nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2019-4-57-60nnp-1210Research ArticleORIGINAL INVESTIGATIONSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕТОДИКИCOMT Val158Met (rs4680) polymorphism and vital exhaustion in an open 45–64-year-old population (international epidemiological WHO MONICA and HAPIEE programs)Полиморфизм Val158Met rs4680 гена COMT и жизненное истощение в открытой популяции 45–64 лет (международные эпидемиологические программы: ВОЗ MONICA, HAPIEE)ГафаровВ. В.GafarovV. V.

630089, Новосибирск, ул. Бориса Богаткова, 175/1

valery.gafarov@gmail.comГромоваЕ. А.GromovaE. A.

630089, Новосибирск, ул. Бориса Богаткова, 175/1

175/1, Boris Bogatkov St., Novosibirsk 630089

ПановД. О.PanovD. O.

630089, Новосибирск, ул. Бориса Богаткова, 175/1

175/1, Boris Bogatkov St., Novosibirsk 630089

МаксимовВ. Н.MaksimovV. N.

630089, Новосибирск, ул. Бориса Богаткова, 175/1

175/1, Boris Bogatkov St., Novosibirsk 630089

ГагулинИ. В.GagulinI. V.

630089, Новосибирск, ул. Бориса Богаткова, 175/1

175/1, Boris Bogatkov St., Novosibirsk 630089

КрымовЭ. А.KrymovE. A.

630089, Новосибирск, ул. Бориса Богаткова, 175/1

175/1, Boris Bogatkov St., Novosibirsk 630089

ГафароваА. В.GafarovaA. V.

175/1, Boris Bogatkov St., Novosibirsk 630089

Научно-исследовательский институт терапии и профилактической медицины – филиал Федерального исследовательского центра «НИИ цитологии и генетики» Сибирского отделения Российской академии наук; Межведомственная лаборатория эпидемиологии сердечно-сосудистых заболеванийРоссияResearch Institute of Internal and Preventive Medicine, Branch, Federal Research Center «Research Institute of Cytology and Genetics», Siberian Branch, Russian Academy of Sciences; Collaborative Laboratory of Cardiovascular Diseases EpidemiologyRussian FederationНаучно-исследовательский институт терапии и профилактической медицины – филиал Федерального исследовательского центра «НИИ цитологии и генетики» Сибирского отделения Российской академии наукРоссияResearch Institute of Internal and Preventive Medicine, Branch, Federal Research Center «Research Institute of Cytology and Genetics», Siberian Branch, Russian Academy of SciencesRussian Federation2019071220191145760Copyright © Gafarov V.V., Gromova E.A., Panov D.O., Maksimov V.N., Gagulin I.V., Krymov E.A., Gafarova A.V., 20192019Гафаров В.В., Громова Е.А., Панов Д.О., Максимов В.Н., Гагулин И.В., Крымов Э.А., Гафарова А.В.Gafarov V.V., Gromova E.A., Panov D.O., Maksimov V.N., Gagulin I.V., Krymov E.A., Gafarova A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/1210

Objective: to study the association of the polymorphic genotypes of rs4680 in the catechol-O-methyl transferase (COMT) gene with vital exhaustion (VE) in a 45–64-year-old population. Patients and methods. A representative sample of a 45–64-year-old population (781 men and 869 women) was surveyed within screening IV of the international Health, Alcohol and Psychological Factors in Eastern Europe (HAPIEE) program and the WHO MONICA-psychosocial program in 2003-2005. All the study participants filled out a VE scale of the WHO MONICA-psychosocial program. COMT Val158Met (rs4680) polymorphism was genotyped. Pearson' χ2 test was used to test the statistical significance of differences between these groups. The statistical significance level was taken to be p≤0.05 in all types of analysis. Results and discussion. Heterozygous G/A polymorphism in the COMT gene was most common in both the general population (48.6%) and men (44.4%) and women (51.5%). In the general population, the A/A genotype was more common in individuals with a high VE (HVE) level; in women and men, it was detected in 13.3 and 30.8% of cases, respectively. The G/G genotype prevailed in individuals with moderate VE in both the general population (31.1%) and women (29.7%) and men (33.3%). Conclusion. In the general population, the A/A genotype was found to be more common in individuals with HVE (18.6%), in women (13.3) and in men (30.8%).

Цель исследования – изучить ассоциацию полиморфных генотипов rs4680 гена катехол-О-метилтрансферазы (Catechol-O-methyl transferase, COMT) с жизненным истощением (ЖИ) в популяции 45–64 лет. Пациенты и методы. В рамках IV скрининга международной программы HAPIEE, программы ВОЗ MONICA-psychosocial в 2003–2005 гг. была обследована репрезентативная выборка населения в возрасте 45–64 лет (781 мужчина и 869 женщин). Все участники исследования заполняли шкалу для определения ЖИ программы ВОЗ MONICA-psychosocial. Было проведено генотипирование полиморфизма Val158Met (rs4680) гена COMT. Для проверки статистической значимости различий между группами использовали критерий χ2 Пирсона. Во всех видах анализа уровень статистической значимости был принят равным p≤0,05. Результаты и обсуждение. Как в общей популяции (48,6%), так и среди мужчин (44,4%) и женщин (51,5%), наиболее распространенным был гетерозиготный полиморфизм G/A гена COMT. Среди лиц с высоким уровнем ЖИ (ВЖИ) в общей популяции чаще встречался генотип A/A (18,6%), у женщин он выявлен в 13,3% случаев, у мужчин – в 30,8%. Генотип гена G/G преобладал у лиц со средним уровнем ЖИ как в общей популяции (31,1%), так и у женщин (29,7%) и мужчин (33,3%). Заключение. Установлено, что у лиц с ВЖИ в общей популяции чаще встречался генотип A/A (18,6%): у женщин – в 13,3% наблюдений, у мужчин – в 30,8%.

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The authors declare that there are no conflicts of interest present.