nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2020-1-39-44nnp-1259Research ArticleORIGINAL INVESTIGATIONSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИComparative efficacy and tolerance of centrally acting muscle relaxants in elderly patients with nonspecific musculoskeletal painСравнительная эффективность и переносимость центральных миорелаксантов у пациентов пожилого возраста с неспецифической скелетно-мышечной больюГоренковР. В.GorenkovR. V.ДадашеваМ. Н.DadashevaM. N.donveles777@inbox.ruЗолотовскаяИ. А.ZolotovskayaI. A.КругловВ. А.KruglovV. A.Высшая школа управления здравоохранением Института лидерства и управления здравоохранением ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский университет)»
Минздрава РоссииРоссияHigher School of Health Management, Institute of Healthcare Leadership and Management, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian FederationГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»РоссияM.F. Vladimirsky Moscow Regional Research Clinical InstituteRussian FederationФГБОУ ВО «Самарский государственный медицинский университет» Минздрава РоссииРоссияSamara State Medical University, Ministry of Health of RussiaRussian Federation2020190220201213944Copyright © Gorenkov R.V., Dadasheva M.N., Zolotovskaya I.A., Kruglov V.A., 20202020Горенков Р.В., Дадашева М.Н., Золотовская И.А., Круглов В.А.Gorenkov R.V., Dadasheva M.N., Zolotovskaya I.A., Kruglov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1259острая неспецифическая скелетно-мышечная больцентральные миорелаксантынимесулид (немулекс)толперизон (калмирекс)тизанидинбаклофенacute nonspecific musculoskeletal paincentrally acting muscle relaxantsnimesulide (nemulex)tolperisone (calmyrex)tizanidinebaclofenПубликация статьи поддержана ЗАО «ФармФирма «Сотекс».ReferencesPatel K, Guralnik J, Dansie E, Turk D. Prevalence and impact of pain among older adults in the United States: Findings from the 2011 National Health and Aging Trends Study. Pain. 2013 Dec;154(12):2649-57. doi: 10.1016/j.pain.2013.07.029.Patel K, Guralnik J, Dansie E, Turk D. Prevalence and impact of pain among older adults in the United States: Findings from the 2011 National Health and Aging Trends Study. Pain. 2013 Dec;154(12):2649-57. doi: 10.1016/j.pain.2013.07.029.Яхно НН, Кукушкин МЛ, редакторы. Боль. Практическое руководство для врачей. Москва: Издательство РАМН; 2011. 565 с.Yakhno NN, Kukushkin ML, editors. Bol'. Prakticheskoe rukovodstvo dlya vrachei [Pain. Practical guide for doctors]. Moscow: Izdatel'stvo RAMN; 2011. 565 p.Weiner DK, Fang M, Gentili A, et al. Deconstructing chronic low back pain in the older adult-step by step evidence and expertbased recommendations for evaluation and treatment. Part I: Hip osteoarthritis. Pain Med. 2015 May;16(5):886-97. doi: 10.1111/pme.12757. Epub 2015 Apr 3.Weiner DK, Fang M, Gentili A, et al. Deconstructing chronic low back pain in the older adult-step by step evidence and expertbased recommendations for evaluation and treatment. Part I: Hip osteoarthritis. Pain Med. 2015 May;16(5):886-97. doi: 10.1111/pme.12757. Epub 2015 Apr 3.Парфенов ВА, Яхно НН, Кукушкин МЛ и др. Острая неспецифическая (скелетномышечная) поясничная боль: Рекомендации Российского общества по изучению боли (РОИБ). Неврология, нейропсихиатрия, психосоматика. 2018;10(2):4–11. doi: 10.14412/2074-2711-2018-2-4-11Parfenov VA, Yakhno NN, Kukushkin ML, et al. Acute nonspecific (musculoskeletal) low back pain Guidelines of the Russian Society for the Study of Pain (RSSP). Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(2):4–11. (In Russ.). doi: 10.14412/2074-2711-2018-2-4-11Kim S, Lee T, Lim S. Prevalence of Disc Degeneration in Asymptomatic Korean Subjects. Part 1: Lumbar Spine. J Korean Neurosurg Soc. 2013 Jan;53(1):31-8. doi: 10.3340/jkns.2013.53.1.31. Epub 2013 Jan 31.Kim S, Lee T, Lim S. Prevalence of Disc Degeneration in Asymptomatic Korean Subjects. Part 1: Lumbar Spine. J Korean Neurosurg Soc. 2013 Jan;53(1):31-8. doi: 10.3340/jkns.2013.53.1.31. Epub 2013 Jan 31.Treede RD, Jensen TS, Campbell JN, et al. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology. 2008 Apr 29;70(18):1630-5. Epub 2007 Nov 14.Treede RD, Jensen TS, Campbell JN, et al. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology. 2008 Apr 29;70(18):1630-5. Epub 2007 Nov 14.Lisi AJ, Breuer P, Gallagher RM, et al. Deconstructing chronic low back pain in the older adult-step by step evidence and expertbased recommendations for evaluation and treatment. Part II: Myofascial pain. Pain Med. 2015 Jul;16(7):1282-9. doi: 10.1111/pme.12821. Epub 2015 Jun 18.Lisi AJ, Breuer P, Gallagher RM, et al. Deconstructing chronic low back pain in the older adult-step by step evidence and expertbased recommendations for evaluation and treatment. Part II: Myofascial pain. Pain Med. 2015 Jul;16(7):1282-9. doi: 10.1111/pme.12821. Epub 2015 Jun 18.Fatemi G, Fang MA, Breuer P, et al. Deconstructing chronic low back pain in the older adult-step by step evidence and expertbased recommendations for evaluation and treatment. Part III: Fibromyalgia syndrome. Pain Med. 2015 Sep;16(9):1709-19. doi: 10.1111/pme.12863. Epub 2015 Aug 14.Fatemi G, Fang MA, Breuer P, et al. Deconstructing chronic low back pain in the older adult-step by step evidence and expertbased recommendations for evaluation and treatment. Part III: Fibromyalgia syndrome. Pain Med. 2015 Sep;16(9):1709-19. doi: 10.1111/pme.12863. Epub 2015 Aug 14.Carley JA, Karp JF, Gentili A, et al. Deconstructing chronic low back pain in the older adult-step by step evidence and expertbased recommendations for evaluation and treatment. Part IV: Depression. Pain Med. 2015 Nov; 16(11):2098-108. doi: 10.1111/pme.12935. Epub 2015 Nov 5.Carley JA, Karp JF, Gentili A, et al. Deconstructing chronic low back pain in the older adult-step by step evidence and expertbased recommendations for evaluation and treatment. Part IV: Depression. Pain Med. 2015 Nov; 16(11):2098-108. doi: 10.1111/pme.12935. Epub 2015 Nov 5.DiNapoli EA, Craine M, Dougherty P, et al. Deconstructing chronic low back pain in the older adult-step by step evidence and expertbased recommendations for evaluation and treatment. Part V: Maladaptive coping. Pain Med. 2016 Jan;17(1):64-73. doi: 10.1093/pm/pnv055.DiNapoli EA, Craine M, Dougherty P, et al. Deconstructing chronic low back pain in the older adult-step by step evidence and expertbased recommendations for evaluation and treatment. Part V: Maladaptive coping. Pain Med. 2016 Jan;17(1):64-73. doi: 10.1093/pm/pnv055.Каратеев АЕ, Насонов ЕЛ, Яхно НН и др. Клинические рекомендации «Рациональное применение нестероидных противовоспалительных препаратов (НПВП) в клинической практике». Современная ревматология. 2015;(1):4–23. doi: 10.14412/1996-7012-2015-1-4-23Karateev AE, Nasonov EL, Yakhno NN, et al. Clinical guidelines «Rational use of nonsteroidal anti-inflammatory drugs (NSAIDs) in clinical practice». Sovremennaya revmatologiya = Modern Rheumatology Journal. 2015;(1):4–23. (In Russ.). doi: 10.14412/1996-7012-2015-1-4-23Xu S, Rouzer CA, Marnett LJ. Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond. IUBMB Life. 2014 Dec; 66(12):803-11. doi: 10.1002/iub.1334. Epub 2014 Dec 23.Xu S, Rouzer CA, Marnett LJ. Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond. IUBMB Life. 2014 Dec; 66(12):803-11. doi: 10.1002/iub.1334. Epub 2014 Dec 23.van Tulder MW, Touray T, Furlan AD, et al; Cochrane Back Review Group (2003). Muscle relaxants for nonspecific low back pain: A systematic review within the framework of the cochrane collaboration. Spine (Phila Pa 1976). 2003 Sep 1;28(17):1978-92.van Tulder MW, Touray T, Furlan AD, et al; Cochrane Back Review Group (2003). Muscle relaxants for nonspecific low back pain: A systematic review within the framework of the cochrane collaboration. Spine (Phila Pa 1976). 2003 Sep 1;28(17):1978-92.Кукушкин МЛ. Алгоритмы диагностики и лечения больных с болью в спине. Российский журнал боли. 2014:(3–4):3-6.Kukushkin ML. Algorithms for diagnosis and treatment of patients with back pain. Rossiiskii zhurnal boli. 2014:(3–4):3-6. (In Russ.).Павленко СС. Боли в нижней части спины (эпидемиология, клинико-диагностическая классификация, современные направления в диагностике, лечении и стандартизации медицинской помощи). Новосибирск: Сибмедиздат НГМУ; 2007. 172 с.Pavlenko SS. Boli v nizhnei chasti spiny (epidemiologiya, kliniko-diagnosticheskaya klassifikatsiya, sovremennye napravleniya v diagnostike, lechenii i standartizatsii meditsinskoi pomoshchi) [Lower back pain (epidemiology, clinical and diagnostic classification, current trends in diagnosis, treatment and standardization of medical care]. Novosibirsk: Sibmedizdat NGMU; 2007. 172 p.Mafi JN, McCarthy EP, Davis RB, Landon BE. Worsening trends in the management and treatment of back pain. JAMA Intern Med. 2013 Sep 23;173(17):1573-81. doi: 10.1001/jamainternmed.2013.8992.Mafi JN, McCarthy EP, Davis RB, Landon BE. Worsening trends in the management and treatment of back pain. JAMA Intern Med. 2013 Sep 23;173(17):1573-81. doi: 10.1001/jamainternmed.2013.8992.Чиба Л, Жусупова AС, Лихачев СА и др. Систематический обзор применения миорелаксантов в лечении болей в пояснице. Журнал неврологии и психиатрии им. С.С. Корсакова. 2018;118(12):100-13.Chiba L, Zhusupova AS, Likhachev SA, et al. Systematic review of the use of muscle relaxants in the treatment of low back pain. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2018; 118(12):100-13. (In Russ.).Weiner DK, Gentili A, Rossi M, et al. Aging Back Clinics-a Geriatric Syndrome Approach to Treating Chronic Low Back Pain in Older Adults: Results of a Preliminary Randomized Controlled Trial. Pain Med. 2019 Sep 10. pii: pnz179. doi: 10.1093/pm/pnz179. [Epub ahead of print].Weiner DK, Gentili A, Rossi M, et al. Aging Back Clinics-a Geriatric Syndrome Approach to Treating Chronic Low Back Pain in Older Adults: Results of a Preliminary Randomized Controlled Trial. Pain Med. 2019 Sep 10. pii: pnz179. doi: 10.1093/pm/pnz179. [Epub ahead of print].Pareek A, Chandurkar N, Chandanwale AS, et al. Aceclofenac–tizanidine in the treatment of acute low back pain: a double-blind, doubledummy, randomized, multicentric, comparative study against aceclofenac alone. Eur Spine J. 2009 Dec;18(12):1836-42. doi: 10.1007/s00586-009-1019-4. Epub 2009 May 7.Pareek A, Chandurkar N, Chandanwale AS, et al. Aceclofenac–tizanidine in the treatment of acute low back pain: a double-blind, doubledummy, randomized, multicentric, comparative study against aceclofenac alone. Eur Spine J. 2009 Dec;18(12):1836-42. doi: 10.1007/s00586-009-1019-4. Epub 2009 May 7.Kiel LB, Hoegberg LC, Jansen T, et al. A Nationwide Register Based Survey of Baclofen Toxicity. Basic Clin Pharmacol Toxicol. 2015 May;116(5):452-6. doi:10.1111/bcpt.12344. Epub 2014 Nov 22.Kiel LB, Hoegberg LC, Jansen T, et al. A Nationwide Register Based Survey of Baclofen Toxicity. Basic Clin Pharmacol Toxicol. 2015 May;116(5):452-6. doi:10.1111/bcpt.12344. Epub 2014 Nov 22.Montastruc J, Laborie I, Bagheri H, Senard M. Drug-induced orthostatic hypotension: A five-year experience in a regional pharmacovigilance centre in France. Clin Drug Invest.1997;14(1):61-65.Montastruc J, Laborie I, Bagheri H, Senard M. Drug-induced orthostatic hypotension: A five-year experience in a regional pharmacovigilance centre in France. Clin Drug Invest.1997;14(1):61-65.Остроумова ОД, Черняева МС, Петрова ММ, Головина ОВ. Ортостатическая гипотензия: определение, патофизиология, классификация, прогностические аспекты, диагностика и лечение. Рациональная фармакотерапия в кардиологии. 2018;14(5):747-56.Ostroumova OD, Chernyaeva MS, Petrova MM, Golovina OV. Orthostatic hypotension: definition, pathophysiology, classification, prognostic aspects, diagnosis and treatment. Ratsional'naya farmakoterapiya v kardiologii. 2018;14(5):747-56. (In Russ.).Sonnesyn H, Nilsen DW, Rongve A, et al. High prevalence of orthostatic hypotension in mild dementia. Dement Geriatr Cogn Disord. 2009;28(4):307-13. doi: 10.1159/000247586. Epub 2009 Oct 14.Sonnesyn H, Nilsen DW, Rongve A, et al. High prevalence of orthostatic hypotension in mild dementia. Dement Geriatr Cogn Disord. 2009;28(4):307-13. doi: 10.1159/000247586. Epub 2009 Oct 14.Хабиров ФА. Руководство по клинической неврологии позвоночника. Казань; 2006. 518 с.Khabirov FA. Rukovodstvo po klinicheskoi nevrologii pozvonochnika [Guide to clinical neurology of the spine]. Kazan'; 2006. 518 p..See S, Ginzburg R. Choosing a Skeletal Muscle Relaxant. Am Fam Physician. 2008 Aug 1;78(3):365-70.See S, Ginzburg R. Choosing a Skeletal Muscle Relaxant. Am Fam Physician. 2008 Aug 1;78(3):365-70.
The authors declare that there are no conflicts of interest present.