1):47-54. (In Russ.). doi: 10.14412/2074-2711-2018-1-47-54.

The authors declare that there are no conflicts of interest present.