<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2020-1-56-60</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-1262</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИ</subject></subj-group></article-categories><title-group><article-title>The efficacy and safety of ethyl methyl hydroxypyridine succinate used as part of sequential therapy in patients with chronic cerebral ischemia</article-title><trans-title-group xml:lang="ru"><trans-title>Эффективность и безопасность применения этилметилгидроксипиридина сукцината в рамках последовательной терапии у больных с хронической ишемией головного мозга</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бурдаков</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Burdakov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><email xlink:type="simple">orennevrburd@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Красных</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Krasnykh</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Оренбургский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Orenburg State Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>20</day><month>02</month><year>2020</year></pub-date><volume>12</volume><issue>1</issue><fpage>56</fpage><lpage>60</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Burdakov V.V., Krasnykh D.V., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Бурдаков В.В., Красных Д.В.</copyright-holder><copyright-holder xml:lang="en">Burdakov V.V., Krasnykh D.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/1262">https://nnp.ima-press.net/nnp/article/view/1262</self-uri><abstract/><trans-abstract xml:lang="ru"/><kwd-group xml:lang="ru"><kwd>хроническая ишемия головного мозга</kwd><kwd>когнитивные и двигательные функции</kwd><kwd>астенические и тревожно-депрессивные расстройства</kwd><kwd>Мексидол® ФОРТЕ 250</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic cerebral ischemia</kwd><kwd>cognitive and motor functions</kwd><kwd>asthenic and anxiety-depressive disorders</kwd><kwd>Mexidol® FORTE 250</kwd></kwd-group><funding-group><funding-statement xml:lang="en">Публикация статьи поддержана ООО «Векторфарм».</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА, Захаров ВВ, Преображенская ИС. Когнитивные расстройства. Москва: Ремедиум; 2014. 224 с.</mixed-citation><mixed-citation xml:lang="en">Parfenov VA, Zakharov VV, Preobrazhenskaya IS. Kognitivnye rasstroistva [Cognitive disorders]. Moscow: Remedium; 2014. 224 p.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА. Сосудистые когнитивные нарушения и хроническая ишемия головного мозга (дисциркуляторная энцефалопатия). Неврология, нейропсихиатрия, психосоматика. 2019;11(3S):61-7. doi: 10.14412/2074-2711-2019-3S-61-67</mixed-citation><mixed-citation xml:lang="en">Parfenov VA. Vascular cognitive impairment and chronic cerebral ischemia (dyscirculatory encephalopathy).  Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psichosomatics. 2019;11(3S):61-7. (In Russ.) doi: 10.14412/2074-2711-2019-3S-61-67</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Локшина АБ, Захаров ВВ. Вопросы терапии хронической ишемии головного мозга. Неврология. 2017;(3):14-8.</mixed-citation><mixed-citation xml:lang="en">Lokshina AB, Zakharov VV. Voprosy terapii khronicheskoi ishemii golovnogo mozga. Nevrologiya. 2017; (3):14-8.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Воскресенская ОН, Захарова НБ, Тарасова ЮС и др. О возможных механизмах возникновения когнитивной дисфункции у больных с хроническими формами цереброваскулярных заболеваний. Неврология, нейропсихиатрия, психосоматика. 2018; 10(1):32-6. doi: 10.14412/2074-2711-2018-1-32-36.</mixed-citation><mixed-citation xml:lang="en">Voskresenskaya ON, Zakharova NB, Tarasova YuS, et al. Possible mechanisms of cognitive dysfunction in patients with chronic forms of cerebrovascular diseases. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psichosomatics. 2018;10(1): 32-6. (In Russ.). doi: 10.14412/2074-2711-2018-1-32-36.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Камчатнов ПР, Умарова ХЯ. Хроническая ишемия головного мозга: возможности терапии. Справочник поликлинического врача. 2013;(6):3-7.</mixed-citation><mixed-citation xml:lang="en">Kamchatnov PR, Umarova KhYa. Chronic ischemia of the brain: opportunities for therapy. Spravochnik poliklinicheskogo vracha. 2013;(6):3-7. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Гусев ЕИ, Чуканова ЕИ, Чуканова АС. Хроническая цереброваскулярная недостаточность. Москва: Медицина; 2019. 190 с.</mixed-citation><mixed-citation xml:lang="en">Gusev EI, Chukanova EI, Chukanova AS. Khronicheskaya tserebrovaskulyarnaya nedostatochnost' [Chronic  cerebrovascular insufficiency]. Moscow: Meditsina; 2019. 190 p.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Путилина МВ. Хроническая ишемия мозга. Неврология и нейрохирургия. 2012;(4): 7-12.</mixed-citation><mixed-citation xml:lang="en">Putilina MV. Chronic brain ischemia. Nevrologiya i neirokhirurgiya. 2012;(4):7-12. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Чуканова ЕИ, Чуканова АС. Эффективность и безопасность препарата Мексидол ФОРТЕ 250 в рамках последовательной терапии у пациентов с хронической ишемией мозга. Журнал неврологии и психиатрии им. С.С. Корсакова. 2019;119(9):39-45.</mixed-citation><mixed-citation xml:lang="en">Chukanova EI, Chukanova AS. Efficacy and safety of Mexidol FORTE 250 in sequential therapy in patients with chronic brain ischemia. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2019;119(9):39-45. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Кашин АВ. Эффективность и безопасность мексидола в лечении когнитивной дисфункции у пациентов, перенесших ишемический инсульт. Бюллетень экспериментальной биологии и медицины. 2012; (Прил. 1):36–8.</mixed-citation><mixed-citation xml:lang="en">Kashin AV. Efficacy and safety of Mexidol in the treatment of cognitive dysfunction in patients with ischemic stroke. Byulleten' eksperimental'noi biologii i meditsiny. 2012;(Suppl. 1):36–8. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Стаховская ЛВ, Шамалов НА, Хасанова ДР и др. Результаты рандомизированного двойного слепого мультицентрового плацебо-контролируемого в параллельных группах исследования эффективности и безопасности мексидола при длительной последовательной терапии у пациентов в остром и раннем восстановительном периодах полушарного ишемического инсульта (ЭПИКА). Журнал неврологии и психиатрии им. С.С. Корсакова. 2017;117(3-2): 55-65.</mixed-citation><mixed-citation xml:lang="en">Stakhovskaya LV, Shamalov NA, Khasanova DR, et al. Results of a randomized double-blind multicenter placebo-controlled parallel group study of the efficacy and safety of Mexidol in long-term sequential therapy in patients with acute and early recovery periods of hemispheric ischemic stroke (EPICA). Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2017; 117(3-2):55-65. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Бойко АН, Лебедева АВ, Щукин ИА и др. Возможности медикаментозной коррекции умеренного когнитивного расстройства. Журнал неврологии и психиатрии им. С.С. Корсакова. 2013;113(2):28-32.</mixed-citation><mixed-citation xml:lang="en">Boiko AN, Lebedeva AV, Shchukin IA, et al. Possibilities of medical correction of moderate cognitive disorder. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2013;113(2):28-32. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Воронина ТА. Мексидол: спектр фармакологических эффектов. Журнал неврологии и психиатрии им. С.С. Корсакова. 2012;112(12):86-90.</mixed-citation><mixed-citation xml:lang="en">Voronina TA. Mexidol: spectrum of pharmacological effects. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2012; 112(12):86-90. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Болотова ЕВ, Лушпай ТЮ, Ковригина ИВ. Повышение эффективности лечения гипертонической энцефалопатии препаратом мексидол. Журнал неврологии и психиатрии им. С.С. Корсакова. 2018;118(4):61-4.</mixed-citation><mixed-citation xml:lang="en">Bolotova EV, Lushpai TYu, Kovrigina IV. Improving the effectiveness of treatment of hypertensive encephalopathy with Mexidol. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2018;118(4):61-4. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Tsoi KK, Chan JY, Hirai HW, et al. Cognitive Tests to Detect Dementia: A Systematic Review and Meta-analysis. JAMA Intern Med. 2015 Sep;175(9):1450-8. doi: 10.1001/jamainternmed.2015.2152.</mixed-citation><mixed-citation xml:lang="en">Tsoi KK, Chan JY, Hirai HW, et al. Cognitive Tests to Detect Dementia: A Systematic Review and Meta-analysis. JAMA Intern Med. 2015 Sep;175(9):1450-8. doi: 10.1001/jamainternmed.2015.2152.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Smets EM, Garssen BJ, Bonke B, DeHaes JC. The Multidimensional fatigue inventory (MFI) psychometric properties of an instrument to assess fatigue. J Psychosom Res. 1995 Apr;39(3):315-25.</mixed-citation><mixed-citation xml:lang="en">Smets EM, Garssen BJ, Bonke B, DeHaes JC. The Multidimensional fatigue inventory (MFI) psychometric properties of an instrument to assess fatigue. J Psychosom Res. 1995 Apr;39(3):315-25.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Боровиков ВП, Ивченко ГИ. Учебник по математической статистике с упражнениями в системе Statistica. Москва: StatSoft; 2003. 368 p.</mixed-citation><mixed-citation xml:lang="en">Borovikov VP, Ivchenko GI. Uchebnik po matematicheskoi statistike s uprazhneniyami v sisteme Statistica [Textbook on mathematical statistics with exercises in the Statistica system]. Moscow: StatSoft; 2003. 368 p.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Gorelick PB, Scuteri A, Black SE, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke. 2011 Sep; 42(9):2672-713. doi: 10.1161/STR. 0b013e3182299496. Epub 2011 Jul 21.</mixed-citation><mixed-citation xml:lang="en">Gorelick PB, Scuteri A, Black SE, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the  american heart association/american stroke association. Stroke. 2011 Sep; 42(9):2672-713. doi: 10.1161/STR. 0b013e3182299496. Epub 2011 Jul 21.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
