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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">nnp</journal-id><journal-title-group><journal-title xml:lang="en">Neurology, Neuropsychiatry, Psychosomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>Неврология, нейропсихиатрия, психосоматика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-2711</issn><issn pub-type="epub">2310-1342</issn><publisher><publisher-name>"IMA-Press", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/2074-2711-2020-1-50-55</article-id><article-id custom-type="elpub" pub-id-type="custom">nnp-1261</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИ</subject></subj-group></article-categories><title-group><article-title>Gender characteristics of therapy for genetic generalized epilepsy in adults</article-title><trans-title-group xml:lang="ru"><trans-title>Гендерные особенности терапии генетической генерализованной эпилепсии у взрослых</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Волков</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Volkov</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><email xlink:type="simple">viv114476@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпович</surname><given-names>Г. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpovich</surname><given-names>G. S.</given-names></name></name-alternatives><bio xml:lang="ru"/><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalina</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Волкова</surname><given-names>О. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Volkova</surname><given-names>O. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>630091, Новосибирск, ул. Мичурина, 37 </p></bio><bio xml:lang="en"><p>37, Michurin St., Novosibirsk 630091 </p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Городской неврологический центр «Сибнейромед»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sibneuromed City Neurology Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Городской неврологический центр «Сибнейромед»&#13;
ГБУЗ Новосибирской области «Городская детская клиническая больница скорой медицинской помощи»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sibneuromed City Neurology Center&#13;
City Children's Clinical Emergency Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>20</day><month>02</month><year>2020</year></pub-date><volume>12</volume><issue>1</issue><fpage>50</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Volkov I.V., Karpovich G.S., Kalina A.V., Volkova O.K., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Волков И.В., Карпович Г.С., Калина А.В., Волкова О.К.</copyright-holder><copyright-holder xml:lang="en">Volkov I.V., Karpovich G.S., Kalina A.V., Volkova O.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nnp.ima-press.net/nnp/article/view/1261">https://nnp.ima-press.net/nnp/article/view/1261</self-uri><abstract/><trans-abstract xml:lang="ru"/><kwd-group xml:lang="ru"><kwd>генетическая генерализованная эпилепсия</kwd><kwd>монотерапия</kwd><kwd>политерапия</kwd><kwd>гендерные особенности</kwd></kwd-group><kwd-group xml:lang="en"><kwd>genetic generalized epilepsy</kwd><kwd>monotherapy</kwd><kwd>polytherapy</kwd><kwd>gender characteristics</kwd></kwd-group><funding-group><funding-statement xml:lang="en">Публикация статьи поддержана ООО «Бауш Хелс».</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr; 51(4):676-85. doi: 10.1111/j.1528-1167.2010.02522.x. Epub 2010 Feb 26.</mixed-citation><mixed-citation xml:lang="en">Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr; 51(4):676-85. doi: 10.1111/j.1528-1167.2010.02522.x. Epub 2010 Feb 26.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Tomson T, Marson A, Boon P, et al. Valproate in the treatment of epilepsy in women and girls. Pre-Publication Summary of Recommendations from a joint Task Force of ILAE-Commission on European Affairs and European Academy of Neurology (EAN). 2015. https://www.eaneurology.org/fileadmin/_migrated/content_uploads/ValproateCommentILAE-0315.pdf</mixed-citation><mixed-citation xml:lang="en">Tomson T, Marson A, Boon P, et al. Valproate in the treatment of epilepsy in women and girls. Pre-Publication Summary of Recommendations from a joint Task Force of ILAE-Commission on European Affairs and European Academy of Neurology (EAN). 2015. https://www.eaneurology.org/fileadmin/_migrated/content_uploads/ValproateCommentILAE-0315.pdf</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Мухин КЮ, Петрухин АС. Идиопатические формы эпилепсии: систематика, диагностика, терапия. Москва: Арт-БизнесЦентр; 2000. 19 c.</mixed-citation><mixed-citation xml:lang="en">Mukhin KYu, Petrukhin AS. Idiopaticheskie formy epilepsii: sistematika, diagnostika, terapiya [Idiopathic forms of epilepsy: systematics, diagnostics, therapy]. Moscow: Art-Biznes-Tsentr; 2000. 19 p.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Callaghan B, Schlesinger M, Rodemer W, et al. Remission and relapse in a drug-resistant epilepsy population followed prospectively. Epilepsia. 2011 Mar;52(3):619-26. doi: 10.1111/j.1528-1167.2010.02929.x. Epub 2011 Jan 26.</mixed-citation><mixed-citation xml:lang="en">Callaghan B, Schlesinger M, Rodemer W, et al. Remission and relapse in a drug-resistant epilepsy population followed prospectively. Epilepsia. 2011 Mar;52(3):619-26. doi: 10.1111/j.1528-1167.2010.02929.x. Epub 2011 Jan 26.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Benbadis SR. Practical management issues for idiopathic generalized epilepsies. Epilepsia. 2005;46 Suppl 9:125-32.</mixed-citation><mixed-citation xml:lang="en">Benbadis SR. Practical management issues for idiopathic generalized epilepsies. Epilepsia. 2005;46 Suppl 9:125-32.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Coppola G, Auricchio G, Federico R, et al. Lamotrigine versus valproic acid as first-line monotherapy in newly diagnosed typical absence seizures: an open-label, randomized, parallel-group study. Epilepsia. 2004 Sep; 45(9):1049-53.</mixed-citation><mixed-citation xml:lang="en">Coppola G, Auricchio G, Federico R, et al. Lamotrigine versus valproic acid as first-line monotherapy in newly diagnosed typical absence seizures: an open-label, randomized, parallel-group study. Epilepsia. 2004 Sep; 45(9):1049-53.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Guerrini R, Dravet C, Genton P, et al. Lamotrigine and seizure aggravation in severe myoclonic epilepsy. Epilepsia. 1998 May;39(5): 508-12.</mixed-citation><mixed-citation xml:lang="en">Guerrini R, Dravet C, Genton P, et al. Lamotrigine and seizure aggravation in severe myoclonic epilepsy. Epilepsia. 1998 May;39(5): 508-12.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Crespel A, Genton P, Berramdane M, et al. Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies. Neurology. 2005 Sep 13;65(5):762-4.</mixed-citation><mixed-citation xml:lang="en">Crespel A, Genton P, Berramdane M, et al. Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies. Neurology. 2005 Sep 13;65(5):762-4.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Covanis A. Childhood absence epilepsy. In: Panayiotopoulos CP, editor. Atlas of epilepsies. London: Springer-Verlag; 2010. P. 1013-23.</mixed-citation><mixed-citation xml:lang="en">Covanis A. Childhood absence epilepsy. In: Panayiotopoulos CP, editor. Atlas of epilepsies. London: Springer-Verlag; 2010. P. 1013-23.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Cavitt J, Privitera M. Levetiracetam induces a rapid and sustained reduction of generalized spike-wave and clinical absence. Arch Neurol. 2004 Oct;61(10):1604-7.</mixed-citation><mixed-citation xml:lang="en">Cavitt J, Privitera M. Levetiracetam induces a rapid and sustained reduction of generalized spike-wave and clinical absence. Arch Neurol. 2004 Oct;61(10):1604-7.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Yacubian EM, de Araujo Filho GM. Management issues for patients with idiopathic generalized epilepsies. Epileptology. 2013 Mar; 1(1):1-10.</mixed-citation><mixed-citation xml:lang="en">Yacubian EM, de Araujo Filho GM. Management issues for patients with idiopathic generalized epilepsies. Epileptology. 2013 Mar; 1(1):1-10.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">French JA, Krauss GL, Wechsler RT, et al. Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy A randomized trial. Neurology. 2015 Sep 15;85(11):950-7.</mixed-citation><mixed-citation xml:lang="en">Yacubian EM, de Araujo Filho GM. Management issues for patients with idiopathic generalized epilepsies. Epileptology. 2013 Mar; 1(1):1-10.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Gesche J, Khanevski M, Solberg C, et al. Resistance to valproic acid as predictor of treatment resistance in genetic generalized epilepsies. Epilepsia. 2017 Apr;58(4):e64-e69. doi: 10.1111/epi.13702. Epub 2017 Feb 23.</mixed-citation><mixed-citation xml:lang="en">French JA, Krauss GL, Wechsler RT, et al. Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy A randomized trial. Neurology. 2015 Sep 15;85(11):950-7.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Карлов ВА, Гехт АБ, Гузева ВИ и др. Алгоритмы моно- и политерапии в клинической эпилептологии. Часть 1. Общие принципы выбора фармакотерапии. Журнал неврологии и психиатрии им. С.С. Корсакова. 2016;116(6):109-14.</mixed-citation><mixed-citation xml:lang="en">French JA, Krauss GL, Wechsler RT, et al. Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy A randomized trial. Neurology. 2015 Sep 15;85(11):950-7.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Власов ПН. Применение вальпроатов у женщин детородного возраста и беременных, страдающих эпилепсией. Неврология, нейропсихиатрия, психосоматика. 2015; 7(1S):4-9. doi: 10.14412/2074-2711-2015-1S-4-9</mixed-citation><mixed-citation xml:lang="en">Gesche J, Khanevski M, Solberg C, et al. Resistance to valproic acid as predictor of treatment resistance in genetic generalized epilepsies. Epilepsia. 2017 Apr;58(4):e64-e69. doi: 10.1111/epi.13702. Epub 2017 Feb 23.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Nevitt SJ, Sudell M, Weston J, et al. Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. Cochrane Database Syst Rev. 2017 Dec 15;12:CD011412. doi: 10.1002/14651858.CD011412.pub3.</mixed-citation><mixed-citation xml:lang="en">Gesche J, Khanevski M, Solberg C, et al. Resistance to valproic acid as predictor of treatment resistance in genetic generalized epilepsies. Epilepsia. 2017 Apr;58(4):e64-e69. doi: 10.1111/epi.13702. Epub 2017 Feb 23.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Власов ПН. Применение вальпроата и карбамазепина в терапии эпилепсии (в помощь практическому врачу). Неврология, нейропсихиатрия, психосоматика. 2018; 10 (4):129-38. doi: 10.14412/2074-2711-2018-4-129-138</mixed-citation><mixed-citation xml:lang="en">Karlov VA, Gekht AB, Guzeva VI, et al. Algorithms of mono - and polytherapy in clinical epileptology. Part 1. General principles for selection of pharmacotherapy. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2016;116(6):109-14. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Карлов ВА, Андреева ОВ. Применение инъекционного депакина при лечении эпилептического статуса. Русский медицинский журнал. 2001;20(9):889-93.</mixed-citation><mixed-citation xml:lang="en">Karlov VA, Gekht AB, Guzeva VI, et al. Algorithms of mono - and polytherapy in clinical epileptology. Part 1. General principles for selection of pharmacotherapy. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2016;116(6):109-14. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Shorvon SD. Oxford Textbook of Epilepsy and Epileptic Seizures. Oxford University Press; 2010.</mixed-citation><mixed-citation xml:lang="en">Vlasov PN. Use of valproates in women of childbearing age and pregnant women with epilepsy. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2015;7(1S): 4-9. (In Russ.). doi: 10.14412/2074-2711-2015-1S-4-9</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Kwan P, Brodie MJ. Epilepsy after the first drug fails: substitution or add-on? Seizure. 2000 Oct;9(7):464-8.</mixed-citation><mixed-citation xml:lang="en">Vlasov PN. Use of valproates in women of childbearing age and pregnant women with epilepsy. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2015;7(1S): 4-9. (In Russ.). doi: 10.14412/2074-2711-2015-1S-4-9</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Deckers CL, Hekster YA, Keyser A, et al. Monotherapy versus polytherapy for epilepsy: a multicenter double-blind randomized study. Epilepsia. 2001 Nov;42(11):1387-94.</mixed-citation><mixed-citation xml:lang="en">Nevitt SJ, Sudell M, Weston J, et al. Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. Cochrane Database Syst Rev.  2017 Dec 15;12:CD011412. doi: 10.1002/14651858.CD011412.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Millul A, Iudice A, Adami M, et al. Alternative monotherapy or add-on therapy in patients with epilepsy whose seizures do not respond to the first monotherapy: an Italian multicenter prospective observational study. Epilepsy Behav. 2013 Sep;28(3):494-500. doi: 10.1016/j.yebeh.2013.05.038. Epub 2013 Jul 26.</mixed-citation><mixed-citation xml:lang="en">Nevitt SJ, Sudell M, Weston J, et al. Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. Cochrane Database Syst Rev.  2017 Dec 15;12:CD011412. doi: 10.1002/14651858.CD011412.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Vlasov PN. Use of valproate and carbamazepine in the therapy of epilepsy (guidelines for the practitioner). Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10 (4): 129-38. (In Russ.)]. doi: 10.14412/2074-2711-2018-4-129-138</mixed-citation><mixed-citation xml:lang="en">Vlasov PN. Use of valproate and carbamazepine in the therapy of epilepsy (guidelines for the practitioner). Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10 (4): 129-38. (In Russ.)]. doi: 10.14412/2074-2711-2018-4-129-138</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Vlasov PN. Use of valproate and carbamazepine in the therapy of epilepsy (guidelines for the practitioner). Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10 (4): 129-38. (In Russ.)]. doi: 10.14412/2074-2711-2018-4-129-138</mixed-citation><mixed-citation xml:lang="en">Vlasov PN. Use of valproate and carbamazepine in the therapy of epilepsy (guidelines for the practitioner). Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10 (4): 129-38. (In Russ.)]. doi: 10.14412/2074-2711-2018-4-129-138</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Karlov VA, Andreeva OV. The use of injection depakin in the treatment of epileptic status. Russkii meditsinskii zhurnal. 2001;20(9):889-93. (In Russ.).</mixed-citation><mixed-citation xml:lang="en">Karlov VA, Andreeva OV. The use of injection depakin in the treatment of epileptic status. Russkii meditsinskii zhurnal. 2001;20(9):889-93. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Karlov VA, Andreeva OV. The use of injection depakin in the treatment of epileptic status. Russkii meditsinskii zhurnal. 2001;20(9):889-93. (In Russ.).</mixed-citation><mixed-citation xml:lang="en">Karlov VA, Andreeva OV. The use of injection depakin in the treatment of epileptic status. Russkii meditsinskii zhurnal. 2001;20(9):889-93. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Shorvon SD. Oxford Textbook of Epilepsy and Epileptic Seizures. Oxford University Press; 2010.</mixed-citation><mixed-citation xml:lang="en">Shorvon SD. Oxford Textbook of Epilepsy and Epileptic Seizures. Oxford University Press; 2010.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Shorvon SD. Oxford Textbook of Epilepsy and Epileptic Seizures. Oxford University Press; 2010.</mixed-citation><mixed-citation xml:lang="en">Shorvon SD. Oxford Textbook of Epilepsy and Epileptic Seizures. Oxford University Press; 2010.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kwan P, Brodie MJ. Epilepsy after the first drug fails: substitution or add-on? Seizure. 2000 Oct;9(7):464-8.</mixed-citation><mixed-citation xml:lang="en">Kwan P, Brodie MJ. Epilepsy after the first drug fails: substitution or add-on? Seizure. 2000 Oct;9(7):464-8.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Kwan P, Brodie MJ. Epilepsy after the first drug fails: substitution or add-on? Seizure. 2000 Oct;9(7):464-8.</mixed-citation><mixed-citation xml:lang="en">Kwan P, Brodie MJ. Epilepsy after the first drug fails: substitution or add-on? Seizure. 2000 Oct;9(7):464-8.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Deckers CL, Hekster YA, Keyser A, et al. Monotherapy versus polytherapy for epilepsy: a multicenter double-blind randomized study. Epilepsia. 2001 Nov;42(11):1387-94.</mixed-citation><mixed-citation xml:lang="en">Deckers CL, Hekster YA, Keyser A, et al. Monotherapy versus polytherapy for epilepsy: a multicenter double-blind randomized study. Epilepsia. 2001 Nov;42(11):1387-94.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Deckers CL, Hekster YA, Keyser A, et al. Monotherapy versus polytherapy for epilepsy: a multicenter double-blind randomized study. Epilepsia. 2001 Nov;42(11):1387-94.</mixed-citation><mixed-citation xml:lang="en">Deckers CL, Hekster YA, Keyser A, et al. Monotherapy versus polytherapy for epilepsy: a multicenter double-blind randomized study. Epilepsia. 2001 Nov;42(11):1387-94.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Millul A, Iudice A, Adami M, et al. Alternative monotherapy or add-on therapy in patients with epilepsy whose seizures do not respond to the first monotherapy: an Italian multicenter prospective observational study. Epilepsy Behav. 2013 Sep;28(3):494-500. doi: 10.1016/j.yebeh.2013.05.038. Epub 2013 Jul 26.</mixed-citation><mixed-citation xml:lang="en">Millul A, Iudice A, Adami M, et al. Alternative monotherapy or add-on therapy in patients with epilepsy whose seizures do not respond to the first monotherapy: an Italian multicenter prospective observational study. Epilepsy Behav. 2013 Sep;28(3):494-500. doi: 10.1016/j.yebeh.2013.05.038. Epub 2013 Jul 26.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Millul A, Iudice A, Adami M, et al. Alternative monotherapy or add-on therapy in patients with epilepsy whose seizures do not respond to the first monotherapy: an Italian multicenter prospective observational study. Epilepsy Behav. 2013 Sep;28(3):494-500. doi: 10.1016/j.yebeh.2013.05.038. Epub 2013 Jul 26.</mixed-citation><mixed-citation xml:lang="en">Millul A, Iudice A, Adami M, et al. Alternative monotherapy or add-on therapy in patients with epilepsy whose seizures do not respond to the first monotherapy: an Italian multicenter prospective observational study. Epilepsy Behav. 2013 Sep;28(3):494-500. doi: 10.1016/j.yebeh.2013.05.038. Epub 2013 Jul 26.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
